PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e89741
Objective: To estimate the risk for developing a defined neurodegenerative syndrome in a large cohort of idiopathic REM sleep behavior disorder (IRBD) patients...
DIAGNOSIS | DEMENTIA | MULTIDISCIPLINARY SCIENCES | DISEASE | PARKINSONIAN DISORDER | PATHOLOGY | MILD COGNITIVE IMPAIRMENT | DELAYED EMERGENCE | Disease-Free Survival | Neurodegenerative Diseases - etiology | REM Sleep Behavior Disorder - complications | Humans | Middle Aged | REM Sleep Behavior Disorder - epidemiology | Kaplan-Meier Estimate | Aged | REM Sleep Behavior Disorder - pathology | Neurodegenerative Diseases - epidemiology | Cohort Studies | Medical research | Nervous system diseases | Parkinson's disease | Sleep | Medicine, Experimental | Mental illness | Risk factors | Brain | Neuropathology | Cognitive ability | Parkinsons disease | Otolaryngology | Risk | Sleep (REM) | Family medical history | Eye movements | Atrophy | Neurodegeneration | Dementia disorders | Diagnosis | Movement disorders | Neurological disorders | Dopamine | Neurodegenerative diseases | Behavior disorders | Risk taking | Patients | Lewy bodies | Neurology | Hospitals | Design modifications | Dementia | Case studies | Malaltia d'Alzheimer | Demència amb cossos de Lewy | Sleep disorders | Lewy body dementia | Estudi de casos | Trastorns del son | Malaltia de Parkinson | Alzheimer's disease
DIAGNOSIS | DEMENTIA | MULTIDISCIPLINARY SCIENCES | DISEASE | PARKINSONIAN DISORDER | PATHOLOGY | MILD COGNITIVE IMPAIRMENT | DELAYED EMERGENCE | Disease-Free Survival | Neurodegenerative Diseases - etiology | REM Sleep Behavior Disorder - complications | Humans | Middle Aged | REM Sleep Behavior Disorder - epidemiology | Kaplan-Meier Estimate | Aged | REM Sleep Behavior Disorder - pathology | Neurodegenerative Diseases - epidemiology | Cohort Studies | Medical research | Nervous system diseases | Parkinson's disease | Sleep | Medicine, Experimental | Mental illness | Risk factors | Brain | Neuropathology | Cognitive ability | Parkinsons disease | Otolaryngology | Risk | Sleep (REM) | Family medical history | Eye movements | Atrophy | Neurodegeneration | Dementia disorders | Diagnosis | Movement disorders | Neurological disorders | Dopamine | Neurodegenerative diseases | Behavior disorders | Risk taking | Patients | Lewy bodies | Neurology | Hospitals | Design modifications | Dementia | Case studies | Malaltia d'Alzheimer | Demència amb cossos de Lewy | Sleep disorders | Lewy body dementia | Estudi de casos | Trastorns del son | Malaltia de Parkinson | Alzheimer's disease
Journal Article
MOLECULAR NEUROBIOLOGY, ISSN 0893-7648, 09/2017, Volume 54, Issue 7, pp. 5550 - 5562
Plasma microRNAs (miRNAs) have been proposed as potential biomarkers in Alzheimer's disease (AD). Here, we explored their use as early sensors of the...
CIRCULATING MICRORNAS | CSF BIOMARKERS | HYPOTHETICAL MODEL | MILD COGNITIVE IMPAIRMENT | CEREBROSPINAL-FLUID | DYNAMIC BIOMARKERS | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | Plasma biomarker | AMYLOID-BETA | miRNA | Preclinical | Alzheimer's disease | EXPRESSION | miR-545-3p | BRAIN | miR-34a-5p | Alzheimer Disease - diagnosis | Humans | Middle Aged | Female | Male | ROC Curve | Aged | Gene Expression Profiling | MicroRNAs - blood | Biomarkers - blood | Alzheimer Disease - genetics | Cohort Studies | Biological markers | Analysis | Resveratrol | Plasma | Brain | Parkinson's disease | Neurodegenerative diseases | MiRNA | Cognitive ability | Cerebrospinal fluid | Disease control | Patients | Alterations | Hospitals | Biomarkers | Diagnostic systems | Sensors | Plasmas | Alzheimers disease | Movement disorders | Plasmas (physics)
CIRCULATING MICRORNAS | CSF BIOMARKERS | HYPOTHETICAL MODEL | MILD COGNITIVE IMPAIRMENT | CEREBROSPINAL-FLUID | DYNAMIC BIOMARKERS | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | Plasma biomarker | AMYLOID-BETA | miRNA | Preclinical | Alzheimer's disease | EXPRESSION | miR-545-3p | BRAIN | miR-34a-5p | Alzheimer Disease - diagnosis | Humans | Middle Aged | Female | Male | ROC Curve | Aged | Gene Expression Profiling | MicroRNAs - blood | Biomarkers - blood | Alzheimer Disease - genetics | Cohort Studies | Biological markers | Analysis | Resveratrol | Plasma | Brain | Parkinson's disease | Neurodegenerative diseases | MiRNA | Cognitive ability | Cerebrospinal fluid | Disease control | Patients | Alterations | Hospitals | Biomarkers | Diagnostic systems | Sensors | Plasmas | Alzheimers disease | Movement disorders | Plasmas (physics)
Journal Article
Lancet Neurology, The, ISSN 1474-4422, 2013, Volume 12, Issue 5, pp. 443 - 453
Summary Background We postulated that idiopathic rapid-eye-movement (REM) sleep behaviour disorder (IRBD) represents the prodromal phase of a Lewy body...
