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1. Full Text The frequency and influence of dementia risk factors in prodromal Alzheimer’s disease
by Bos, Isabelle, MSc and Vos, Stephanie J., PhD and Frölich, Lutz, MD and Kornhuber, Johannes, MD and Wiltfang, Jens, MD, PhD and Maier, Wolfgang, MD and Peters, Oliver, MD and Rüther, Eckhart, MD, PhD and Engelborghs, Sebastiaan, MD, PhD and Niemantsverdriet, Ellis, MSc and De Roeck, Ellen Elisa, MSc and Tsolaki, Magda, MD, PhD and Freund-Levi, Yvonne and Johannsen, Peter, MD, PhD and Vandenberghe, Rik, MD, PhD and Lleó, Alberto, MD, PhD and Alcolea, Daniel, MD, PhD and Frisoni, Giovanni B., MD and Galluzzi, Samantha, MD and Nobili, Flavio, MD and Morbelli, Silvia, PhD and Drzezga, Alexander, MD, PhD and Didic, Mira, MD, PhD and van Berckel, Bart N., MD, PhD and Salmon, Eric, MD, PhD and Bastin, Christine, PhD and Dauby, Solene and Santana, Isabel, MD, PhD and Baldeiras, Inês, PhD and de Mendonça, Alexandre, MD, PhD and Silva, Dina, PhD and Wallin, Anders, MD, PhD and Nordlund, Arto, PhD and Coloma, Preciosa M., MD, PhD and Wientzek, Angelika, PhD and Alexander, Myriam and Novak, Gerald P., MD and Gordon, Mark Forrest, MD and the Alzheimer’s Disease Neuroimaging Initiative and Wallin, Åsa K and Hampel, Harald, MD, PhD and Soininen, Hilkka, MD, PhD and Herukka, Sanna-Kaisa, MD, PhD and Scheltens, Philip, MD, PhD and Verhey, Frans R., MD, PhD and Visser, Pieter Jelle, MD, PhD
Neurobiology of Aging, ISSN 0197-4580, 2017
Abstract We investigated whether dementia risk factors were associated with prodromal Alzheimer’s disease (AD) according to the International Working Group-2... 
Neurology | Internal Medicine
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2. Full Text Frontotemporal dementia and its subtypes: a genome-wide association study
by Ferrari, Raffaele, PhD and Hernandez, Dena G, MSc and Nalls, Michael A, PhD and Rohrer, Jonathan D, PhD and Ramasamy, Adaikalavan, PhD and Kwok, John B J, PhD and Dobson-Stone, Carol, PhD and Brooks, William S, MBBS and Schofield, Peter R, Prof and Halliday, Glenda M, Prof and Hodges, John R, Prof and Piguet, Olivier, PhD and Bartley, Lauren, MSc and Thompson, Elizabeth, MD and Haan, Eric, Prof and Hernández, Isabel, MD and Ruiz, Agustín, MD and Boada, Mercè, MD and Borroni, Barbara, MD and Padovani, Alessandro, Prof and Cruchaga, Carlos, PhD and Cairns, Nigel J, Prof and Benussi, Luisa, PhD and Binetti, Giuliano, MD and Ghidoni, Roberta, PhD and Forloni, Gianluigi, PhD and Galimberti, Daniela, PhD and Fenoglio, Chiara, PhD and Serpente, Maria, PhD and Scarpini, Elio, MD and Clarimón, Jordi, PhD and Lleó, Alberto, MD and Blesa, Rafael, MD and Waldö, Maria Landqvist, MD and Nilsson, Karin, PhD and Nilsson, Christer, PhD and Mackenzie, Ian R A, Prof and Hsiung, Ging-Yuek R, MD and Mann, David M A, Prof and Grafman, Jordan, Prof and Morris, Christopher M, PhD and Attems, Johannes, Prof and Griffiths, Timothy D, Prof and McKeith, Ian G, Prof and Thomas, Alan J, Prof and Pietrini, P, Prof and Huey, Edward D, MD and Wassermann, Eric M, MD and Baborie, Atik, MD and Jaros, Evelyn, PhD and Tierney, Michael C, MSc and Pastor, Pau, MD and Razquin, Cristina, PhD and Ortega-Cubero, Sara, MD and Alonso, Elena, BSc and Perneczky, Robert, MD and Diehl-Schmid, Janine, MD and Alexopoulos, Panagiotis, MD and Kurz, Alexander, MD and Rainero, Innocenzo, MD and