Molecules, ISSN 1420-3049, 09/2018, Volume 23, Issue 10, p. 2468
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that mends topoisomerase 1-mediated DNA damage. Tdp1 is a current inhibition target for the...
Chemical space | Synthesis | Tdp1 inhibitor | Molecular modeling | Anticancer agent | Biochemical assay | DNA repair enzyme | Structural-activity relationships | synthesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | structural-activity relationships | ISOPULEGOL | ANALGESIC ACTIVITY | CHEMISTRY, MULTIDISCIPLINARY | anticancer agent | molecular modeling | biochemical assay | TDP1 | BIOLOGICAL EVALUATION | chemical space
Chemical space | Synthesis | Tdp1 inhibitor | Molecular modeling | Anticancer agent | Biochemical assay | DNA repair enzyme | Structural-activity relationships | synthesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | structural-activity relationships | ISOPULEGOL | ANALGESIC ACTIVITY | CHEMISTRY, MULTIDISCIPLINARY | anticancer agent | molecular modeling | biochemical assay | TDP1 | BIOLOGICAL EVALUATION | chemical space
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 05/2015, Volume 23, Issue 9, pp. 2168 - 2175
A system for delivery of analogues of AZT-triphosphates (AZT∗TP) based on SiO nanoparticles was proposed. For this purpose, a simple and versatile method was...
3′-Triazole derivatives of thymidine | nanoparticles | Delivery of triphosphate into cells | SiO | triphosphates | Substrate properties | AZT 'Click' chemistry
3′-Triazole derivatives of thymidine | nanoparticles | Delivery of triphosphate into cells | SiO | triphosphates | Substrate properties | AZT 'Click' chemistry
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2015, Volume 23, Issue 9, pp. 2168 - 2175
A system for delivery of analogues of AZT-triphosphates (AZT*TP) based on SiO nanoparticles was proposed. For this purpose, a simple and versatile method was...
SiO2 nanoparticles | 3′-Triazole derivatives of thymidine triphosphates | ‘Click’ chemistry | AZT | Delivery of triphosphate into cells | Substrate properties | 'Click' chemistry | CHEMISTRY, MEDICINAL | THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | 3 '-Triazole derivatives of thymidine triphosphates | Dideoxynucleotides - chemistry | Nanoparticles - chemistry | Triazoles - chemistry | Cercopithecus aethiops | Structure-Activity Relationship | Drug Delivery Systems | Zidovudine - administration & dosage | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Variola virus - growth & development | Simplexvirus - growth & development | Molecular Structure | Vero Cells | Simplexvirus - drug effects | Thymine Nucleotides - pharmacology | Cell Survival - drug effects | Dideoxynucleotides - pharmacology | Click Chemistry | Silicon Dioxide - chemistry | Cells, Cultured | Zidovudine - pharmacology | Thymine Nucleotides - chemistry | Variola virus - drug effects | Zidovudine - chemistry | Animals | Zidovudine - analogs & derivatives | Dideoxynucleotides - administration & dosage | Thymine Nucleotides - administration & dosage
SiO2 nanoparticles | 3′-Triazole derivatives of thymidine triphosphates | ‘Click’ chemistry | AZT | Delivery of triphosphate into cells | Substrate properties | 'Click' chemistry | CHEMISTRY, MEDICINAL | THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | 3 '-Triazole derivatives of thymidine triphosphates | Dideoxynucleotides - chemistry | Nanoparticles - chemistry | Triazoles - chemistry | Cercopithecus aethiops | Structure-Activity Relationship | Drug Delivery Systems | Zidovudine - administration & dosage | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Variola virus - growth & development | Simplexvirus - growth & development | Molecular Structure | Vero Cells | Simplexvirus - drug effects | Thymine Nucleotides - pharmacology | Cell Survival - drug effects | Dideoxynucleotides - pharmacology | Click Chemistry | Silicon Dioxide - chemistry | Cells, Cultured | Zidovudine - pharmacology | Thymine Nucleotides - chemistry | Variola virus - drug effects | Zidovudine - chemistry | Animals | Zidovudine - analogs & derivatives | Dideoxynucleotides - administration & dosage | Thymine Nucleotides - administration & dosage
Journal Article
Medicinal Chemistry Research, ISSN 1054-2523, 4/2019, Volume 28, Issue 4, pp. 450 - 464
A set of chiral polyhydrochromenes was synthesized by clay-catalyzed reactions of monoterpenoids (−)-isopulegol, (+)-neoisopulegol and...
