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Science, ISSN 0036-8075, 12/2010, Volume 330, Issue 6009, pp. 1385 - 1389
Journal Article
Nature Genetics, ISSN 1061-4036, 04/2018, Volume 50, Issue 4, pp. 613 - 620
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2016, Volume 62, Issue 2, pp. 157 - 168
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 3039 - 3039
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2016, Volume 63, Issue 3, pp. 514 - 525
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific... 
COMBINED INHIBITION | FISSION YEAST | REPAIR | TUMOR MUTATIONS | STRATEGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETIC INTERACTION MAP | DNA-DAMAGE | SACCHAROMYCES-CEREVISIAE | DRUGGABLE GENOME | CHK1 INHIBITION | CELL BIOLOGY | Protein Interaction Maps - drug effects | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | Humans | RecQ Helicases - genetics | Saccharomyces cerevisiae - drug effects | Antineoplastic Agents - therapeutic use | Synthetic Lethal Mutations | Gene Regulatory Networks - drug effects | Molecular Targeted Therapy | Dose-Response Relationship, Drug | Saccharomyces cerevisiae - metabolism | Gene Expression Regulation, Fungal - drug effects | Transfection | RNA Interference | Time Factors | Uterine Cervical Neoplasms - metabolism | Cell Cycle Proteins - genetics | Female | Gene Expression Regulation, Neoplastic - drug effects | Genes, Tumor Suppressor | Uterine Cervical Neoplasms - mortality | Cell Survival - drug effects | Genetic Predisposition to Disease | Cell Cycle Proteins - metabolism | Kaplan-Meier Estimate | Uterine Cervical Neoplasms - drug therapy | Saccharomyces cerevisiae Proteins - genetics | Uterine Cervical Neoplasms - genetics | Phenotype | Signal Transduction - drug effects | Saccharomyces cerevisiae Proteins - metabolism | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | HeLa Cells | Mutation | Precision Medicine - methods | Antimitotic agents | Care and treatment | Analysis | Drug therapy, Combination | Antineoplastic agents | Health aspects | Phosphotransferases | Cancer
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 07/2018, Volume 17, Issue 7, pp. 1585 - 1594
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2017, Volume 65, Issue 4, pp. 761 - 774.e5
Journal Article
Cell Reports, ISSN 2211-1247, 01/2013, Volume 3, Issue 1, pp. 128 - 137
Classic "position-effect" experiments repositioned genes near telomeres to demonstrate that the epigenetic landscape can dramatically alter gene expression.... 
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 129 - 129
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 34, pp. 35755 - 35769
Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular... 
RAD17 | Biomarker | Synthetic lethal | DNA damage | Checkpoint kinase inhibitor | synthetic lethal | checkpoint kinase inhibitor | ADVANCED SOLID TUMORS | PANCREATIC-CANCER | CHK1 INHIBITORS | OVARIAN-CANCER | biomarker | I DOSE-ESCALATION | CANCER-THERAPY | CELL BIOLOGY | BREAST-CANCER | WEE1 INHIBITION | PRECLINICAL MODELS | TARGETING CHK1
Journal Article