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gene expression regulation, neoplastic (6) 6
genomic characterization (6) 6
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loss of heterozygosity (6) 6
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1. Full Text Integrated genomic characterization of adrenocortical carcinoma
by Assié, Guillaume and Letouzé, Eric and Fassnacht, Martin and Jouinot, Anne and Luscap, Windy and Barreau, Olivia and Omeiri, Hanin and Rodriguez, Stéphanie and Perlemoine, Karine and René-Corail, Fernande and Elarouci, Nabila and Sbiera, Silviu and Kroiss, Matthias and Allolio, Bruno and Waldmann, Jens and Quinkler, Marcus and Mannelli, Massimo and Mantero, Franco and Papathomas, Thomas and De Krijger, Ronald and Tabarin, Antoine and Kerlan, Véronique and Baudin, Eric and Tissier, Frédérique and Dousset, Bertrand and Groussin, Lionel and Amar, Laurence and Clauser, Eric and Bertagna, Xavier and Ragazzon, Bruno and Beuschlein, Felix and Libé, Rossella and De Reyniès, Aurélien and Bertherat, Jérôme
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 6, pp. 607 - 612
Adrenocortical carcinomas (ACCs) are aggressive cancers originating in the cortex of the adrenal gland(1). Despite overall poor prognosis, ACC outcome is... 
MOLECULAR CLASSIFICATION | COPY-NUMBER CHANGES | MANAGEMENT | LONG NONCODING RNAS | GENE | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | MUTATIONS | EXPRESSION | HUMAN CANCER | MICRORNA | Multigene Family | Prognosis | Telomere - ultrastructure | Genomics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | MicroRNAs - metabolism | Gene Expression Profiling | Loss of Heterozygosity | Exome | Young Adult | DNA Methylation | DNA Mutational Analysis | Aged, 80 and over | Adult | Female | Adrenocortical Carcinoma - genetics | Ubiquitin-Protein Ligases - metabolism | beta Catenin - metabolism | Adrenal Cortex Neoplasms - genetics | Adolescent | Aged | Polymorphism, Single Nucleotide | Mutation | Cohort Studies | Single nucleotide polymorphisms | Identification and classification | Methods | Exome sequencing | Genomes | Gene expression | Experiments | Cancer therapies | Medical prognosis | Software | Arrays | Charitable foundations | Chromosomes | Bioinformatics | Deoxyribonucleic acid--DNA | Tumors | Cancer | Life Sciences | Human health and pathology
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2. Full Text Adrenocortical carcinoma: A clinician's update
by Fassnacht, Martin and Libé, Rossella and Kroiss, Matthias and Allolio, Bruno
Nature Reviews Endocrinology, ISSN 1759-5029, 06/2011, Volume 7, Issue 6, pp. 323 - 335
Adrenocortical carcinoma is a rare heterogeneous neoplasm with an incompletely understood pathogenesis and a poor prognosis. Previous studies have identified... 
WNT SIGNALING PATHWAY | CUSHINGS-SYNDROME | POSITRON-EMISSION-TOMOGRAPHY | PROGNOSTIC-FACTORS | LONG-TERM SURVIVAL | STEROIDOGENIC FACTOR-1 | ENDOCRINOLOGY & METABOLISM | PLATINUM-BASED CHEMOTHERAPY | ADRENAL-CORTICAL CARCINOMA | DELAYED ENHANCED CT | NEEDLE-ASPIRATION-CYTOLOGY | Education, Medical, Continuing | Endocrinology - trends | Oncogenes - genetics | Endocrinology - education | Adrenocortical Carcinoma - genetics | Humans | Adrenocortical Carcinoma - diagnosis | Adrenocortical Carcinoma - etiology | Oncogenes - physiology | Adrenocortical Carcinoma - therapy | Clinical Laboratory Techniques - trends | Adrenal Cortex Neoplasms - genetics | Adrenal Cortex Neoplasms - therapy | Adrenal Cortex Neoplasms - diagnosis | Algorithms | Models, Biological | Genes, Tumor Suppressor - physiology | Adrenal Cortex Neoplasms - etiology | Physiological aspects | Genetic aspects | Research | Gene expression | Insulin-like growth factor 1
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3. Clinical and molecular prognostic factors in adrenocortical carcinoma
by Libé, Rossella
Minerva endocrinologica, 03/2019, Volume 44, Issue 1, p. 58
Adrenocortical carcinoma (ACC) is a rare cancer, with an incidence less than 0.7-1.5 per 1 million people per year, with a poor prognosis. The overall survival... 
