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Journal of Electroanalytical Chemistry, ISSN 1572-6657, 06/2018, Volume 819, p. 214
Classical electrochemical approaches were evaluated for investigating the basic properties of deep eutectic solvents (DES) with a special focus on the mass... 
Solvents | Transport phenomena | Eutectics | Choline | Ionic liquids | Voltammetry | Oxidation | Lactic acid | Diffusion | Species diffusion
Journal Article
Journal of Electroanalytical Chemistry, ISSN 1572-6657, 06/2018, Volume 819, pp. 214 - 219
Classical electrochemical approaches were evaluated for investigating the basic properties of deep eutectic solvents (DES) with a special focus on the mass... 
Deep eutectic solvents. Redox probes. Cyclic voltammetry. Diffusion coefficients | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | Redox probes | TEMPERATURE IONIC LIQUIDS | CHOLINE CHLORIDE | Cyclic voltammetry | QUATERNARY AMMONIUM | MIXTURES | NMR | Deep eutectic solvents | COUPLE | COEFFICIENTS | Diffusion coefficients | VOLTAMMETRY | Local transit | Metallocenes
Journal Article
Marine Drugs, ISSN 1660-3397, 10/2017, Volume 15, Issue 10, p. 316
A large diversity of 2-aminoimidazolone alkaloids is produced by various marine invertebrates, especially by the marine Calcareous sponges Leucetta and... 
CLK | Alzheimer’s disease | 2-aminoimidazolone alkaloids | Marine sponge | Polyandrocarpamines | Down syndrome | Kinase inhibitor | DYRK | Leucettine | Ascidian | Calcarea | Porifera | Polyandrocarpa | Protein kinases | Leucettamine B | HYMENIALDISINE | leucettine | CYCLIN D1 | protein kinases | marine sponge | BENZYLIDENE 2-AMINOIMIDAZOLONES | AFFINITY-CHROMATOGRAPHY | Alzheimer's disease | IMMOBILIZED AXIN | CHEMISTRY, MEDICINAL | NATURAL-PRODUCTS | RECEPTOR ANTAGONIST | ascidian | kinase inhibitor | SPONGE ALKALOIDS | polyandrocarpamines | LEUCETTINE L41 | leucettamine B | IMIDAZOLE ALKALOIDS | Phosphorylation | Protozoan Proteins - antagonists & inhibitors | Humans | Imidazoles - chemistry | Alkaloids - chemical synthesis | Structure-Activity Relationship | Phylogeny | Protozoan Infections - drug therapy | Amines - therapeutic use | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Antiprotozoal Agents - chemical synthesis | Imidazoles - chemical synthesis | Imidazoles - therapeutic use | Porifera - chemistry | Protein Kinase Inhibitors - chemical synthesis | Alkaloids - pharmacology | Alzheimer Disease - drug therapy | Imidazoles - pharmacology | Amines - chemical synthesis | Antiprotozoal Agents - pharmacology | Porifera - genetics | Animals | Protein Kinase Inhibitors - therapeutic use | Down Syndrome - drug therapy | Alkaloids - therapeutic use | Protein Kinase Inhibitors - pharmacology | Antiprotozoal Agents - therapeutic use | Amines - pharmacology | Urochordata - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Drugs | Cdc2 protein | Disease | Cyclin D1 | Drug development | Kinases | Proteins | Alkaloids | Marine invertebrates | Microorganisms | Specificity | Plankton | Down's syndrome | Tyrosine | Medical treatment | Sponges | Pharmacology | Mammals | Cells | Diseases | Inhibitors | Reviews | Invertebrates | Chemical Sciences
Journal Article
Disease models & mechanisms, ISSN 1754-8403, 09/2018, Volume 11, Issue 9, p. dmm035634
Growing evidence supports the implication of DYRK1A in the development of cognitive deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here... 
Leucettine | DYRK1A | Down syndrome | Synapsin | Kinase inhibitor | FUNCTIONAL CONNECTIVITY | BINDING-PROTEIN | DUAL-SPECIFICITY | PATHOLOGY | MICROTUBULE DYNAMICS | CELL BIOLOGY | INTELLECTUAL DISABILITY | TRANSMITTER RELEASE | REGULATED KINASE 1A | SYNDROME CRITICAL REGION | INCREASED DOSAGE | SYNAPSIN-I | Dioxoles - therapeutic use | Phosphorylation | Protein-Tyrosine Kinases - metabolism | Imidazoles - chemistry | Cytoplasm - metabolism | Nerve Net - drug effects | RNA, Messenger - metabolism | Synapsins - metabolism | Protein Kinase Inhibitors - chemistry | Protein-Tyrosine Kinases - genetics | Synapses - metabolism | Protein Binding - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Dioxoles - pharmacology | Down Syndrome - complications | Cognitive Dysfunction - complications | Imidazoles - therapeutic use | Nerve Net - physiopathology | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Cognitive Dysfunction - drug therapy | Amino Acid Sequence | Down Syndrome - pathology | Synapses - drug effects | Biocatalysis | Brain - physiopathology | Mice, Inbred C57BL | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Imidazoles - pharmacology | Cognitive Dysfunction - pathology | Dioxoles - chemistry | Synapsins - chemistry | Brain - drug effects | Magnetic Resonance Imaging | Animals | Protein Kinase Inhibitors - therapeutic use | Proteomics | Brain - pathology | Cytoskeleton - metabolism | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Cytoskeleton - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors | Chemical Sciences | 302
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 03/2014, Volume 85, Issue 3, pp. 441 - 450
Leucettines, a family of pharmacological inhibitors of dual-specificity tyrosine phosphorylation regulated kinases and cdc-like kinases (CLKs), are currently... 
