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Life Sciences, ISSN 0024-3205, 04/2018, Volume 198, p. 25
Aims This study uncovered that the genetically endowed intracellular glutathione contents (iGSH) regulated by the catalytic subunit of γ‑glutamylcysteine... 
Flow cytometry | Arsenic | Toxicity | Cytotoxicity | Hepatocellular carcinoma | Arsenic trioxide | Radio | Liquid chromatography | Radiation therapy | Drug resistance | Gene expression | High-performance liquid chromatography | Doxorubicin | Cisplatin | Anticancer properties | Liver cancer | Sensitivity | Mitochondria | Measurement methods | Membrane potential | Catalysis | Glutathione | Cancer | Apoptosis
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. 4970 - 4970
Journal Article
Life Sciences, ISSN 0024-3205, 09/2015, Volume 136, p. 7
This study delineated the mechanisms of paclitaxel (PTX) assistance in overcoming radioresistance in hepatoma and human lung adenocarcinoma (HLAC) cells. 
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, pp. e0139232 - e0139232
To search for reliable biomarkers and drug targets for management of hepatocellular carcinoma (HCC), we performed a global proteomic analysis of a pair of HCC... 
Annexins - metabolism | Heat-Shock Proteins - metabolism | Humans | Neoplasm Proteins - metabolism | Hep G2 Cells | Up-Regulation - physiology | Liver Neoplasms - metabolism | Biomarkers, Tumor - metabolism | Cell Line, Tumor | HSP27 Heat-Shock Proteins - metabolism | Proteomics - methods | Cell Differentiation - physiology | Gene Expression Regulation, Neoplastic - physiology | Superoxide Dismutase - metabolism | Carcinoma, Hepatocellular - metabolism | Care and treatment | Analysis | Chemical properties | Research | Hepatoma | Biological markers | Annexins | Intermediate filament proteins | Risk factors | Vimentin | Peroxiredoxin | Oxidative stress | Phosphorylation | Dehydrogenases | Laboratories | Superoxide dismutase | Hepatocellular carcinoma | Biology | Metastasis | Dehydrogenase | Western blotting | Cell adhesion & migration | Antioxidants | Proteins | Liver cancer | Glucose dehydrogenase | Surgery | Life sciences | Bioindicators | NADP | Stains | Isocitrate dehydrogenase | Phosphopyruvate hydratase | Medical research | Invasiveness | Therapeutic applications | Heat shock proteins | Gene expression | Medicine | UDP-glucose 6-dehydrogenase | Hospitals | Hsp27 protein | Cell lines | Biomarkers | Protein expression | Protein disulfide-isomerase | Clinical medicine | Immunofluorescence | Cell migration | Heat shock | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0136340 - e0136340
Here, we present evidence of a novel microtubule-disrupting agent, N-deacetyl-N-(chromone-2-carbonyl)-thiocolchicine (TCD), exhibiting potent antitumor... 
APOPTOSIS | COLCHICINE | MULTIDISCIPLINARY SCIENCES | BIOLOGICAL EVALUATION | RESISTANCE | CANCER STATISTICS | ANTICANCER DRUGS | MECHANISMS | INHIBITORS | TUBULIN | HEPATOMA | Colchicine - pharmacology | Molecular Chaperones - metabolism | Colchicine - therapeutic use | Humans | Antineoplastic Agents - therapeutic use | Membrane Potential, Mitochondrial - drug effects | Colchicine - analogs & derivatives | Dose-Response Relationship, Drug | Microtubules - metabolism | Carcinoma, Hepatocellular - drug therapy | Caspases - metabolism | G2 Phase Cell Cycle Checkpoints - drug effects | Time Factors | Microtubules - drug effects | Inhibitory Concentration 50 | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Liver Neoplasms - enzymology | Endoplasmic Reticulum Stress - drug effects | Liver Neoplasms - drug therapy | Carcinoma, Hepatocellular - enzymology | Enzyme Activation - drug effects | Hep G2 Cells | Animals | Signal Transduction - drug effects | Mice, Nude | Carcinoma, Hepatocellular - pathology | Mice, Inbred BALB C | Microtubules | Cancer cells | Physiological aspects | Development and progression | Genetic aspects | Research | Hepatoma | Biotechnology | Transcription factors | DNA damage | Multiple myeloma | Hepatocellular carcinoma | Homology | CCAAT/enhancer-binding protein | Kinases | Cancer therapies | CCAAT-enhancer binding protein | Anticancer properties | Proteins | Liver cancer | Signal transduction | Mitochondria | Medical laboratories | Surgery | Cell cycle | Xenografts | Membrane potential | Deoxyribonucleic acid--DNA | Carbonyls | Activating transcription factor 3 | Pharmacology | Tumor cell lines | Ribonucleic acid--RNA | Chemical compounds | Patients | Hospitals | Protein kinase | Cell death | Cell lines | Antitumor activity | Disruption | Apoptosis | Index Medicus | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Tumor Biology, ISSN 1010-4283, 6/2017, Volume 39, Issue 6, pp. 1010428317702649 - 1010428317702649
We provide herein several lines of evidence to substantiate that folic acid (or folate) is a micronutrient capable of functioning as a novel redox regulator on... 
