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1. Full Text Developing a newdefinition and assessing newclinical criteria for Septic shock: For the third international consensus definitions for sepsis and septic shock (sepsis-3)
by Shankar-Hari, Manu and Phillips, Gary S and Levy, Mitchell L and Seymour, Christopher W and Liu, Vincent X and Deutschman, Clifford S and Angus, Derek C and Rubenfeld, Gordon D and Singer, Mervyn
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 02/2016, Volume 315, Issue 8, pp. 775 - 787
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2. Full Text Toward the "Plateau of Productivity": Enhancing the Value of Machine Learning in Critical Care
by Liu, VX
CRITICAL CARE MEDICINE, ISSN 0090-3493, 07/2018, Volume 46, Issue 7, pp. 1196 - 1197
critical care outcomes | risk prediction | SCORES | machine learning | MEDICINE | PREDICTION | CRITICAL CARE MEDICINE | Critical Care | Intensive Care Units | Algorithms | Machine Learning | Humans
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3. Full Text Toward the “Plateau of Productivity”: Enhancing the Value of Machine Learning in Critical Care
by Liu, Vincent X
Critical Care Medicine, ISSN 0090-3493, 07/2018, Volume 46, Issue 7, pp. 1196 - 1197
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4. Full Text More Than We Bargained For: The “Dominating” Cost Effectiveness of Sepsis Quality Improvement?
by Peltan, Ithan D and Liu, Vincent X
Critical Care Medicine, ISSN 0090-3493, 10/2019, Volume 47, Issue 10, pp. 1464 - 1467
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5. Full Text Towards the ‘Plateau of Productivity’: enhancing the value of machine learning in critical care
by Liu, Vincent X
Critical care medicine, ISSN 0090-3493, 7/2018, Volume 46, Issue 7, pp. 1196 - 1197
machine learning | critical care outcomes | risk prediction
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6. Full Text Postoperative Opioid Use Before and After Enhanced Recovery After Surgery Program Implementation
by Liu, Vincent X and Eaton, Abigail and Lee, Derrick C and Reyes, Vivian M and Paulson, Shirley S and Campbell, Cynthia I and Avins, Andy L and Parodi, Stephen M
Annals of Surgery, ISSN 0003-4932, 12/2019, Volume 270, Issue 6, pp. e69 - e71
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7. Full Text Reply
by Liu, Vincent X and Fielding-Singh, Vikram and Iwashyna, Theodore J and Bhattacharya, Jay and Escobar, Gabriel J
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2017, Volume 196, Issue 7, pp. 935 - 936
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8. Full Text 16 Years and Counting? Time to Implement Noninvasive Screening for ARDS
by Rogers, Angela J., MD, MPH and Liu, Vincent X., MD
Chest, ISSN 0012-3692, 2016, Volume 150, Issue 2, pp. 266 - 267
Pulmonary/Respiratory | MORTALITY | VENTILATION | INTENSIVE-CARE-UNIT | RESPIRATORY SYSTEM | ACUTE LUNG INJURY | RATIO | RESPIRATORY-DISTRESS-SYNDROME | CRITICAL CARE MEDICINE | Noninvasive Ventilation | Intensive Care Units | Respiratory Distress Syndrome, Adult | Humans | Acute respiratory distress syndrome | Usage | Management | Diagnosis | Diagnosis, Noninvasive | Evidence-based medicine
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9. Full Text Assessing the clinical impact of CYP2C9 pharmacogenetic variation on phenytoin prescribing practice and patient response in an integrated health system
by Fohner, Alison E and Ranatunga, Dilrini K and Thai, Khanh K and Lawson, Brian L and Risch, Neil and Oni-Orisan, Akinyemi and Jelalian, Aline T and Rettie, Allan E and Liu, Vincent X and Schaefer, Catherine A
Pharmacogenetics and Genomics, ISSN 1744-6872, 10/2019, Volume 29, Issue 8, pp. 192 - 199
OBJECTIVETo assess the impact of CYP2C9 variation on phenytoin patient response and clinician prescribing practice where genotype was unknown during treatment.... 
