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1. Full Text Activity and safety of ceritinib in patients with ALK -rearranged non-small-cell lung cancer (ASCEND-1): updated results from the multicentre, open-label, phase 1 trial
by Kim, Dong-Wan, MD and Mehra, Ranee, MD and Tan, Daniel S W, MD and Felip, Enriqueta, MD and Chow, Laura Q M, MD and Camidge, D Ross, Prof and Vansteenkiste, Johan, Prof and Sharma, Sunil, Prof and De Pas, Tommaso, MD and Riely, Gregory J, MD and Solomon, Benjamin J, MBBS and Wolf, Jürgen, Prof and Thomas, Michael, Prof and Schuler, Martin, Prof and Liu, Geoffrey, MD and Santoro, Armando, Prof and Sutradhar, Santosh, PhD and Li, Siyu, PhD and Szczudlo, Tomasz, MD and Yovine, Alejandro, MD and Shaw, Alice T, Dr
Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 17, Issue 4, pp. 452 - 463
Summary Background ALK -rearranged non-small-cell lung cancer (NSCLC) is sensitive to ALK tyrosine kinase inhibitors (ALK inhibitors) such as crizotinib, but... 
Hematology, Oncology and Palliative Medicine | TYROSINE KINASE INHIBITORS | ONCOLOGY | CLINICAL BENEFIT | ADULT PATIENTS PTS | DISEASE | ACQUIRED-RESISTANCE | BRAIN METASTASES | CRIZOTINIB | SINGLE-ARM | CSF CONCENTRATION | CHEMOTHERAPY | Carcinoma, Non-Small-Cell Lung - pathology | Carcinoma, Non-Small-Cell Lung - genetics | Pyrimidines - administration & dosage | Humans | Middle Aged | Sulfones - adverse effects | Male | Protein Kinase Inhibitors - adverse effects | Blood-Brain Barrier - drug effects | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Receptor Protein-Tyrosine Kinases - genetics | Gene Rearrangement | Pyrimidines - adverse effects | Adult | Female | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Sulfones - administration & dosage | Tyrosine | Care and treatment | Product development | Lung cancer, Non-small cell | Analysis
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2. Full Text Season and temperature modify the short-term effect of nitrogen dioxide on cardiovascular mortality: a time-series study
by Duan, Yanran and Liu, Xuehan and Li, Hongyan and Yan, Siyu and Yan, Mingming and Mang, Yilie and Yin, Ping
The Lancet, ISSN 0140-6736, 10/2019, Volume 394, pp. S57 - S57
Abstract Background Global climate change has increased concerns about the interactive effects of temperature and air pollution on human health. The aim of... 
Weather | Global temperature changes | Analysis | Mortality | China | Air pollution | Aged | Nitrogen dioxide | Health aspects | Environmental health | Pollution monitoring | High temperature | Meteorological services | Disease control | Climate change | Synergistic effects | Side effects | Pollution | Temperature effects | Cold season | Air temperature | Pollution effects | Aging | Aging (natural) | Pollutants | Cardiovascular diseases | Public health | Low temperature | Air pollution effects
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3. Full Text Association of ORAI1 Gene Polymorphisms with Chronic Spontaneous Urticaria and the Efficacy of the Nonsedating H1-antihistamine Desloratadine
by Li, Jie, MD, PhD and Guo, Aiyuan, MD, PhD and Chen, Wangqing, PhD and Bin, Lianghua, PhD and He, Yijing, MD, PhD and Zhu, Wu, MD, PhD and Yan, Siyu, MD and Peng, Cong, PhD and Chen, Mingliang, MD, PhD and Zhang, Jianglin, MD, PhD and Su, Juan, MD, PhD and Yi, Mei, MD, PhD and Liu, Zhaoqian, MD, PhD and Zhang, Wei, MD, PhD and Zeng, Weiqi, PhD and Leung, Donald Y.M., MD, PhD and Chen, Xiang, MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 4, pp. 1386 - 1388.e9
Capsule Summary Human ORAI1 polymorphisms were associated with susceptibility to CSU, and the South Han Chinese CSU who carry rs3741595C allele have reduced... 
