Arthritis Research and Therapy, ISSN 1478-6354, 10/2009, Volume 11, Issue 5, pp. 247 - 247
B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we...
RHEUMATOID-ARTHRITIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | SJOGRENS-SYNDROME | MURINE LUPUS | COMMON VARIABLE IMMUNODEFICIENCY | PERIPHERAL-BLOOD | RHEUMATOLOGY | ANTI-CD4 MONOCLONAL-ANTIBODY | PLASMA-CELLS | UNDIFFERENTIATED ARTHRITIS | FC-GAMMA-RIIB | Cell Differentiation - immunology | B-Lymphocytes - cytology | Lymphocyte Activation - immunology | Animals | B-Lymphocytes - immunology | Autoimmunity - immunology | Humans | Autoimmune Diseases - immunology | B-Lymphocyte Subsets - immunology | Review
RHEUMATOID-ARTHRITIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | SJOGRENS-SYNDROME | MURINE LUPUS | COMMON VARIABLE IMMUNODEFICIENCY | PERIPHERAL-BLOOD | RHEUMATOLOGY | ANTI-CD4 MONOCLONAL-ANTIBODY | PLASMA-CELLS | UNDIFFERENTIATED ARTHRITIS | FC-GAMMA-RIIB | Cell Differentiation - immunology | B-Lymphocytes - cytology | Lymphocyte Activation - immunology | Animals | B-Lymphocytes - immunology | Autoimmunity - immunology | Humans | Autoimmune Diseases - immunology | B-Lymphocyte Subsets - immunology | Review
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 10/2011, Volume 13, Issue 5, pp. 243 - 243
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is known to be associated with polyclonal B-cell hyper-reactivity. The underlying...
RHEUMATOID-ARTHRITIS | ADHESION MOLECULE EXPRESSION | SYSTEMIC-LUPUS-ERYTHEMATOSUS | TOLERANCE CHECKPOINTS | SOMATIC HYPERMUTATION | VARIABLE REGION GENES | HUMAN PLASMA-CELLS | PERIPHERAL-BLOOD | DEPLETION THERAPY | LYMPHOCYTE HOMEOSTASIS | RHEUMATOLOGY | Animals | Apoptosis - immunology | B-Lymphocytes - immunology | Humans | Autoimmune Diseases - immunology | Lupus Erythematosus, Systemic - immunology | B-Lymphocytes - pathology | Autoimmune Diseases - pathology | Lupus Erythematosus, Systemic - pathology | Review
RHEUMATOID-ARTHRITIS | ADHESION MOLECULE EXPRESSION | SYSTEMIC-LUPUS-ERYTHEMATOSUS | TOLERANCE CHECKPOINTS | SOMATIC HYPERMUTATION | VARIABLE REGION GENES | HUMAN PLASMA-CELLS | PERIPHERAL-BLOOD | DEPLETION THERAPY | LYMPHOCYTE HOMEOSTASIS | RHEUMATOLOGY | Animals | Apoptosis - immunology | B-Lymphocytes - immunology | Humans | Autoimmune Diseases - immunology | Lupus Erythematosus, Systemic - immunology | B-Lymphocytes - pathology | Autoimmune Diseases - pathology | Lupus Erythematosus, Systemic - pathology | Review
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e67003
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized by defective immune tolerance combined with immune cell hyperactivity...
