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Chemical Reviews, ISSN 0009-2665, 02/2018, Volume 118, Issue 3, p. 889
Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their activity, stability, subcellular localization, or macromolecular... 
Proteins | Enzymes | Chemistry | Cascades | Lipids | Conjugation | Machinery | Cells
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2018, Volume 115, Issue 24, p. E5506
The nuclear exosome-targeting (NEXT) complex functions as an RNA exosome cofactor and is involved in surveillance and turnover of aberrant transcripts and... 
Transcription factors | Saccharomyces | Ribonucleic acid--RNA | Substrates | Zinc | Cofactors | Proteins | Fungi | DNA helicase | RNA-binding protein | Polyadenylation | Uridine | Saccharomyces cerevisiae | Binding sites | Adenosine triphosphatase | Crystal structure | RNA helicase
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 11/2015, Volume 22, Issue 12
Journal Article
Structure, ISSN 0969-2126, 04/2015, Volume 23, Issue 4, pp. 605 - 605
Journal Article
Nature, ISSN 0028-0836, 7/2014, Volume 511, Issue 7510, pp. 435 - 439
The eukaryotic RNA exosome processes and degrades RNA by directing substrates to the distributive or processive 3′ to 5′ exoribonuclease activities of Rrp6 or... 
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 4, pp. 734 - 745
The eukaryotic RNA exosome is an essential and conserved 3′-to-5′ exoribonuclease complex that degrades or processes nearly every class of cellular RNA. The... 
X-ray crystallography | RNA | RNA decay | click chemistry | exoribonuclease | nuclear | exosome | multi-subunit complex | structure | Saccharomyces cerevisiae - genetics | Allosteric Regulation | Substrate Specificity | Crystallography, X-Ray | Protein Subunits - metabolism | Saccharomyces cerevisiae - metabolism | Thermodynamics | Cell Nucleus - metabolism | Exosome Multienzyme Ribonuclease Complex - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Exosome Multienzyme Ribonuclease Complex - metabolism | Protein Interaction Domains and Motifs | RNA, Fungal - genetics | Exosome Multienzyme Ribonuclease Complex - genetics | Binding Sites | Exosome Multienzyme Ribonuclease Complex - ultrastructure | Protein Subunits - genetics | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | RNA, Fungal - chemistry | Models, Molecular | Recombinant Proteins - chemistry | RNA Cleavage | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Motifs | RNA, Fungal - metabolism | Cell Nucleus - genetics | Protein Conformation, beta-Strand | Escherichia coli - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Protein Subunits - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Phosphates | Structure | Crystals
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2014, Volume 124, Issue 10, pp. 4564 - 4564
Retinal and choroidal neovascularization (NV) and vascular leakage contribute to visual impairment in several common ocular diseases. The angiopoietin/TIE2... 
Journal Article
SAE technical paper series, Volume 2014-36-0243.
On Current Automotive Application, including Brazil, there are significant initiatives to reduce fuel consumption and emissions, like INOVAR Auto and others... 
Thermal management | Electric vehicles | Hybrid electric vehicles
eBook
Current Opinion in Structural Biology, ISSN 0959-440X, 02/2014, Volume 24, Issue 1, pp. 132 - 140
Journal Article