Allergy and Immunology | NASOPHARYNGEAL MICROBIOTA | PROSPECTIVE MULTICENTER | ALLERGY | SEVERE BRONCHIOLITIS | DISEASE | GENOMIC LOAD | OUTCOMES | IMMUNOLOGY | RESPIRATORY SYNCYTIAL VIRUS | SEVERITY | CHILDREN | UNIFRAC | Genetic Predisposition to Disease - genetics | ORAI1 Protein - genetics | Genetic Association Studies | Histamine H1 Antagonists, Non-Sedating - therapeutic use | Humans | Middle Aged | Urticaria - genetics | Genotype | Male | Urticaria - drug therapy | Polymorphism, Single Nucleotide - genetics | Adult | Female | Loratadine - analogs & derivatives | Loratadine - therapeutic use | Chronic Disease | Genetic research | Antihistamines | Genetic aspects | Urticaria | Genetic polymorphisms | Calcium channels | Transcription factors | Effectiveness | Ionomycin | Serine | Amino acids | Gene expression | Orai1 protein | Dosage | Glycine | Patients | Dermatitis | Calcium influx | Studies | Histamine | Alleles | Acetic acid | Phorbol 12-myristate 13-acetate | Polymorphism
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4. Full Text Genome-Wide Association Studies Reveal Genetic Variants in CTNND2 for High Myopia in Singapore Chinese
by Li, Yi-Ju, PhD and Goh, Liang, PhD and Khor, Chiea-Chuen, MD, PhD and Fan, Qiao, MS and Yu, Miao, MS and Han, Siyu, BS and Sim, Xueling, BS and Ong, Rick Twee-Hee, MS and Wong, Tien-Yin, MD, PhD and Vithana, Eranga Nishanthie, PhD and Yap, Eric, MD, PhD and Nakanishi, Hideo, MD and Matsuda, Fumihiko, PhD and Ohno-Matsui, Kyoko, MD and Yoshimura, Nagahisa, MD, PhD and Seielstad, Mark, PhD and Tai, E.-Shyong, MD and Young, Terri L., MD and Saw, Seang-Mei, MD, PhD
Ophthalmology, ISSN 0161-6420, 2011, Volume 118, Issue 2, pp. 368 - 375
Objective To determine susceptibility genes for high myopia in Singaporean Chinese. Design A meta-analysis of 2 genome-wide association (GWA) datasets in... 
Ophthalmology | REFRACTIVE ERROR | POPULATION | PROJECT | RISK-FACTORS | DISEASES | ENVIRONMENT | OPHTHALMOLOGY | PREVALENCE | INDIANS | CARDIOVASCULAR RISK | CHILDREN | Japan - epidemiology | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Asian Continental Ancestry Group - genetics | Genotype | Male | Chromosome Mapping | Myopia, Degenerative - genetics | Catenins - genetics | Phenotype | Singapore - epidemiology | Polymorphism, Single Nucleotide - genetics | Female | Child | Medical colleges | Genomics | Myopia | Genetic research | Genomes | Disease susceptibility | Public health | myopia | genetics | single nucleotide polymorphism | genome wide association | CTNND2
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5. Full Text Hospital Inpatient Costs for Single-ventricle Patients Surviving the Fontan Procedure
by Huang, Li, PhD and Schilling, Chris, MSc and Dalziel, Kim M., PhD and Xie, Siyu, MPH and Celermajer, David S., MBBS, PhD, DSc and McNeil, John J., MBBS, PhD and Winlaw, David, MBBS(Hons), MD and Hornung, Tim S., MB, BChir and Radford, Dorothy J., MBBS, MD and Grigg, Leeanne E., MBBS and Bullock, Andrew, MBBS and Wheaton, Gavin R., MBBS and Justo, Robert N., MBBS and Blake, Jayne and Bishop, Rachel, BAppSc and Du Plessis, Karin, PhD and d’Udekem, Yves, MD, PhD
American Journal of Cardiology, The, ISSN 0002-9149, 2017, Volume 120, Issue 3, pp. 467 - 472
Abstract We estimated the inpatient resource use for a Fontan patient from birth to adulthood and explored factors that might induce cost differences (2014 US... 
Cardiovascular | AUSTRALIA | CARDIAC & CARDIOVASCULAR SYSTEMS | LEFT-HEART SYNDROME | DISEASE | INFANTS | CHARGES | RESOURCE UTILIZATION | PALLIATION | REGISTRY | Hospital Costs | Fontan Procedure - economics | Survival Rate - trends | Heart Defects, Congenital - surgery | Humans | Child, Preschool | Infant | Male | Australia - epidemiology | Heart Defects, Congenital - economics | Heart Ventricles - abnormalities | Inpatients | Adolescent | Heart Ventricles - surgery | Female | Registries | Heart Defects, Congenital - mortality | Retrospective Studies | Child | Infant, Newborn | Heart | Congenital heart disease | Genetic disorders | Children's hospitals | Cardiac patients | Medical care, Cost of | Pediatrics | Costs | Congenital diseases | Cardiovascular disease | Birth | Patients | Tricuspid atresia | Coronary artery disease | Children & youth | Childbirth & labor | Confidence intervals | Demographics | Hospitals | Diagnosis related groups--DRGs | Surgery | Trends | Ventricle | Heart diseases | Age
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6. Full Text Learning daily activity patterns with probabilistic grammar
by Siyu Li and Der-Horng Lee
Transportation, ISSN 0049-4488, 01/2017, Volume 44, Issue 1, p. 49
  Daily activity pattern is the reflection and abstraction of actual individual activity participation on daily basis. It carries information on activity type,... 
