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performing operations (424) 424
transporting (424) 424
after-treatment of the shaped products, e.g. repairing (400) 400
shaping of material in a plastic state, not otherwise providedfor (400) 400
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indexing scheme associated with subclasses b29b, b29c or b29d, relating to moulding materials (254) 254
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making granules or preforms (53) 53
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recovery of plastics or other constituents of waste materialcontaining plastics (53) 53
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devices or arrangements, the optical operation of which ismodified by changing the optical properties of the medium of thedevices or arrangements for the control of the intensity,colour, phase, polarisation or direction of light, e.g.switching, gating, modulating or demodulating (8) 8
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investigating or analysing materials by determining theirchemical or physical properties (7) 7
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rats (7) 7
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1. Full Text Complete genome sequence of the myxobacterium Sorangium cellulosum
by Krug, Daniel and Bolten, Christoph J and Whitworth, David E and Rachid, Shwan and Suen, Garret and Pradella, Silke and Jelsbak, Lotte and Wenzel, Silke C and Schuster, Stephan C and Bekel, Thomas and Gerth, Klaus and Bode, Edna and Perlova, Olena and Mahmud, Taifo and McHardy, Alice C and Pühler, Alfred and Doss, Sabrina and Rosenau, Frank and Groeger, Carolin and Sasse, Florenz and Linke, Bukhard and Mormann, Sascha and Wilhelm, Susanne and Muñoz-Dorado, Jose and Kegler, Carsten and Martinez-Arias, Rosa and Konietzny, Sebastian and Welch, Roy D and Beyer, Stefan and Gross, Frank and Wittmann, Christoph and Bartels, Daniela and Merai, Michelle and Knauber, Tina and Scharfe, Maren and Bode, Helge B and Schneiker, Susanne and Gaigalat, Lars and Altmeyer, Matthias O and Frank, Bettina and Weissman, Kira J and Perez, Juana and Rückert, Christian and Müller, Rolf and Kaiser, Olaf and Kalinowski, Jörn and Kopp, Maren and Alici, Aysel and Goesmann, Alexander and Jelsbak, Lars and Raddatz, Günter and Treuner-Lange, Anke and Blöcker, Helmut and Meyer, Folker and Elnakady, Yasser A and Krause, Lutz and Vorhölter, Frank-Jörg and Choudhuri, Jomuna V and Velicer, Gregory J
Nature Biotechnology, ISSN 1087-0156, 11/2007, Volume 25, Issue 11, pp. 1281 - 1289
The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We... 
SECONDARY METABOLITES | MYXOCOCCUS-XANTHUS | GENE-CLUSTER | PHOSPHOPEPTIDES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOSYNTHESIS | ANNOTATION | STREPTOMYCES-COELICOLOR | GLIDING MOTILITY | IDENTIFICATION | PROTEIN-KINASES | Biotechnology | Genome, Bacterial - genetics | Myxococcales - classification | Myxococcales - genetics | Base Sequence | Molecular Sequence Data | Myxococcales - metabolism | Phylogeny | Sequence Analysis, DNA
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2. Full Text Humoral response to catumaxomab correlates with clinical outcome: Results of the pivotal phase II/III study in patients with malignant ascites
by Ott, Marion G and Marmé, Frederik and Moldenhauer, Gerhard and Lindhofer, Horst and Hennig, Michael and Spannagl, Rolf and Essing, Mirko M and Linke, Rolf and Seimetz, Diane
International Journal of Cancer, ISSN 0020-7136, 05/2012, Volume 130, Issue 9, pp. 2195 - 2203
The trifunctional antibody catumaxomab is a targeted immunotherapy for the intraperitoneal treatment of malignant ascites. In a Phase II/III trial in cancer... 