ANTIBODIES | PATHWAYS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | MEMORY | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | AUTOIMMUNE-DISEASE | DISEASE-ACTIVITY | PROTEIN-INTERACTION | IFN-ALPHA | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Gene Expression Profiling | Lupus Erythematosus, Systemic - blood | RNA, Messenger - metabolism | Young Adult | Lupus Erythematosus, Systemic - immunology | Adult | Female | B-Lymphocytes - pathology | Interferons - genetics | B-Lymphocytes - metabolism | RNA - metabolism | Reproducibility of Results | RNA, Messenger - genetics | Up-Regulation - genetics | Transcriptome - genetics | DNA - metabolism | T-Lymphocyte Subsets - pathology | T-Lymphocyte Subsets - metabolism | Lupus Erythematosus, Systemic - genetics | Interferons - metabolism | Myeloid Cells - metabolism | Myeloid Cells - pathology | Lupus | Autoimmunity | Medical research | Autoantibodies | Systemic lupus erythematosus | Genes | Medicine, Experimental | Interferon | B cells | Biological response modifiers | T cells | Gene expression | Disease | Transcription | Pathogenesis | Leukocytes (mononuclear) | Lymphocytes T | Arthritis | Kinases | Blood | Cell adhesion & migration | Defects | Immunology | Lymphocytes | CD38 antigen | Peripheral blood mononuclear cells | Deoxyribonucleic acid--DNA | Myeloid cells | CD19 antigen | Internal medicine | CD63 antigen | Inflammation | CD3 antigen | Ribonucleic acid--RNA | Patients | Immunological tolerance | CD4 antigen | White blood cells | Medicine | Chronic conditions | Centenarians | Lymphocytes B | Autoimmune diseases | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
ANTIBODIES | PATHWAYS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | MEMORY | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | AUTOIMMUNE-DISEASE | DISEASE-ACTIVITY | PROTEIN-INTERACTION | IFN-ALPHA | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Gene Expression Profiling | Lupus Erythematosus, Systemic - blood | RNA, Messenger - metabolism | Young Adult | Lupus Erythematosus, Systemic - immunology | Adult | Female | B-Lymphocytes - pathology | Interferons - genetics | B-Lymphocytes - metabolism | RNA - metabolism | Reproducibility of Results | RNA, Messenger - genetics | Up-Regulation - genetics | Transcriptome - genetics | DNA - metabolism | T-Lymphocyte Subsets - pathology | T-Lymphocyte Subsets - metabolism | Lupus Erythematosus, Systemic - genetics | Interferons - metabolism | Myeloid Cells - metabolism | Myeloid Cells - pathology | Lupus | Autoimmunity | Medical research | Autoantibodies | Systemic lupus erythematosus | Genes | Medicine, Experimental | Interferon | B cells | Biological response modifiers | T cells | Gene expression | Disease | Transcription | Pathogenesis | Leukocytes (mononuclear) | Lymphocytes T | Arthritis | Kinases | Blood | Cell adhesion & migration | Defects | Immunology | Lymphocytes | CD38 antigen | Peripheral blood mononuclear cells | Deoxyribonucleic acid--DNA | Myeloid cells | CD19 antigen | Internal medicine | CD63 antigen | Inflammation | CD3 antigen | Ribonucleic acid--RNA | Patients | Immunological tolerance | CD4 antigen | White blood cells | Medicine | Chronic conditions | Centenarians | Lymphocytes B | Autoimmune diseases | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
The Journal of Immunology, ISSN 0022-1767, 08/2007, Volume 179, Issue 3, pp. 1634 - 1647
1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) can modulate immune responses, but whether it directly affects B cell function is unknown. Patients with systemic...