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4. Full Text SDHA is a tumor suppressor gene causing paraganglioma
by Burnichon, Nelly and Brière, Jean-Jacques and Libé, Rossella and Vescovo, Laure and Rivière, Julie and Tissier, Frédérique and Jouanno, Elodie and Jeunemaitre, Xavier and Bénit, Paule and Tzagoloff, Alexander and Rustin, Pierre and Bertherat, Jérôme and Favier, Judith and Gimenez-Roqueplo, Anne-Paule
Human Molecular Genetics, ISSN 0964-6906, 08/2010, Volume 19, Issue 15, pp. 3011 - 3020
Mitochondrial succinate-coenzyme Q reductase (complex II) consists of four subunits, SDHA, SDHB, SDHC and SDHD. Heterozygous germline mutations in SDHB, SDHC,... 
HYDROXYLASE | CHAIN COMPLEX-II | SPORADIC PHEOCHROMOCYTOMAS | LEIGH-SYNDROME | SUCCINATE-UBIQUINONE REDUCTASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | FLAVOPROTEIN SUBUNIT | MUTATIONS | EXPRESSION | CHROMOSOMES 1P | DEHYDROGENASE | Gene Frequency - genetics | Oligonucleotide Array Sequence Analysis | Saccharomyces cerevisiae - genetics | Humans | Genetic Loci - genetics | Molecular Sequence Data | Neovascularization, Pathologic - complications | Loss of Heterozygosity - genetics | Glycolysis - genetics | Base Sequence | Adult | Female | Genes, Tumor Suppressor | Electron Transport Complex II - chemistry | Amino Acid Sequence | Paraganglioma - enzymology | Paraganglioma - pathology | Electron Transport Complex II - genetics | Paraganglioma - genetics | Oxidative Phosphorylation | Models, Molecular | Genotype | Hypoxia - complications | Mutation - genetics | Hypoxia - genetics | Succinate Dehydrogenase - genetics | Neovascularization, Pathologic - genetics
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5. Full Text MiR‐483‐5p and miR‐139‐5p promote aggressiveness by targeting N‐myc downstream‐regulated gene family members in adrenocortical cancer
by Agosta, Claire and Laugier, Jonathan and Guyon, Laurent and Denis, Josiane and Bertherat, Jérôme and Libé, Rossella and Boisson, Bruno and Sturm, Nathalie and Feige, Jean‐Jacques and Chabre, Olivier and Cherradi, Nadia
International Journal of Cancer, ISSN 0020-7136, 08/2018, Volume 143, Issue 4, pp. 944 - 957
Adrenocortical carcinoma (ACC) is a tumor with poor prognosis in which overexpression of a panel of microRNAs has been associated with malignancy but a very... 