catumaxomab | malignant ascites | trifunctional antibody | clinical outcome | humoral response | SURVIVAL | ACTIVATION | INDUCTION | CANCER | BENEFIT | LASTING ANTITUMOR IMMUNITY | THERAPY | ONCOLOGY | ACCESSORY CELLS | MONOCLONAL-ANTIBODIES | T-CELLS | Immunotherapy - methods | Immunity, Humoral - immunology | Peritoneal Neoplasms - blood | Humans | Ovarian Neoplasms - pathology | Antibodies, Monoclonal - therapeutic use | Stomach Neoplasms - pathology | Peritoneal Neoplasms - drug therapy | Antibodies, Bispecific - administration & dosage | Ascites - blood | Ascites - immunology | Female | Ovarian Neoplasms - drug therapy | Peritoneal Neoplasms - immunology | Peritoneal Neoplasms - pathology | Antibodies, Anti-Idiotypic - blood | Ovarian Neoplasms - blood | Rats | Treatment Outcome | Stomach Neoplasms - drug therapy | Antibodies, Bispecific - immunology | Ascites - drug therapy | Biomarkers, Pharmacological - blood | Stomach Neoplasms - immunology | Paracentesis - methods | Animals | Stomach Neoplasms - blood | Survival Analysis | Mice | Ovarian Neoplasms - immunology | Medical research | Clinical outcomes | Cancer Therapy
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3. Full Text Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial
by Wu, Yi-Long and Cheng, Ying and Zhou, Xiangdong and Lee, Ki Hyeong and Nakagawa, Kazuhiko and Niho, Seiji and Tsuji, Fumito and Linke, Rolf and Rosell, Rafael and Corral, Jesus and Migliorino, Maria Rita and Pluzanski, Adam and Sbar, Eric I and Wang, Tao and White, Jane Liang and Nadanaciva, Sashi and Sandin, Rickard and Mok, Tony S
The Lancet Oncology, ISSN 1470-2045, 11/2017, Volume 18, Issue 11, pp. 1454 - 1466
Dacomitinib is a second-generation, irreversible EGFR tyrosine kinase inhibitor. We compared its efficacy and safety with that of the reversible EGFR tyrosine... 
MULTICENTER | ONCOLOGY | ADENOCARCINOMA | CLINICALLY SELECTED PATIENTS | DOUBLE-BLIND | QLQ-C30 | QUALITY-OF-LIFE | AFATINIB | INHIBITOR | ERLOTINIB | CHEMOTHERAPY | Genes, erbB-1 - drug effects | Lung Neoplasms - drug therapy | Confidence Intervals | Prognosis | Lung Neoplasms - mortality | Humans | Middle Aged | Male | Dose-Response Relationship, Drug | Adult | Female | Lung Neoplasms - genetics | Drug Administration Schedule | Carcinoma, Non-Small-Cell Lung - genetics | Genes, erbB-1 - genetics | Kaplan-Meier Estimate | Treatment Outcome | Carcinoma, Non-Small-Cell Lung - mortality | Disease-Free Survival | Maximum Tolerated Dose | Quinazolines - therapeutic use | Quinazolines - adverse effects | Survival Analysis | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Quinazolinones - therapeutic use | Quinazolinones - adverse effects | Care and treatment | Product development | Lung cancer, Non-small cell | Gefitinib | Tyrosine
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4. Full Text Measurements and impulse pattern formulation (IPF) model of phase transitions in free-reed wind instruments
by Bader, Rolf and Linke, Simon and Mores, Robert
The Journal of the Acoustical Society of America, ISSN 0001-4966, 10/2019, Volume 146, Issue 4, pp. 2779 - 2779
Free-reed wind instruments have a free reed attached to a tube, and are a unique instrument of Laos, Thailand, China, or Japan. Three examples, a 5-pipe... 
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5. Full Text Multiphonic modeling using impulse pattern formulation
by Linke, Simon and Bader, Rolf and Mores, Robert
The Journal of the Acoustical Society of America, ISSN 0001-4966, 03/2019, Volume 145, Issue 3, pp. 1676 - 1676
Multiphonics, the presence of multiple pitches within the sound of wind-instruments can be produced in several ways. Either complex fingerings are used or the... 
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6. Full Text The impulse pattern formulation (IPF) as a model of musical instruments—Investigation of stability and limits
by Linke, Simon and Bader, Rolf and Mores, Robert
Chaos: An Interdisciplinary Journal of Nonlinear Science, ISSN 1054-1500, 10/2019, Volume 29, Issue 10, p. 103109
The Impulse Pattern Formulation (IPF) is an analytical modeling approach for synergetic systems in general, motivated by research on musical instruments. Based... 
