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Cell and Tissue Research, ISSN 0302-766X, 6/2006, Volume 324, Issue 3, pp. 411 - 422
A spheroid is an in vitro multicellular aggregate that provides a microenvironment resembling that of normal tissue in vivo. Although cell adhesion molecules... 
Human Genetics | Hepatoma cell lines (Human) | Biomedicine | Aggregates | Dynamics | Proteomics | Cadherins | Molecular Medicine | Spheroids | Integrins
Journal Article
Journal of Materials Chemistry B, ISSN 2050-7518, 2016, Volume 4, Issue 29, pp. 4969 - 4974
We report a dynamic hydrogel system with on-demand tunable matrix stiffness. The hydrogels are formed by thiol-allylether photo-click reaction using thiolated... 
MATERIALS SCIENCE, BIOMATERIALS | MATRIX STIFFNESS | DRUG-DELIVERY | INSULIN-SECRETION | TISSUE | POLY(ETHYLENE GLYCOL) HYDROGELS | CROSS-LINKING | PROTEIN-RELEASE | CHEMISTRY | DIFFERENTIATION | SUPRAMOLECULAR HYDROGELS
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 01/2017, Volume 48, p. 258
The complex network of biochemical and biophysical cues in the pancreatic desmoplasia not only presents challenges to the fundamental understanding of tumor... 
Coma | Encapsulation | Hydrogels | Peptides | Spatial discrimination | Paracrine signalling | Activation | Metastases | Cell fate | Reaction kinetics | Extracellular matrix | Stiffness | Oxidation | Matrix protein | Hypoxia-inducible factors | Tyrosine | Cues | Dihydroxyphenylalanine | Stellate cells | Enzymes | Quinone | Crosslinking | Stiffening | Stromal cells | Pancreatic cancer | Hypoxia | Kinetics | Dopa | Tyrosinase | Cancer
Journal Article
BioFactors, ISSN 0951-6433, 01/2018, Volume 44, Issue 1, pp. 69 - 82
Over the past years, several studies have found that foods rich in polyphenols protect against age‐related disease, such as atherosclerosis, cardiovascular... 
aging | healthspan | resveratrol | lifespan | pterostilbene | OXIDATIVE STRESS | INFLAMMATORY RESPONSES | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYOCARDIAL ISCHEMIA/REPERFUSION INJURY | SACCHAROMYCES-CEREVISIAE | INSULIN SENSITIVITY | ISCHEMIA-REPERFUSION INJURY | PROLONGS LIFE-SPAN | GLUCOSE-METABOLISM | ENDOCRINOLOGY & METABOLISM | CALORIE RESTRICTION | Neoplasms - metabolism | Sirtuin 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Longevity - drug effects | Cardiovascular Diseases - prevention & control | Humans | Cataract - pathology | Neurodegenerative Diseases - prevention & control | Neoplasms - prevention & control | Stilbenes - pharmacology | Cardiovascular Diseases - pathology | Cardiovascular Diseases - genetics | Sirtuin 1 - genetics | Neoplasms - genetics | Osteoporosis - metabolism | Cellular Senescence | NF-E2-Related Factor 2 - genetics | Osteoporosis - genetics | Neurodegenerative Diseases - pathology | Cardiovascular Diseases - metabolism | Osteoporosis - prevention & control | Neurodegenerative Diseases - genetics | Antioxidants - pharmacology | Longevity - genetics | Neurodegenerative Diseases - metabolism | Cataract - metabolism | Animals | Osteoporosis - pathology | NF-E2-Related Factor 2 - metabolism | Cataract - genetics | Cataract - prevention & control | Inflammation - prevention & control | Oxidative Stress - drug effects | Neoplasms - pathology | Telomere Homeostasis - drug effects | AMP-Activated Protein Kinases - genetics | Type 2 diabetes | Polyphenols | Telomeres | Resveratrol
Journal Article
Biomaterials Science, ISSN 2047-4830, 2014, Volume 2, Issue 8, pp. 1063 - 1072
Covalently cross-linked gelatin hydrogels have received considerable attention in biomedical fields due to the inherent bioactivity of gelatin and the... 
PEG HYDROGELS | 3D | MORPHOGENESIS | PHOTOCROSSLINKABLE GELATIN | MATERIALS SCIENCE, BIOMATERIALS | TISSUE-ENGINEERING SCAFFOLDS | MICHAEL-TYPE ADDITION | CROSS-LINKING | CHEMISTRY | PHOTOPOLYMERIZATIONS | METHACRYLATE HYDROGELS | Encapsulation | Thiols | Hydrogels | Photopolymerization | Polymerization | Crosslinking | Chains (polymeric) | Gelatins
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2011, Volume 108, Issue 16, p. 6380
A biomimetic hydrogel platform was designed to signal encapsulated cells using immobilized cell - cell communication cues, with a focus on enhancing the... 