adrenocortical cancer | NDRG4 | N‐myc downstream‐regulated gene family | invasion | miR‐483‐5p | NDRG2 | miR‐139‐5p | miR-483-5p | N-myc downstream-regulated gene family | miR-139-5p | CELLS | METASTASIS | CLASSIFICATION | MICRORNAS | MESENCHYMAL TRANSITION | IDENTIFICATION | TUMORS | ONCOLOGY | GENOMIC CHARACTERIZATION | CARCINOMA | EXPRESSION | Genetic aspects | RNA | Genes | Stem cells | Cancer | Prognosis | Aggressive behavior | Mesenchyme | Pathogenesis | Therapeutic applications | Invasiveness | MiRNA | mRNA | Malignancy | Myc protein | Gene expression | Proteins | Correlation analysis | Cell lines | Bioinformatics | Life Sciences
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6. Molecular genetics of adrenocortical tumours, from familial to sporadic diseases
by Libé, Rossella and Bertherat, Jérôme
European Journal of Endocrinology, ISSN 0804-4643, 10/2005, Volume 153, Issue 4, pp. 477 - 487
Adrenal masses can be detected in up to 4%, of the population, and are mostly of adrenocortical origin. Adrenocortical tumours (ACTs) may be responsible for... 
PROTEIN-KINASE-A | DEPENDENT CUSHINGS-SYNDROME | BECKWITH-WIEDEMANN-SYNDROME | LI-FRAUMENI-SYNDROME | RIBONUCLEIC-ACID EXPRESSION | MACRONODULAR ADRENAL-HYPERPLASIA | ENDOCRINOLOGY & METABOLISM | ELEMENT-BINDING PROTEIN | CARNEY COMPLEX | GASTRIC-INHIBITORY POLYPEPTIDE | GROWTH-FACTOR-II | Adrenal Cortex Neoplasms - genetics | Molecular Biology | Humans
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7. Full Text Adrenocortical cancer: pathophysiology and clinical management
by Rossella Libè and Amato Fratticci and Jérôme Bertherat
Endocrine-Related Cancer, ISSN 1351-0088, 03/2007, Volume 14, Issue 1, pp. 13 - 28
Adrenocortical cancer (ACC) is a rare tumor with a poor prognosis. By contrast, benign adrenocortical tumors are frequent, underlying the importance of a... 
PROTEIN-KINASE-A | WNT SIGNALING PATHWAY | POSITRON-EMISSION-TOMOGRAPHY | BECKWITH-WIEDEMANN-SYNDROME | LI-FRAUMENI-SYNDROME | ONCOLOGY | RIBONUCLEIC-ACID EXPRESSION | ENDOCRINOLOGY & METABOLISM | TUMOR-SUPPRESSOR GENE | CARNEY COMPLEX | ADRENAL-CORTICAL CARCINOMA | GROWTH-FACTOR-II | Adrenal Cortex Neoplasms - genetics | Adrenal Cortex Neoplasms - therapy | Oncogenes - genetics | Genes, Tumor Suppressor | Humans
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8. Full Text Urine Steroid Metabolomics as a Biomarker Tool for Detecting Malignancy in Adrenal Tumors
by Arlt, Wiebke and Biehl, Michael and Taylor, Angela E and Hahner, Stefanie and Libé, Rossella and Hughes, Beverly A and Schneider, Petra and Smith, David J and Stiekema, Han and Krone, Nils and Porfiri, Emilio and Opocher, Giuseppe and Bertherat, Jerôme and Mantero, Franco and Allolio, Bruno and Terzolo, Massimo and Nightingale, Peter and Shackleton, Cedric H. L and Bertagna, Xavier and Fassnacht, Martin and Stewart, Paul M
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 12/2011, Volume 96, Issue 12, pp. 3775 - 3784
Context: Adrenal tumors have a prevalence of around 2% in the general population. Adrenocortical carcinoma (ACC) is rare but accounts for 2–11% of incidentally... 
