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PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, pp. e35240 - e35240
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 20
Agonists of G-protein-coupled receptor 142 (GPR142) are reported to increase insulin secretion and lower glucose in preclinical models. We identified a novel... 
Animal models | G protein-coupled receptors | Glucagon | Secretion | Diabetes mellitus | Lead | Agonists | Glucose | Diabetes | Diabetes mellitus (non-insulin dependent) | Insulin
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, pp. e0154452 - e0154452
GPR142 is an islet-enriched G protein-coupled receptor that has been investigated as a novel therapeutic target for the treatment of type 2 diabetes by virtue... 
SYSTEM | CELLS | PROTEIN-COUPLED RECEPTORS | MULTIDISCIPLINARY SCIENCES | Islets of Langerhans - drug effects | Phosphorylation | Receptors, G-Protein-Coupled - metabolism | Humans | Male | Receptors, G-Protein-Coupled - agonists | Protein Subunits - metabolism | Islets of Langerhans - metabolism | Islets of Langerhans - cytology | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Cyclic AMP - metabolism | Insulin Secretion | Protein Subunits - genetics | Pyrazoles - pharmacology | Recombinant Proteins - metabolism | Insulin - agonists | Mitogen-Activated Protein Kinase 3 - genetics | Colforsin - pharmacology | Mice, Inbred C57BL | Protein Subunits - agonists | Gene Expression Regulation | Glucose - pharmacology | Recombinant Proteins - genetics | Signal Transduction - genetics | Insulin - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Aminopyridines - pharmacology | Glucose - metabolism | Mice | Receptors, G-Protein-Coupled - genetics | Tryptophan - pharmacology | Primary Cell Culture | Mitogen-Activated Protein Kinase 1 - metabolism | Type 2 diabetes | Usage | Care and treatment | Therapeutics | G proteins | Research | Hypoglycemic sulfonylureas | Sulfonylurea compounds | Homeopathy | Materia medica and therapeutics | Research & development--R&D | Secretion | Therapeutic applications | Diabetes mellitus | Cloning | Stimulation | Glucose | Kinases | Insulin | Proteins | Signal transduction | Signaling | Antibiotics | Rodents | Diabetes | Islets of Langerhans | Pancreas | Diabetes mellitus (non-insulin dependent) | Index Medicus | Research & development | R&D
Journal Article
Journal Article
Journal Article
Cell, ISSN 0092-8674, 09/2012, Volume 150, Issue 6, p. 1223
Diabetes is associated with [beta] cell failure. But it remains unclear whether the latter results from reduced [beta] cell number or function. FoxO1... 
Pancreatic beta cells | Hyperglycemia | Analysis | Universities and colleges | Diabetes
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, pp. e0157298 - e0157298
GPR142, a putative amino acid receptor, is expressed in pancreatic islets and the gastrointestinal tract, but the ligand affinity and physiological role of... 
CHOLECYSTOKININ | STIMULATION | GASTRIC INHIBITORY POLYPEPTIDE | CALCIUM-SENSING RECEPTOR | MULTIDISCIPLINARY SCIENCES | PROTEIN-COUPLED RECEPTORS | MICE | RELEASE | TAK-875 | AGONISTS | GLUCAGON | Diabetes Mellitus, Type 2 - genetics | Humans | Incretins - metabolism | Tryptophan - administration & dosage | Diabetes Mellitus, Type 2 - metabolism | Receptors, G-Protein-Coupled - agonists | Tryptophan - metabolism | Incretins - genetics | Islets of Langerhans - metabolism | Insulin - genetics | Insulin-Secreting Cells | Receptors, G-Protein-Coupled - drug effects | Insulin Secretion | Phenylalanine - metabolism | Blood Glucose | Glucose - genetics | Mice, Knockout | Insulin - metabolism | Animals | Glucose - metabolism | Mice | Receptors, G-Protein-Coupled - genetics | Diabetes Mellitus, Type 2 - pathology | Diabetes Mellitus, Type 2 - drug therapy | Phenylalanine - administration & dosage | Type 2 diabetes | Glucose metabolism | Care and treatment | Analysis | Tryptophan | Influence | Research | Laboratories | Homeostasis | Amino acids | Chemoreception | Hormones | Glucose | Metabolites | Rodents | L-Tryptophan | Physiology | Pancreas | Diabetes mellitus (non-insulin dependent) | Polypeptides | Phenylalanine | Secretion | Research & development--R&D | Diabetes mellitus | Gastrointestinal tract | GIP protein | Metabolism | Insulin | Signaling | Insulin resistance | Diabetes | Index Medicus | Research & development | R&D
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 17, pp. 13944 - 13951
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2009, Volume 15, Issue 10, pp. 1195 - 1201
Journal Article
Cell Metabolism, ISSN 1550-4131, 09/2016, Volume 24, Issue 3, pp. 420 - 433
Journal Article
Diabetes, ISSN 0012-1797, 08/2007, Volume 56, Issue 8, pp. 1969 - 1976
Journal Article