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Nature cell biology, ISSN 1476-4679, 2015, Volume 17, Issue 5, pp. 545 - 557
How embryonic stem cells (ESCs) commit to specific cell lineages and yield all cell types of a fully formed organism remains a major question. ESC... 
GENOMIC INSTABILITY | OCT4 | METHYLATION | 5-METHYLCYTOSINE | CONVERSION | ROLES | DNA | HYDROXYLATION | PROTEINS | REVEALS | CELL BIOLOGY | Cytosine - analogs & derivatives | 5-Methylcytosine - analogs & derivatives | Homeodomain Proteins - metabolism | Humans | Mice, 129 Strain | Sirtuins - deficiency | Neurogenesis | SOXB1 Transcription Factors - metabolism | DNA-Binding Proteins - metabolism | Octamer Transcription Factor-3 - genetics | Transfection | RNA Interference | SOXB1 Transcription Factors - genetics | Cytosine - metabolism | Gene Expression Regulation, Developmental | Cell Differentiation | Acetylation | Sirtuins - genetics | Proto-Oncogene Proteins - metabolism | Induced Pluripotent Stem Cells - enzymology | Nanog Homeobox Protein | Teratoma - enzymology | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Chromatin Assembly and Disassembly | Embryonic Stem Cells - enzymology | Genotype | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Mice, SCID | Homeodomain Proteins - genetics | Mice, Knockout | Cell Lineage | Phenotype | Teratoma - pathology | Animals | Embryonic Stem Cells - transplantation | Octamer Transcription Factor-3 - metabolism | Embryonic Stem Cells - pathology | Histones - metabolism | Sirtuins - metabolism | Enzymes | Hydrolases | Genetic aspects | Properties | Embryonic stem cells | Cell differentiation
Journal Article
Nature protocols, ISSN 1750-2799, 2016, Volume 11, Issue 10, pp. 1889 - 1907
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 31, pp. E4236 - E4245
Dioxygenases of the TET (Ten-Eleven Translocation) family produce oxidized methylcytosines, intermediates in DNA demethylation, as well as new epigenetic... 
5hmC | Dna methylation | Tet methylcytosine oxidases | 5-hydroxymethylcytosine | Cholesterol biosynthesis | MAMMALIAN ZYGOTE | MULTIDISCIPLINARY SCIENCES | TET methylcytosine oxidases | DNA-METHYLATION | 5-METHYLCYTOSINE OXIDATION | MOUSE ZYGOTES | SINGLE-CELL | cholesterol biosynthesis | EMBRYONIC STEM-CELLS | DNA methylation | GENE-EXPRESSION | PREIMPLANTATION EMBRYOS | POSTNATAL-DEVELOPMENT | THYMINE DNA | Genomic Imprinting | Hedgehog Proteins - metabolism | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Embryo Loss - metabolism | Blastomeres - metabolism | Embryo Loss - pathology | Gene Expression Regulation, Developmental | Gene Deletion | Biomarkers - metabolism | Proto-Oncogene Proteins - metabolism | Repetitive Sequences, Nucleic Acid - genetics | Embryo, Mammalian - pathology | Mice, Inbred C57BL | Blastocyst - metabolism | Embryonic Development - genetics | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Transcriptome - genetics | Blastomeres - pathology | DNA - metabolism | Proto-Oncogene Proteins - deficiency | DNA-Binding Proteins - genetics | Down-Regulation - genetics | Mice, Knockout | Cell Lineage | Animals | Sequence Analysis, RNA | 5-Methylcytosine - metabolism | Cholesterol - biosynthesis | Oxidases | Physiological aspects | Embryonic development | Genetic aspects | Genetic transcription | Observations | Biological Sciences | PNAS Plus
Journal Article
Journal Article