Immunologic Factors - deficiency | Apoptosis - drug effects | Humans | Middle Aged | Calcitriol - physiology | Apoptosis - genetics | Male | Receptors, Calcitriol - genetics | Plasma Cells - pathology | Receptors, Calcitriol - biosynthesis | Plasma Cells - drug effects | Cell Differentiation - genetics | Calcitriol - deficiency | Lupus Erythematosus, Systemic - drug therapy | Lupus Erythematosus, Systemic - immunology | Adult | Female | Growth Inhibitors - genetics | Steroid Hydroxylases - genetics | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Immunologic Factors - physiology | Cells, Cultured | Vitamin D3 24-Hydroxylase | Down-Regulation - drug effects | Down-Regulation - genetics | Vitamin D - blood | Gene Expression Regulation - drug effects | B-Lymphocytes - drug effects | Cell Differentiation - immunology | Apoptosis - immunology | B-Lymphocytes - immunology | Vitamin D - antagonists & inhibitors | Cell Differentiation - drug effects | Down-Regulation - immunology | Lymphocyte Activation - drug effects | ADP-ribosyl Cyclase 1 - biosynthesis | Calcitriol - pharmacology | Adolescent | Growth Inhibitors - physiology | Vitamin D - analogs & derivatives | Aged | Lupus Erythematosus, Systemic - pathology | Steroid Hydroxylases - biosynthesis | Immunologic Factors - pharmacology
Immunologic Factors - deficiency | Apoptosis - drug effects | Humans | Middle Aged | Calcitriol - physiology | Apoptosis - genetics | Male | Receptors, Calcitriol - genetics | Plasma Cells - pathology | Receptors, Calcitriol - biosynthesis | Plasma Cells - drug effects | Cell Differentiation - genetics | Calcitriol - deficiency | Lupus Erythematosus, Systemic - drug therapy | Lupus Erythematosus, Systemic - immunology | Adult | Female | Growth Inhibitors - genetics | Steroid Hydroxylases - genetics | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Immunologic Factors - physiology | Cells, Cultured | Vitamin D3 24-Hydroxylase | Down-Regulation - drug effects | Down-Regulation - genetics | Vitamin D - blood | Gene Expression Regulation - drug effects | B-Lymphocytes - drug effects | Cell Differentiation - immunology | Apoptosis - immunology | B-Lymphocytes - immunology | Vitamin D - antagonists & inhibitors | Cell Differentiation - drug effects | Down-Regulation - immunology | Lymphocyte Activation - drug effects | ADP-ribosyl Cyclase 1 - biosynthesis | Calcitriol - pharmacology | Adolescent | Growth Inhibitors - physiology | Vitamin D - analogs & derivatives | Aged | Lupus Erythematosus, Systemic - pathology | Steroid Hydroxylases - biosynthesis | Immunologic Factors - pharmacology
Journal Article
Blood, ISSN 0006-4971, 06/2005, Volume 105, Issue 11, pp. 4390 - 4398
Murine B-cell development begins in bone marrow and results in the generation of immature transitional B cells that transit to the spleen to complete their...
HEAT-STABLE ANTIGEN(HI) | SYSTEMIC-LUPUS-ERYTHEMATOSUS | VARIABLE REGION GENES | BONE-MARROW | LYMPHOCYTE-B | RECEPTOR-INDUCED APOPTOSIS | PERIPHERAL-BLOOD | T-CELL | HEMATOLOGY | CENTER FOUNDER CELLS | ACTIVATING FACTOR | Blood Cells | B-Lymphocytes - cytology | Cell Survival | Lymphocyte Activation | Coculture Techniques | Humans | Immunophenotyping | Lupus Erythematosus, Systemic - blood | Membrane Proteins - pharmacology | Stromal Cells | Tumor Necrosis Factor-alpha - pharmacology | Interleukin-4 - pharmacology | B-Cell Activating Factor | Bone Marrow Cells | Flow Cytometry | Cell Cycle | Immunobiology
HEAT-STABLE ANTIGEN(HI) | SYSTEMIC-LUPUS-ERYTHEMATOSUS | VARIABLE REGION GENES | BONE-MARROW | LYMPHOCYTE-B | RECEPTOR-INDUCED APOPTOSIS | PERIPHERAL-BLOOD | T-CELL | HEMATOLOGY | CENTER FOUNDER CELLS | ACTIVATING FACTOR | Blood Cells | B-Lymphocytes - cytology | Cell Survival | Lymphocyte Activation | Coculture Techniques | Humans | Immunophenotyping | Lupus Erythematosus, Systemic - blood | Membrane Proteins - pharmacology | Stromal Cells | Tumor Necrosis Factor-alpha - pharmacology | Interleukin-4 - pharmacology | B-Cell Activating Factor | Bone Marrow Cells | Flow Cytometry | Cell Cycle | Immunobiology
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 2/2012, Volume 54, Issue 3, pp. 393 - 407
The standard recommendation for treating chronic osteomyelitis is 6 weeks of parenteral antibiotic therapy. However, oral antibiotics are available that...