Survival analysis | Signal transduction | Molecules | Hydrogels | Tissue engineering | Glucose | Pancreas | Insulin | Cells | Cell adhesion & migration
Journal Article
Biomaterials, ISSN 0142-9612, 2014, Volume 35, Issue 36, pp. 9668 - 9677
Abstract The development of pancreatic ductal adenocarcinoma (PDAC) is heavily influenced by local stromal tissues, or desmoplasia. Biomimetic hydrogels... 
Advanced Basic Science | Dentistry | Chemo-resistance | Epithelial-mesenchymal transition | Pancreatic cancer stem cell | Hydrogel | Pancreatic ductal adenocarcinoma | PEG HYDROGELS | STEM-CELLS | MATERIALS SCIENCE, BIOMATERIALS | TGF-BETA | TUMOR PROGRESSION | DUCTAL ADENOCARCINOMA | ENGINEERING, BIOMEDICAL | HIPPO PATHWAY | COLLAGEN RECEPTORS | SIGNALING PATHWAY | CONTACT INHIBITION | Adenocarcinoma - pathology | Cell Proliferation | Humans | Pancreatic Neoplasms - pathology | Pancreas - drug effects | Pancreas - pathology | Drug Resistance, Neoplasm | Adenocarcinoma - drug therapy | Carcinoma, Pancreatic Ductal - pathology | Cell Culture Techniques - methods | Pancreatic Neoplasms - drug therapy | Carcinoma, Pancreatic Ductal - drug therapy | Neoplasm Invasiveness - pathology | Epithelial-Mesenchymal Transition | Cell Line, Tumor | Sulfhydryl Compounds - chemistry | Biomimetic Materials - chemistry | Hydrogels - chemistry | Ethylene glycol | Biological products | Thiols | Peptides | Growth | Drug resistance | Transforming growth factors | Carbocyclic compounds | Chemotherapy | Biomimetics | Proteases | Collagen | Pancreatic cancer | Stem cells | Models | Vascular endothelial growth factor | Biomedical engineering | Cancer | Drugs | Cytokines | Hydrogels | Collagens | Crosslinking | Three dimensional | pancreatic cancer stem cell | epithelial-mesenchymal transition | chemo-resistance | hydrogel
Journal Article
Biomaterials, ISSN 0142-9612, 2014, Volume 35, Issue 25, pp. 6898 - 6906
Abstract De-differentiation and loss of function in hepatocytes during two-dimensional (2D) tissue culture significantly hinders the progress of liver... 
Advanced Basic Science | Dentistry | Liver tissue engineering | Microenvironment | Hepatocytes | Thiol-ene hydrogels | PEG HYDROGELS | MATERIALS SCIENCE, BIOMATERIALS | HEPATITIS-B-VIRUS | TRANSPORTERS | ENGINEERING, BIOMEDICAL | HUMAN HEPATOCYTE CULTURES | METABOLISM | LIVER | LINE | INFECTION | EXPRESSION | Up-Regulation | Humans | Cell Dedifferentiation | Polyethylene Glycols - chemistry | RNA, Messenger - metabolism | Organic Anion Transporters, Sodium-Dependent - genetics | Cytochrome P-450 CYP3A - genetics | Urea - metabolism | Dithiothreitol - chemistry | Hepatocytes - drug effects | Cell Survival - drug effects | Fibronectins - pharmacology | Norbornanes - chemistry | Click Chemistry | Tissue Culture Techniques | RNA, Messenger - genetics | Symporters - metabolism | Hep G2 Cells | Fibronectins - chemistry | Cytochrome P-450 CYP3A - metabolism | Symporters - genetics | Cells, Immobilized | Liver Neoplasms - metabolism | Cell Line, Tumor | Matrix Metalloproteinases - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Hydrogels - chemistry | Carcinoma, Hepatocellular - metabolism | Carbocyclic compounds | Fibronectins | Ethylene glycol | Cysteine | Thiols | Peptides | RNA | Genetically modified organisms | Cytochrome P-450 | Health aspects | Encapsulation | Biotechnology | Hydrogels | Liver | Polarity | Two dimensional | Three dimensional
Journal Article
Advanced Energy Materials, ISSN 1614-6832, 10/2011, Volume 1, Issue 5, pp. 901 - 907
Journal Article