DIAGNOSIS | INCIDENTALOMAS | FOLLOW-UP | CLASSIFICATION | SUBCLINICAL CUSHINGS-SYNDROME | TANDEM MASS-SPECTROMETRY | ADRENOCORTICAL TUMORS | CARCINOMA | CANCER | COMPUTED-TOMOGRAPHY | ENDOCRINOLOGY & METABOLISM | Metabolomics | Diagnosis, Differential | Adrenocortical Adenoma - diagnosis | Adrenocortical Carcinoma - urine | Biomarkers - urine | Adrenocortical Adenoma - urine | Humans | Middle Aged | Adrenocortical Carcinoma - diagnosis | Male | Adrenal Cortex Neoplasms - pathology | Adrenocortical Adenoma - pathology | Adrenal Cortex Neoplasms - diagnosis | Adrenocortical Carcinoma - pathology | Adrenal Cortex Hormones - urine | Mass Spectrometry | Aged, 80 and over | Adult | Female | Aged | Adrenal Cortex Neoplasms - urine | Endocrine Research
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9. Full Text ARMC5 Mutations in Macronodular Adrenal Hyperplasia with Cushing's Syndrome
by Assié, Guillaume and Libé, Rossella and Espiard, Stéphanie and Rizk-Rabin, Marthe and Guimier, Anne and Luscap, Windy and Barreau, Olivia and Lefèvre, Lucile and Sibony, Mathilde and Guignat, Laurence and Rodriguez, Stéphanie and Perlemoine, Karine and René-Corail, Fernande and Letourneur, Franck and Trabulsi, Bilal and Poussier, Alix and Chabbert-Buffet, Nathalie and Borson-Chazot, Françoise and Groussin, Lionel and Bertagna, Xavier and Stratakis, Constantine A and Ragazzon, Bruno and Bertherat, Jérôme
The New England Journal of Medicine, ISSN 0028-4793, 11/2013, Volume 369, Issue 22, pp. 2105 - 2114
This study showed that there were mutations in ARMC5, a putative tumor-suppressor gene, in a substantial proportion of patients with corticotropin-independent... 
MEDICINE, GENERAL & INTERNAL | FREQUENT | PROTEIN | CANCERS | PATHWAY | DISEASE | GENE-EXPRESSION | GASTRIC-INHIBITORY POLYPEPTIDE | RECEPTORS | HYPERCORTISOLISM | ADRENOCORTICAL TUMORS | Adrenal Glands - pathology | Cushing Syndrome - genetics | Humans | Middle Aged | Transcriptome | Male | Genotyping Techniques | Sequence Analysis, DNA | Cushing Syndrome - complications | Cushing Syndrome - pathology | Adult | Female | Aged | Polymorphism, Single Nucleotide | Genes, Tumor Suppressor | Tumor Suppressor Proteins | Cell culture | Medical research | Nervous system diseases | Cell survival | Microsatellites | Adrenal glands | Glands | Hyperplasia | Cushing's syndrome | Genomes | Single-nucleotide polymorphism | Gene expression | Genetic screening | Nodules | Heterozygosity | Genetic markers | Adrenocorticotropic hormone | Pituitary | Loss of heterozygosity | Steroidogenesis | Mutation | Deoxyribonucleic acid--DNA | Tumors | Life Sciences | Cellular Biology
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10. Clinical and molecular prognostic factors in adrenocortical carcinoma
by Libé, Rossella
Minerva endocrinologica, ISSN 0391-1977, 03/2019, Volume 44, Issue 1, pp. 58 - 69
INTRODUCTION: Adrenocortical carcinoma (ACC) is a rare cancer, with an incidence less than 0.7-1.5 per 1 million people per year, with a poor prognosis. The... 
