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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2015, Volume 112, Issue 47, pp. E6486 - E6495
Defects in the innate immune system in the lung with attendant bacterial infections contribute to lung tissue damage, respiratory insufficiency, and ultimately... 
Roscovitine | Cystic fibrosis | TRPC6 | Phagosome | Alveolar macrophage | CELLS | alveolar macrophage | PHAGOCYTOSIS | RESPIRATORY-DISEASE | MULTIDISCIPLINARY SCIENCES | ACIDIFICATION | IDENTIFICATION | DRUG TARGETS | roscovitine | cystic fibrosis | LIPID RAFTS | phagosome | ALVEOLAR MACROPHAGES | CYSTIC-FIBROSIS | CFTR | Small Molecule Libraries - pharmacology | Receptors, G-Protein-Coupled - metabolism | Calcium - metabolism | Humans | Protein Transport - drug effects | Acids - metabolism | Exocytosis - drug effects | Diglycerides - metabolism | Cell Membrane - metabolism | Cell Membrane - drug effects | Pertussis Toxin - pharmacology | Phagosomes - drug effects | Cell Line | TRPC6 Cation Channel | Microbial Viability - drug effects | Purines - pharmacology | Phagosomes - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Small Molecule Libraries - chemistry | Patch-Clamp Techniques | Animals | Purines - chemistry | Calcium Signaling - drug effects | Macrophages, Alveolar - drug effects | Models, Biological | Fluorescent Antibody Technique | TRPC Cation Channels - metabolism | Intracellular Membranes - drug effects | Mice | Macrophages, Alveolar - metabolism | Intracellular Membranes - metabolism | Ion Channel Gating - drug effects | Phagocytes | Immune response | Translocation (Genetics) | Genetic research | Ion channels | Genetic aspects | Research | Properties | Biological Sciences | PNAS Plus
Journal Article
Molecules, ISSN 1420-3049, 10/2014, Volume 19, Issue 10, pp. 15546 - 15571
Journal Article
Marine Drugs, ISSN 1660-3397, 10/2017, Volume 15, Issue 10, p. 316
A large diversity of 2-aminoimidazolone alkaloids is produced by various marine invertebrates, especially by the marine Calcareous sponges Leucetta and... 
CLK | Alzheimer’s disease | 2-aminoimidazolone alkaloids | Marine sponge | Polyandrocarpamines | Down syndrome | Kinase inhibitor | DYRK | Leucettine | Ascidian | Calcarea | Porifera | Polyandrocarpa | Protein kinases | Leucettamine B | HYMENIALDISINE | leucettine | CYCLIN D1 | protein kinases | marine sponge | BENZYLIDENE 2-AMINOIMIDAZOLONES | AFFINITY-CHROMATOGRAPHY | Alzheimer's disease | IMMOBILIZED AXIN | CHEMISTRY, MEDICINAL | NATURAL-PRODUCTS | RECEPTOR ANTAGONIST | ascidian | kinase inhibitor | SPONGE ALKALOIDS | polyandrocarpamines | LEUCETTINE L41 | leucettamine B | IMIDAZOLE ALKALOIDS | Phosphorylation | Protozoan Proteins - antagonists & inhibitors | Humans | Imidazoles - chemistry | Alkaloids - chemical synthesis | Structure-Activity Relationship | Phylogeny | Protozoan Infections - drug therapy | Amines - therapeutic use | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Antiprotozoal Agents - chemical synthesis | Imidazoles - chemical synthesis | Imidazoles - therapeutic use | Porifera - chemistry | Protein Kinase Inhibitors - chemical synthesis | Alkaloids - pharmacology | Alzheimer Disease - drug therapy | Imidazoles - pharmacology | Amines - chemical synthesis | Antiprotozoal Agents - pharmacology | Porifera - genetics | Animals | Protein Kinase Inhibitors - therapeutic use | Down Syndrome - drug therapy | Alkaloids - therapeutic use | Protein Kinase Inhibitors - pharmacology | Antiprotozoal Agents - therapeutic use | Amines - pharmacology | Urochordata - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Drugs | Cdc2 protein | Disease | Cyclin D1 | Drug development | Kinases | Proteins | Alkaloids | Marine invertebrates | Microorganisms | Specificity | Plankton | Down's syndrome | Tyrosine | Medical treatment | Sponges | Pharmacology | Mammals | Cells | Diseases | Inhibitors | Reviews | Invertebrates | Chemical Sciences
Journal Article
Disease models & mechanisms, ISSN 1754-8403, 09/2018, Volume 11, Issue 9, p. dmm035634
Growing evidence supports the implication of DYRK1A in the development of cognitive deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here... 
