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Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2017, Volume 377, Issue 3, pp. 211 - 221
Loss-of-function variants in ANGPTL3 were associated with lower plasma levels of lipids and lower rates of coronary disease. A monoclonal antibody against... 
MEDICINE, GENERAL & INTERNAL | HEART-DISEASE | REMNANT CHOLESTEROL | PLASMA-LIPIDS | IMMUNOGLOBULIN GENES | ATHEROSCLEROSIS | RISK | CORONARY-ARTERY-DISEASE | FAMILIAL COMBINED HYPOLIPIDEMIA | LIPOPROTEIN-LIPASE GENE | TRANSGENIC MICE | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Angiopoietins - antagonists & inhibitors | Dose-Response Relationship, Drug | Dyslipidemias - blood | Angiopoietin-like Proteins | Lipids - blood | Female | Disease Models, Animal | Dyslipidemias - drug therapy | Atherosclerosis - drug therapy | Double-Blind Method | Antibodies, Monoclonal - pharmacology | Coronary Artery Disease - metabolism | Mice, Inbred Strains | Atherosclerosis - metabolism | Animals | Antibodies, Monoclonal - administration & dosage | Coronary Artery Disease - genetics | Lipid Metabolism - drug effects | Aged | Mice | Mutation | Angiopoietins - genetics | Cholesterol, LDL | Research | Antibiosis | Atherosclerosis | Lipoproteins (low density) | Medical research | Angiopoietin | Genomics | Genes | Coronary artery | Triglycerides | Biochemistry | Gene expression | Cholesterol | Serum levels | Proteins | Antagonism | Arteriosclerosis | Plasma levels | Cardiovascular diseases | Lipoproteins (high density) | Heart diseases | Drug dosages | Pharmaceuticals
Journal Article
Canadian Journal of Cardiology, ISSN 0828-282X, 04/2019, Volume 35, Issue 4, pp. 544.e7 - 544.e9
A young female patient was referred for pulmonary arterial hypertension (PAH). Catheterization revealed a large sinus venosus interatrial communication... 
Journal Article
by Ehret, Georg B and Ferreira, Teresa and Chasman, Daniel I and Jackson, Anne U and Schmidt, Ellen M and Johnson, Toby and Thorleifsson, Gudmar and Luan, Jian'an and Donnelly, Louise A and Kanoni, Stavroula and Petersen, Ann-Kristin and Pihur, Vasyl and Strawbridge, Rona J and Shungin, Dmitry and Hughes, Maria F and Meirelles, Osorio and Kaakinen, Marika and Bouatia-Naji, Nabila and Kristiansson, Kati and Shah, Sonia and Kleber, Marcus E and Guo, Xiuqing and Lyytikäinen, Leo-Pekka and Fava, Cristiano and Eriksson, Niclas and Nolte, Ilja M and Magnusson, Patrik K and Salfati, Elias L and Rallidis, Loukianos S and Theusch, Elizabeth and Smith, Anew J. P and Folkersen, Lasse and Witkowska, Kate and Pers, Tune H and Joehanes, Roby and Kim, Stuart K and Lataniotis, Lazaros and Jansen, Rick and Johnson, Anew D and Warren, Helen and Kim, Young Jin and Zhao, Wei and Wu, Ying and Tayo, Bamidele O and Bochud, Murielle and Absher, Devin and Adair, Linda S and Amin, Najaf and Arking, Dan E and Axelsson, Tomas and Baldassarre, Damiano and Balkau, Beverley and Bandinelli, Stefania and Barnes, Michael R and Barroso, Inês and Bevan, Stephen and Bis, Joshua C and Bjornsdottir, Gyda and Boehnke, Michael and Boerwinkle, Eric and Bonnycastle, Lori L and Boomsma, Dorret I and Bornstein, Stefan R and Brown, Morris J and Burnier, Michel and Cabrera, Claudia P and Chambers, John C and Chang, I.-Shou and Cheng, Ching-Yu and Chines, Peter S and Chung, Ren-Hua and Collins, Francis S and Connell, John M and Döring, Angela and Dallongeville, Jean and Danesh, John and de Faire, Ulf and Delgado, Graciela and Dominiczak, Anna F and Doney, Alex S. F and nos, Fotios and Edkins, Sarah and Eicher, John D and Elosua, Roberto and Enroth, Stefan and Erdmann, Jeanette and Eriksson, Per and Esko, Tonu and Evangelou, Evangelos and Evans, Alun and Fall, Tove and Farrall, Martin and Felix, Janine F and Ferrières, Jean and Ferrucci, Luigi and Fornage, Myriam and Forrester, Terrence and Franceschini, Nora and Franco, Oscar H and Franco-Cereceda, Anders and ... and CHARGE-HF Consortium and Wellcome Trust Case Control Consor and CHARGE-EchoGen Consortium and Wellcome Trust Case Control Consortium and Medicinska fakulteten and Avdelningen för medicin and Umeå universitet and Medicin and Institutionen för odontologi and Institutionen för folkhälsa och klinisk medicin and Enheten för biobanksforskning and Näringsforskning
Nature genetics, ISSN 1061-4036, 2016, Volume 48, Issue 10, pp. 1171 - 1184
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays... 
