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The New England Journal of Medicine, ISSN 0028-4793, 07/2013, Volume 369, Issue 1, pp. 11 - 19
In this trial involving patients with minor stroke or transient ischemic attack, treatment with a combination of clopidogrel and aspirin within 24 hours after...
EMERGENCY | MEDICINE, GENERAL & INTERNAL | SHORT-TERM PROGNOSIS | HIGH-RISK PATIENTS | THERAPY | CHINA | DOUBLE-BLIND | RECURRENCE | BURDEN | Stroke - prevention & control | Ischemic Attack, Transient - drug therapy | Double-Blind Method | Ticlopidine - therapeutic use | Humans | Middle Aged | Proportional Hazards Models | Male | Secondary Prevention | Stroke - drug therapy | Ticlopidine - analogs & derivatives | Disease-Free Survival | Aspirin - adverse effects | Ticlopidine - adverse effects | Clopidogrel | Female | Aged | Aspirin - therapeutic use | Hemorrhage - chemically induced | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Care and treatment | Aspirin | Myocardial ischemia | Dosage and administration | Drug therapy, Combination | Research | Stroke | Transient ischemic attack | Motivation | Ischemia | Risk groups | Acute coronary syndromes | Drug therapy | Hemorrhage | Patients
EMERGENCY | MEDICINE, GENERAL & INTERNAL | SHORT-TERM PROGNOSIS | HIGH-RISK PATIENTS | THERAPY | CHINA | DOUBLE-BLIND | RECURRENCE | BURDEN | Stroke - prevention & control | Ischemic Attack, Transient - drug therapy | Double-Blind Method | Ticlopidine - therapeutic use | Humans | Middle Aged | Proportional Hazards Models | Male | Secondary Prevention | Stroke - drug therapy | Ticlopidine - analogs & derivatives | Disease-Free Survival | Aspirin - adverse effects | Ticlopidine - adverse effects | Clopidogrel | Female | Aged | Aspirin - therapeutic use | Hemorrhage - chemically induced | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Care and treatment | Aspirin | Myocardial ischemia | Dosage and administration | Drug therapy, Combination | Research | Stroke | Transient ischemic attack | Motivation | Ischemia | Risk groups | Acute coronary syndromes | Drug therapy | Hemorrhage | Patients
Journal Article
Journal of Tribology, ISSN 0742-4787, 02/2019, Volume 141, Issue 2
Journal Article
Journal of Tribology, ISSN 0742-4787, 02/2019, Volume 141, Issue 2
Journal Article
Journal of Biomedical Materials Research Part A, ISSN 1549-3296, 11/2018, Volume 106, Issue 11, pp. 2955 - 2962
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e38627
l-Tetrahydropalmatine (l-THP) is an active ingredients of Corydalis yanhusuo W.T. Wang, which protects against acute global cerebral ischaemia-reperfusion...
CYTOCHROME-C | APOPTOSIS | ACTIVATION | PEROXYNITRITE | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | SEPTIC SHOCK | TNF-ALPHA | NF-KAPPA-B | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Vascular Endothelial Growth Factor A - biosynthesis | Anti-Arrhythmia Agents - pharmacology | Rats | Male | Phosphatidylinositol 3-Kinases - metabolism | Anti-Arrhythmia Agents - chemistry | Berberine Alkaloids - pharmacology | Rats, Sprague-Dawley | Corydalis - chemistry | Myocardial Reperfusion Injury - metabolism | Myocardial Reperfusion Injury - pathology | Animals | Berberine Alkaloids - chemistry | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Nitric Oxide - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Myocardial Reperfusion Injury - prevention & control | Nitric Oxide Synthase Type II - metabolism | Heart | Creatine | Creatine kinase | Vascular endothelial growth factor | Reperfusion injury | Reproductive health | Occlusion | Phosphorylation | Heart attacks | Cardiovascular disease | AKT protein | Kinases | Reperfusion | Ischemia | Analgesics | Cerebral blood flow | Rodents | Heart diseases | Injuries | Coronary artery | Cardiomyocytes | Inflammation | Tumor necrosis factor-α | Nitric-oxide synthase | 1-Phosphatidylinositol 3-kinase | Hospitals | Coronary vessels | Nitric oxide | Myocardium | Sepsis | Hypoxia | Laboratory animals | Tumors | Apoptosis | Veins & arteries | Geriatrics