Studies | Transportation | Mathematical models
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7. Full Text Influence of node mobility on virus spreading behaviors in multi-hop network
by Li, Peng and Liu, Siyu and Jin, Jiyu and Wang, Zhisen
EURASIP Journal on Wireless Communications and Networking, ISSN 1687-1472, 12/2016, Volume 2016, Issue 1, pp. 1 - 10
Multi-hop network has received growing attention recently with the widely use of wireless network communication technology. At the same time, the security of... 
Node mobility | Engineering | Multi-hop network | Virus spreading | Contact duration of virus | Signal, Image and Speech Processing | Communications Engineering, Networks | Information Systems Applications (incl. Internet) | Wireless communication | Networks | Computer viruses | Computer simulation | Spreading | Viruses | Density | Contact
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8. Full Text One-Step Synthesis of Large-Scale Graphene Film Doped with Gold Nanoparticles at Liquid–Air Interface for Electrochemistry and Raman Detection Applications
by Zhang, Panpan and Huang, Ying and Lu, Xin and Zhang, Siyu and Li, Jingfeng and Wei, Gang and Su, Zhiqiang
Langmuir, ISSN 0743-7463, 07/2014, Volume 30, Issue 29, pp. 8980 - 8989
We demonstrated a facile one-step synthesis strategy for the preparation of a large-scale reduced graphene oxide multilayered film doped with gold... 
LAYER GRAPHENE | THIN-FILMS | FUNCTIONALIZATION | OXIDE | OXYGEN REDUCTION | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | METAL NANOPARTICLES | CHEMISTRY, MULTIDISCIPLINARY | CARBON NANOTUBES | SCATTERING | COMPOSITE | Gold - chemistry | Aniline Compounds - analysis | Limit of Detection | Electrochemical Techniques | Oxidation-Reduction | Metal Nanoparticles - chemistry | Spectrum Analysis, Raman - methods | Thiouracil - analysis | Sulfhydryl Compounds - analysis | Hydrogen Peroxide - analysis | Biosensing Techniques | Oxygen - chemistry | Graphite - chemistry | Metal Nanoparticles - ultrastructure
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9. Full Text Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24
by Yu, T and Gan, SC and Zhu, QC and Dai, DF and Li, N and Wang, H and Chen, XS and Hou, D and Wang, Y and Pan, Q and Xu, J and Zhang, XL and Liu, JL and Pei, SY and Peng, C and Wu, P and Romano, S and Mao, CM and Huang, MZ and Zhu, XD and Shen, KW and Qin, J and Xiao, YC
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 1 - 15
Stat6 is known to drive macrophage M2 polarization. However, how macrophage polarization is fine-tuned by Stat6 is poorly understood. Here, we find that Lys383... 
IMMUNITY | DNA-BINDING | ACTIVATION | RECOGNITION | ACETYLATION | MULTIDISCIPLINARY SCIENCES | TUMOR-ASSOCIATED MACROPHAGES | RECEPTOR | FAMILY PROTEINS | TRANSCRIPTION FACTOR | EXPRESSION | Polarization | Immune response | Crosstalk | Macrophages | Cyclic AMP response element-binding protein | CREB-binding protein | Ubiquitination | Cell activation | Stat6 protein | Regulatory mechanisms (biology) | Antitumor activity | Acetyltransferase | Acetylation | Ubiquitin-protein ligase | Niches
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10. Full Text An R3-MYB gene of Phalaenopsis, MYBx1, represses anthocyanin accumulation
by Fu, ZZ and Wang, LM and Shang, HQ and Dong, XY and Jiang, H and Zhang, J and Wang, HJ and Li, YM and Yuan, X and Meng, SY and Gao, J and Feng, NX and Zhang, HC
PLANT GROWTH REGULATION, ISSN 0167-6903, 06/2019, Volume 88, Issue 2, pp. 129 - 138
Anthocyanins are secondary metabolites that are involved in providing flower petal pigmentation. In plants, anthocyanin synthesis is regulated positively by a... 