Prognosis | Survival rate | Adrenocortical carcinoma | Mortality | SURVIVAL | ENDOCRINE SURGEONS ESES | ADRENAL CANCER | BETA-CATENIN | EUROPEAN-SOCIETY | TUMORS | STAGING SYSTEM | HELSINKI SCORE | ENDOCRINOLOGY & METABOLISM | GENOMIC CHARACTERIZATION | EXPRESSION
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11. Full Text DNA methylation is an independent prognostic marker of survival in adrenocortical cancer
by Jouinot, Anne and Assie, Guillaume and Libe, Rossella and Fassnacht, Martin and Papathomas, Thomas and Barreau, Olivia and De La Villeon, Bruno and Faillot, Simon and Hamzaoui, Nadim and Neou, Mario and Perlemoine, Karine and Rene-Corail, Fernande and Roiguez, Stephanie and Sibony, Mathilde and Tissier, Frederique and Dousset, Bertrand and Sbiera, Silviu and Ronchi, Cristina and Kroiss, Matthias and Korpershoek, Esther and De Krijger, Ronald and Waldmann, Jens and Bartsch, Detlef K and Quinkler, Marcus and Haissaguerre, Magalie and Tabarin, Antoine and Chabre, Olivier and Sturm, Nathalie and Luconi, Michaela and Mantero, Franco and Mannelli, Massimo and Cohen, Regis and Kerlan, Veronique and Touraine, Philippe and Barrande, Gaelle and Groussin, Lionel and Bertagna, Xavier and Baudin, Eric and Amar, Laurence and Beuschlein, Felix and Clauser, Eric and Coste, Joel and Bertherat, Jerome
Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, 03/2017, Volume 102, Issue 3, pp. 923 - 932
Context: Adrenocortical cancer (ACC) is an aggressive tumor with a heterogeneous outcome. Prognostic stratification is difficult even based on tumor stage and... 
Clinical Biochemistry | Biochemistry | Biochemistry, medical | Endocrinology, Diabetes and Metabolism | Endocrinology | Journal Article | COLORECTAL TUMORS | MICROSATELLITE INSTABILITY | PREDICTORS | ENDOCRINOLOGY & METABOLISM | PHENOTYPE | CLASSIFICATION | GENOMIC CHARACTERIZATION | KI67 | CARCINOMA | EXPRESSION | ADULT | Multivariate Analysis | Prognosis | Humans | Middle Aged | Ki-67 Antigen - metabolism | Male | Adrenocortical Carcinoma - pathology | DNA Methylation | Adult | Female | Adrenocortical Carcinoma - mortality | Retrospective Studies | Adrenal Cortex Neoplasms - mortality | Adrenocortical Carcinoma - genetics | Proportional Hazards Models | Survival Rate | Adrenal Cortex Neoplasms - pathology | Tumor Burden | Multiplex Polymerase Chain Reaction | Adrenal Cortex Neoplasms - genetics | Disease-Free Survival | CpG Islands | Aged | DNA, Neoplasm - genetics | Neoplasm Staging | DNA probes | Pax5 protein | Patients | Survival | Training | Pax6 protein | Glutathione transferase | Medical prognosis | DNA methylation | Methylation | Islands | Deoxyribonucleic acid--DNA | Tumors | Cancer | CpG islands | Life Sciences | Human health and pathology | Endocrinology and metabolism
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12. Full Text Intraadrenal Corticotropin in Bilateral Macronodular Adrenal Hyperplasia
by Louiset, Estelle and Duparc, Céline and Young, Jacques and Renouf, Sylvie and Tetsi Nomigni, Milène and Boutelet, Isabelle and Libé, Rossella and Bram, Zakariae and Groussin, Lionel and Caron, Philippe and Tabarin, Antoine and Grunenberger, Fabienne and Christin-Maitre, Sophie and Bertagna, Xavier and Kuhn, Jean-Marc and Anouar, Youssef and Bertherat, Jérôme and Lefebvre, Hervé
The New England Journal of Medicine, ISSN 0028-4793, 11/2013, Volume 369, Issue 22, pp. 2115 - 2125
This study showed that cortisol secretion by the adrenals in patients with macronodular hyperplasia is probably regulated by corticotropin produced within the... 