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10. Full Text The Timing of Early Antibiotics and Hospital Mortality in Sepsis: Playing Devil’s Advocate/Reply
by Jason Chertoff and Ali Ataya and Vincent X Liu and Vikram Fielding-Singh and Theodore J Iwashyna and Jay Bhattacharya and Gabriel J Escobar
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2017, Volume 196, Issue 7, p. 934
[...]the authors make mention of this in their introduction when they list the potential harms of timely antibiotic administration (i.e., receipt of... 
Costs | Mortality | Bias | Antimicrobial agents | Emergency medical care | Drug resistance | Patients | Studies | Copyright | Hospitals | Antibiotics | Sepsis | Viral infections
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11. Full Text Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
by Shankar-Hari, Manu and Phillips, Gary S and Levy, Mitchell L and Seymour, Christopher W and Liu, Vincent X and Deutschman, Clifford S and Angus, Derek C and Rubenfeld, Gordon D and Singer, Mervyn and Sepsis Definitions Task Force and for the Sepsis Definitions Task Force
JAMA, ISSN 0098-7484, 02/2016, Volume 315, Issue 8, pp. 775 - 787
IMPORTANCE: Septic shock currently refers to a state of acute circulatory failure associated with infection. Emerging biological insights and reported... 
INFLAMMATORY RESPONSE SYNDROME | 10 UNIVERSITY HOSPITALS | MEDICINE, GENERAL & INTERNAL | PROSPECTIVE MULTICENTER | EMERGENCY-DEPARTMENT | INFECTION-ASSOCIATED SEPSIS | ACQUIRED SEVERE SEPSIS | INTENSIVE-CARE UNITS | SURVIVING SEPSIS | LONG-TERM MORTALITY | CRITICALLY-ILL PATIENTS | Fluid Therapy | Lactates - blood | Vasoconstrictor Agents - therapeutic use | Resuscitation - methods | Humans | Shock, Septic - epidemiology | Hypotension - diagnosis | Biomarkers - blood | Shock, Septic - diagnosis | Shock, Septic - therapy | Consensus | Advisory Committees | Delphi Technique | Review Literature as Topic | Shock, Septic - blood | Observational Studies as Topic | Adult | Blood Pressure Determination | Cohort Studies | Care and treatment | Analysis | Septic shock | Dosage and administration | Health risk assessment | Epidemiology | Risk factors | Vasoconstrictors | Sepsis | Intensive care | Adults | Clinical outcomes
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12. Full Text Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
by Seymour, Christopher W and Liu, Vincent X and Iwashyna, Theodore J and Brunkhorst, Frank M and Rea, Thomas D and Scherag, André and Rubenfeld, Gordon and Kahn, Jeremy M and Shankar-Hari, Manu and Singer, Mervyn and Deutschman, Clifford S and Escobar, Gabriel J and Angus, Derek C
JAMA, ISSN 0098-7484, 02/2016, Volume 315, Issue 8, pp. 762 - 774
IMPORTANCE: The Third International Consensus Definitions Task Force defined sepsis as “life-threatening organ dysfunction due to a dysregulated host response... 