Neurology | LEWY-BODY DISEASE | MULTIPLE SYSTEM ATROPHY | ALZHEIMERS ASSOCIATION GUIDELINES | OLFACTORY DYSFUNCTION | NATIONAL INSTITUTE | BRAINNET EUROPE CONSORTIUM | MILD COGNITIVE IMPAIRMENT | CLINICAL NEUROLOGY | PARKINSONS-DISEASE | REM-SLEEP | NEUROPATHOLOGIC ASSESSMENT | Humans | Lewy Body Disease - pathology | Male | Prodromal Symptoms | REM Sleep Behavior Disorder - pathology | Disease Progression | Nerve Degeneration - metabolism | Nerve Degeneration - pathology | Brain - metabolism | Lewy Body Disease - metabolism | Disease-Free Survival | Aged, 80 and over | Brain - pathology | Female | Aged | REM Sleep Behavior Disorder - metabolism | alpha-Synuclein - metabolism | Cohort Studies | Medical research | Nervous system diseases | Sleep | Analysis | Medicine, Experimental | Mental illness | Dementia
Neurology | LEWY-BODY DISEASE | MULTIPLE SYSTEM ATROPHY | ALZHEIMERS ASSOCIATION GUIDELINES | OLFACTORY DYSFUNCTION | NATIONAL INSTITUTE | BRAINNET EUROPE CONSORTIUM | MILD COGNITIVE IMPAIRMENT | CLINICAL NEUROLOGY | PARKINSONS-DISEASE | REM-SLEEP | NEUROPATHOLOGIC ASSESSMENT | Humans | Lewy Body Disease - pathology | Male | Prodromal Symptoms | REM Sleep Behavior Disorder - pathology | Disease Progression | Nerve Degeneration - metabolism | Nerve Degeneration - pathology | Brain - metabolism | Lewy Body Disease - metabolism | Disease-Free Survival | Aged, 80 and over | Brain - pathology | Female | Aged | REM Sleep Behavior Disorder - metabolism | alpha-Synuclein - metabolism | Cohort Studies | Medical research | Nervous system diseases | Sleep | Analysis | Medicine, Experimental | Mental illness | Dementia
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 2/2013, Volume 125, Issue 2, pp. 201 - 213
Autosomal-dominant Alzheimer disease (ADAD) is a genetic disorder caused by mutations in Amyloid Precursor Protein (APP) or Presenilin (PSEN) genes. Studies...