Rubino, Elisa, MD and Pinessi, Lorenzo, Prof and Rogaeva, Ekaterina, PhD and St George-Hyslop, Peter, MD and Rossi, Giacomina, PhD and Tagliavini, Fabrizio, MD and Giaccone, Giorgio, MD and Rowe, James B, PhD and Schlachetzki, Johannes C M, MD and Uphill, James, BSc and Collinge, John, Prof and Mead, Simon, Prof and Danek, Adrian, MD and Van Deerlin, Vivianna M, PhD and Grossman, Murray, Prof and Trojanowski, John Q, Prof and van der Zee, Julie, PhD and Deschamps, William, MSc and Van Langenhove, Tim, MD and Cruts, Marc, PhD and Van Broeckhoven, Christine, Prof and Cappa, Stefano F, Prof and Le Ber, Isabelle, MD and Hannequin, Didier, Prof and Golfier, Véronique, MD and Vercelletto, Martine, MD and Brice, Alexis, MD and Nacmias, Benedetta, PhD and Sorbi, Sandro, Prof and Bagnoli, Silvia, PhD and Piaceri, Irene, PhD and Nielsen, Jørgen E, MD and Hjermind, Lena E, MD and Riemenschneider, Matthias, Prof and Mayhaus, Manuel, PhD and Ibach, Bernd, PhD and Gasparoni, Gilles, PhD and Pichler, Sabrina, MSc and Gu, Wei, PhD and Rossor, Martin N, Prof and ... and Lund University and Psychiatry (Lund) and MultiPark: Multidisciplinary research focused on Parkinson´s disease and Psykiatri, Lund and Lunds universitet
Lancet Neurology, The, ISSN 1474-4422, 2014, Volume 13, Issue 7, pp. 686 - 699
Summary Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological... 
Neurology | GENETIC-VARIATION | COMMON VARIANTS | PROTEIN | LOBAR DEGENERATION | DISEASE | SUSCEPTIBILITY LOCI | RISK | MUTATIONS | HEXANUCLEOTIDE REPEAT | BRAIN | CLINICAL NEUROLOGY | Frontotemporal Dementia - genetics | Humans | Middle Aged | Aged, 80 and over | Adult | Female | Genotype | Male | Aged | Frontotemporal Dementia - diagnosis | Genome-Wide Association Study - methods | Frontotemporal Dementia - classification | Genetic research | Genomics | Dementia | Genealogy | Principal components analysis | Genomes | Patients | Proteins | Studies | Pathology | Semantics | Consent | Quality control | Aging | Aphasia | DNA methylation | Mutation | Genetic testing | Chromosomes | Deoxyribonucleic acid--DNA | Neurologi | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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3. Full Text Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
by Sims, Rebecca and Van Der Lee, Sven J and Naj, Adam C and Bellenguez, Céline and Badarinarayan, Nandini and Jakobsdottir, Johanna and Kunkle, Brian W and Boland, Anne and Raybould, Rachel and Bis, Joshua C and Martin, Eden R and Grenier-Boley, Benjamin and Heilmann-Heimbach, Stefanie and Chouraki, Vincent and Kuzma, Amanda B and Sleegers, Kristel and Vronskaya, Maria and Ruiz, Agustin and Graham, Robert R and Olaso, Robert and Hoffmann, Per and Grove, Megan L and Vardarajan, Badri N and Hiltunen, Mikko and Nöthen, Markus M and White, Charles C and Hamilton-Nelson, Kara L and Epelbaum, Jacques and Maier, Wolfgang and Choi, Seung-Hoan and Beecham, Gary W and Dulary, Cécile and Herms, Stefan and Smith, Albert V and Funk, Cory C and Derbois, Céline and Forstner, Andreas J and Ahmad, Shahzad and Li, Hongdong and Bacq, Delphine and Harold, Denise and Satizabal, Claudia L and Valladares, Otto and Squassina, Alessio and Thomas, Rhodri and Brody, Jennifer A and Qu, Liming and Sánchez-Juan, Pascual and Morgan, Taniesha and Wolters, Frank J and Zhao, Yi and Garcia, Florentino Sanchez and Denning, Nicola and