CYTOCHROME-C | APOPTOSIS | ACTIVATION | PEROXYNITRITE | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | SEPTIC SHOCK | TNF-ALPHA | NF-KAPPA-B | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Vascular Endothelial Growth Factor A - biosynthesis | Anti-Arrhythmia Agents - pharmacology | Rats | Male | Phosphatidylinositol 3-Kinases - metabolism | Anti-Arrhythmia Agents - chemistry | Berberine Alkaloids - pharmacology | Rats, Sprague-Dawley | Corydalis - chemistry | Myocardial Reperfusion Injury - metabolism | Myocardial Reperfusion Injury - pathology | Animals | Berberine Alkaloids - chemistry | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Nitric Oxide - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Myocardial Reperfusion Injury - prevention & control | Nitric Oxide Synthase Type II - metabolism | Heart | Creatine | Creatine kinase | Vascular endothelial growth factor | Reperfusion injury | Reproductive health | Occlusion | Phosphorylation | Heart attacks | Cardiovascular disease | AKT protein | Kinases | Reperfusion | Ischemia | Analgesics | Cerebral blood flow | Rodents | Heart diseases | Injuries | Coronary artery | Cardiomyocytes | Inflammation | Tumor necrosis factor-α | Nitric-oxide synthase | 1-Phosphatidylinositol 3-kinase | Hospitals | Coronary vessels | Nitric oxide | Myocardium | Sepsis | Hypoxia | Laboratory animals | Tumors | Apoptosis | Veins & arteries | Geriatrics
Journal Article
Stroke, ISSN 0039-2499, 11/2019
Journal Article
Circulation, ISSN 0009-7322, 2015, Volume 132, Issue 1, pp. 40 - 46
Background The Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial showed that the combined treatment of...
Patient outcome assessment | Clopidogrel | Ischemic attack | Stroke | Transient | clopidogrel | CARDIAC & CARDIOVASCULAR SYSTEMS | EVENTS | RATIONALE | stroke | TIA | HIGH-RISK PATIENTS | DUAL ANTIPLATELET THERAPY | ischemic attack | transient | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | patient outcome assessment | Ischemic Attack, Transient - drug therapy | Double-Blind Method | Follow-Up Studies | Humans | Middle Aged | Stroke - diagnosis | Male | Treatment Outcome | Stroke - drug therapy | Ischemic Attack, Transient - diagnosis | Ticlopidine - analogs & derivatives | Aspirin - administration & dosage | Ischemic Attack, Transient - epidemiology | Ticlopidine - administration & dosage | Female | Stroke - epidemiology | Aged | Drug Therapy, Combination
Patient outcome assessment | Clopidogrel | Ischemic attack | Stroke | Transient | clopidogrel | CARDIAC & CARDIOVASCULAR SYSTEMS | EVENTS | RATIONALE | stroke | TIA | HIGH-RISK PATIENTS | DUAL ANTIPLATELET THERAPY | ischemic attack | transient | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | patient outcome assessment | Ischemic Attack, Transient - drug therapy | Double-Blind Method | Follow-Up Studies | Humans | Middle Aged | Stroke - diagnosis | Male | Treatment Outcome | Stroke - drug therapy | Ischemic Attack, Transient - diagnosis | Ticlopidine - analogs & derivatives | Aspirin - administration & dosage | Ischemic Attack, Transient - epidemiology | Ticlopidine - administration & dosage | Female | Stroke - epidemiology | Aged | Drug Therapy, Combination
Journal Article
Nature Communications, ISSN 2041-1723, 07/2016, Volume 7, Issue 1, p. 11935
Different emotional states lead to distinct behavioural consequences even when faced with the same challenging events. Emotions affect learning and memory...
FEAR | DORSAL HIPPOCAMPUS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | LONG-TERM POTENTIATION | DEPRESSIVE SYMPTOMS | HIPPOCAMPAL-FORMATION | STRESS | PROJECTIONS | AMYGDALA | CA1 Region, Hippocampal - physiology | Synapses - physiology | Mice, Inbred C57BL | Male | Mice, Transgenic | Spatial Learning - physiology | Animals | Neuronal Plasticity - physiology | Basolateral Nuclear Complex - physiology | Models, Neurological | Helplessness, Learned | Hope | Memory - physiology
FEAR | DORSAL HIPPOCAMPUS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | LONG-TERM POTENTIATION | DEPRESSIVE SYMPTOMS | HIPPOCAMPAL-FORMATION | STRESS | PROJECTIONS | AMYGDALA | CA1 Region, Hippocampal - physiology | Synapses - physiology | Mice, Inbred C57BL | Male | Mice, Transgenic | Spatial Learning - physiology | Animals | Neuronal Plasticity - physiology | Basolateral Nuclear Complex - physiology | Models, Neurological | Helplessness, Learned | Hope | Memory - physiology
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2019, Volume 116, Issue 13, pp. 6308 - 6312
Liquid biopsies, based on cell free DNA (cfDNA) and proteins, have shown the potential to detect early stage cancers of diverse tissue types. However, most of...