Pathology | Neurosciences | Autosomal-dominant Alzheimer disease | Medicine & Public Health | β -Site APP-cleaving enzyme | Presenilin | β -Amyloid | Amyloid precursor protein | β-Amyloid | β-Site APP-cleaving enzyme | BETA-SECRETASE ACTIVITY | PATHOLOGY | CEREBROSPINAL-FLUID | NEUROSCIENCES | CEREBRAL-CORTEX | CLINICAL NEUROLOGY | SENILE PLAQUES | PRESENILIN-1 MUTATIONS | beta-Site APP-cleaving enzyme | BRAIN INTERSTITIAL FLUID | IN-VIVO | beta-Amyloid | EXPRESSION | TRANSGENIC MICE | Immunohistochemistry | Central Nervous System - metabolism | Humans | Middle Aged | Male | Apolipoproteins E - metabolism | Amyloid beta-Protein Precursor - cerebrospinal fluid | Amyloid beta-Protein Precursor - metabolism | Adult | Female | Presenilin-1 - cerebrospinal fluid | Presenilin-1 - genetics | Alzheimer Disease - cerebrospinal fluid | Mutation - genetics | Amyloid Precursor Protein Secretases - cerebrospinal fluid | Blotting, Western | Neurites - pathology | Amyloid Precursor Protein Secretases - metabolism | Aspartic Acid Endopeptidases - cerebrospinal fluid | Apolipoproteins E - genetics | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Heterozygote | Aged | Alzheimer Disease - genetics | Physiological aspects | Enzymes | Alzheimer's disease | Amyloid beta-protein | Brain | Neurodegenerative diseases | BACE protein | Central nervous system | Clinical trials | Data processing | beta -Amyloid | Cerebrospinal fluid | beta -Site APP cleaving enzyme | Amyloid | Mutation | Original Paper
Pathology | Neurosciences | Autosomal-dominant Alzheimer disease | Medicine & Public Health | β -Site APP-cleaving enzyme | Presenilin | β -Amyloid | Amyloid precursor protein | β-Amyloid | β-Site APP-cleaving enzyme | BETA-SECRETASE ACTIVITY | PATHOLOGY | CEREBROSPINAL-FLUID | NEUROSCIENCES | CEREBRAL-CORTEX | CLINICAL NEUROLOGY | SENILE PLAQUES | PRESENILIN-1 MUTATIONS | beta-Site APP-cleaving enzyme | BRAIN INTERSTITIAL FLUID | IN-VIVO | beta-Amyloid | EXPRESSION | TRANSGENIC MICE | Immunohistochemistry | Central Nervous System - metabolism | Humans | Middle Aged | Male | Apolipoproteins E - metabolism | Amyloid beta-Protein Precursor - cerebrospinal fluid | Amyloid beta-Protein Precursor - metabolism | Adult | Female | Presenilin-1 - cerebrospinal fluid | Presenilin-1 - genetics | Alzheimer Disease - cerebrospinal fluid | Mutation - genetics | Amyloid Precursor Protein Secretases - cerebrospinal fluid | Blotting, Western | Neurites - pathology | Amyloid Precursor Protein Secretases - metabolism | Aspartic Acid Endopeptidases - cerebrospinal fluid | Apolipoproteins E - genetics | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Heterozygote | Aged | Alzheimer Disease - genetics | Physiological aspects | Enzymes | Alzheimer's disease | Amyloid beta-protein | Brain | Neurodegenerative diseases | BACE protein | Central nervous system | Clinical trials | Data processing | beta -Amyloid | Cerebrospinal fluid | beta -Site APP cleaving enzyme | Amyloid | Mutation | Original Paper
Journal Article
Transportation Research Part A, ISSN 0965-8564, 07/2017, Volume 101, pp. 86 - 97
The market for parking is characterized by intrinsic distortions such as cruising in search of a parking space and garage market power. Theoretical studies...
Curbside parking | Garage parking | Parking regulation | Price | CAPACITY | TRANSPORTATION | PRICING PARKING | DEMAND | POLICY | COMPETITION | SHOPPING MALLS | TRANSPORTATION SCIENCE & TECHNOLOGY | ECONOMICS | Laws, regulations and rules | Price fixing | Garages | Planificació del transport | Transportation planning | Garatges | Vehicles
Curbside parking | Garage parking | Parking regulation | Price | CAPACITY | TRANSPORTATION | PRICING PARKING | DEMAND | POLICY | COMPETITION | SHOPPING MALLS | TRANSPORTATION SCIENCE & TECHNOLOGY | ECONOMICS | Laws, regulations and rules | Price fixing | Garages | Planificació del transport | Transportation planning | Garatges | Vehicles
Journal Article
Neurodegenerative Diseases, ISSN 1660-2854, 11/2015, Volume 15, Issue 6, pp. 350 - 360
Background: Rapidly progressive dementia (RPD) is caused by a heterogeneous group of both neurodegenerative and non-neurodegenerative disorders. The presence...