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7. Full Text Catumaxomab
: Clinical development and future directions
by Linke, Rolf and Klein, Anke and Seimetz, Diane
mAbs, ISSN 1942-0862, 03/2010, Volume 2, Issue 2, pp. 129 - 136
Catumaxomab, a monoclonal bispecific trifunctional antibody, was approved in the European Union in April 2009 for the intraperitoneal treatment of patients... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Catumaxomab | EpCAM | Immunotherapy | Malignant ascites | Peritoneal carcinomatosis | Trifunctional | Monoclonal antibody | Removab | CANCER PATIENTS | PROSTATE | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | trifunctional | catumaxomab | ANTIBODY | EPCAM X ANTI-CD3 | peritoneal carcinomatosis | CHEMOTHERAPY | malignant ascites | EP-CAM | immunotherapy | Removab (R) | monoclonal antibody | EXPRESSION
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8. Full Text Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function
by Unger, Andreas and Beckendorf, Lisa and Böhme, Pierre and Kley, Rudolf and von Frieling-Salewsky, Marion and Lochmüller, Hanns and Schröder, Rolf and Fürst, Dieter O and Vorgerd, Matthias and Linke, Wolfgang A
Acta neuropathologica communications, ISSN 2051-5960, 09/2017, Volume 5, Issue 1, pp. 72 - 14
Myopathies encompass a wide variety of acquired and hereditary disorders. The pathomechanisms include structural and functional changes affecting, e.g.,... 
Immunoelectron microscopy | Muscle stiffness | Myofibrillar myopathy | Molecular chaperones | Muscular dystrophy | SIGNALING PATHWAYS | ALPHA-B-CRYSTALLIN | NEUROSCIENCES | HEAT-SHOCK PROTEINS | DEFICIENT MUSCLE | ECCENTRIC EXERCISE | DUCHENNE MUSCULAR-DYSTROPHY | PROTEOMIC ANALYSIS | DESMIN | MUSCLE-CONTRACTION | AGGREGATION | Protein Kinases - metabolism | Phosphorylation | Muscle, Skeletal - metabolism | alpha-Crystallin B Chain - metabolism | Calpain - genetics | Muscular Dystrophies - genetics | Microscopy, Immunoelectron | Myofibrils - ultrastructure | Muscular Dystrophies, Limb-Girdle - genetics | Mice, Inbred mdx | Myosins - metabolism | Filamins - genetics | Muscular Dystrophies, Limb-Girdle - pathology | Disease Models, Animal | Muscular Dystrophies - metabolism | Sarcomeres - metabolism | Mice, Inbred C57BL | Muscle, Skeletal - ultrastructure | Muscular Dystrophies - pathology | Muscle Proteins - genetics | Sarcomeres - ultrastructure | Animals | Muscular Dystrophies, Limb-Girdle - metabolism | Connectin - metabolism | Fluorescent Antibody Technique | HSP27 Heat-Shock Proteins - metabolism | HSP90 Heat-Shock Proteins - metabolism | Myofibrils - metabolism | Myosin | Physiological aspects | Heat shock proteins | Genetic aspects | Muscle proteins | Comparative analysis | Protein binding | Musculoskeletal system | Protein folding | Biopsy | Genes | Rodents | Quality control | Mutation | Localization | Autophagy
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9. Full Text Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2 and Cytokines
by Linke, Bona and Schreiber, Yannick and Picard-Willems, Bettina and Slattery, Patrick and Nüsing, Rolf M and Harder, Sebastian and Geisslinger, Gerd and Scholich, Klaus
Mediators of Inflammation, ISSN 0962-9351, 2017, Volume 2017
  Platelets are well known for their role in hemostasis and are also increasingly recognized for their roles in the innate immune system during inflammation... 
Signal transduction | Blood platelets | Cytokines | Gangrene | Bone marrow | Tumor necrosis factor-TNF | Scientific imaging | Inflammation | Mass spectrometry | Inflammatory diseases | Chemokines | Chromatography
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10. Full Text Myofibrillar instability exacerbated by acute exercise in filaminopathy
by Chevessier, Frédéric and Schuld, Julia and Orfanos, Zacharias and Plank, Anne-C and Wolf, Lucie and Maerkens, Alexandra and Unger, Andreas and Schlötzer-Schrehardt, Ursula and Kley, Rudolf A and Von Hörsten, Stephan and Marcus, Katrin and Linke, Wolfgang A and Vorgerd, Matthias and Van der Ven, Peter F.M and Fürst, Dieter O and Schröder, Rolf
Human Molecular Genetics, ISSN 0964-6906, 2015, Volume 24, Issue 25, pp. 7207 - 7220
Filamin C (FLNC) mutations in humans cause myofibrillar myopathy (MFM) and cardiomyopathy, characterized by protein aggregation and myofibrillar degeneration.... 