BIOMARKERS | early detection of cancer | CIRCULATING TUMOR DNA | MULTIDISCIPLINARY SCIENCES | HBsAg-seropositive | cell free DNA | hepatocellular carcinoma | FEATURES | BLOOD | Early Detection of Cancer - methods | Carcinoma, Hepatocellular - diagnosis | Hepatitis B, Chronic | Liquid Biopsy - methods | Humans | Hepatitis B Surface Antigens - blood | Biomarkers, Tumor - blood | Liver Neoplasms - blood | Liver Neoplasms - diagnosis | Cell-Free Nucleic Acids | Sensitivity and Specificity | Carcinoma, Hepatocellular - pathology | Ultrasonography | Liver Neoplasms - pathology | Carcinoma, Hepatocellular - blood | Hepatitis B virus | Hepatitis B surface antigen | Communities | Liver | Viruses | Hepatocellular carcinoma | Assaying | Nodules | Proteins | Hepatitis | Liver cancer | Sensitivity | Biopsy | Deoxyribonucleic acid--DNA | Hepatitis B | Biological Sciences
BIOMARKERS | early detection of cancer | CIRCULATING TUMOR DNA | MULTIDISCIPLINARY SCIENCES | HBsAg-seropositive | cell free DNA | hepatocellular carcinoma | FEATURES | BLOOD | Early Detection of Cancer - methods | Carcinoma, Hepatocellular - diagnosis | Hepatitis B, Chronic | Liquid Biopsy - methods | Humans | Hepatitis B Surface Antigens - blood | Biomarkers, Tumor - blood | Liver Neoplasms - blood | Liver Neoplasms - diagnosis | Cell-Free Nucleic Acids | Sensitivity and Specificity | Carcinoma, Hepatocellular - pathology | Ultrasonography | Liver Neoplasms - pathology | Carcinoma, Hepatocellular - blood | Hepatitis B virus | Hepatitis B surface antigen | Communities | Liver | Viruses | Hepatocellular carcinoma | Assaying | Nodules | Proteins | Hepatitis | Liver cancer | Sensitivity | Biopsy | Deoxyribonucleic acid--DNA | Hepatitis B | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 8, pp. 2775 - 2780
Flowering time (i.e., heading date in crops) is an important ecological trait that determines growing seasons and regional adaptability of plants to specific...
Wild rice | Genes | Alleles | Plant domestication | Flowering | Genetic loci | Plants | Nucleotides | Transgenic plants | Rice | CONSTANS-LIKE GENE | BARLEY HORDEUM-VULGARE | ARABIDOPSIS-THALIANA | ARTIFICIAL SELECTION | MULTIDISCIPLINARY SCIENCES | FLOWERING TIME GENE | HEADING DATE | DOMESTICATION | VERNALIZATION | WHEAT | LATITUDINAL CLINE | Plant Proteins - genetics | Up-Regulation | Oryza - genetics | Asia | Genes, Plant | Plant Proteins - physiology | Transcriptional Activation | Cloning, Molecular | Molecular Sequence Data | Crops, Agricultural - genetics | Circadian Rhythm | Polymorphism, Genetic | Quantitative genetics | Quantitative trait loci | Plant chromosomes | Genetic aspects | Research | Properties | Genetic polymorphisms | Biological Sciences
Wild rice | Genes | Alleles | Plant domestication | Flowering | Genetic loci | Plants | Nucleotides | Transgenic plants | Rice | CONSTANS-LIKE GENE | BARLEY HORDEUM-VULGARE | ARABIDOPSIS-THALIANA | ARTIFICIAL SELECTION | MULTIDISCIPLINARY SCIENCES | FLOWERING TIME GENE | HEADING DATE | DOMESTICATION | VERNALIZATION | WHEAT | LATITUDINAL CLINE | Plant Proteins - genetics | Up-Regulation | Oryza - genetics | Asia | Genes, Plant | Plant Proteins - physiology | Transcriptional Activation | Cloning, Molecular | Molecular Sequence Data | Crops, Agricultural - genetics | Circadian Rhythm | Polymorphism, Genetic | Quantitative genetics | Quantitative trait loci | Plant chromosomes | Genetic aspects | Research | Properties | Genetic polymorphisms | Biological Sciences
Journal Article
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 07/2018, Volume 320, Issue 3, pp. 245 - 254
IMPORTANCE In China and other parts of the world, hospital personnel adherence to evidence-based stroke care is limited. OBJECTIVE To determine whether a...
