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Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Cell Reports, ISSN 2211-1247, 10/2014, Volume 7, Issue 1, pp. 86 - 93
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 07/2018, Volume 24, Issue 7, pp. 961 - 961
RAS mutations are frequent in human cancer, especially in pancreatic, colorectal and non-small-cell lung cancers (NSCLCs)(1-3). Inhibition of the RAS... 
MEDICINE, RESEARCH & EXPERIMENTAL | TYROSINE PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEK INHIBITORS | INDUCED SENESCENCE | CELL BIOLOGY | THERAPY | K-RAS | RESISTANCE | MUTATIONS | EXPRESSION | PROGRESSION | PHOSPHOTYROSINE PHOSPHATASE | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Cellular Senescence - drug effects | Lung Neoplasms - pathology | Guanosine Triphosphate - metabolism | Mutation - genetics | Xenograft Model Antitumor Assays | Mitogen-Activated Protein Kinase Kinases - metabolism | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins p21(ras) - metabolism | Tyrosine | Ras genes | Genetic aspects | Epidermal growth factor | Lung cancer, Non-small cell | Analysis | Cell culture | Senescence | Lung cancer | Extracellular signal-regulated kinase | Antibodies | Raf protein | Signaling | Immunotherapy | Pancreatic cancer | Protein-tyrosine kinase receptors | Colon | Inhibition | Mutation | Pancreas | Growth factors | Protein-tyrosine kinase | Cancer | Tumors | Index Medicus
Journal Article
Cell Reports, ISSN 2211-1247, 09/2015, Volume 12, Issue 12, pp. 1978 - 1985
Most ( ) mutant melanomas are sensitive to selective BRAF inhibitors, but mutant colon cancers are intrinsically resistant to these drugs because of feedback... 
COLON-CANCER | SHP2 PTPN11 | LUNG-CANCER | MEK INHIBITION | BRAF(V600E) INHIBITION | GROWTH | PROTEIN-TYROSINE PHOSPHATASES | RAF INHIBITORS | MUTATIONS | NOONAN-SYNDROME | CELL BIOLOGY | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Colonic Neoplasms - genetics | Colonic Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Genomic Library | ras Proteins - metabolism | Colonic Neoplasms - metabolism | MAP Kinase Signaling System | Receptor, Epidermal Growth Factor - metabolism | Melanoma - genetics | Indoles - pharmacology | Lentivirus - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Transduction, Genetic | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Melanoma - pathology | Sulfonamides - pharmacology | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Melanoma - drug therapy | Cell Line, Tumor | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Genetic Vectors | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 04/2018, Volume 17, Issue 4, pp. 849 - 857
Journal Article
European Urology, ISSN 0302-2838, 2017, Volume 71, Issue 6, pp. 858 - 862
Abstract Activating mutations and translocations of the FGFR3 gene are commonly seen in urothelial cell carcinoma (UCC) of the bladder and urinary tract.... 
Urology | Synergy | PI3K | FGFR | Bladder cancer | ACTIVATION | UROLOGY & NEPHROLOGY | FUSIONS | CANCER | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | Humans | Urinary Bladder Neoplasms - enzymology | Molecular Targeted Therapy | Urothelium - pathology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Transfection | Urinary Bladder Neoplasms - genetics | RNA Interference | Time Factors | Carcinoma - enzymology | Receptors, Fibroblast Growth Factor - genetics | Urinary Bladder Neoplasms - pathology | Urothelium - enzymology | Benzamides - pharmacology | Carcinoma - pathology | Pyrazoles - pharmacology | Carcinoma - drug therapy | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Morpholines - pharmacology | Urinary Bladder Neoplasms - drug therapy | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Piperazines - pharmacology | Drug Synergism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Aminopyridines - pharmacology | Receptors, Fibroblast Growth Factor - metabolism | Cell Line, Tumor | Carcinoma - genetics | Protein Kinase Inhibitors - pharmacology | Mutation | Urothelium - drug effects | Tyrosine | Epidermal growth factor | Carcinoma | Lung cancer | Therapeutics | Fibroblast growth factors | Protein kinases | Genetic screening | Homeopathy | Materia medica and therapeutics | Cancer | Index Medicus
Journal Article
STEM CELLS, ISSN 1066-5099, 01/2017, Volume 35, Issue 1, pp. 147 - 157
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