by Altshuler, David M and Durbin, Richard M and Abecasis, Gonçalo R and Bentley, David R and Chakravarti, Aravinda and Clark, Andrew G and Donnelly, Peter and Eichler, Evan E and Flicek, Paul and Gabriel, Stacey B and Gibbs, Richard A and Green, Eric D and Hurles, Matthew E and Knoppers, Bartha M and Korbel, Jan O and Lander, Eric S and Lee, Charles and Lehrach, Hans and Mardis, Elaine R and Marth, Gabor T and McVean, Gil A and Nickerson, Deborah A and Schmidt, Jeanette P and Sherry, Stephen T and Wang, Jun and Wilson, Richard K and Dinh, Huyen and Kovar, Christie and Lee, Sandra and Lewis, Lora and Muzny, Donna and Reid, Jeff and Wang, Min and Fang, Xiaodong and Guo, Xiaosen and Jian, Min and Jiang, Hui and Jin, Xin and Li, Guoqing and Li, Jingxiang and Li, Yingrui and Li, Zhuo and Liu, Xiao and Lu, Yao and Ma, Xuedi and Su, Zhe and Tai, Shuaishuai and Tang, Meifang and Wang, Bo and Wang, Guangbiao and Wu, Honglong and Wu, Renhua and Yin, Ye and Zhang, Wenwei and Zhao, Jiao and Zhao, Meiru and Zheng, Xiaole and Zhou, Yan and Gupta, Namrata and Clarke, Laura and Leinonen, Rasko and Smith, Richard E and Zheng-Bradley, Xiangqun and Grocock, Russell and Humphray, Sean and James, Terena and Kingsbury, Zoya and Sudbrak, Ralf and Albrecht, Marcus W and Amstislavskiy, Vyacheslav S and Borodina, Tatiana A and Lienhard, Matthias and Mertes, Florian and Sultan, Marc and Timmermann, Bernd and Yaspo, Marie-Laure and Fulton, Lucinda and Fulton, Robert and Weinstock, George M and Balasubramaniam, Senduran and Burton, John and Danecek, Petr and Keane, Thomas M and Kolb-Kokocinski, Anja and McCarthy, Shane and Stalker, James and Quail, Michael and Davies, Christopher J and Gollub, Jeremy and Webster, Teresa and Wong, Brant and Zhan, Yiping and Auton, Adam and Yu, Fuli and Bainbridge, Matthew and Challis, Danny and Evani, Uday S and Lu, James and Nagaswamy, Uma and Sabo, Aniko and ... and The 1000 Genomes Project Consortium and 1000 Genomes Project Consortium
Nature (London), ISSN 1476-4687, 2012, Volume 491, Issue 7422, pp. 56 - 65
Journal Article
Journal Article
Genome medicine, ISSN 1756-994X, 2018, Volume 10, Issue 1, pp. 55 - 16
...Author(s): Sabrina Grasse[sup.1,4], Matthias Lienhard[sup.2], Steffen Frese[sup.3], Martin Kerick[sup.4,5], Anne Steinbach[sup.1,6], Christina Grimm[sup.1... 
Epigenomics | NSCLC | Patient-derived xenografts | Non-small cell lung cancer | DNA methylation | Carboplatin resistance | Therapy response | Predictive biomarker | READ ALIGNMENT | ACTIVATION | CISPLATIN RESISTANCE | AUTOPHAGY | INACTIVATION | TUMOR XENOGRAFTS | GENE | GENETICS & HEREDITY | MUTATIONS | CYTOSINE METHYLATION | Lung Neoplasms - genetics | Promoter Regions, Genetic | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Treatment Outcome | DNA Methylation - genetics | Low Density Lipoprotein Receptor-Related Protein-1 - genetics | Xenograft Model Antitumor Assays | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | Animals | Carboplatin - therapeutic use | Mice, Nude | Biomarkers, Tumor - metabolism | Biomarkers, Tumor - genetics | Carcinoma, Non-Small-Cell Lung - drug therapy | Carboplatin - pharmacology | Genome, Human | Genes, Tumor Suppressor | Epigenetic inheritance | Usage | Xenotransplantation | Carboplatin | Dosage and administration | Genetic aspects | Research | Diagnosis | Drug resistance | Lung cancer, Non-small cell | Drug therapy | Methylation | Adenocarcinoma | Lipoproteins (low density) | Lung cancer | Colorectal cancer | Non-small cell lung carcinoma | Genomes | Gene expression | Kinases | Patients | Cancer therapies | Cisplatin | Proteins | Chemotherapy | Platinum | Surgery | Xenografts | Biomarkers | Epigenetics | Mutation | Deoxyribonucleic acid--DNA | Tumors | CpG islands
Journal Article