Leucettine | DYRK1A | Down syndrome | Synapsin | Kinase inhibitor | FUNCTIONAL CONNECTIVITY | BINDING-PROTEIN | DUAL-SPECIFICITY | PATHOLOGY | MICROTUBULE DYNAMICS | CELL BIOLOGY | INTELLECTUAL DISABILITY | TRANSMITTER RELEASE | REGULATED KINASE 1A | SYNDROME CRITICAL REGION | INCREASED DOSAGE | SYNAPSIN-I | Dioxoles - therapeutic use | Phosphorylation | Protein-Tyrosine Kinases - metabolism | Imidazoles - chemistry | Cytoplasm - metabolism | Nerve Net - drug effects | RNA, Messenger - metabolism | Synapsins - metabolism | Protein Kinase Inhibitors - chemistry | Protein-Tyrosine Kinases - genetics | Synapses - metabolism | Protein Binding - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Dioxoles - pharmacology | Down Syndrome - complications | Cognitive Dysfunction - complications | Imidazoles - therapeutic use | Nerve Net - physiopathology | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Cognitive Dysfunction - drug therapy | Amino Acid Sequence | Down Syndrome - pathology | Synapses - drug effects | Biocatalysis | Brain - physiopathology | Mice, Inbred C57BL | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Imidazoles - pharmacology | Cognitive Dysfunction - pathology | Dioxoles - chemistry | Synapsins - chemistry | Brain - drug effects | Magnetic Resonance Imaging | Animals | Protein Kinase Inhibitors - therapeutic use | Proteomics | Brain - pathology | Cytoskeleton - metabolism | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Cytoskeleton - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors | Chemical Sciences | 302
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2013, Volume 56, Issue 18, pp. 7289 - 7301
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2014, Volume 83, pp. 274 - 283
Trypanosomes from the “brucei” complex are pathogenic parasites endemic in sub-Saharan Africa and causative agents of severe diseases in humans and livestock.... 
Nagana | Chalcones | Cinnamides | Trypanosoma brucei brucei | Paullones | Human trypanosomiasis | CHEMISTRY, MEDICINAL | VALIDATION | BRUCEI | HUMAN SERUM | SIDE-CHAINS | TRYPANOTHIONE SYNTHETASE | BLOOD-STREAM | AFFINITY-CHROMATOGRAPHY | DRUG TARGET | IMMOBILIZED AXIN | Cell Line | Humans | Trypanocidal Agents - toxicity | Trypanocidal Agents - chemistry | Structure-Activity Relationship | Benzazepines - pharmacology | Benzazepines - chemical synthesis | Trypanosoma brucei brucei - drug effects | Trypanosoma brucei brucei - physiology | Trypanosomiasis, African - parasitology | Animals | Trypanocidal Agents - pharmacology | Drug Design | Trypanocidal Agents - chemical synthesis | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Benzazepines - toxicity | Benzazepines - chemistry | Substitution reactions | Antiparasitic agents | Livestock | Trypanocidal Agents/chemistry | Trypanocidal Agents/chemical synthesis | Trypanosoma brucei brucei/drug effects | Trypanocidal Agents/pharmacology | Biochemistry, Molecular Biology | Benzazepines/pharmacology | Trypanosomiasis, African/parasitology | Life Sciences | Benzazepines/toxicity | Macrophages/drug effects | Benzazepines/chemistry | Trypanosoma brucei brucei/physiology | Trypanocidal Agents/toxicity | Cell Proliferation/drug effects | Benzazepines/chemical synthesis
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2015, Volume 92, pp. 124 - 134
This paper reports the design and synthesis of a novel series of 8-arylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amines via microwave-assisted multi-step... 
Medicinal Chemistry | Organic chemistry | Chemical Sciences
Journal Article