Biochemistry, general | Isopulegol | Biomedicine | Fatty acid amide hydrolase (FAAH) | Monoacylglycerol lipase (MAGL) | Pharmacology/Toxicology | Aldehyde | CB 2 | Cell Biology | CB 1 | Anandamide | CHEMISTRY, MEDICINAL | METHOXY GROUPS | OCTAHYDRO-2H-CHROMEN-4-OL | RECEPTOR | MODEL | CB2 | CB1 | INHIBITION | ACID AMIDE HYDROLASE | VANILLIN | POTENT ANALGESIC ACTIVITY | CATALYZED PRINS | Amines | Lipase | Aldehydes | Fatty acids
Biochemistry, general | Isopulegol | Biomedicine | Fatty acid amide hydrolase (FAAH) | Monoacylglycerol lipase (MAGL) | Pharmacology/Toxicology | Aldehyde | CB 2 | Cell Biology | CB 1 | Anandamide | CHEMISTRY, MEDICINAL | METHOXY GROUPS | OCTAHYDRO-2H-CHROMEN-4-OL | RECEPTOR | MODEL | CB2 | CB1 | INHIBITION | ACID AMIDE HYDROLASE | VANILLIN | POTENT ANALGESIC ACTIVITY | CATALYZED PRINS | Amines | Lipase | Aldehydes | Fatty acids
Journal Article
Molecules (Basel, Switzerland), 09/2018, Volume 23, Issue 10
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that mends topoisomerase 1-mediated DNA damage. Tdp1 is a current inhibition target for the...
Benzopyrans - chemistry | Phosphoric Diester Hydrolases - metabolism | Humans | Models, Molecular | Phosphodiesterase Inhibitors - pharmacology | Structure-Activity Relationship | Phosphodiesterase Inhibitors - chemistry | Phosphoric Diester Hydrolases - chemistry
Benzopyrans - chemistry | Phosphoric Diester Hydrolases - metabolism | Humans | Models, Molecular | Phosphodiesterase Inhibitors - pharmacology | Structure-Activity Relationship | Phosphodiesterase Inhibitors - chemistry | Phosphoric Diester Hydrolases - chemistry
Journal Article
2015 IEEE 15th International Conference on Nanotechnology (IEEE-NANO), 07/2015, pp. 1054 - 1057
SiO 2 nanoparticles as platform for delivery of 3'-triazole analogues of AZT-triphosphate into cells were proposed. The results confirmed the successfulness of...
3′- triazole derivatives of thymidine triphosphates | SiO2 nanoparticles | Substrates | Nanoparticles | “click” chemistry | Chemistry | Nanocomposites | DNA | substrate properties | AZT | Polymers | delivery of triphosphate into cells | Viruses (medical) | click chemistry | Cycloaddition | Reproduction | Delivery systems | Nucleosides | Nanostructure | Silicon dioxide
3′- triazole derivatives of thymidine triphosphates | SiO2 nanoparticles | Substrates | Nanoparticles | “click” chemistry | Chemistry | Nanocomposites | DNA | substrate properties | AZT | Polymers | delivery of triphosphate into cells | Viruses (medical) | click chemistry | Cycloaddition | Reproduction | Delivery systems | Nucleosides | Nanostructure | Silicon dioxide
Conference Proceeding
Proceedings, ISSN 2504-3900, 08/2019, Volume 22, Issue 1, p. 35
The cytotoxic effects of chemotherapy and radiation that are clinically used to treat malignancies are directly related to their propensity to generate DNA...
synthesis | pentathiepine | adamantane | Tdp1 inhibitor | molecular modeling | coumarin | DNA repair enzyme | terpene | usnic acid | anticancer agent
synthesis | pentathiepine | adamantane | Tdp1 inhibitor | molecular modeling | coumarin | DNA repair enzyme | terpene | usnic acid | anticancer agent
Journal Article
Molecular Catalysis, ISSN 2468-8231, 11/2019, Volume 478, p. 110569
Prins cyclization of (-)-isopulegol with benzaldehyde was investigated with sulphur containing halloysite nanotubes, K10 clays and Cloisite clays. The...
Chromenols | Isopulegol | Organosulfonic clays | Prins reaction | ACID | OCTAHYDRO-2H-CHROMEN-4-OL | ESTERIFICATION | CHEMISTRY, PHYSICAL | ANALGESIC ACTIVITY | MECHANICAL-PROPERTIES | NANOCOMPOSITES | MODIFIED HALLOYSITE NANOTUBES | ABSORPTION | CATALYSTS
Chromenols | Isopulegol | Organosulfonic clays | Prins reaction | ACID | OCTAHYDRO-2H-CHROMEN-4-OL | ESTERIFICATION | CHEMISTRY, PHYSICAL | ANALGESIC ACTIVITY | MECHANICAL-PROPERTIES | NANOCOMPOSITES | MODIFIED HALLOYSITE NANOTUBES | ABSORPTION | CATALYSTS
Journal Article
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