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Journal of the American Chemical Society, ISSN 0002-7863, 04/2018, Volume 140, Issue 15, pp. 5045 - 5048
Gluco-azoles competitively inhibit glucosidases by transition-state mimicry and their ability to interact with catalytic acid residues in glucosidase active... 
Azoles - chemistry | beta-Glucosidase - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Humans | Molecular Conformation | Enzyme Inhibitors - pharmacology | Models, Molecular | beta-Glucosidase - metabolism | Azoles - chemical synthesis | Azoles - pharmacology | Enzyme Inhibitors - chemical synthesis
Journal Article
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 04/2018, Volume 140, Issue 15, pp. 5045 - 5048
Gluco-azoles competitively inhibit glucosidases by transition-state mimicry and their ability to interact with catalytic acid residues in glucosidase active... 
GLUCOCEREBROSIDASE | ACID | CHAPERONES | MECHANISM | GLYCOSIDASE INHIBITORS | NAGSTATIN | CELLOBIOSE | BINDING | CHEMISTRY, MULTIDISCIPLINARY | GAUCHER-DISEASE | Usage | Imidazole | Chemical reactions | Chemical properties | Research | Glucose | Chemical synthesis | Transition state (Chemistry) | Dextrose | Communication
Journal Article
The Journal of Biological Chemistry, ISSN 0021-9258, 12/2014, Volume 289, Issue 51, pp. 35351 - 35362
Retaining β-exoglucosidases operate by a mechanism in which the key amino acids driving the glycosidic bond hydrolysis act as catalytic acid/base and... 
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 2014, Volume 12, Issue 39, pp. 7786 - 7791
The natural product, cyclophellitol and its aziridine analogue are potent mechanism-based retaining β-glucosidase inhibitors. In this paper we explore the... 
(+)-CYCLOPHELLITOL | BIOCHEMISTRY | NOJIRIMYCIN | CHEMISTRY, ORGANIC | GLYCOSIDASE INHIBITORS | IN-SITU | ACTIVITY-BASED PROBES | GLYCOBIOLOGY | beta-Glucosidase - antagonists & inhibitors | Cyclohexanols - pharmacology | Cyclohexanols - chemistry | Enzyme Inhibitors - chemistry | Humans | Enzyme Inhibitors - pharmacology | Index Medicus
Journal Article
Chemistry, ISSN 0947-6539, 08/2014, Volume 20, Issue 35, pp. 10864 - 10872
Activity-based protein profiling has emerged as a powerful discovery tool in chemical biology and medicinal chemistry research. Success of activity-based... 
Journal Article
Journal of biological chemistry, ISSN 0021-9258, 2014, Volume 289, Issue 51, pp. 35351 - 35362
Journal Article
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, ISSN 1099-0690, 2014, Volume 2014, Issue 27, pp. 6030 - 6043
Cyclitol epoxides and aziridines are potent and selective irreversible inhibitors of retaining glycosidases. We have previously reported on our studies on the... 
Azides | Enzyme inhibitors | Aziridines | Fluorescent probes | Epoxides | Cyclitols | D-XYLOSE | (+)-CYCLOPHELLITOL | CONVERSION | CHEMISTRY, ORGANIC | GLYCOSIDASE INHIBITORS | PROBES | BODIPY DYES | CYCLOADDITION | BETA-GLUCOSIDASE INHIBITOR | BIOCHEMISTRY | IN-SITU | Glucose metabolism | Enzymes | Glucose | Dextrose | Cellulose
Journal Article
Organic & Biomolecular Chemistry, ISSN 1477-0520, 10/2014, Volume 12, Issue 39, pp. 7786 - 7791
The natural product, cyclophellitol and its aziridine analogue are potent mechanism-based retaining beta-glucosidase inhibitors. In this paper we explore the... 
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 09/2014, Issue 27, pp. 6030 - 6043
Cyclitol epoxides and aziridines are potent and selective irreversible inhibitors of retaining glycosidases. We have previously reported on our studies on the... 
Journal Article
Angewandte Chemie, ISSN 1433-7851, 12/2012, Volume 51, Issue 50, p. 12529
  A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian [beta]-glucosidases (GBA1, GBA2,... 
Journal Article
ChemBioChem, ISSN 1439-4227, 05/2011, Volume 12, Issue 8, pp. 1263 - 1269
Activity-based protein profiling (ABPP) is a versatile strategy to report on enzyme activity in vitro, in situ, and in vivo. The development and use of ABPP... 
Journal Article
ChemBioChem, ISSN 1439-7633, 2011, Volume 12, Issue 8, pp. 1263 - 1269
Activity-based protein profiling (ABPP) is a versatile strategy to report on enzyme activity in vitro, in situ, and in vivo. The development and use of ABPP... 
Journal Article
Nature Chemical Biology, ISSN 1552-4469, 2010, Volume 6, Issue 12, pp. 907 - 913
Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been... 
Journal Article
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