Osteomyelitis | Debridement | Antibiotics | CLINICAL PRACTICE | Bones | Infections | Dosage | Pharmacokinetics | Joints | Staphylococcus | Staphylococcus aureus | SOFT-TISSUE INFECTIONS | ORAL CIPROFLOXACIN THERAPY | INFECTIOUS DISEASES | DIABETIC FOOT INFECTIONS | MICROBIOLOGY | IMMUNOLOGY | RESISTANT STAPHYLOCOCCUS-AUREUS | PROSTHETIC JOINT INFECTIONS | GRAM-NEGATIVE BACILLI | MULTIPLE-DOSE PHARMACOKINETICS | PSEUDOMONAS-AERUGINOSA | INFECTED ORTHOPEDIC IMPLANTS | TRIMETHOPRIM-SULFAMETHOXAZOLE | Anti-Bacterial Agents - therapeutic use | Injections, Intravenous | Humans | Adult | Anti-Bacterial Agents - administration & dosage | Osteomyelitis - drug therapy | Chronic Disease - drug therapy | Care and treatment | Dosage and administration | Risk factors | Intravenous catheterization | Invited
Osteomyelitis | Debridement | Antibiotics | CLINICAL PRACTICE | Bones | Infections | Dosage | Pharmacokinetics | Joints | Staphylococcus | Staphylococcus aureus | SOFT-TISSUE INFECTIONS | ORAL CIPROFLOXACIN THERAPY | INFECTIOUS DISEASES | DIABETIC FOOT INFECTIONS | MICROBIOLOGY | IMMUNOLOGY | RESISTANT STAPHYLOCOCCUS-AUREUS | PROSTHETIC JOINT INFECTIONS | GRAM-NEGATIVE BACILLI | MULTIPLE-DOSE PHARMACOKINETICS | PSEUDOMONAS-AERUGINOSA | INFECTED ORTHOPEDIC IMPLANTS | TRIMETHOPRIM-SULFAMETHOXAZOLE | Anti-Bacterial Agents - therapeutic use | Injections, Intravenous | Humans | Adult | Anti-Bacterial Agents - administration & dosage | Osteomyelitis - drug therapy | Chronic Disease - drug therapy | Care and treatment | Dosage and administration | Risk factors | Intravenous catheterization | Invited
Journal Article
Diabetes Care, ISSN 0149-5992, 03/2014, Volume 37, Issue 3, pp. 593 - 595
DIAGNOSIS | INFECTIONS | SERIES | EXTREMITY | ENDOCRINOLOGY & METABOLISM | ADULTS | CONSERVATIVE MANAGEMENT | BONE | GANGRENE | SURGICAL-TREATMENT | Osteomyelitis - surgery | Humans | Diabetic Foot - drug therapy | Diabetic Foot - surgery | Female | Male | Anti-Bacterial Agents - administration & dosage | Osteomyelitis - drug therapy | Osteomyelitis | Antibiotics | Health aspects | Diabetic foot
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2007, Volume 179, Issue 9, pp. 5886 - 5896
During T cell-B cell collaboration, plasma cell (PC) differentiation and Ig production are known to require T cell-derived soluble factors. However, the exact...
RESPONSES | IMMUNOAFFINITY CAPILLARY-ELECTROPHORESIS | MEMORY | IMMUNOGLOBULIN | CD40 LIGAND | RECEPTOR | ANTIBODY | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | LYMPHOCYTES-T | B-Lymphocytes - cytology | Humans | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Interleukins - metabolism | CD4-Positive T-Lymphocytes - immunology | Plasma Cells - drug effects | B-Lymphocytes - drug effects | Immunity, Innate - immunology | Lymphocyte Activation - immunology | B-Lymphocytes - immunology | Lymphocyte Activation - drug effects | Interleukins - immunology | CD3 Complex - immunology | Antibodies - immunology | Cell Differentiation | Cell Proliferation - drug effects | Interleukins - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Immunologic Memory - immunology | Plasma Cells - cytology | Plasma Cells - immunology
RESPONSES | IMMUNOAFFINITY CAPILLARY-ELECTROPHORESIS | MEMORY | IMMUNOGLOBULIN | CD40 LIGAND | RECEPTOR | ANTIBODY | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | LYMPHOCYTES-T | B-Lymphocytes - cytology | Humans | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Interleukins - metabolism | CD4-Positive T-Lymphocytes - immunology | Plasma Cells - drug effects | B-Lymphocytes - drug effects | Immunity, Innate - immunology | Lymphocyte Activation - immunology | B-Lymphocytes - immunology | Lymphocyte Activation - drug effects | Interleukins - immunology | CD3 Complex - immunology | Antibodies - immunology | Cell Differentiation | Cell Proliferation - drug effects | Interleukins - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Immunologic Memory - immunology | Plasma Cells - cytology | Plasma Cells - immunology
Journal Article
Nature Immunology, ISSN 1529-2908, 09/2001, Volume 2, Issue 9, pp. 764 - 766
B cells can regulate many aspects of immune reactivity, as well as differentiate into anti body-producing cells. In SLE, a systemic autoimmune disease, recent...