TARGET | PIKFYVE | PROTEIN-KINASE | AMYLOID-BETA | SPLICEOSOME | PHARMACOLOGY & PHARMACY | PTDINS(3,5)P-2 | POTENT INHIBITORS | SELECTIVITY | CYCLIN | FAMILY | Osteosarcoma - drug therapy | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Autophagy - immunology | Phosphorylation - genetics | Protein-Tyrosine Kinases - genetics | TOR Serine-Threonine Kinases - genetics | Dioxoles - pharmacology | Phosphorylation - immunology | Autophagy - genetics | Phosphorylation - drug effects | Osteosarcoma - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Alzheimer Disease - drug therapy | Imidazoles - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Tyrosine - metabolism | Animals | Alzheimer Disease - metabolism | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Alzheimer Disease - genetics | Tyrosine - genetics | Tyrosine | Enzyme Inhibitors | Phosphorylation | Protein-Serine-Threonine Kinases | Microtubule-Associated Proteins | Alzheimer Disease | Autophagy | Phosphatidylinositol 3-Kinases | Dioxoles | Chemical Sciences | Imidazoles | Osteosarcoma | TOR Serine-Threonine Kinases | Protein-Tyrosine Kinases
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 03/2014, Volume 85, Issue 3, pp. 441 - 450
Leucettines, a family of pharmacological inhibitors of dual-specificity tyrosine phosphorylation regulated kinases and cdc-like kinases (CLKs), are currently... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 04/2013, Volume 62, pp. 728 - 737
Journal Article
by Bouckaert, Charlotte and Goffin, Eric and Dilly, Sebastien and Hanson, Julien and Pochet, Lionel and Kastrup, Jette Sandholm and Francotte, Pierre and Pirotte, Bernard and Michiels, Carine and Champire, Anthony and Ple, Karen and Robin, Laurent and Suzenet, Franck and Bouyssou, Pascal and Burgy, Guillaume and Limanton, Emmanuelle and Guiheneuf, Solene and Carreaux, Francois and Tahtouh, Tania and Durieu, Emilie and Meijer, Laurent and Pipelier, Muriel and Plenevaux, Alain and Place, Mattieu and Copin, Chloe and Ambeu, Christelle and Coulibaly, Wacothon Karime and Mamyrbekova-Berkro, Janat and Benie, Anoubile and Corlu, Anne and Bach, Stephane and Dago, Camille Deliko and Paquin, Ludovic and Mamyrbekova-Bekro, Janat Akhanovna and Bekro, Yves-Alain and Ruchaud, Sandrine and Le Guevel, Remy and Brigaudeau, Christophe and Mignen, Olivier and Bazureau, Jean-Pierre and Gally, Jose-Manuel and Heinrich, Jean-Thomas and Obled, Alan and Aci-Seche, Samia and Bonnet, Pascal and Gibault, Floriane and Corvaisier, Matthieu and Bailly, Fabrice and Huet, Guillemette and Cotelle, Philippe and Duroux, Romain and Renault, Nicolas and Agouridas, Laurence and Lopes, Luisa and Melnyk, Patricia and Yous, Said and Piguel, Sandrine and Stutzmann, Aurelien and Schnetterle, Marine and Caclard, Arnaud and Biot, Fabrice and Valade, Eric and Bolla, Jean-Michel and Pages, Jean-Marie and Boyer, Gerard and Alibert, Sandrine and Neulat-Ripoll, Fabienne and Elie, Jonathan and Bidault, Rudy and Arlicot, Nicolas and GUILLOTEAU, Denis and Vercouille, Johnny and D'Attoma, Joseph and Brun, Pierre-Louis and Robin, Yves and Bostyn, Stephane and Ejjoummany, Abdelaziz and Buron, Frederic and El Hakmaoui, Ahmed and Routier, Sylvain and Guillaumet, Gerald and Akssira, Mohamed and Marx, Sebastien and Dal Maso, Thomas and Michiels, Cerine and Wouters, Johan and Prevost, Julien R. C and Van Ham, Nicolas J. P and Kozlova, Arina and Frederick, Raphael and Drapier, Thomas and Geubelle, Pierre
Pharmaceuticals, ISSN 1424-8247, 2016, Volume 9, Issue 4
Journal Article
ChemInform, ISSN 0931-7597, 08/2013, Volume 44, Issue 32, pp. no - no
Review: 166 refs. 
Pyridine
Journal Article
12/2012, ISBN 9783527331161, Volume 2, 63
This chapter contains sections titled: Introduction Microwave‐Assisted Synthesis of Four‐ and Five‐Membered Systems with One and More Than Two Heteroatoms... 
microwave‐assisted synthesis | heterocyclic compound synthesis | Microwave-assisted synthesis | Heterocyclic compound synthesis
Book Chapter
07/2005, 7
The invention relates to compounds of formula (I) having PDE2 inhibitory activities, as well as therapeutic methods by administering said compounds, in... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
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