SKELETAL-MUSCLE | DISTAL MYOPATHY | Z-DISC PROTEINS | ECCENTRIC EXERCISE | INTERACTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | C CAUSE | GENETICS & HEREDITY | ACTININ-BINDING | MUTATIONS | BINDING PROTEIN | GAMMA-FILAMIN | Phenotype | Animals | Myofibrils - pathology | Genotype | Myofibrils - genetics | Mice | Muscular Diseases - pathology | Filamins - genetics | Muscle, Skeletal - pathology | Muscular Diseases - genetics | Microscopy, Electron | Muscular Dystrophies - genetics
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11. Full Text Improvement in overall survival in a randomized study that compared dacomitinib with gefitinib in patients with advanced non–small-cell lung cancer and EGFR-activating mutations
by Mok, Tony S and Cheng, Ying and Zhou, Xiangdong and Lee, Ki Hyeong and Nakagawa, Kazuhiko and Niho, Seiji and Lee, Min and Linke, Rolf and Rosell, Rafael and Corral, Jesus and Migliorino, Maria Rita and Pluzanski, Adam and Sbar, Eric I and Wang, Tao and White, Jane Liang and Wu, Yi-Long
Journal of Clinical Oncology, ISSN 0732-183X, 08/2018, Volume 36, Issue 22, pp. 2244 - 2250
PurposeARCHER 1050, a randomized, open-label, phase III study of dacomitinib versus gefitinib in treatment-naive patients with advanced non-small-cell lung... 
1ST-LINE TREATMENT | CONTROLLED-TRIAL | MULTICENTER | ONCOLOGY | ADENOCARCINOMA | PHASE-3 TRIAL | OPEN-LABEL | AFATINIB | INHIBITOR | CHEMOTHERAPY | ERLOTINIB
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12. Effects of dose modifications on the safety and efficacy of dacomitinib for EGFR mutation-positive non-small-cell lung cancer
Future oncology (London, England), 07/2019
Aim: We evaluated reasons for dacomitinib dose reduction (DR) and examined adverse event (AE) incidence, key efficacy end points (progression-free survival... 
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13. Full Text Bacterial Response from Exposure to Selected Aliphatic Nitramines
by Gundersen, Cathrine Brecke and Andersen, Tom and Lindahl, Sofia and Linke, Dirk and Vogt, Rolf D
Energy Procedia, ISSN 1876-6102, 2014, Volume 63, pp. 791 - 800
Currently the most promising method for capturing anthropogenic produced carbon dioxide (CO ) from suitable point sources is the technique using amines in... 
Nitramine | bacteria | Post-combustion CO2 capture (PCC) | BIOLOG Ecoplate | acute toxicity | BIOLOG ecoplate | capture (PCC) | Bacteria | Post-combustion CO | Acute toxicity
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14. Full Text Dacomitinib (daco) versus gefitinib (gef) for first-line treatment of advanced NSCLC (ARCHER 1050): Final overall survival (OS) analysis
by Mok, Tony and Cheng, Ying and Zhou, Xiangdong and Lee, Ki Hyeong and Nakagawa, Kazuhiko and Niho, Seiji and Lee, Min Young and Linke, Rolf Gerhard and Rosell, Rafael and Corral Jaime, Jesus and Migliorino, Maria Rita and Pluzanski, Adam and Sbar, Eric I and Wang, Tao and Liang White, Jane and Wu, Yi-Long
Journal of Clinical Oncology, ISSN 0732-183X, 05/2018, Volume 36, Issue 15_suppl, pp. 9004 - 9004
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15. Full Text Adjuvant axitinib dose modification in renal cell carcinoma (RCC): Analysis of the ATLAS study
by Quinn, David I and Kwon, Tae Gyun and Eto, Masatoshi and Ye, Dingwei and Miyake, Hideaki and Seo, Seong Il and Byun, Seok-Soo and Lee, Jae-Lyun and Master, Viraj A and Ng, Chi-Fai and Linke, Rolf Gerhard and Rosbrook, Brad and Thakur, Mahgull Nazar and Grande, Enrique and Gross-Goupil, Marine and Chang, Chao-Hsiang
Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. 4573 - 4573
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16. Full Text GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation
by Pierre, Sandra and Linke, Bona and Suo, Jing and Tarighi, Neda and Del Turco, Domenico and Thomas, Dominique and Ferreiros, Nerea and Stegner, David and Frölich, Stefanie and Sisignano, Marco and Meyer Dos Santos, Sascha and deBruin, Natasja and Nüsing, Rolf M and Deller, Thomas and Nieswandt, Bernhard and Geisslinger, Gerd and Scholich, Klaus
Journal of Investigative Dermatology, ISSN 0022-202X, 03/2017, Volume 137, Issue 3, pp. 686 - 695
Platelets are well known for their role in hemostasis but are also increasingly recognized for their supporting role in innate immune responses. Here, we... 