RECEPTOR | IMMUNOLOGY | T-CELLS | GENES | Genes, Immunoglobulin | Genetic Predisposition to Disease | Models, Immunological | Animals | B-Lymphocytes - immunology | Lymphocyte Activation | Humans | Lupus Erythematosus, Systemic - genetics | Lupus Erythematosus, Systemic - immunology | Mice | Mutation | Autoantibodies - biosynthesis
RECEPTOR | IMMUNOLOGY | T-CELLS | GENES | Genes, Immunoglobulin | Genetic Predisposition to Disease | Models, Immunological | Animals | B-Lymphocytes - immunology | Lymphocyte Activation | Humans | Lupus Erythematosus, Systemic - genetics | Lupus Erythematosus, Systemic - immunology | Mice | Mutation | Autoantibodies - biosynthesis
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 19, pp. 4586 - 4594
Mature B-cell differentiation provides an important mechanism for the acquisition of adaptive immunity. Malignancies derived from mature B cells constitute the...
BLIMP-1 | PROFILES | MICROARRAY | BURKITTS-LYMPHOMA | GENE-EXPRESSION | CHRONIC LYMPHOCYTIC-LEUKEMIA | PROLIFERATION | HEMATOLOGY | TRANSCRIPTION FACTOR | PROTEIN-SYNTHESIS | PREDICTION | Enzyme-Linked Immunosorbent Assay | Lymphoma, Large B-Cell, Diffuse - pathology | Humans | RNA, Messenger - genetics | Cells, Cultured | Gene Expression Regulation, Neoplastic | B-Lymphocytes - physiology | Burkitt Lymphoma - metabolism | Gene Expression Profiling | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Lymphoma, Large B-Cell, Diffuse - metabolism | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Burkitt Lymphoma - pathology | Cell Lineage | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Burkitt Lymphoma - genetics | Cell Differentiation | MicroRNAs - genetics | Lymphoma, Large B-Cell, Diffuse - genetics | Immunobiology
BLIMP-1 | PROFILES | MICROARRAY | BURKITTS-LYMPHOMA | GENE-EXPRESSION | CHRONIC LYMPHOCYTIC-LEUKEMIA | PROLIFERATION | HEMATOLOGY | TRANSCRIPTION FACTOR | PROTEIN-SYNTHESIS | PREDICTION | Enzyme-Linked Immunosorbent Assay | Lymphoma, Large B-Cell, Diffuse - pathology | Humans | RNA, Messenger - genetics | Cells, Cultured | Gene Expression Regulation, Neoplastic | B-Lymphocytes - physiology | Burkitt Lymphoma - metabolism | Gene Expression Profiling | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Lymphoma, Large B-Cell, Diffuse - metabolism | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Burkitt Lymphoma - pathology | Cell Lineage | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Burkitt Lymphoma - genetics | Cell Differentiation | MicroRNAs - genetics | Lymphoma, Large B-Cell, Diffuse - genetics | Immunobiology
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2005, Volume 175, Issue 12, pp. 7867 - 7879
IL-21 is a type I cytokine that influences the function or T cells, NK cells, and B cells. In this study, we report that IL-21 plays a major role in...