MORTALITY | SYSTEM | MEDICINE, GENERAL & INTERNAL | EMERGENCY CARE | GUIDELINES | SOFA SCORE | OUTCOMES | ORGAN DYSFUNCTION/FAILURE | PNEUMONIA | EPIDEMIOLOGY | PREDICTION | Length of Stay | Reproducibility of Results | Hospital Mortality | Lactic Acid - blood | Humans | Infection - blood | Sepsis - diagnosis | Intensive Care Units - statistics & numerical data | Male | Hypotension - diagnosis | Consensus | Sepsis - mortality | Regression Analysis | Infection - epidemiology | Infection - diagnosis | Adult | Female | Organ Dysfunction Scores | Retrospective Studies | Sepsis - blood | Pennsylvania - epidemiology | Systemic Inflammatory Response Syndrome - diagnosis | Tachypnea - diagnosis | Hospital patients | Sepsis | Septic shock | Care and treatment | Health aspects | Risk factors | Intensive care | Mortality | Clinical outcomes
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13. Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
by Shankar-Hari, Manu and Phillips, Gary S and Levy, Mitchell L and Seymour, Christopher W and Liu, Vincent X and Deutschman, Clifford S and Angus, Derek C and Rubenfeld, Gordon D and Singer, Mervyn
JAMA: Journal of the American Medical Association, ISSN 0098-7484, 02/2016, Volume 315, Issue 8, pp. 775 - 775
Septic shock currently refers to a state of acute circulatory failure associated with infection. Emerging biological insights and reported variation in... 
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14. Full Text Toward smarter lumping and smarter splitting: Rethinking strategies for sepsis and acute respiratory distress syndrome clinical trial design
by Prescott, Hallie C and Calfee, Carolyn S and Taylor Thompson, B and Angus, Derek C and Liu, Vincent X
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2016, Volume 194, Issue 2, pp. 147 - 155
Both quality improvement and clinical research efforts over the past fewdecades have focused on consensus definition of sepsis and acute respiratory distress... 
Acute respiratory distress syndrome | Sepsis | Endotype | Predictive enrichment | Cprognostic enrichment | MORTALITY | COMMUNITY-ACQUIRED PNEUMONIA | EFFICACY | SAFETY | predictive enrichment | CARE | DEFINITIONS | endotype | RESPIRATORY SYSTEM | acute respiratory distress syndrome | FRAMEWORK | prognostic enrichment | INFLAMMATORY RESPONSE | CORTICOSTEROIDS | sepsis | EPIDEMIOLOGY | CRITICAL CARE MEDICINE | Prognosis | Humans | Biomarkers | Sepsis - diagnosis | Clinical Trials as Topic - methods | Research Design | Respiratory Distress Syndrome, Adult - diagnosis | Critical Care
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15. Full Text The number needed to benefit: estimating the value of predictive analytics in healthcare
by Liu, Vincent X and Bates, David W and Wiens, Jenna and Shah, Nigam H
Journal of the American Medical Informatics Association : JAMIA, ISSN 1527-974X, 06/2019, Volume 26, Issue 12, pp. 1655 - 1659
Predictive analytics in health care has generated increasing enthusiasm recently, as reflected in a rapidly growing body of predictive models reported in... 
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16. Full Text The timing of early antibiotics and hospital mortality in sepsis
by Liu, Vincent X and Fielding-Singh, Vikram and Greene, John D and Baker, Jennifer M and Iwashyna, Theodore J and Bhattacharya, Jay and Escobar, Gabriel J
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2017, Volume 196, Issue 7, pp. 856 - 863
Rationale: Prior sepsis studies evaluating antibiotic timing have shown mixed results. Objectives: To evaluate the association between antibiotic timing and... 