Fornage, Myriam and Malamon, John and Naranjo, Maria Candida Deniz and Majounie, Elisa and Mosley, Thomas H and Dombroski, Beth and Wallon, David and Lupton, Michelle K and Dupuis, Josée and Whitehead, Patrice and Fratiglioni, Laura and Medway, Christopher and Jian, Xueqiu and Mukherjee, Shubhabrata and Keller, Lina and Brown, Kristelle and Lin, Honghuang and Cantwell, Laura B and Panza, Francesco and McGuinness, Bernadette and Moreno-Grau, Sonia and Burgess, Jeremy D and Solfrizzi, Vincenzo and Proitsi, Petra and Adams, Hieab H and Allen, Mariet and Seripa, Davide and Pastor, Pau and Cupples, L Adrienne and Price, Nathan D and Hannequin, Didier and Frank-García, Ana and Levy, Daniel and Chakrabarty, Paramita and Caffarra, Paolo and Giegling, Ina and Beiser, Alexa S and Giedraitis, Vilmantas and Hampel, Harald and Garcia, Melissa E and Wang, Xue and Lannfelt, Lars and Mecocci, Patrizia and Eiriksdottir, Gudny and Crane, Paul K and Pasquier, Florence and Boccardi, Virginia and ... and EADI and GERAD PERADES and ARUKConsortium and CHARGE and ADGC and GERAD/PERADES, CHARGE, ADGC, EADI and ARUK Consortium and Stockholms universitet and Centrum för forskning om äldre och åldrande (ARC), (tills m KI) and Samhällsvetenskapliga fakulteten
Nature Genetics, ISSN 1061-4036, 09/2017, Volume 49, Issue 9, pp. 1373 - 1384
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174... 
COMMON VARIANTS | IDENTIFIES VARIANTS | METAANALYSIS | GENOTYPE IMPUTATION | LOW-FREQUENCY | SUSCEPTIBILITY | GENETICS & HEREDITY | RISK | LOCI | WAVE2 COMPLEX | GENOME-WIDE ASSOCIATION | Amino Acid Sequence | Microglia - metabolism | Genetic Predisposition to Disease - genetics | Gene Frequency | Humans | Immunity, Innate - genetics | Genotype | Gene Expression Profiling | Case-Control Studies | Linkage Disequilibrium | Membrane Glycoproteins - genetics | Sequence Homology, Amino Acid | Exome - genetics | Protein Interaction Maps - genetics | Adaptor Proteins, Signal Transducing - genetics | Phospholipase C gamma - genetics | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Odds Ratio | Receptors, Immunologic - genetics | Immune response | Genetic variation | Physiological aspects | Development and progression | Genetic aspects | Research | Alzheimer's disease | Neurodegenerative diseases | Genes | Genomics | Health risks | Innate immunity | Genomes | Disease control | Immunity | Microglia | Proteins | Studies | Consortia | DNA microarrays | Genotyping | Gene frequency | DNA methylation | Alzheimers disease | Protein interaction | Bioinformatics | Genotypes | Immune system | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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4. Full Text Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A beta, tau, immunity and lipid processing
by Kunkle, BW and Grenier-Boley, B and Sims, R and Bis, JC and Damotte, V and Naj, AC and Boland, A and Vronskaya, M and van der Lee, SJ and Amlie-Wolf, A and Bellenguez, C and Frizatti, A and Chouraki, V and Martin, ER and Sleegers, K and Badarinarayan, N and Jakobsdottir, J and Hamilton-Nelson, KL and Moreno-Grau, S and Olaso, R and Raybould, R and Chen, YN and Kuzma, AB and Hiltunen, M and Morgan, T and Ahmad, S and Vardarajan, BN and Epelbaum, J and Hoffmann, P and Boada, M and Beecham, GW and Garnier, JG and Harold, D and Fitzpatrick, AL and Valladares, O and Moutet, ML and Gerrish, A