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ISSN 2211-1247, 2018
Abnormalities of the endolysosomal and autophagy systems are found in Alzheimer’s disease, but it is not clear whether defects in these systems are a cause or... 
Journal Article
Nature biotechnology, ISSN 1087-0156, 10/2018, Volume 36, Issue 10, p. 1016
This corrects the article DOI: 10.1038/nbt.3906. 
Organoids | Brain | Cortex
Journal Article
Cell Reports, ISSN 2211-1247, 12/2018, Volume 25, Issue 13, pp. 3647 - 3660.e2
Abnormalities of the endolysosomal and autophagy systems are found in Alzheimer’s disease, but it is not clear whether defects in these systems are a cause or... 
axonal transport | endosome | autophagy | Alzheimer’s disease | lysosome | live-cell imaging
Journal Article
Cell Reports, ISSN 2211-1247, 12/2018, Volume 25, Issue 13, pp. 3647 - 3660.e2
Abnormalities of the endolysosomal and autophagy systems are found in Alzheimer's disease, but it is not clear whether defects in these systems are a cause or... 
axonal transport | endosome | autophagy | Alzheimer's disease | lysosome | live-cell imaging | BACE1 | TRANSPORT | DOWN-SYNDROME | MOUSE MODEL | MUTATION | NEURONS | AMYLOID PRECURSOR PROTEIN | DYSFUNCTION | ACCUMULATION | EXPRESSION | CELL BIOLOGY
Journal Article
Cell Reports, ISSN 2211-1247, 01/2019, Volume 26, Issue 3, pp. 582 - 593.e5
The neuronal microtubule-associated protein tau, MAPT, is central to the pathogenesis of many dementias. Autosomal-dominant mutations in cause inherited... 
Alzheimer’s disease | human neurons | iPSC | microtubule dynamics | frontotemporal dementia | Tau | nucleocytoplasmic transport | MAPT | nuclear membrane | Alzheimer's disease | PLURIPOTENT STEM-CELLS | LOCALIZATION | REPEAT EXPANSION | PROTEIN | LINC COMPLEX | ALZHEIMERS-DISEASE | NEURONS | HYPERPHOSPHORYLATION | NEURODEGENERATION | PATHOLOGY | CELL BIOLOGY
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2017, Volume 216, Issue 10, p. 3405
Filopodia have important sensory and mechanical roles in motile cells. The recruitment of actin regulators, such as ENA/VASP proteins, to sites of protrusion... 
Growth cones | Regulators | Fluorescence | Pseudopodia | Recruitment | Proteins | Dynamic tests | Molecular modelling | Cellular biology | Cones | Actin | Graphical user interface | Cytoplasm | Tips
Journal Article
Cell reports, 03/2018, Volume 22, Issue 13, p. 3612
In Alzheimer's disease, neurofibrillary tangle pathology appears to spread along neuronal connections, proposed to be mediated by the release and uptake of... 
Journal Article
Nature Protocols, ISSN 1754-2189, 09/2012, Volume 7, Issue 10, pp. 1836 - 1846
Efficient derivation of human cerebral neocortical neural stem cells (NSCs) and functional neurons from pluripotent stem cells (PSCs) facilitates functional... 
FAMILIAL ALZHEIMERS-DISEASE | PATIENT | EVOLUTION | BIOCHEMICAL RESEARCH METHODS | Cell Line | Pluripotent Stem Cells - cytology | Humans | Nerve Net | Neurons - cytology | Cell Differentiation | Cell Culture Techniques | Cerebral Cortex - cytology | Synapses | Cerebral cortex | Neural circuitry | Growth | Neurons | Research | Embryonic stem cells | Cell differentiation
Journal Article
Nature Cell Biology, ISSN 1465-7392, 10/2012, Volume 14, Issue 10, pp. 987 - 989
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 10/2019, p. 201908762
Mutations in the thyroid hormone receptor α 1 gene (THRA) have recently been identified as a cause of intellectual deficit in humans. Patients present with... 
Journal Article
Stem Cell Reports, ISSN 2213-6711, 04/2017, Volume 8, Issue 4, pp. 870 - 882
Human stem cell models have the potential to provide platforms for phenotypic screens to identify candidate treatments and cellular pathways involved in the... 
iPSCs | selamectin | human neurons | neural stem cells | dementia | phenotypic screening | Down syndrome | Alzheimer's disease | ivermectin | amyloid beta | PEPTIDES | INHIBITION | PHARMACOLOGY | CSF | A-BETA | NEURONS | DUPLICATION | BETA ISOFORM PATTERN | CEREBROSPINAL-FLUID | GAMMA-SECRETASE MODULATOR | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Induced Pluripotent Stem Cells - pathology | Down Syndrome - pathology | Neurons - pathology | Down Syndrome - metabolism | Humans | Cells, Cultured | Alzheimer Disease - drug therapy | Drug Discovery - methods | Ivermectin - chemistry | Ivermectin - pharmacology | Anthelmintics - chemistry | Neurogenesis | Alzheimer Disease - pathology | Amyloid Precursor Protein Secretases - metabolism | Phenotype | Anthelmintics - pharmacology | Alzheimer Disease - metabolism | Amyloid beta-Protein Precursor - metabolism | Ivermectin - analogs & derivatives | Neurons - metabolism | Neurons - drug effects | Induced Pluripotent Stem Cells - metabolism | chemistry | Neurosciences | drug therapy | pathology | Neurons | methods | Anthelmintics | drug effects | Alzheimer Disease | Drug Discovery | Cells | Down Syndrome | analogs & derivatives | Amyloid Precursor Protein Secretases | pharmacology | metabolism | Cultured | Induced Pluripotent Stem Cells | Amyloid beta-Protein Precursor | Neurovetenskaper | Ivermectin
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2015, Volume 112, Issue 20, pp. 6250 - 6251
Journal Article
2000, Practical approach series, ISBN 9780199637744, xviii, 253
Book
Nature Neuroscience, ISSN 1097-6256, 03/2012, Volume 15, Issue 3, pp. 477 - 486
Efforts to study the development and function of the human cerebral cortex in health and disease have been limited by the availability of model systems.... 
SUBTYPE | HUMAN ES | EVOLUTION | NEOCORTICAL NEURONOGENESIS | NEURONS | NEUROGENESIS | SUBVENTRICULAR ZONE | SPECIFICATION | DIFFERENTIATION | MODEL | NEUROSCIENCES | Disks Large Homolog 4 Protein | Embryonic Stem Cells - cytology | Humans | Synaptic Potentials - drug effects | Ki-67 Antigen - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Cerebral Cortex - cytology | Piperidines - pharmacology | Time Factors | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Fetus | Membrane Proteins - metabolism | Tetrodotoxin - pharmacology | Cell Differentiation - physiology | Potassium Channel Blockers - pharmacology | Cell Line | Synapses - drug effects | Synaptic Potentials - physiology | Pluripotent Stem Cells - cytology | Glutamic Acid - pharmacology | Synapses - physiology | Pluripotent Stem Cells - physiology | Cells, Cultured | Gene Expression Regulation, Developmental - drug effects | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Embryonic Stem Cells - physiology | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Patch-Clamp Techniques | Cerebral Cortex - embryology | Signal Transduction - drug effects | Cell Differentiation - drug effects | Neurogenesis - physiology | Pluripotent Stem Cells - drug effects | RNA, Messenger | Retinoids - pharmacology | Physiological aspects | Cerebral cortex | Research | Synapses | Stem cells
Journal Article
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 2014, Volume 23, Issue 1, pp. R35 - R39
Journal Article