Anthocyanin | TRANSCRIPTION FACTORS | PROTEIN | Gene function | CELL FATE | NEGATIVE REGULATOR | PLANT SCIENCES | EVOLUTION | BIOSYNTHESIS | FUNCTIONAL-ANALYSIS | PETUNIA ENCODES | Phalaenopsis | ARABIDOPSIS | Transcription factor | PIGMENTATION | Yuan (China) | Analysis | Genes | Genetically modified organisms | Genetic research | Genetic engineering | Plants | DNA binding proteins | Plant metabolites
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11. Full Text Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases
by Li, Qi and Xing, Shuaishuai and Chen, Ying and Liao, Qinghong and Li, Qihang and Liu, Yang and He, Siyu and Feng, Feng and Chen, Yao and Zhang, Jie and Liu, Wenyuan and Guo, Qinglong and Sun, Yuan and Sun, Haopeng
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2020, Volume 185, p. 111862
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12. Full Text Identification and Functional Inference for Tumor-Associated Long Non-Coding RNA
by Li, Ying and He, Ye and Han, Siyu and Liang, Yanchun
IEEE/ACM Transactions on Computational Biology and Bioinformatics, ISSN 1545-5963, 07/2019, Volume 16, Issue 4, pp. 1288 - 1301
Gastric cancer is one of the top leading causes of cancer mortality worldwide especially in China. In recent years, some lncRNAs are discovered to be... 
Databases | RNA | tumor | Encoding | long non-coding RNA | Probes | Bioinformatics | differential express | Cancer | Tumors | co-expression network | Differential express | Tumor | Co-expression network | Long non-coding RNA | BIOCHEMICAL RESEARCH METHODS | STATISTICS & PROBABILITY | DISCOVERY | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | MATHEMATICS, INTERDISCIPLINARY APPLICATIONS | DATABASE | GENE | POOR-PROGNOSIS | ANNOTATION | cancer | EXPRESSION | GENCODE | RESOURCE | MICRORNA
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13. Full Text One-pot green synthesis, characterizations, and biosensor application of self-assembled reduced graphene oxide-gold nanoparticle hybrid membranes
by Zhang, Panpan and Zhang, Xiaoyuan and Zhang, Siyu and Lu, Xin and Li, Qing and Su, Zhiqiang and Wei, Gang
Journal of Materials Chemistry B, ISSN 2050-7518, 12/2013, Volume 1, Issue 47, pp. 6525 - 6531
We report here a facile one-pot green synthesis method to prepare a self-assembled membrane of reduced graphene oxide-gold nanoparticle (RGO-AuNP) nanohybrids... 
HIGH-PERFORMANCE | FUNCTIONALIZATION | MATERIALS SCIENCE, BIOMATERIALS | FILMS | LITHIUM ION BATTERIES | ELECTRODES | ENHANCED RAMAN-SCATTERING | DOPED GRAPHENE | DERIVATIVES | TRANSPARENT | CARBON NANOTUBES | Scanning electron microscopy | Self assembly | Multilayers | Membranes | Synthesis | Graphene | Nanostructure | Biosensors
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14. Full Text Origin of high thermoelectric performance with a wide range of compositions for BixSb2-xTe3 single quintuple layers
by Li, Z and Han, SY and Pan, YC and Miao, NH and Zhou, J and Xu, HB and Sun, ZM
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, ISSN 1463-9076, 01/2019, Volume 21, Issue 3, pp. 1315 - 1323
Composition regulation of semiconductors can engineer the band structures and hence optimize their properties for better applications. Herein, we report a... 
TRANSPORT | SB2TE3 | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | BISMUTH TELLURIDE | CHEMISTRY, PHYSICAL | STATE | BI2TE3 | COHP | THERMAL-CONDUCTIVITY | EFFICIENCY | FIGURE | MXENES
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15. Nucleic acid-mimicking coordination polymer for label-free fluorescent activity assay of histone acetyltransferases
by Chen, Siyu and Li, Yong and Hu, Yufang and Han, Yitao and Huang, Yan and Nie, Zhou and Yao, Shouzhuo
Chemical Communications: Chem Comm, ISSN 1359-7345, 02/2015, Volume 51, Issue 21, pp. 4469 - 4472
A novel and label-free fluorescence assay for histone acetyltransferase (HAT) activity was established via in situgeneration of a nucleic acid-mimicking... 
Drugs | Screening | Coordination polymers | Inhibitors | Histones | Fluorescence | Assaying
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16. Full Text Nucleic acid-mimicking coordination polymer for label-free fluorescent activity assay of histone acetyltransferasesElectronic supplementary information (ESI) available. See DOI: 10.1039/c5cc00067j
by Chen, Siyu and Li, Yong and Hu, Yufang and Han, Yitao and Huang, Yan and Nie, Zhou and Yao, Shouzhuo
ISSN 1359-7345, 2/2015, Volume 51, Issue 21, pp. 4469 - 4472
A novel and label-free fluorescence assay for histone acetyltransferase (HAT) activity was established via in situ generation of a nucleic acid-mimicking... 