and Smith, AV and Qu, LM and Bacq, D and Denning, N and Jian, XQ and Zhao, Y and Del Zompo, M and Fox, NC and Choi, SH and Mateo, I and Hughes, JT and Adams, HH and Malamon, J and Sanchez-Garcia, F and Patel, Y and Brody, JA and Dombroski, BA and Naranjo, MCD and Daniilidou, M and Eiriksdottir, G and Mukherjee, S and Wallon, D and Uphill, J and Aspelund, T and Cantwell, LB and Garzia, F and Galimberti, D and Hofer, E and Butkiewicz, M and Fin, B and Scarpini, E and Sarnowski, C and Bush, WS and Meslage, S and Kornhuber, J and White, CC and Song, Y and Barber, RC and Engelborghs, S and Sordon, S and Voijnovic, D and Adams, PM and Vandenberghe, R and Mayhaus, M and Cupples, LA and Albert, MS and De Deyn, PP and Gu, W and Himali, JJ and Beekly, D and Squassina, A and Hartmann, AM and Orellana, A and Blacker, D and Rodriguez-Rodriguez, E and Lovestone, S and Garcia, ME and Doody, RS and Munoz-Fernadez, C and Sussams, R and Lin, HH and Fairchild, TJ and Benito, YA and ... and Cohorts Heart Aging Res Genomic Ep and Alzheimer Dis Genetics Consortium and European Alzheimers Dis Initiative and Genetic Environm Risk AD Defining and Alzheimer Disease Genetics Consortium (ADGC) and Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) and European Alzheimer’s Disease Initiative (EADI) and Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES)
NATURE GENETICS, ISSN 1061-4036, 03/2019, Volume 51, Issue 3, pp. 414 - 414
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large... 
COMMON VARIANTS | GENOTYPE IMPUTATION | AMYLOID-BETA | GENETICS & HEREDITY | DOMAIN-CONTAINING OXIDOREDUCTASE | MUTATIONS | ANGIOTENSIN-CONVERTING ENZYME | TRANSCRIPTION FACTOR | ONSET | GENOME-WIDE ASSOCIATION | APOLIPOPROTEIN-E | Genetic Predisposition to Disease - genetics | Lipids - genetics | Humans | Genetic Loci - genetics | Male | Genetic Testing - methods | Case-Control Studies | Haplotypes - genetics | tau Proteins - genetics | Amyloid beta-Peptides - genetics | Female | Lipid Metabolism - genetics | Aged | Alzheimer Disease - genetics | Genome-Wide Association Study - methods | Immunity - genetics | Ontology | Genomics | Genes | Lipids | Genomes | Mapping | Family medical history | Immunity | Risk factors | Protein turnover | Datasets | Proteins | Consortia | Genetic analysis | Dementia disorders | Genetics | Lipid metabolism | Alzheimer's disease | Age | ADAMTS-1 protein | Neurodegenerative diseases | Health risks | Metabolism | Risk analysis | Amyloid precursor protein | Meta-analysis | White blood cells | Genetic variance | Tau protein | Histocompatibility antigen HLA | Gene loci | Gene mapping | Alzheimers disease | Secretase | Dementia | Index Medicus
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5. Full Text Use of amyloid-PET to determine cutpoints for CSF markers A multicenter study
by Zwan, Marissa D and Rinne, Juha O and Hasselbalch, Steen G and Nordberg, Agneta and Lleo, Alberto and Herukka, Sanna-Kaisa and Soininen, Hilkka and Law, Ian and Bahl, Justyna M. C and Carter, Stephen F and Fortea, Juan and Blesa, Rafael and Teunissen, Charlotte E and Bouwman, Femke H and van Berckel, Bart N. M and Visser, Pieter J
Neurology, ISSN 0028-3878, 01/2016, Volume 86, Issue 1, pp. 50 - 58
Objectives:To define CSF -amyloid 1-42 (A(42)) cutpoints to detect cortical amyloid deposition as assessed by C-11-Pittsburgh compound B ([C-11]PiB)-PET and to... 
