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Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5067 - 5074
(V600E)B-RAF mutation is found in 50% to 60% of melanomas, and the novel agents PLX4032/vemurafenib and GSK2118436 that inhibit the (V600E)B-RAF kinase achieve... 
Apoptosis - drug effects | Humans | Multiprotein Complexes | Neoplasm Proteins - physiology | Recombinant Fusion Proteins - physiology | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptor, Platelet-Derived Growth Factor beta - genetics | Quinolines - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Spheroids, Cellular - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Proteins - physiology | Transcription Factors - physiology | Receptor, Platelet-Derived Growth Factor beta - physiology | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Imidazoles - pharmacology | Proto-Oncogene Proteins c-akt - physiology | Melanoma - pathology | Sulfonamides - pharmacology | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Point Mutation | Vemurafenib | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | TOR Serine-Threonine Kinases | Drug Resistance, Neoplasm - physiology | Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | Index Medicus | vemurafenib | targeted therapy | melanoma | AKT | B-RAF | acquired resistance
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2012, Volume 22, Issue 6, pp. 945 - 947
The BRAF inhibitors (BRAFi) induce anti-tumor responses in nearly 60% of patients with advanced ^v600BRAF-mutant melanomas but only 5% of patients with... 
诱发突变 | 抑制剂 | 受体酪氨酸激酶 | 大肠癌 | 抗肿瘤 | 黑色素瘤
Journal Article
Nature, ISSN 0028-0836, 12/2010, Volume 468, Issue 7326, pp. 973 - 977
Journal Article
Cell, ISSN 0092-8674, 03/2016, Volume 165, Issue 1, pp. 35 - 44
Journal Article
2006, ISBN 9780817314767, xii, 443
Book
Nature, ISSN 0028-0836, 07/2012, Volume 487, Issue 7408, pp. 500 - 504
Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By... 
COLON-CANCER | OVEREXPRESSION | MELANOMA | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | C-MET | ACQUIRED-RESISTANCE | V600E MUTATION | BRAF | GROWTH-FACTOR | VEMURAFENIB | Proto-Oncogene Proteins c-met - metabolism | Prognosis | Hepatocyte Growth Factor - secretion | Coculture Techniques | Humans | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Tumor Microenvironment - physiology | Molecular Targeted Therapy | Melanoma - genetics | Stromal Cells - drug effects | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Melanoma - metabolism | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Stromal Cells - metabolism | Antineoplastic Combined Chemotherapy Protocols | Melanoma - pathology | Sulfonamides - pharmacology | Hepatocyte Growth Factor - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Stromal Cells - secretion | Signal Transduction - drug effects | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Proteomics | Cell Line, Tumor | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Mutation | Stromal Cells - cytology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Physiological aspects | Genetic aspects | Research | Gene expression | Drug resistance | Growth factors | Health aspects | Liver cells | Cancer | Cytotoxicity | Epidermal growth factor | FDA approval | Cancer therapies | Tumors | Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2016, Volume 375, Issue 9, pp. 819 - 829
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7547, pp. 368 - 372
Drug resistance invariably limits the clinical efficacy of targeted therapy with kinase inhibitors against cancer(1,2). Here we show that targeted therapy with... 
CNS CELL-TYPES | MELANOMA | METASTASIS | MICROENVIRONMENT | TRANSLATIONAL PROFILING APPROACH | MULTIDISCIPLINARY SCIENCES | RAF INHIBITOR RESISTANCE | ACQUIRED-RESISTANCE | KINASE INHIBITORS | DRUG-RESISTANCE | CANCER CHEMORESISTANCE | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Clone Cells - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-fos - deficiency | Adenocarcinoma - metabolism | Neoplasm Metastasis - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Tumor Microenvironment - drug effects | Cell Survival - drug effects | Melanoma - pathology | Down-Regulation - drug effects | Enzyme Activation - drug effects | Adenocarcinoma - drug therapy | Disease Progression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Cell Movement - drug effects | Lung Neoplasms - secretion | Melanoma - secretion | Animals | Clone Cells - pathology | Metabolome - drug effects | Signal Transduction - drug effects | Neoplasm Metastasis - pathology | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Adenocarcinoma - secretion | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Pharmaceutical research | Care and treatment | Oncology, Experimental | Dosage and administration | Research | Drug therapy | Drug resistance | Antineoplastic agents | Tumors | Cancer | Melanoma | Mutation | Metastasis | Kinases | Cancer therapies | Index Medicus
Journal Article
Journal Article
Cell, ISSN 0092-8674, 1999, Volume 97, Issue 1, pp. 29 - 39
Following TGFβ receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target promoters in association with... 
Journal Article