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1996, Lung biology in health and disease, ISBN 0824797299, Volume 96, xix, 594
Book
Trends in Biochemical Sciences, ISSN 0968-0004, 04/2018, Volume 43, Issue 4, pp. 227 - 229
G-protein-coupled receptors (GPCRs) are the targets for many drugs, but the response shows interindividual variability. The ‘one-drug-fits-all’ approach has... 
coupling | heart failure | mutation | asthma | polymorphism | G protein | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | RECEPTOR POLYMORPHISMS | Genetic Variation | Receptors, G-Protein-Coupled - genetics | Mutation | Humans | Polymorphism
Journal Article
Journal of Personalized Medicine, ISSN 2075-4426, 09/2018, Volume 8, Issue 3, p. 23
While many diverse ‘pharmacogenes’ are recognized (e.g., TPMT, G6PD, HLA, etc.), a thorough understanding of the implications of genetic variation in the CYP... 
Consortia | Cytochrome | Prescription drugs | Precision medicine | Genomics | Genes | Cytochrome P450 | Conflicts of interest | n/a
Journal Article
Science Signaling, ISSN 1945-0877, 08/2011, Volume 4, Issue 185, p. 1
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 2000, Volume 161, Issue 3, pp. S197 - S201
Journal Article
Transactions of the American Clinical and Climatological Association, ISSN 0065-7778, 2014, Volume 125, pp. 5 - 64
Journal Article
Science Translational Medicine, ISSN 1946-6234, 12/2009, Volume 1, Issue 12
Journal Article
The FASEB Journal, ISSN 0892-6638, 07/2018, Volume 32, Issue 7, pp. 3680 - 3688
β 2 -Adrenergic receptors (β 2 ARs) desensitize during continuous agonist activation, which manifests clinically as tachyphylaxis. β-Agonist desensitization of... 
microRNA | asthma | Research | tachyphylaxis | G protein
Journal Article
Biochemistry, ISSN 0006-2960, 1994, Volume 33, Issue 32, pp. 9414 - 9419
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/1998, Volume 102, Issue 11, pp. 1927 - 1932
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 1997, Volume 156, Issue 4, pp. S156 - S162
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2010, Volume 16, Issue 11, pp. 1299 - 1304
Bitter taste receptors (TAS2Rs) on the tongue probably evolved to evoke signals for avoiding ingestion of plant toxins. We found expression of TAS2Rs on human... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | CONTRACTILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELAXATION | CELL BIOLOGY | HETEROGENEITY | LACTONES | ASTHMA | CHANNELS | MAMMALIAN TASTE | EXPRESSION | SPARKS | Asthma - metabolism | Large-Conductance Calcium-Activated Potassium Channels - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Bronchi - physiopathology | Myocytes, Smooth Muscle - pathology | RNA, Messenger - metabolism | Airway Obstruction - metabolism | Bronchi - drug effects | Dose-Response Relationship, Drug | Muscle, Smooth - drug effects | Muscle Relaxation - physiology | Bronchoconstriction - drug effects | Bronchi - metabolism | Bronchi - pathology | Myocytes, Smooth Muscle - metabolism | Membrane Potentials - drug effects | Bronchoconstriction - physiology | Asthma - physiopathology | Cell Separation | RNA, Messenger - genetics | Airway Obstruction - physiopathology | Muscle, Smooth - metabolism | Membrane Potentials - physiology | Taste - physiology | Gene Expression Regulation - drug effects | Animals | Taste - drug effects | Asthma - complications | Calcium Signaling - drug effects | Airway Obstruction - pathology | Muscle, Smooth - physiopathology | Mice | Receptors, G-Protein-Coupled - genetics | Muscle Relaxation - drug effects | Muscle, Smooth - pathology | Saccharin - pharmacology | Taste buds | Care and treatment | Usage | Animal models in research | Physiological aspects | Smooth muscle | Genetic aspects | Airway obstruction (Medicine) | Research | Risk factors | Signal transduction | Taste | Calcium | Cellular biology | Respiratory diseases
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 12/2002, Volume 110, Issue 6, pp. S223 - S228
The proposed manner by which β -adrenergic receptors signal has dramatically changed from earlier concepts that centered on a lock-and-key mechanism in which... 
gene therapy | Adenylyl cyclase | desensitization | G protein | Desensitization | Gene therapy
Journal Article
Science, ISSN 0036-8075, 4/2009, Volume 324, Issue 5923, pp. 55 - 59
Journal Article
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 2002, Volume 39, Issue 2, pp. 155 - 160
Journal Article
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