POSITRON-EMISSION-TOMOGRAPHY | INTERNATIONAL WORKSHOP | DEMENTIA | CEREBROSPINAL-FLUID BIOMARKERS | ALZHEIMERS-DISEASE | PIB-PET | PHOSPHORYLATED TAU | MILD COGNITIVE IMPAIRMENT | DIAGNOSTIC-CRITERIA | CLINICAL NEUROLOGY | PROGRESSIVE SUPRANUCLEAR PALSY
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6. Full Text A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers
by Zhang, Ming and Ferrari, Raffaele and Tartaglia, Maria Carmela and Keith, Julia and Surace, Ezequiel I and Wolf, Uri and Sato, Christine and Grinberg, Mark and Liang, Yan and Xi, Zhengrui and Dupont, Kyle and McGoldrick, Philip and Weichert, Anna and McKeever, Paul M and Schneider, Raphael and McCorkindale, Michael D and Manzoni, Claudia and Rademakers, Rosa and Graff-Radford, Neill R and Dickson, Dennis W and Parisi, Joseph E and Boeve, Bradley F and Petersen, Ronald C and Miller, Bruce L and Seeley, William W and van Swieten, John C and van Rooij, Jeroen and Pijnenburg, Yolande and van der Zee, Julie and Van Broeckhoven, Christine and Le Ber, Isabelle and Van Deerlin, Vivianna and Suh, EunRan and Rohrer, Jonathan D and Mead, Simon and Graff, Caroline and Öijerstedt, Linn and Pickering-Brown, Stuart and Rollinson, Sara and Rossi, Giacomina and Tagliavini, Fabrizio and Brooks, William S and Dobson-Stone, Carol and Halliday, Glenda M and Hodges, John R and Piguet, Olivier and Binetti, Giuliano and Benussi, Luisa and Ghidoni, Roberta and Nacmias, Benedetta and Sorbi, Sandro and Bruni, Amalia C and Galimberti, Daniela and Scarpini, Elio and Rainero, Innocenzo and Rubino, Elisa and Clarimon, Jordi and Lleó, Alberto and Ruiz, Agustin and Hernández, Isabel and Pastor, Pau and Diez-Fairen, Monica and Borroni, Barbara and Pasquier, Florence and Deramecourt, Vincent and Lebouvier, Thibaud and Perneczky, Robert and Diehl-Schmid, Janine and Grafman, Jordan and Huey, Edward D and Mayeux, Richard and Nalls, Michael A and Hernandez, Dena and Singleton, Andrew and Momeni, Parastoo and Zeng, Zhen and Hardy, John and Robertson, Janice and Zinman, Lorne and Rogaeva, Ekaterina and Int FTD-Genomics Consortium IFGC and International FTD-Genomics Consortium (IFGC)
Brain, ISSN 0006-8950, 10/2018, Volume 141, Issue 10, pp. 2895 - 2907
Discovery of disease age-of-onset modifiers is important for clinical trials and drug design. Zhang et al. perform a genome-wide analysis of epigenetic... 
