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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2012, Volume 109, Issue 50, pp. 20467 - 20472
Impairment of ribosomal biogenesis can activate the p53 protein independently of DNA damage. The ability of ribosomal proteins L5, L11, L23, L26, or S7 to bind... 
Up regulation | Cell nucleolus | Ribosomal proteins | Ribosomes | Cell cycle | Antibodies | HeLa cells | Small interfering RNA | Cell aggregates | Cellular immunity | Ribosomal stress | Proteasome | HDM2 | proteasome | CELLS | INHIBITION | RNA | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | 40S | MDM2 | CHECKPOINT | ribosomal stress | RNA, Small Interfering - genetics | Up-Regulation | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Stress, Physiological | Ribosomes - metabolism | RNA, Messenger - metabolism | Tumor Suppressor Protein p53 - genetics | Ribosomal Proteins - metabolism | Base Sequence | Cell Nucleolus - metabolism | Tumor Suppressor Proteins - genetics | Active Transport, Cell Nucleus | Protein Stability | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Ribosomal Proteins - antagonists & inhibitors | Tumor Suppressor Proteins - metabolism | Ribosomal Proteins - genetics | RNA, Messenger - genetics | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Models, Biological | Cell Line, Tumor | Mice | Proteasome Endopeptidase Complex - metabolism | Dactinomycin - pharmacology | Promyelocytic Leukemia Protein | DNA damage | Physiological aspects | Biosynthesis | Stress (Physiology) | Research | Health aspects | Biological Sciences
Journal Article
ISSN 1932-6203, 2013
Changes to the nucleolus, the site of ribosome production, have long been linked to cancer, and mutations in several ribosomal proteins (RPs) have been... 
Ubiquitin | Nucleoproteins | Small interfering RNA | Biology | Gene expression | Molecular biology
Journal Article
01/2013, ISBN 9781303321238
The Mdm2-p53 axis is an important pathway in cells that is frequently misregulated in cancer. Under basal conditions, Mdm2 suppresses p53 through multiple... 
Cellular biology | Molecular biology
Dissertation
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2012, Volume 109, Issue 50, p. 20467
  Impairment of ribosomal biogenesis can activate the p53 protein independently of DNA damage. The ability of ribosomal proteins L5, L11, L23, L26, or S7 to... 
Proteins | Pathogenesis | DNA damage | Leukemia | Biosynthesis
Journal Article
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