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Frontiers in Oncology, ISSN 2234-943X, 2015, Volume 5, p. 278
The Aurora kinase family comprises of cell cycle-regulated serine/threonine kinases important for mitosis. Their activity and protein expression are cell cycle... 
Hematologic diseases | Small molecules | Aurora kinase | Neuroblastoma | Kinase inhibitors | Chromosomes | Hematologic Diseases | kinase inhibitors | small molecules
Journal Article
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2013, Volume 986, pp. 97 - 104
Cellular models for siRNA and small molecule high throughput screening have been widely used in the last decade to identify targets for drug discovery. As an... 
High-content screening | High-throughput screening | Centrosome amplification | Centrosome clustering | SiRNA screening | Target discovery | RNA, Small Interfering - genetics | High-Throughput Screening Assays | RNA Interference | Small Molecule Libraries | Drug Design
Journal Article
Nature Communications, ISSN 2041-1723, 04/2014, Volume 5, Issue 1, p. 3686
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2015, Volume 58, Issue 13, pp. 5186 - 5188
The quest for potent and selective small molecule inhibitors of the Aurora kinases has been long and resource intensive with multiple agents progressed to the... 
POTENT | CHEMISTRY, MEDICINAL | CANCER | AMG 900 | DISCOVERY | PROBES | Neoplasms - enzymology | Phthalazines - pharmacology | Aurora Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Humans | Neoplasms - drug therapy
Journal Article
Oncotarget, ISSN 1949-2553, 04/2018, Volume 9, Issue 28, pp. 19525 - 19542
Accurate chromosome segregation is dependent on the spindle assembly checkpoint (SAC). In current models, the key direct role of Aurora B in the SAC has been... 
Inhibition | SAC | Mitosis | MPS1 | Aurora B
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 05/2015, Volume 136, Issue 9, pp. 2146 - 2157
Journal Article
Journal Article
Journal Article
British Journal of Cancer, ISSN 0007-0920, 04/2017, Volume 116, Issue 9, pp. 1166 - 1176
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 4950 - 4950
Journal Article
Journal Article