genetic association | frontotemporal dementia | amyotrophic lateral sclerosis | age of onset | C9orf72 | REPEAT EXPANSION | DEMENTIA | DNA METHYLATION | ALS | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | NEUROSCIENCES | CLINICAL NEUROLOGY | DISEASE | FTD | DIAGNOSTIC-CRITERIA | HEXANUCLEOTIDE REPEAT | C9orf72 Protein - genetics | Frontotemporal Dementia - genetics | Gene Expression Regulation - genetics | Amyotrophic Lateral Sclerosis - genetics | Humans | Middle Aged | Genotype | Male | DNA Methylation | Age of Onset | CpG Islands | Female | Heterozygote | Aged | Polymorphism, Single Nucleotide | Original
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7. Full Text Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis
by Jansen, W.J and Ossenkoppele, R and Knol, D.L and Tijms, B.M and Scheltens, P.J and Verhey, F.R.J and Visser, P.J and Aalten, P and Aarsland, D and Alcolea, D and Alexander, M and Almdahl, I.S and Arnold, S.E and Baldeiras, I and Barthel, H and Berckel, B.N. van and Bibeau, K and Blennow, K and Brooks, D.J and Buchem, M.A. van and Camus, V and Cavedo, E and Chen, K and Chetelat, G and Cohen, A.D and ezga, A and Engelborghs, S and Fagan, A.M and Fladby, T and Fleisher, A.S and Flier, W.M. van der and Ford, L and Forster, S and Fortea, J and Foskett, N and Frederiksen, K.S and Freund-Levi, Y and Frisoni, G.B and Froelich, L and Gabryelewicz, T and Gill, K.D and Gkatzima, O and Gomez-Tortosa, E and Gordon, M.F and Grimmer, T and Hampel, H and Hausner, L and Hellwig, S and Herukka, S.K and Hildebrandt, H and Ishihara, L and Ivanoiu, A and Jagust, W.J and Johannsen, P and Kandimalla, R and Kapaki, E and Klimkowicz-Mrowiec, A and Klunk, W.E and Kohler, S and Koglin, N and Kornhuber, J and Kramberger, M.G and Laere, K. Van and Landau, S.M and Lee, D.Y and Leon, M and Lisetti, V and Lleo, A and Madsen, K and Maier, W and Marcusson, J and Mattsson, N and Mendonca, A. de and Meulenbroek, O.V and Meyer, P.T and Mintun, M.A and Mok, V and Molinuevo, J.L and Mollergard, H.M and Morris, J.C and Mroczko, B and Mussele, S. Van der and Na, D.L and Newberg, A and Nordberg, A and Nordlund, A and Novak, G.P and Paraskevas, G.P and Parnetti, L and Perera, G and Peters, O and Popp, J and Prabhakar, S and Rabinovici, G.D and Ramakers, I.H and Rami, L and Oliveira, C.R and Rinne, J.O and Roigue, K.M and Roiguez-Roiguez, E and ... and Amyloid Biomarker Study Grp and Amyloid Biomarker Study Group and Sahlgrenska akademin and Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi and Göteborgs universitet and Gothenburg University and Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry and Sahlgrenska Academy
Jama : Journal of the American Medical Association, ISSN 0098-7484, 2015, Volume 313, Issue 19, pp. 1924 - 1938
IMPORTANCE: Cerebral amyloid-beta aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of... 
OLDER PERSONS | POPULATION | MEDICINE, GENERAL & INTERNAL | CEREBROSPINAL-FLUID BIOMARKERS | COHORT | MILD COGNITIVE IMPAIRMENT | DIAGNOSTIC-CRITERIA | BETA-AMYLOIDOSIS | ASSOCIATION | PIB PET | ALZHEIMER-DISEASE PATHOLOGY | Apolipoprotein E4 - genetics | Dementia - pathology | Prevalence | Age Factors | Humans | Middle Aged | Risk Factors | Biomarkers - analysis | Genotype | Male | Positron-Emission Tomography | Cognitive Dysfunction - pathology | Cerebrospinal Fluid - chemistry | Aged, 80 and over | Amyloid beta-Peptides - analysis | Brain - pathology | Adult | Female | Aged | Usage | Analysis | Amyloidosis | Cognition | Research | Biological markers | Risk factors | Meta-analysis | Prevalence studies (Epidemiology) | Pathology | Medical research | Neurological disorders | Brain | Neurosciences | pathology | Biological Markers | 80 and over | genetics | Amyloid beta-Peptides | Neurovetenskaper | chemistry | Apolipoprotein E4 | Cerebrospinal Fluid | analysis | Mild Cognitive Impairment | Dementia
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8. Full Text Assessing the role of TUBA4A gene in frontotemporal degeneration
by Dols-Icardo, Oriol and Iborra, Oriol and Valdivia, Jessica and Pastor, Pau and Ruiz, Agustín and López de Munain, Adolfo and Sánchez-Valle, Raquel and Álvarez, Victoria and Sánchez-Juan, Pascual and Lleó, Alberto and Fortea, Juan and Blesa, Rafael and Cardona, Fernando and Baquero, Miquel and Alonso, María Dolores and Ortega-Cubero, Sara and Pastor, María A and Razquin, Cristina and Boada, Mercè and Hernández, Isabel and Gorostidi, Ana and Moreno, Fermín and Zulaika, Miren and Lladó, Albert and Coto, Eliecer and Combarros, Onofre and Pérez-Tur, Jordi and Clarimón, Jordi and Dementia Genet Spanish Consortium and Dementia Genetics Spanish Consortium (DEGESCO)
Neurobiology of Aging, ISSN 0197-4580, 2016, Volume 38, pp. 215.e13 - 215.e14
Abstract The tubulin alpha 4a ( TUBA4A ) gene has been recently associated with amyotrophic lateral sclerosis. Interestingly, some of the mutation carriers... 