COMMON VARIANTS | METAANALYSIS | SUSCEPTIBILITY | GENETICS & HEREDITY | LOCI | TRAITS | HYPERTENSION | GENOME-WIDE ASSOCIATION | Studies | Consortia | Hypotheses | Genealogy | Genetics | Blood pressure | Genomes | Meta-analysis | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Clinica Chimica Acta, ISSN 0009-8981, 09/2017, Volume 472, p. 80
We investigated the associations of fibroblast growth factor 21 (FGF-21) with cardiovascular risk and [beta]-cell function in patients who had no history of... 
Pancreatic beta cells | Fibroblast growth factors | Cardiovascular diseases | Risk factors | Medical research | Medicine, Experimental | Insulin resistance | Glucose | Coronary heart disease | Glucose tolerance tests | Prediabetic state | Dextrose
Journal Article
by Zhao, Wei and Rasheed, Asif and Tikkanen, Emmi and Lee, Jung-Jin and Butterworth, Adam S and Howson, Joanna M. M and Assimes, Themistocles L and Chowdhury, Rajiv and Orho-Melander, Marju and Damrauer, Scott and Small, Aeron and Asma, Senay and Imamura, Minako and Yamauch, Toshimasa and Chambers, John C and Chen, Peng and Sapkota, Bishwa R and Shah, Nabi and Jabeen, Sehrish and Surendran, Praveen and Lu, Yingchang and Zhang, Weihua and Imran, Atif and Abbas, Shahid and Majeed, Faisal and Trindade, Kevin and Qamar, Nadeem and Mallick, Nadeem Hayyat and Yaqoob, Zia and Saghir, Tahir and Hasan Rizvi, Syed Nadeem and Memon, Anis and Rasheed, Syed Zahed and Memon, Fazal-Ur-Rehman and Mehmood, Khalid and Ahmed, Naveeduddin and Hussain Qureshi, Irshad and Tanveer-Us-Salam, Tanveer-Us-Salam and Iqbal, Wasim and Malik, Uzma and Mehra, Narinder and Kuo, Jane Z and Sheu, Wayne H.-H and Guo, Xiuqing and Hsiung, Chao A and Juang, Jyh-Ming J and Taylor, Kent D and Hung, Yi-Jen and Lee, Wen-Jane and Quertermous, Thomas and Lee, I-Te and Hsu, Chih-Cheng and Bottinger, Erwin P and Ralhan, Sarju and Teo, Yik Ying and Wang, Tzung-Dau and Alam, Dewan S and Di Angelantonio, Emanuele and Epstein, Steve and Nielsen, Sune F and Nordestgaard, Borge G and Tybjaerg-Hansen, Anne and Young, Robin and Benn, Marianne and Frikke-Schmidt, Ruth and Kamstrup, Pia R and Jukema, J. Wouter and Sattar, Naveed and Smit, Roelof and Chung, Ren-Hua and Liang, Kae-Woei and Anand, Sonia and Sanghera, Dharambir K and Ripatti, Samuli and Loos, Ruth J. F and Kooner, Jaspal S and Tai, E. Shyong and Rotter, Jerome I and Ida Chen, Yii-Der and Frossard, Philippe and Maeda, Shiro and Kadowaki, Takashi and Reilly, Muredach and Pare, Guillaume and Melander, Olle and Salomaa, Veikko and Rader, Daniel J and Danesh, John and Voight, Benjamin F and Saleheen, Danish and EPIC-CVD Consortium and CHD Exome Consortium and EPIC-Interact Consortium and Michigan Biobank and CHD Exome+ Consortium
Nature Genetics, ISSN 1061-4036, 10/2017, Volume 49, Issue 10, pp. 1450 - 1457
Journal Article
Journal of Diabetes, ISSN 1753-0393, 12/2018, Volume 10, Issue 12, p. 958
The aim of the present study was to investigate the association between serum aryl hydrocarbon receptor (AhR) levels and insulin resistance and [beta]-cell... 
