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PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e25454
The DNA damage response (DDR) encompasses multi-step processes by which cells evolve to sense DNA damage, transduce the signal and initiate the repair of... 
CELLS | REPAIR | METHYLATION | PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | DOUBLE-STRAND BREAKS | HOMOLOGOUS RECOMBINATION | MUTATIONS | MICRORNA EXPRESSION | CHECKPOINTS | Tumor Suppressor Proteins - metabolism | Recombinational DNA Repair - genetics | Humans | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | 3' Untranslated Regions - genetics | Radiation Tolerance - genetics | Signal Transduction - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Down-Regulation - genetics | DNA-Binding Proteins - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cell Line, Tumor | DNA Damage - genetics | Adult | Cell Cycle Checkpoints - genetics | Female | MicroRNAs - genetics | Protein-Serine-Threonine Kinases - metabolism | Prevention | DNA damage | DNA | Ataxia telangiectasia | Ataxia | DNA repair | Cancer | Transcription factors | Radiosensitivity | Laboratories | Genes | Biological evolution | Homologous recombination | Homology | Biochemistry | Kinases | Cell adhesion & migration | Proteins | Homologous recombination repair | Signal transduction | Cell cycle | Damage | Repair | Deoxyribonucleic acid--DNA | Breast cancer | siRNA | Substrates | Augmentation | Medicine | Molecular modelling | 3' Untranslated regions | MicroRNAs | Cell lines | Regulatory mechanisms (biology) | Irradiation | Ataxia telangiectasia mutated protein | Mutation | Apoptosis | Deoxyribonucleic acid
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2009, Volume 119, Issue 12, pp. 3626 - 3636
The polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is dysregulated in various cancers, and its upregulation strongly correlates... 
MEDICINE, RESEARCH & EXPERIMENTAL | BREAST-CANCER CELLS | DEVELOPMENTAL REGULATORS | CELLULAR MEMORY | E-CADHERIN EXPRESSION | HEMATOPOIETIC STEM-CELLS | PROSTATE-CANCER | MYC TRANSGENIC MICE | SELF-RENEWAL | NF-KAPPA-B | TRANSCRIPTION FACTOR | Nasopharyngeal Neoplasms - genetics | Neoplasm Transplantation | Nasopharyngeal Neoplasms - metabolism | Epithelial Cells - metabolism | Cadherins - metabolism | Humans | Glycogen Synthase Kinase 3 beta | Transplantation, Heterologous | Phosphatidylinositol 3-Kinases - metabolism | Mesoderm - cytology | Repressor Proteins - antagonists & inhibitors | Nasopharyngeal Neoplasms - pathology | Cadherins - genetics | Epithelial Cells - cytology | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Nasopharyngeal Neoplasms - etiology | Snail Family Transcription Factors | Nasopharynx - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | PTEN Phosphohydrolase - genetics | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Neoplasm Invasiveness | Down-Regulation | Gene Silencing | PTEN Phosphohydrolase - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Glycogen Synthase Kinase 3 - metabolism | Transcription Factors - metabolism | Animals | Polycomb Repressive Complex 1 | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mesoderm - metabolism | Mice | Nasopharynx - cytology | Chromatin | Care and treatment | Lymphomas | Research | Analysis | Cancer
Journal Article
The Journal of infectious diseases, ISSN 0022-1899, 05/2019, Volume 220, Issue 9, pp. 1540 - 1542
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, p. e19946
The aim of this study was to investigate the mechanism through which Sphingosine kinase-1 (SPHK1) exerts its antiapoptosis activity in glioma cancer cells. We... 
BREAST-CANCER | SURVIVAL | FORKHEAD TRANSCRIPTION FACTOR | LUNG-CANCER | AKT ACTIVATION | HUMAN GLIOBLASTOMA CELLS | BIM | BIOLOGY | BCL-2 FAMILY-MEMBERS | UP-REGULATION | EXPRESSION | RNA, Small Interfering - genetics | Phosphorylation | Luciferases - metabolism | Humans | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Immunoenzyme Techniques | Proto-Oncogene Proteins c-akt - genetics | Glioma - metabolism | Glioma - genetics | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Glioma - pathology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins - metabolism | Signal Transduction | Membrane Proteins - genetics | Phosphatidylinositol 3-Kinase | RNA, Messenger - genetics | Brain Neoplasms - genetics | Phosphotransferases (Alcohol Group Acceptor) - genetics | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Animals | Mice, Nude | Mice | Forkhead Box Protein O3 | Apoptosis | Development and progression | Gliomas | Sphingosine | Motility | Bax protein | Bcl-2 protein | Transcription | Laboratories | Brain tumors | Brain cancer | Colorectal cancer | AKT protein | Kinases | Inactivation | Cancer therapies | Tropical diseases | Proteins | Cell growth | Education | Rodents | Glioma cells | Cell cycle | Tumorigenesis | FOXO3 protein | Sphingosine kinase | Deactivation | RNA-mediated interference | Pharmacology | Disease control | Mcl-1 protein | 1-Phosphatidylinositol 3-kinase | Medicine | Ribonucleic acids | Hypoxia | In vivo methods and tests | BIM protein | Cancer | Tumors
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e99419
Background: Acute lower respiratory infections (ALRIs) are an important cause of acute illnesses and mortality worldwide and in China. However, a large-scale... 
GLOBAL BURDEN | MORTALITY | CHILDHOOD PNEUMONIA | MULTIDISCIPLINARY SCIENCES | HUMAN METAPNEUMOVIRUS | SEASONAL INFLUENZA | SURVEILLANCE | SYNCYTIAL VIRUS | YOUNG-CHILDREN | Metapneumovirus - isolation & purification | Humans | Middle Aged | Child, Preschool | Infant | Male | Adenoviridae - pathogenicity | Adenoviridae - isolation & purification | Paramyxoviridae Infections - virology | Respiratory Syncytial Virus Infections - etiology | China | Respiratory Syncytial Virus Infections - blood | Adult | Female | Respiratory Tract Infections - etiology | Respiratory Tract Infections - virology | Seasons | Paramyxoviridae Infections - blood | Respiratory Syncytial Virus Infections - virology | Child | Coronavirus - isolation & purification | Coronavirus - pathogenicity | Paramyxoviridae Infections - etiology | Metapneumovirus - pathogenicity | Respiratory Syncytial Viruses - isolation & purification | Bocavirus - isolation & purification | Bocavirus - pathogenicity | Adolescent | Aged | Orthomyxoviridae - pathogenicity | Orthomyxoviridae - isolation & purification | Respiratory Syncytial Viruses - pathogenicity | Respiratory Tract Infections - blood | Elderly people | Pneumonia | Vaccination | Viruses | Systematic review | Infections | Epidemiology | Tropical diseases | Streptococcus infections | Illnesses | Etiology | Medical laboratories | Children | Parainfluenza | Public health | Mortality | Hospitalization | Patients | Disease control | Disease prevention | Infectious diseases | Respiratory syncytial virus | Hospitals | Surveillance | Influenza | Adenoviruses | Adults | Diagnostic systems | Elderly | Viral infections | Geriatrics
Journal Article