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Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 08/2019, Volume 10, Issue 1, pp. 3763 - 12
The tumor milieu consists of numerous cell types each existing in a different environment. However, a characterization of metabolic heterogeneity at... 
HETEROGENEITY | PATHWAYS | ATLAS | HEAD | CANCER-ASSOCIATED FIBROBLASTS | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTOMIC ANALYSIS | HEALTH | HALLMARKS | Heterogeneity | Mitochondria | Algorithms | Stromal cells | Discordance | Melanoma | Computer applications | Glycolysis | Head and neck | Hypoxia | Metabolism | Tumors
Journal Article
Nature, ISSN 0028-0836, 08/2017, Volume 548, Issue 7669, pp. 533 - 534
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 04/2017, Volume 42, Issue 4, p. 274
Metabolomics generates a profile of small molecules that are derived from cellular metabolism and can directly reflect the outcome of complex networks of... 
Metabolomics | Separation | Data acquisition | Mass spectroscopy | Liquid chromatography | Biochemistry | Metabolism | Utilities | Reviews | Cellular communication | Water analysis | Physiology | Mass spectrometry | Expansion
Journal Article
Trends in Cell Biology, ISSN 0962-8924, 09/2019, Volume 29, Issue 9, pp. 695 - 703
Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and... 
acetate metabolism | nutrition | lipogenesis | cancer | alcoholism | CELLS | ACETYL-COA | GUT-MICROBIOTA | LACTATE | BLOOD ACETATE | ELIMINATION | HISTONE ACETYLATION | BRAIN | AXIS | CELL BIOLOGY | Glucose metabolism | Enzymes | Medical colleges | Alcoholism | Physiological aspects | Acetates | Cancer | Glycolysis | Pyruvic acid | Coenzyme A | Lipids | Protein biosynthesis | Physiology | Acetylation | Metabolism | Cell interactions | Acetic acid
Journal Article
Nature reviews. Cancer, ISSN 1474-175X, 09/2019, Volume 19, Issue 11, pp. 625 - 637
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5442 - 5442
Phosphoglycerate dehydrogenase (PHGDH) catalyzes the committed step in de novo serine biosynthesis. Paradoxically, PHGDH and serine synthesis are required in... 
FLUX ANALYSIS | TARGET | NETWORK | PATHWAY | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | INHIBITORS | DEHYDROGENASE | Pentose phosphate | Toxicity | Serine | Biosynthesis | Phosphoglycerate dehydrogenase | Carboxylic acids | Metabolism | Carbon | Mass balance | Alterations | Pentose | Pentose phosphate pathway | Disruption | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 809 - 15
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. It thrives in a nutrient-poor environment; however, the mechanisms by which... 
GLUTAMINE DEPRIVATION | DIAGNOSIS | INHIBITION | MICRORNA 135 | ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | GROWTH | MUTANT P53 | HYPOXIA | EXPRESSION | PROGRESSION | Adenocarcinoma | Tricarboxylic acid cycle | Deprivation | p53 Protein | MiRNA | Metabolism | Ribonucleic acid--RNA | Bioaccumulation | Pancreatic cancer | Glycolysis | Nutrients | Phosphofructokinase | Tumors | Cancer | Adaptation | Glutamine
Journal Article
Nature, ISSN 0028-0836, 08/2017, Volume 548, Issue 7669, pp. 533 - 534
BIOCHEMISTRY Formaldehyde, a DNA-damaging agent formed in cells, has now been shown to support metabolic processes that involve molecular units containing a... 
GLYCINE | SERINE | PATHWAY | MULTIDISCIPLINARY SCIENCES | CANCER | TUMORS | ONE-CARBON METABOLISM | Biological research | Physiological aspects | Toxins | Research | Metabolism | Biology, Experimental | Enzymes | CRISPR | Vitamin B | Amino acids | Biochemistry | Aldehydes | Carbon | Deoxyribonucleic acid--DNA | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 51, pp. 19725 - 19739
Nutrition and metabolism are fundamental to cellular function. Metabolic activity (i.e. rates of flow, most commonly referred to as flux) is constrained by... 
computational biology | GLYCOLYSIS | metabolic control analysis | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | thermodynamics | metabolism | NETWORKS | CONTROL COEFFICIENTS | enzyme kinetics | metabolic regulation | Glycolysis | Thermodynamics | Kinetics | Metabolic Networks and Pathways | Models, Biological
Journal Article
Nature Immunology, ISSN 1529-2908, 11/2019, Volume 20, Issue 11, pp. 1555 - 1555
An amendment to this paper has been published and can be accessed via a link at the top of the paper. 
Glycerin | Phosphates | Glycerol | Enzymes | Medical colleges | Macrophages | Inflammation
Journal Article
Cell, ISSN 0092-8674, 11/2017, Volume 171, Issue 4, pp. 736 - 737
Nearly 3% of the human population carries bi-allelic loss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit... 
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2018, Volume 28, Issue 5, pp. 669 - 670
Studies have shown that tumors commonly exhibit normal or enhanced respiration in addition to glycolytic metabolism. In this issue, report a reduction in... 
METABOLISM | CANCER | ENDOCRINOLOGY & METABOLISM | CELL BIOLOGY | Glycolysis | Carcinoma, Renal Cell | Mitochondria | Glucose | Isotopes | Humans | Tumors
Journal Article
Cell, ISSN 0092-8674, 11/2017, Volume 171, Issue 4, p. 736
Nearly 3% of the human population carries bi-allelic loss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit... 
Physiological aspects | Vitamins | Medical colleges | Metabolites
Journal Article
CELL, ISSN 0092-8674, 11/2017, Volume 171, Issue 4, pp. 736 - 737
Nearly 3% of the human population carries bi-allelicloss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY
Journal Article
Cancer Cell, ISSN 1535-6108, 03/2019, Volume 35, Issue 3, pp. 339 - 341
Altered metabolism is a common feature of new and recurring malignancy. In this issue of , Reina-Campos and colleagues report upregulation of the serine,... 
ONCOLOGY | METHYLATION | CELL BIOLOGY | Physiological aspects | Medical colleges | Disease susceptibility | Glycine | Prostate cancer | Serine
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 388 - 388
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2018, Volume 70, Issue 4, pp. 663 - 678.e6
Lysine 2-hydroxyisobutyrylation (Khib) is an evolutionarily conserved and widespread histone mark like lysine acetylation (Kac). Here we report that EP300... 
lysine 2-hydroxyisobutyrylation | EP300 | cell survival | glycolysis | TERT-BUTYL ETHER | CROTONYLATION | BIODEGRADATION | ACETYLATION | P300 | BIOCHEMISTRY & MOLECULAR BIOLOGY | METABOLIC-REGULATION | GUT MICROBIOTA | ORGANIC-ACIDS | IDENTIFICATION | BUTYRYLATION | CELL BIOLOGY
Journal Article