MEDICINE, GENERAL & INTERNAL | CUSHINGS-SYNDROME | ADRENOCORTICAL HYPERPLASIA | IN-VIVO | ACTH | GASTRIC-INHIBITORY POLYPEPTIDE | PHOSPHODIESTERASE 11A PDE11A | RECEPTORS | TUMORS | EXPRESSION | PROOPIOMELANOCORTIN TRANSCRIPTS | Adrenal Glands - pathology | Gene Expression | Humans | Middle Aged | Male | Cushing Syndrome - metabolism | Adrenocorticotropic Hormone - secretion | RNA, Messenger - biosynthesis | Cushing Syndrome - pathology | Pro-Opiomelanocortin - biosynthesis | Adult | Female | Adrenal Glands - secretion | Aged | Adrenal Glands - drug effects | Gastric Inhibitory Polypeptide - pharmacology | Pro-Opiomelanocortin - genetics | Adrenocorticotropic Hormone - blood | Explants | Plasma | Nervous system diseases | Dexamethasone | Adrenal glands | Secretion | Mortality | Hyperplasia | Pituitary (anterior) | Cushing's syndrome | Proopiomelanocortin | Hydrocortisone | Gene expression | Corticotropin-releasing hormone | Adrenocorticotropic hormone | Pituitary | Tumors | Gastric Inhibitory Polypeptide | Adrenal Glands | Neurons and Cognition | Neurobiology | Life Sciences | Human health and pathology | Endocrinology and metabolism | Adrenocorticotropic Hormone | Cushing Syndrome | RNA, Messenger | Pro-Opiomelanocortin
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13. Full Text 18F-FDG PET reveals an adrenocortical carcinoma in a bilateral adrenal multinodular disease
by Libé, Rossella and Libé, Rossella and Jazeron, Jean-François and Jazeron, Jean-François and Louiset, Estelle and Louiset, Estelle and Groussin, Lionel and Groussin, Lionel
Endocrine, ISSN 1355-008X, 1/2019, Volume 63, Issue 1, pp. 188 - 189
Internal Medicine | Diabetes | Medicine & Public Health | Science, Humanities and Social Sciences, multidisciplinary | Endocrinology | ENDOCRINOLOGY & METABOLISM
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14. Full Text Adrenocortical carcinoma (ACC): diagnosis, prognosis, and treatment
by Libé, Rossella
Frontiers in cell and developmental biology, ISSN 2296-634X, 2015, Volume 3, p. 45
Adrenocortical carticnoma (ACC) is a rare malignancy with an incidence of 0.7-2.0 cases/million habitants/year. The diagnosis of malignancy relies on careful... 
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15. Full Text Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas
by Castro-Vega, Luis Jaime and Letouzé, Eric and Burnichon, Nelly and Buffet, Alexandre and Disderot, Pierre-Hélie and Khalifa, Emmanuel and Loriot, Céline and Elarouci, Nabila and Morin, Aurélie and Menara, Mélanie and Lepoutre-Lussey, Charlotte and Badoual, Cécile and Sibony, Mathilde and Dousset, Bertrand and Libé, Rossella and Zinzindohoue, Franck and Plouin, Pierre François and Bertherat, Jérôme and Amar, Laurence and De Reyniès, Aurélien and Favier, Judith and Gimenez-Roqueplo, Anne-Paule
Nature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 6044
Pheochromocytomas and paragangliomas (PCCs/PGLs) are neural crest-derived tumours with a very strong genetic component. Here we report the first integrated... 
MALIGNANT PHEOCHROMOCYTOMAS | H-RAS | BENIGN | MULTIDISCIPLINARY SCIENCES | GENETIC LANDSCAPE | EXPRESSION PROFILES | MICRORNAS | CANCER | SOMATIC MUTATIONS | DRIVER MUTATIONS | SDHB GENE | Humans | Middle Aged | Male | MicroRNAs - metabolism | Gene Expression Profiling | DNA Copy Number Variations | Young Adult | Aged, 80 and over | Adult | Female | Genomics - methods | Child | Genetic Predisposition to Disease | Paraganglioma - genetics | DNA Methylation - genetics | Mutation - genetics | Sequence Analysis, DNA | Genome, Human - genetics | Exome - genetics | Adolescent | Pheochromocytoma - genetics | Aged | MicroRNAs - genetics | Adrenal Gland Neoplasms - genetics | Cohort Studies
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