SOMATIC HYPERMUTATION | INDUCED CYTIDINE DEAMINASE | COMMON GAMMA-CHAIN | GENE-EXPRESSION | RECEPTOR | MONOCLONAL-ANTIBODY | GENERATION | CD40 LIGATION | IMMUNOLOGY | T-CELLS | CUTTING EDGE | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | CD40 Antigens - metabolism | Cell Proliferation | Cell Differentiation - drug effects | Antibody Formation - drug effects | Humans | Immunologic Memory | Plasma Cells - metabolism | Interleukins - pharmacology | Receptors, Antigen, B-Cell - metabolism | Immunoglobulin Class Switching
SOMATIC HYPERMUTATION | INDUCED CYTIDINE DEAMINASE | COMMON GAMMA-CHAIN | GENE-EXPRESSION | RECEPTOR | MONOCLONAL-ANTIBODY | GENERATION | CD40 LIGATION | IMMUNOLOGY | T-CELLS | CUTTING EDGE | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | CD40 Antigens - metabolism | Cell Proliferation | Cell Differentiation - drug effects | Antibody Formation - drug effects | Humans | Immunologic Memory | Plasma Cells - metabolism | Interleukins - pharmacology | Receptors, Antigen, B-Cell - metabolism | Immunoglobulin Class Switching
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 07/2014, Volume 6, Issue 246, pp. 246ra99 - 246ra99
PTEN regulates normal signaling through the B cell receptor (BCR). In systemic lupus erythematosus (SLE), enhanced BCR signaling contributes to increased B...
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | INTERLEUKIN-21 RECEPTOR | SIGNALING PATHWAY | TUMOR-SUPPRESSOR | IDENTIFICATION | PHOSPHOINOSITIDE 3-KINASE | ANTIGEN RECEPTOR | EXPRESSION | PROTEIN-KINASE B | IL-21 | CELL BIOLOGY | Lupus Erythematosus, Systemic - complications | Humans | Molecular Sequence Data | Male | MicroRNAs - metabolism | Plasma Cells - drug effects | Young Adult | Lymphocyte Activation - immunology | Base Sequence | Lupus Erythematosus, Systemic - immunology | Adult | Female | Plasma Cells - metabolism | B-Lymphocytes - pathology | Interleukins - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Lupus Erythematosus, Systemic - enzymology | PTEN Phosphohydrolase - genetics | Proteinuria - immunology | PTEN Phosphohydrolase - metabolism | Down-Regulation - drug effects | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Calcium Signaling - drug effects | Cell Differentiation - drug effects | Lymphocyte Activation - drug effects | Adolescent | ADP-ribosyl Cyclase 1 - metabolism | Cell Proliferation - drug effects | Lupus Erythematosus, Systemic - pathology | Proteinuria - complications
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | INTERLEUKIN-21 RECEPTOR | SIGNALING PATHWAY | TUMOR-SUPPRESSOR | IDENTIFICATION | PHOSPHOINOSITIDE 3-KINASE | ANTIGEN RECEPTOR | EXPRESSION | PROTEIN-KINASE B | IL-21 | CELL BIOLOGY | Lupus Erythematosus, Systemic - complications | Humans | Molecular Sequence Data | Male | MicroRNAs - metabolism | Plasma Cells - drug effects | Young Adult | Lymphocyte Activation - immunology | Base Sequence | Lupus Erythematosus, Systemic - immunology | Adult | Female | Plasma Cells - metabolism | B-Lymphocytes - pathology | Interleukins - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Lupus Erythematosus, Systemic - enzymology | PTEN Phosphohydrolase - genetics | Proteinuria - immunology | PTEN Phosphohydrolase - metabolism | Down-Regulation - drug effects | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Calcium Signaling - drug effects | Cell Differentiation - drug effects | Lymphocyte Activation - drug effects | Adolescent | ADP-ribosyl Cyclase 1 - metabolism | Cell Proliferation - drug effects | Lupus Erythematosus, Systemic - pathology | Proteinuria - complications
Journal Article