Neurology | Internal Medicine | Genetics | Amyotrophic lateral sclerosis | Frontotemporal degeneration | TUBA4A | CRITERIA | DEMENTIA | AMYOTROPHIC-LATERAL-SCLEROSIS | MUTATIONS | VARIANT | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | Frontotemporal Dementia - genetics | Genetic Association Studies | Amyotrophic Lateral Sclerosis - genetics | Humans | Middle Aged | Male | Tubulin - genetics | Aged, 80 and over | Adult | Female | Heterozygote | Aged | Mutation | Cohort Studies | Medical colleges | Nervous system diseases | Neurosciences | Molecular genetics | Genes | Genetic research | Physiological aspects | Tubulins | Alzheimer's disease
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9. Full Text A Common BACE1 Polymorphism Is a Risk Factor for Sporadic Creutzfeldt-Jakob Disease
by Calero, Olga and Bullido, María J and Clarimón, Jordi and Frank-García, Ana and Martínez-Martín, Pablo and Lleó, Alberto and Rey, María Jesús and Sastre, Isabel and Rábano, Alberto and de Pedro-Cuesta, Jesús and Ferrer, Isidro and Calero, Miguel
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e43926
The beta site APP cleaving enzyme 1 (BACE1) is the rate-limiting beta-secretase enzyme in the amyloidogenic processing of APP and A beta formation, and... 
ALLELE | BETA-SECRETASE CLEAVAGE | GENE | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | AMYLOID PRECURSOR PROTEIN | MILD COGNITIVE IMPAIRMENT | CEREBROSPINAL-FLUID | ASSOCIATION | CELLULAR PRION PROTEIN | SENILE PLAQUES | Amyloid Precursor Protein Secretases - genetics | Genetic Predisposition to Disease - genetics | Humans | Aged | Polymorphism, Single Nucleotide | Aspartic Acid Endopeptidases - genetics | Codon - genetics | Creutzfeldt-Jakob Syndrome - genetics | Case-Control Studies | Creutzfeldt-Jakob Syndrome - enzymology | Proteases | Creutzfeldt-Jakob disease | Physiological aspects | Development and progression | Genetic aspects | Research | Risk factors | Genetic polymorphisms | Amyloidogenesis | Toxicity | Genes | Genomes | Proteins | Oligomers | Apolipoprotein E | Aging | Prion protein | Alzheimer's disease | Age | Enzymes | b-Site APP cleaving enzyme 1 | Neurodegenerative diseases | Health risks | Risk analysis | Studies | Neurology | Hospitals | Plasticity (synaptic) | Secretase | Polymorphism | Plastic foam | Malaltia d'Alzheimer | Protein metabolism | Malalties per prions | Prion diseases | Disorders of metabolism | Metabolisme de proteïnes | Trastorns del metabolisme | Malaltia de Creutzfeldt-Jakob
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