Original Paper | Neurodegenerative disease | Prion diseases | Alzheimer's disease | Creutzfeldt-Jakob disease | Dementia | ALZHEIMERS-DISEASE | GUIDELINES | CLASSIFICATION | NEUROSCIENCES | CLINICAL NEUROLOGY | BETA | NATIONAL INSTITUTE | CREUTZFELDT-JAKOB-DISEASE | NEUROPATHOLOGY | DIAGNOSTIC-CRITERIA | PROTEINS | LEWY BODIES | Prions - metabolism | Diagnosis, Differential | Alzheimer Disease - complications | Humans | Middle Aged | Male | Disease Progression | Alzheimer Disease - pathology | Alzheimer Disease - diagnosis | Young Adult | Creutzfeldt-Jakob Syndrome - diagnosis | Amyloid - metabolism | Aged, 80 and over | Brain - pathology | Adult | Creutzfeldt-Jakob Syndrome - pathology | Female | Aged | Retrospective Studies
Original Paper | Neurodegenerative disease | Prion diseases | Alzheimer's disease | Creutzfeldt-Jakob disease | Dementia | ALZHEIMERS-DISEASE | GUIDELINES | CLASSIFICATION | NEUROSCIENCES | CLINICAL NEUROLOGY | BETA | NATIONAL INSTITUTE | CREUTZFELDT-JAKOB-DISEASE | NEUROPATHOLOGY | DIAGNOSTIC-CRITERIA | PROTEINS | LEWY BODIES | Prions - metabolism | Diagnosis, Differential | Alzheimer Disease - complications | Humans | Middle Aged | Male | Disease Progression | Alzheimer Disease - pathology | Alzheimer Disease - diagnosis | Young Adult | Creutzfeldt-Jakob Syndrome - diagnosis | Amyloid - metabolism | Aged, 80 and over | Brain - pathology | Adult | Creutzfeldt-Jakob Syndrome - pathology | Female | Aged | Retrospective Studies
Journal Article
Transport Policy, ISSN 0967-070X, 04/2016, Volume 47, pp. 160 - 168
Parking regulation is seen as a good option to encourage modal shift in order to tackle congestion and pollution in metropolitan areas. Market-clearing...
On-street parking | Keywords | Parking regulation | R48 | Curbside parking | Parking | Garage parking | Price elasticity | Off-street parking | R41 | PRICE | TRANSPORTATION | BEHAVIOR | CHARGES | COMPETITION | MODE CHOICE | ECONOMICS | Laws, regulations and rules | Analysis | Econometric models | Demand | Control | Policies | Demand (economics) | Pricing | Garages | Markets | Planificació del transport | Transportation planning | Garatges | Vehicles
On-street parking | Keywords | Parking regulation | R48 | Curbside parking | Parking | Garage parking | Price elasticity | Off-street parking | R41 | PRICE | TRANSPORTATION | BEHAVIOR | CHARGES | COMPETITION | MODE CHOICE | ECONOMICS | Laws, regulations and rules | Analysis | Econometric models | Demand | Control | Policies | Demand (economics) | Pricing | Garages | Markets | Planificació del transport | Transportation planning | Garatges | Vehicles
Journal Article
Utilities Policy, ISSN 0957-1787, 06/2019, Volume 58, pp. 158 - 165
Theoretical research on cooperation between public and private partners in infrastructure projects suggests that they can be a tool for preventing white...
Infrastructure | PPP | Political favoritism | PARTIAL PRIVATIZATION | CONTRACTS | SERVICES | PROJECTS | ENERGY & FUELS | PERFORMANCE | COMPARATIVE POLICY-ANALYSIS | LESSONS | CHOICE | ENVIRONMENTAL SCIENCES | PUBLIC-PRIVATE PARTNERSHIPS | ENVIRONMENTAL STUDIES | OWNERSHIP | Case studies | Infrastructure (Economics) | Lobbying | Political aspects | Public-private sector cooperation | Practical politics | Risk | Tàctiques polítiques | Risc (Economia) | Variables (Mathematics) | Variables (Matemàtica)
Infrastructure | PPP | Political favoritism | PARTIAL PRIVATIZATION | CONTRACTS | SERVICES | PROJECTS | ENERGY & FUELS | PERFORMANCE | COMPARATIVE POLICY-ANALYSIS | LESSONS | CHOICE | ENVIRONMENTAL SCIENCES | PUBLIC-PRIVATE PARTNERSHIPS | ENVIRONMENTAL STUDIES | OWNERSHIP | Case studies | Infrastructure (Economics) | Lobbying | Political aspects | Public-private sector cooperation | Practical politics | Risk | Tàctiques polítiques | Risc (Economia) | Variables (Mathematics) | Variables (Matemàtica)
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 9/2017, Volume 54, Issue 7, pp. 5550 - 5562
Plasma microRNAs (miRNAs) have been proposed as potential biomarkers in Alzheimer’s disease (AD). Here, we explored their use as early sensors of the...