Medical research | Pancreatic beta cells | Care and treatment | Angiography | Glucose | Glucose tolerance tests | Insulin | Dextrose | Analysis | Cardiac patients | Medicine, Experimental | Insulin resistance | Prediabetic state
Journal Article
by Gerstein, Hertzel C and Colhoun, Helen M and Dagenais, Gilles and Dagenais, Gilles R and Diaz, Rafael and Diaz, Sarahy and Lakshmanan, Mark and Pais, Prem and Probstfield, Jeffrey and Riesmeyer, Jeffrey S and Riddle, Matthew C and Rydén, Lars and Xavier, Denis and Atisso, Charles Messan and Dyal, Leanne and Hall, Stephanie and Hall, Charles and Rao-Melacini, Purnima and Wong, Gloria and Avezum, Alvaro and Basile, Jan and Chung, Ming-Min and Chung, Namsik and Chung, Jin-Wook and Conget, Ignacio and Cushman, William C and Franek, Edward and Hancu, Nicolae and Hanefeld, Christoph and Hanefeld, Markolf and Holt, Shaun and Jansky, Petr and Keltai, Matyas and Keltai, Katalin and Lanas, Fernando and Leiter, Lawrence A and Lopez-Jaramillo, Patricio and Cardona Munoz, Ernesto German and Pirags, Valdis and Pogosova, Nana and Raubenheimer, Peter J and Shaw, Jonathan E and Sheu, Wayne H-H and Temelkova-Kurktschiev, Theodora and Abella, Mercedes and Alebuena, Andrea and Almagro, Sandra and Amoroso, Eduardo and Anadon, Paula and Andreu, Elizabeth and Aristimuño, Guillermo and Arzadun, Maria and Barbieri, Maria and Barcudi, Raul and Bartolacci, Ines and Bolobanich, Gabriel and Bordonava, Anselmo and Bustamante Labarta, Miguel and Bustos, Betina and Caccavo, Alberto and Camino, Alejandra and Cantero, Maria and Carignano, Maria and Cartasegna, Luis and Cipullo, Marcela and Commendatore, Víctor and Conosciuto, Victoria and Costamagna, Osvaldo and Crespo, Claudia and Cuello, Jose and Cuneo, Carlos and Cusimano, Sandra and Dean, Sofia and Dituro, Claudio and Dominguez, Andrea and Farah, Miguel and Fernandez, Alberto and Fernandez, Florencia and Ferrari, Adriana and Flammia, Patricia and Fuentealba, Jose and Gallardo, Karina Beatriz and Garcia, Mar and Garcia, Celso and Garcia, Maria and Garcia Duran, Ruben and Garrido, Marcelo and Gavicola, Rodolfo and Gerbaudo, Claudio and Gilli, Graciela and Giotto, Ana Paula and Godoy Bolzán, Pedro and Gomez Vilamajo, Oscar and Guerlloy, Fernando and Guridi, Cristian and Gutierrez Garrido, Narcisa and Hasbani, Eduardo and Hermida, Sonia and Hominal, Miguel and Hrabar, Adrian and ... and REWIND Investigators
The Lancet, ISSN 0140-6736, 07/2019, Volume 394, Issue 10193, pp. 121 - 130
Journal Article