ACTIVATION | COLLAGEN RECEPTOR | DENDRITIC CELLS | P-SELECTIN | GENE-EXPRESSION | ATHEROSCLEROSIS | SURFACE-ADHERENT PLATELETS | HUMAN MONOCYTES | LEUKOCYTE INTEGRIN MAC-1 | GLYCOPROTEIN VI | DERMATOLOGY | Mannose-Binding Lectins - metabolism | Receptors, Thromboxane A2, Prostaglandin H2 - metabolism | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Collagen - chemistry | Male | Inflammation | Thromboxane A2 - metabolism | Lectins, C-Type - metabolism | Macrophages - metabolism | Phenotype | Animals | Blood Platelets - metabolism | Gene Deletion | Platelet Membrane Glycoproteins - metabolism | Female | Mice | Skin - pathology
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17. Full Text Dacomitinib versus gefitinib for the first-line treatment of advanced EGFR mutation positive non-small cell lung cancer (ARCHER 1050): A randomized, open-label phase III trial
by Mok, Tony and Cheng, Ying and Zhou, Xiangdong and Lee, Ki Hyeong and Nakagawa, Kazuhiko and Niho, Seiji and Tsuji, Fumito and Rosell, Rafael and Corral Jaime, Jesus and Migliorino, Maria Rita and Pluzanski, Adam and Linke, Rolf Gerhard and Sbar, Eric and Wang, Tao and Wu, Yi-Long
Journal of Clinical Oncology, ISSN 0732-183X, 06/2017, Volume 35, Issue 18_suppl, pp. LBA9007 - LBA9007
LBA9007 Background: Dacomitinib is a 2nd generation EGFR TKI with encouraging clinical activity as 1st-line therapy in patients with EGFR-activating mutation... 
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18. Full Text Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PG[E.sub.2] and Cytokines
by Linke, Bona and Schreiber, Yannick and Picard-Willems, Bettina and Slattery, Patrick and Nusing, Rolf M and Harder, Sebastian and Geisslinger, Gerd and Scholich, Klaus
Mediators of Inflammation, ISSN 0962-9351, 01/2017, Volume 2017
Monocytes | Blood platelets | Cytokines | Physiological research | Research | Macrophages | Health aspects
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19. Full Text Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2and Cytokines
by Linke, Bona and Schreiber, Yannick and Picard-Willems, Bettina and Slattery, Patrick and Nüsing, Rolf M and Harder, Sebastian and Geisslinger, Gerd and Scholich, Klaus
Mediators of Inflammation, ISSN 0962-9351, 2017, Volume 2017, pp. 1 - 14
Platelets are well known for their role in hemostasis and are also increasingly recognized for their roles in the innate immune system during inflammation and... 
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20. Full Text Dacomitinib versus gefitinib for the first-line treatment of advanced EGFR mutation positive non-small cell lung cancer (ARCHER 1050): A randomized, open-label phase III trial
by Mok, Tony and Cheng, Ying and Zhou, Xiangdong and Lee, Ki Hyeong and Nakagawa, Kazuhiko and Niho, Seiji and Tsuji, Fumito and Rosell, Rafael and Corral Jaime, Jesus and Migliorino, Maria Rita and Pluzanski, Adam and Linke, Rolf Gerhard and Sbar, Eric and Wang, Tao and Wu, Yi-Long
Journal of Clinical Oncology, ISSN 0732-183X, 05/2017, Volume 35, Issue 15_suppl, pp. LBA9007 - LBA9007
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