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Cancer Research, ISSN 0008-5472, 07/2015, Volume 75, Issue 14 Supplement, pp. B14 - B14
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 181 - 181
Journal Article
JOURNAL OF GASTROINTESTINAL ONCOLOGY, ISSN 2078-6891, 06/2019, Volume 10, Issue 3, pp. 412 - 420
Background: Despite the clinical success of vascular endothelial growth factor (VEGF) blockade in metastatic colorectal cancers (mCRC), resistance to... 
1ST-LINE TREATMENT | LEUCOVORIN | ALLERGIC RHINITIS | RANDOMIZED-TRIAL | IMPROVES SURVIVAL | OXALIPLATIN | FOLFIRI | IN-VITRO | ONCOLOGY | cytokine IL-8 | DOUBLE-BLIND | anti-angiogenic resistance | metastatic colorectal cancer | GASTROENTEROLOGY & HEPATOLOGY | Levocetirizine | PLUS | Clinical Trial
Journal Article
Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7691, pp. 189 - 194
Journal Article
2010, ISBN 9780230212145, xxxi, 536
Book
Clinical Cancer Research, ISSN 1078-0432, 04/2017, Volume 23, Issue 7, pp. 1748 - 1759
Purpose: Aberrant activation of the NF-kB transcription factors underlies the aggressive behavior and poor outcome of pancreatic ductal adenocarcinoma(PDAC).... 
KINASE-ACTIVITY | SIGNALING PATHWAYS | INHIBITION | ONCOLOGY | MACROPHAGES | STELLATE CELLS | CANCER MICROENVIRONMENT | COMBINATION | NF-KAPPA-B | EXPRESSION | PROMOTES | Adenocarcinoma - pathology | Interleukin-1 Receptor-Associated Kinases - genetics | Prognosis | Apoptosis - drug effects | Deoxycytidine - administration & dosage | Humans | Adenocarcinoma - drug therapy | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - genetics | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Drug Resistance, Neoplasm - genetics | Animals | Adenocarcinoma - genetics | Cell Proliferation - drug effects | Mice | Gene Expression Regulation, Neoplastic - drug effects | Deoxycytidine - analogs & derivatives | Cell proliferation | Adenocarcinoma | Phosphorylation | Transcription factors | Gemcitabine | Interleukin | Chemoresistance | Staining | Activation | Kinases | Proteins | Receptors | Transcription activation | Surgery | Interleukin 1 | Toll-like receptors | Pancreas | IRAK protein | CRISPR | NF-κB protein | Aggressive behavior | Cytokines | Secretion | RNA-mediated interference | Pharmacology | Inflammation | Ribonucleic acid--RNA | Ablation | Immune systems | Signaling | Inhibitors | DNA microarrays | Experimental design | Medical prognosis | Cell lines | Fibrosis | In vivo methods and tests | Aberration | Cancer | Apoptosis | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e77243 - e77243
Patients with pancreatic cancer have dismal prognoses, and novel therapies are urgently needed. Mutations of the KRAS oncogene occur frequently in pancreatic... 
PHASE-III TRIAL | BREAST-CANCER | ACTIVATION | RAS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | KINASE | AZD6244 ARRY-142886 | INHIBITOR GDC-0941 | ANTITUMOR-ACTIVITY | PLASMA-MEMBRANE | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Pancreatic Neoplasms - pathology | Pancreas - drug effects | Pancreas - pathology | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Pancreas - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Pancreatic Neoplasms - drug therapy | Animals | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Health aspects | Analysis | Protein binding | Biotechnology | Phosphorylation | Xenotransplantation | Clinical trials | Oncology | Feedback loops | Kinases | K-Ras protein | Ovarian cancer | Anticancer properties | Proteins | Synergistic effects | Pathways | Surgery | Xenografts | Bioindicators | Inhibition | Cell survival | MEK inhibitors | MAP kinase | Breast cancer | Tumor cell lines | Radiation therapy | 1-Phosphatidylinositol 3-kinase | Medicine | Inhibitors | Protein kinase | Pancreatic cancer | Cell lines | Biomarkers | Antitumor activity | Mutation | Control theory | Viability | Cancer | Apoptosis | Tumors | Index Medicus
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 5/2015, Volume 129, Issue 5, pp. 695 - 713
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 05/2015, Volume 33, Issue 15, pp. 2538 - 2538
Conference Proceeding
Journal Article
Investigational New Drugs, ISSN 0167-6997, 6/2013, Volume 31, Issue 3, pp. 707 - 713
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 05/2017, Volume 35, Issue 15_suppl, pp. 2553 - 2553
Conference Proceeding
Cancer Research, ISSN 0008-5472, 09/2018, Volume 78, Issue 18, pp. 5398 - 5407
MEK inhibition is of interest in cancer drug development, but clinical activity in metastatic colorectal cancer (mCRC) has been limited. Preclinical studies... 
SURVIVAL | CETUXIMAB | CELLS | MELANOMA | ONCOLOGY | ORAL MEK INHIBITOR | COBIMETINIB | INHIBITOR AZD6244 ARRY-142886 | KRAS | MECHANISMS | VEMURAFENIB
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 02/2017, Volume 35, Issue 4, pp. 138 - 138
Conference Proceeding
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 02/2017, Volume 35, Issue 4, pp. TPS505 - TPS505
Conference Proceeding
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 05/2016, Volume 34, Issue 15, pp. 2588 - 2588
Conference Proceeding
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 05/2017, Volume 35, Issue 15_suppl, pp. TPS4131 - TPS4131
Conference Proceeding
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 05/2017, Volume 35, Issue 15_suppl, pp. 108 - 108
Conference Proceeding
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