Mitochondrial redox homeostasis | Hepatocellular carcinoma | Mitochondrial isocitrate dehydrogenase | Reactive oxygen species sinker proteins | Redox regulator | Folic acid | OXIDATIVE STRESS | NADP(+)-DEPENDENT ISOCITRATE DEHYDROGENASE | reactive oxygen species sinker proteins | CELL-SURVIVAL | BETA-CATENIN | CANCER | BCL-2 | 2-OXOGLUTARATE CARRIER | ONCOLOGY | GLUTATHIONE | RESISTANCE | mitochondrial redox homeostasis | mitochondrial isocitrate dehydrogenase | redox regulator | hepatocellular carcinoma | FOLATE | Reactive Oxygen Species - metabolism | Glutathione - metabolism | Inhibitor of Apoptosis Proteins - genetics | Humans | Gene Expression Regulation, Neoplastic | Homeostasis | Apoptosis - genetics | Heat-Shock Proteins - antagonists & inhibitors | Endoplasmic Reticulum Stress - genetics | Heat-Shock Proteins - genetics | Carcinoma, Hepatocellular - drug therapy | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Liver Neoplasms - pathology | Oxidation-Reduction | Liver Neoplasms - drug therapy | Oxidative Stress - genetics | Isocitrate Dehydrogenase - genetics | Mitochondria - metabolism | Mitochondria - pathology | Hep G2 Cells | Animals | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Folic Acid - metabolism | Mice | Folic Acid - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Carcinoma, Hepatocellular - metabolism | Cell culture | Reactive oxygen species | Bcl-2 protein | Authorship | Biosynthesis | Drug resistance | Antioxidants | Proteins | Liver cancer | Mitochondria | Glutathione reductase | Vitamin B | Penicillin | Isocitrate dehydrogenase | Species | Glutathione | Enzymes | Oxygen | Free radicals | NADPH-diaphorase | Adenine | siRNA | Survivin | Microscopy | Endoplasmic reticulum | Apoptosis | Reductase | Index Medicus
Journal Article
Annals of Surgical Oncology, ISSN 1068-9265, 2/2010, Volume 17, Issue 2, pp. 603 - 612
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e77931 - e77931
Journal Article
Oncotarget, ISSN 1949-2553, 05/2016, Volume 7, Issue 22, pp. 33246 - 33256
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 28, pp. 26104 - 26118
Patients with hepatocellular carcinoma (HCC) are prone to folate deficiency (FD). Here we showed that, in cell line-specific manner, FD caused resistance to... 
multi-drug resistance | GRP78 | chemotherapy | hepatoma | Folate | APOPTOSIS | TUMOR PROGRESSION | DNA-DAMAGE | CELL BIOLOGY | BREAST-CANCER CELLS | folate | UNFOLDED PROTEIN RESPONSE | INDUCED OXIDATIVE STRESS | IN-VIVO | HYDROGEN-PEROXIDE | HEP G2 CELLS | UP-REGULATION | Index Medicus
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 02/2006, Volume 44, Issue 2, pp. 227 - 235
Reports elsewhere demonstrated that Epimedin C, a constituent isolated from the leaves of Epimedium sagittatum, possessed anti-tumor activity. However, its... 
phase | p27 | MAP kinase | Epimedin C | p21
Journal Article
Annals of Surgical Oncology, ISSN 1068-9265, 8/2011, Volume 18, Issue 8, pp. 2395 - 2403
Journal Article