Sepsis | Septic shock | Antibacterial agents | septic shock | ANTIMICROBIAL THERAPY | PERFORMANCE | CARE | INPATIENT MORTALITY | IMPACT | EMERGENCY-DEPARTMENT | APPROPRIATE | RESPIRATORY SYSTEM | antibacterial agents | GOAL-DIRECTED RESUSCITATION | OUTCOMES | sepsis | CRITICAL CARE MEDICINE | Emergency Service, Hospital | Hospital Mortality | California - epidemiology | Humans | Middle Aged | Male | Treatment Outcome | Sepsis - mortality | Anti-Bacterial Agents - therapeutic use | Sepsis - drug therapy | Time Factors | Aged, 80 and over | Female | Aged | Retrospective Studies | Anti-Bacterial Agents - administration & dosage | Length of Stay - statistics & numerical data | Pneumonia | Automation | Intensive care | Comorbidity | Laboratories | Mortality | Medical records | Clinical trials | Hospitalization | Vital signs | Patients | Data bases | Studies | Heart rate | Antibiotics | Registration | Blood pressure | Original
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17. Full Text Loud and clear: Sensory impairment, delirium, and functional recovery in critical illness
by LaHue, Sara C and Liu, Vincent X
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 08/2016, Volume 194, Issue 3, pp. 252 - 253
DISABILITY | OUTCOMES | RESPIRATORY SYSTEM | INTENSIVE-CARE | CRITICAL CARE MEDICINE
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18. Full Text Machine Learning and Sepsis: On the Road to Revolution
by Liu, VX and Walkey, AJ
CRITICAL CARE MEDICINE, ISSN 0090-3493, 11/2017, Volume 45, Issue 11, pp. 1946 - 1947
early warning scores | TRIAL | risk prediction | HEALTH-CARE | machine learning | MEDICINE | sepsis | CRITICAL CARE MEDICINE | Sepsis | Systemic Inflammatory Response Syndrome | Machine Learning | Humans
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19. Full Text Multicenter implementation of a treatment bundle for patients with sepsis and intermediate lactate values
by Liu, Vincent X and Morehouse, John W and Marelich, Gregory P and Soule, Jay and Russell, Thomas and Skeath, Melinda and Adams, Carmen and Escobar, Gabriel J and Whippy, Alan
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 06/2016, Volume 193, Issue 11, pp. 1264 - 1270
Rationale: Treatments for patients with sepsis with intermediate lactate values (>= 2 and <4 mmol/L) are poorly defined. Objectives: To evaluate multicenter... 
Sepsis | Hospital Mortality | Quality Improvement | Resuscitation | MORTALITY | CARE | TRIAL | SERUM LACTATE | THERAPY | RESPIRATORY SYSTEM | quality improvement | IMPROVEMENT | resuscitation | EARLY SEPTIC SHOCK | SURVIVING SEPSIS | GOAL-DIRECTED RESUSCITATION | EMERGENCY-DEPARTMENT PATIENTS | hospital mortality | sepsis | CRITICAL CARE MEDICINE | Emergency Service, Hospital | Drug Administration Schedule | Lactic Acid - blood | Humans | Male | Treatment Outcome | Anti-Bacterial Agents - therapeutic use | Sepsis - drug therapy | Fluid Therapy - methods | Sepsis - therapy | Female | Aged | Emergency Medical Services - methods | Sepsis - blood | Anti-Bacterial Agents - administration & dosage | Original
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20. Full Text Enhanced Recovery After Surgery Program Implementation in 2 Surgical Populations in an Integrated Health Care Delivery System
by Liu, Vincent X and Rosas, Efren and Hwang, Judith and Cain, Eric and Foss-Durant, Anne and Clopp, Molly and Huang, Mengfei and Lee, Derrick C and Mustille, Alex and Kipnis, Patricia and Parodi, Stephen
JAMA Surgery, ISSN 2168-6254, 07/2017, Volume 152, Issue 7, pp. e171032 - e171032
IMPORTANCE: Novel approaches to perioperative surgical care focus on optimizing nutrition, mobility, and pain management to minimize adverse events after... 
COLORECTAL SURGERY | MORTALITY | SURGERY | METAANALYSIS | COSTS | QUALITY IMPROVEMENT PROGRAM | PRIVATE-SECTOR | RECOMMENDATIONS | DATABASES | COMPLICATIONS | INPATIENT | Hip Fractures - surgery | Delivery of Health Care, Integrated | Humans | Middle Aged | Pain Management | Patient Participation | Clinical Protocols | Patient Discharge | Male | Dietary Services | Female | Rectum - surgery | Postoperative Complications | Drug Utilization - statistics & numerical data | Length of Stay - statistics & numerical data | Hospital Mortality | Emergencies | Analgesics, Opioid - therapeutic use | California | Colon - surgery | Nutrition Therapy | Perioperative Care - methods | Aged | Program Evaluation | Early Ambulation | Elective Surgical Procedures
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