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Science, ISSN 0036-8075, 02/2019, Volume 363, Issue 6428, pp. 690 - 691
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2013, Volume 123, Issue 2, pp. 560 - 560
The cytokine TNF- alpha is a major drug target for rheumatoid arthritis, an inflammatory joint disorder. An alternative approach is to target the protease TNF-... 
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 04/2019, Volume 11, Issue 4
Journal Article
Trends in Neurosciences, ISSN 0166-2236, 03/2016, Volume 39, Issue 3, p. 158
  The protease β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is required for the production of the amyloid-β (Aβ) peptide, which is central... 
Enzymes | Proteases | Pathogenesis | Alzheimers disease | Knowledge
Journal Article
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 08/2018, Volume 38, Issue 15
Prions of lower eukaryotes are transmissible protein particles that propagate by converting homotypic soluble proteins into growing protein assemblies. Prion... 
YEAST PSI+ PRION | BIOCHEMISTRY & MOLECULAR BIOLOGY | neurodegeneration | GUANIDINE-HYDROCHLORIDE | PARALLEL BETA-SHEET | SACCHAROMYCES-CEREVISIAE | SPECIES BARRIERS | CELL BIOLOGY | AMYLOID CORES | amyloid | IDENTIFY PROTEINS | prion-like | protein misfolding | prions | HSP104 INACTIVATION | OLIGOPEPTIDE REPEATS | DETERMINANT PSI(+)
Journal Article
Progress in Neurobiology, ISSN 0301-0082, 12/2015, Volume 135, pp. 1 - 20
Journal Article
Frontiers in Neuroscience, ISSN 1662-453X, 02/2019, Volume 13
Amyloid precursor protein (APP) transgenic animal models of Alzheimer’s disease have become versatile tools for basic and translational research. However,... 
interneuron | Alzheimer’s disease | hippocampus | animal model | amyloid precursor protein | calcium-binding proteins
Journal Article
Frontiers in Physiology, ISSN 1664-042X, 2012, Volume 3, p. 8
The beta-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease involved in Alzheimer's disease (AD) pathogenesis and in myelination. BACE1... 
Aspartic protease | Regulated intramembrane proteolysis | Beta-secretase | Neurodegeneration | Amyloid-beta | amyloid-beta | neurodegeneration | PHYSIOLOGY | regulated intramembrane proteolysis | beta-secretase | aspartic protease
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 11/2015, Volume 211, Issue 3, p. 553
  Cell division cycle 42 (Cdc42) is a member of the Rho guanosine triphosphatase family and has pivotal functions in actin organization, cell migration, and... 
Antigens | Dendritic cells | Maturation | Cell cycle | Cell division
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 01/2011, Volume 116, Issue 1, p. 10
Ectodomain shedding of the amyloid precursor protein (APP) by the metalloprotease activity [alpha]-secretase is a key regulatory event preventing the... 
Neurochemistry | Peptides | Cellular biology | Proteases | Alzheimers disease
Journal Article