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17. Full Text Nucleic acid-mimicking coordination polymer for label-free fluorescent activity assay of histone acetyltransferases
by Chen, Siyu and Li, Yong and Hu, Yufang and Han, Yitao and Huang, Yan and Nie, Zhou and Yao, Shouzhuo
Chemical Communications, ISSN 1359-7345, 03/2015, Volume 51, Issue 21, pp. 4469 - 4472
A novel and label-free fluorescence assay for histone acetyltransferase (HAT) activity was established via in situ generation of a nucleic acid-mimicking... 
CLUSTERS | CHEMISTRY, MULTIDISCIPLINARY | COMPLEXES | Gold - chemistry | Fluorescent Dyes - chemistry | Nucleic Acids - chemistry | Histone Acetyltransferases - metabolism | Organic Chemicals - chemistry | Coenzyme A - chemistry | Spectrometry, Fluorescence | Polymers - chemistry | Biomimetic Materials - chemistry
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18. Full Text Learning daily activity patterns with probabilistic grammars
by Li, Siyu and Li, Siyu and Lee, Der-Horng and Lee, Der-Horng
Transportation, ISSN 0049-4488, 1/2017, Volume 44, Issue 1, pp. 49 - 68
Daily activity pattern is the reflection and abstraction of actual individual activity participation on daily basis. It carries information on activity type,... 
Economics | Daily activity pattern | Activity-based modeling | Innovation/Technology Management | Context-free grammar | Probabilistic grammar | Economic Geography | Activity sequence | Engineering Economics, Organization, Logistics, Marketing | Regional/Spatial Science | HUMAN MOBILITY | ENGINEERING, CIVIL | TRAVEL-ACTIVITY BEHAVIOR | TRANSPORTATION | MODE CHOICE | TRANSPORTATION SCIENCE & TECHNOLOGY | Analysis | Green technology | Learning | Households | Trip surveys | Probability theory | Mathematical models | Probabilistic methods | Modelling | Grammars
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19. Non-Isothermal Decomposition Kinetic of Polypropylene/Hydrotalcite Composite
by Xu, S and Zhang, M and Li, SY and Yi, MY and Shen, SG and Zeng, HY and Du, JZ and Pan, Y
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, ISSN 1533-4880, 11/2019, Volume 19, Issue 11, pp. 7493 - 7501
P3O105- pillared Mg/Al hydrotalcite (HTs) as a functional fire-retarding filler was successfully prepared by impregnation-reconstruction, where the HTs was... 
PHYSICS, CONDENSED MATTER | Malek Method | PHYSICS, APPLIED | Thermal Decomposition | Polypropylene | MATERIALS SCIENCE, MULTIDISCIPLINARY | NANOSCIENCE & NANOTECHNOLOGY | Flame Retardant | Mg/Al Hydrotalcite | CHEMISTRY, MULTIDISCIPLINARY | Organic chemistry | Thermal decomposition | Aluminum | Thermogravimetry | Decomposition reactions | Chemical reactions | Decomposition | Magnesium | Thermodynamic properties | Thermal stability
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20. Full Text Exploring the kidney hazard of exposure to mercuric chloride in mice:Disorder of mitochondrial dynamics induces oxidative stress and results in apoptosis
by Li, Siyu and Li, Jiayi and Baiyun, Ruiqi and Lv, Zhanjun and Han, Dongxu and Zhao, Wenyue and Yu, Lanjie and Deng, Ning and Liu, Zhiyan and Zhang, Zhigang
Chemosphere, ISSN 0045-6535, 11/2019, Volume 234, pp. 822 - 829
Mercury is one of the 10 toxic chemicals with major public health concerns. Continuous exposure to low levels of heavy metals including mercury is related to... 
Sirt1/PGC-1α | HgCl2 | Nrf2 | Mitochondrial dynamics | Kidney hazard | Apoptosis | HgCl | PPAR-ALPHA | CELLS | HOMEOSTASIS | TRANSCRIPTION | Sirt1/PGC-1 alpha | ENVIRONMENTAL SCIENCES | DIETARY LUTEOLIN | LIVER-INJURY | SIGNALING PATHWAY | DISEASE | RISK-ASSESSMENT | Oxidative stress | Transmission electron microscopes | Analysis | Genes | Superoxide | Children | Injuries | Index Medicus
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