GLOBAL BURDEN | MORTALITY | MEDICINE, GENERAL & INTERNAL | TISSUE-PLASMINOGEN ACTIVATOR | DISEASE | PREVENTION | OUTCOMES | GUIDELINES-STROKE | CARE | Medical personnel | Stroke (Disease) | Care and treatment | Analysis | Practice | Health care industry | Stroke patients | Health aspects | Patients | Quality management | Performance evaluation | Intervention | Stroke | Statistical analysis | Mortality | Clinical trials | Personnel | Adhesion | Randomization | Hospitals | Ischemia | Quality control | Quality of care
GLOBAL BURDEN | MORTALITY | MEDICINE, GENERAL & INTERNAL | TISSUE-PLASMINOGEN ACTIVATOR | DISEASE | PREVENTION | OUTCOMES | GUIDELINES-STROKE | CARE | Medical personnel | Stroke (Disease) | Care and treatment | Analysis | Practice | Health care industry | Stroke patients | Health aspects | Patients | Quality management | Performance evaluation | Intervention | Stroke | Statistical analysis | Mortality | Clinical trials | Personnel | Adhesion | Randomization | Hospitals | Ischemia | Quality control | Quality of care
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Full Text
Atmospheric new particle formation from sulfuric acid and amines in a Chinese megacity
Science, ISSN 0036-8075, 07/2018, Volume 361, Issue 6399, pp. 278 - 281
Atmospheric new particle formation (NPF) is an important global phenomenon that is nevertheless sensitive to ambient conditions. According to both observation...
AMMONIA | CLUSTERS | EMISSIONS | NUMBER CONCENTRATIONS | MULTIDISCIPLINARY SCIENCES | OXIDIZED ORGANIC-MOLECULES | GROWTH | AEROSOL NUCLEATION | TIME | YANGTZE-RIVER DELTA | SIZE DISTRIBUTION | Environmental aspects | Air quality | Particles | Sulfuric acid | Megacities | Amines | Growth rate | Climate effects | Environmental policy | Atmospheric pollutant deposition | Pollution control | Vapors | Particulates | Condensation | Molecular chains | Acids | Precursors | Clusters | Air pollution | Water pollution | Dimers | Kinetics | Naturvetenskap | Natural Sciences | Earth and Related Environmental Sciences | Geovetenskap och miljövetenskap
AMMONIA | CLUSTERS | EMISSIONS | NUMBER CONCENTRATIONS | MULTIDISCIPLINARY SCIENCES | OXIDIZED ORGANIC-MOLECULES | GROWTH | AEROSOL NUCLEATION | TIME | YANGTZE-RIVER DELTA | SIZE DISTRIBUTION | Environmental aspects | Air quality | Particles | Sulfuric acid | Megacities | Amines | Growth rate | Climate effects | Environmental policy | Atmospheric pollutant deposition | Pollution control | Vapors | Particulates | Condensation | Molecular chains | Acids | Precursors | Clusters | Air pollution | Water pollution | Dimers | Kinetics | Naturvetenskap | Natural Sciences | Earth and Related Environmental Sciences | Geovetenskap och miljövetenskap
Journal Article
JAMA Neurology, ISSN 2168-6149, 2019, Volume 76, Issue 5, pp. 552 - 560
IMPORTANCE Genetic variants of ABCB1 may affect intestinal absorption of clopidogrel bisulfate. However, it is unclear whether ABCB1 polymorphisms are...
EVENTS | EFFICACY | CARDIOVASCULAR OUTCOMES | RESISTANCE | CYP2C19 | ASPIRIN | CLINICAL NEUROLOGY | Transient ischemic attack | Clinical trials | Single-nucleotide polymorphism | Nucleotides | Gene polymorphism | Bleeding | Genotype & phenotype | Randomization | Ischemia | Intestine | Safety engineering | Secondary analysis | Intestinal absorption | Genotypes | Aspirin | Stroke | Effectiveness | Risk groups | Health risks | Risk reduction | Patients | Genetic variance | Clopidogrel | Risk management | Polymorphism
EVENTS | EFFICACY | CARDIOVASCULAR OUTCOMES | RESISTANCE | CYP2C19 | ASPIRIN | CLINICAL NEUROLOGY | Transient ischemic attack | Clinical trials | Single-nucleotide polymorphism | Nucleotides | Gene polymorphism | Bleeding | Genotype & phenotype | Randomization | Ischemia | Intestine | Safety engineering | Secondary analysis | Intestinal absorption | Genotypes | Aspirin | Stroke | Effectiveness | Risk groups | Health risks | Risk reduction | Patients | Genetic variance | Clopidogrel | Risk management | Polymorphism
Journal Article