Neurology | Neurosciences | Biomedicine | Alzheimer’s disease | Plasma biomarker | Neurobiology | miRNA | Preclinical | miR-545-3p | Cell Biology | miR-34a-5p
Neurology | Neurosciences | Biomedicine | Alzheimer’s disease | Plasma biomarker | Neurobiology | miRNA | Preclinical | miR-545-3p | Cell Biology | miR-34a-5p
Journal Article
The Lancet Neurology, ISSN 1474-4422, 06/2018, Volume 17, Issue 6, pp. 548 - 558
Loss-of-function mutations in cause frontotemporal lobar degeneration (FTLD). Patients with mutations present with a uniform subtype of TAR DNA-binding protein...
b_open_article_in_toll_access_journal | GDNF FAMILY | PROTEIN-LEVELS | DEMENTIA | THERAPY | PLASMA | TMEM106B | COMMON | AMYOTROPHIC-LATERAL-SCLEROSIS | CLINICAL NEUROLOGY | PARKINSONS-DISEASE | Genetic research | Physiological aspects | Genetic aspects | Genomics | Aging | Mutation
b_open_article_in_toll_access_journal | GDNF FAMILY | PROTEIN-LEVELS | DEMENTIA | THERAPY | PLASMA | TMEM106B | COMMON | AMYOTROPHIC-LATERAL-SCLEROSIS | CLINICAL NEUROLOGY | PARKINSONS-DISEASE | Genetic research | Physiological aspects | Genetic aspects | Genomics | Aging | Mutation
Journal Article
Revista Catalana de Dret Públic, ISSN 1885-5709, 12/2018, Issue 57, pp. 166 - 191
L'aprovació de la Llei de Contractes del Sector Públic del 2017 comporta una notable sèrie de canvis, novetats i adequacions en la regulació, gestió i...
dret administratiu | associació per la innovació | contractació pública | llei de contractes | universitats
dret administratiu | associació per la innovació | contractació pública | llei de contractes | universitats
Journal Article
Nature Genetics, ISSN 1061-4036, 03/2010, Volume 42, Issue 3, pp. 234 - 239
Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. The predominant neuropathology is FTLD with TAR DNA-binding...
Genetic Predisposition to Disease | Genome-Wide Association Study | Membrane Proteins - genetics | Gene Frequency | Humans | Intercellular Signaling Peptides and Proteins - genetics | Genotype | Chromosomes, Human, Pair 7 | Case-Control Studies | Linkage Disequilibrium | DNA-Binding Proteins - metabolism | Inclusion Bodies - genetics | Frontotemporal Lobar Degeneration - metabolism | Polymorphism, Single Nucleotide | Frontotemporal Lobar Degeneration - genetics | Inclusion Bodies - metabolism | Temporal lobes | Nervous system | Degeneration | Genetic aspects | Genetic variation | Health aspects | Genotype & phenotype | Genetics | Software packages | Mutation | Gene expression | Basic Medicine | Medical and Health Sciences | Internal medicine | Medicin och hälsovetenskap | Molekylär medicin (genetik och patologi) | Cell and Molecular Biology | Molecular medicine (genetics and pathology) | Patologi | MEDICINE | Dermatology and venerology,clinical genetics, internal medicine | Morphology, cell biology, pathology | Medical Genetics | Medicinsk genetik | Pathology | Morfologi, cellbiologi, patologi | MEDICIN | Medicinska och farmaceutiska grundvetenskaper | Invärtesmedicin | Dermatologi och venerologi, klinisk genetik, invärtesmedicin | Cell- och molekylärbiologi
Genetic Predisposition to Disease | Genome-Wide Association Study | Membrane Proteins - genetics | Gene Frequency | Humans | Intercellular Signaling Peptides and Proteins - genetics | Genotype | Chromosomes, Human, Pair 7 | Case-Control Studies | Linkage Disequilibrium | DNA-Binding Proteins - metabolism | Inclusion Bodies - genetics | Frontotemporal Lobar Degeneration - metabolism | Polymorphism, Single Nucleotide | Frontotemporal Lobar Degeneration - genetics | Inclusion Bodies - metabolism | Temporal lobes | Nervous system | Degeneration | Genetic aspects | Genetic variation | Health aspects | Genotype & phenotype | Genetics | Software packages | Mutation | Gene expression | Basic Medicine | Medical and Health Sciences | Internal medicine | Medicin och hälsovetenskap | Molekylär medicin (genetik och patologi) | Cell and Molecular Biology | Molecular medicine (genetics and pathology) | Patologi | MEDICINE | Dermatology and venerology,clinical genetics, internal medicine | Morphology, cell biology, pathology | Medical Genetics | Medicinsk genetik | Pathology | Morfologi, cellbiologi, patologi | MEDICIN | Medicinska och farmaceutiska grundvetenskaper | Invärtesmedicin | Dermatologi och venerologi, klinisk genetik, invärtesmedicin | Cell- och molekylärbiologi
Journal Article