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Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 5606 - 5606
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 4713 - 4713
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2017, Volume 23, Issue 14, pp. 3711 - 3720
Purpose: To explore whether a cross-talk exists between PARP inhibition and PD-L1/PD-1 immune checkpoint axis, and determine whether blockade of PD-L1/PD-1... 
CELL LUNG-CANCER | BREAST-CANCER | OVEREXPRESSION | ACTIVATION | THERAPY | PEMBROLIZUMAB | ONCOLOGY | OVARIAN-CANCER | PROVIDES | COMBINATION | CHEMOTHERAPY | Tumor Microenvironment - drug effects | Poly (ADP-Ribose) Polymerase-1 - immunology | Breast Neoplasms - immunology | Humans | Poly(ADP-ribose) Polymerase Inhibitors - immunology | Lymphocytes, Tumor-Infiltrating - drug effects | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Breast Neoplasms - drug therapy | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Tumor Microenvironment - immunology | Xenograft Model Antitumor Assays | Immunosuppression | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Female | Mice | Gene Expression Regulation, Neoplastic - drug effects | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Cell culture | Flow cytometry | Biotechnology | Animal models | PD-1 protein | Immunoblotting | Lymphocytes T | Immunity | Anticancer properties | Lymphocytes | Xenografts | Tumor-infiltrating lymphocytes | Tumor cells | Poly(ADP-ribose) polymerase | Breast cancer | Tumor cell lines | Inhibitors | Immune checkpoint | Experimental design | PD-L1 protein | Cell lines | Breast | In vivo methods and tests | Tumors | Cancer
Journal Article
Nature Communications, ISSN 2041-1723, 08/2016, Volume 7, Issue 1, p. 12632
Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) leads to tumour-associated immune escape. Here... 
EPITHELIAL-MESENCHYMAL TRANSITION | B7 FAMILY-MEMBER | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | N-LINKED GLYCANS | DEGRADATION | PROMOTES TUMORIGENESIS | PD-1 | CANCER | EXPRESSION | Phosphorylation | Breast Neoplasms - immunology | Humans | Antineoplastic Agents - therapeutic use | Lymphocyte Activation - immunology | Ubiquitination | beta-Transducin Repeat-Containing Proteins - metabolism | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Female | Antineoplastic Agents - pharmacology | Gefitinib | Breast - pathology | Tumor Escape - immunology | Programmed Cell Death 1 Receptor - metabolism | Epidermal Growth Factor - metabolism | Glycosylation | B7-H1 Antigen - immunology | Breast Neoplasms - drug therapy | Glycogen Synthase Kinase 3 beta - metabolism | Immunologic Surveillance - immunology | Xenograft Model Antitumor Assays | B7-H1 Antigen - metabolism | Animals | Breast Neoplasms - pathology | Quinazolines - therapeutic use | Protein Stability - drug effects | Cell Line, Tumor | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Quinazolines - pharmacology | Animal models | PD-1 protein | Lymphocytes T | Kinases | Inactivation | Immunity | Proteins | Signal transduction | Epidermal growth factor | Growth factors | Deactivation | Glycogen | Mortality | Glycogen synthase kinase 3 | Breast cancer | Immunosuppression | Cell death | PD-L1 protein | Ligands | Cancer | Tumors | Apoptosis
Journal Article
FEBS Letters, ISSN 0014-5793, 11/2011, Volume 585, Issue 21, pp. 3436 - 3441
► In HCC cells, Oct-1 binds to the catalase promoter and acts as an activator. ► ROS induce methylation of CpG sites in the Oct-1 promoter. ► Oct-1 expression... 
Hepatocellular carcinoma | Reactive oxygen species | Oct-1 | Catalase | Methylation | HCC | bisulfite sequencing | MSP | ChIP | chromatin immunoprecipitation | DNMT | electrophoretic mobility shift assay | methylation-specific polymerase chain reaction | EMSA | PMS | ROS | reactive oxygen species | DNA methyltransferase | phenazine methosulfate | 5-aza-dC | hepatocellular carcinoma | 5-aza-2′-deoxycytidine | ACTIVATION | HYPERMETHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHENOTYPE | CANCER | POU-DOMAIN | CELL BIOLOGY | TRANSCRIPTION FACTOR OCT-1 | HEPATOCELLULAR-CARCINOMA | BIOPHYSICS | GENE | EPIGENETIC ALTERATIONS | Gene Expression Regulation, Enzymologic - drug effects | CpG Islands - drug effects | Humans | Reactive Oxygen Species - pharmacology | Promoter Regions, Genetic - drug effects | Promoter Regions, Genetic - genetics | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Gene Expression Regulation, Neoplastic - drug effects | Liver Neoplasms - enzymology | Gene Expression Regulation, Neoplastic - genetics | Liver Neoplasms - genetics | Catalase - genetics | Neoplasm Invasiveness | Azacitidine - analogs & derivatives | Octamer Transcription Factor-1 - genetics | Carcinoma, Hepatocellular - enzymology | Down-Regulation - drug effects | Enzyme Activation - drug effects | Catalase - metabolism | Azacitidine - pharmacology | Gene Expression Regulation, Enzymologic - genetics | Acetylcysteine - pharmacology | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | CpG Islands - genetics | DNA Methylation - drug effects | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 05/2013, Volume 497, Issue 7449, pp. 383 - 387
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 135, Issue 6, pp. 2128 - 2140.e8
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2018, Volume 33, Issue 2, pp. 187 - 201.e10
Journal Article