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Molecular pharmaceutics, ISSN 1543-8384, 09/2019, Volume 16, Issue 10, pp. 4089 - 4103
Many pharmaceutical drugs in the marketplace and discovery pipeline suffer from poor aqueous solubility, thereby limiting their effectiveness for oral... 
Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 6, pp. 1890 - 1894
The structure–activity relationships of a series of -pyridylpyrazinones as corticotropin-releasing factor-1 receptor antagonists was investigated. A series of... 
Corticotropin-releasing factor | Pyridyl | G-protein coupled receptors | CRF | Pyrimidyl | Pyrazinone | TARGET | DEPRESSION | CHEMISTRY, MEDICINAL | ANXIETY | CHEMISTRY, ORGANIC | N-3-PHENYLPYRAZINONES | HORMONE | PHARMACOLOGY | AGENTS | SMALL-MOLECULE ANTAGONISTS
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 04/2011, Volume 21, Issue 8, pp. 2484 - 2488
A series of N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-al k ylpyrazolo[1,5-a][1,3,5]triazin-4-amines were prepared and evaluated as... 
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, p. e0159996
The development of alpha7 nicotinic acetylcholine receptor agonists is considered a promising approach for the treatment of cognitive symptoms in schizophrenia... 
ACETYLCHOLINE-RECEPTORS | HUMAN BRAIN | TROPISETRON | MULTIDISCIPLINARY SCIENCES | IN-VIVO | RATS | EVP-6124 | DEFICITS | BINDING | PREFRONTAL CORTEX | PROOF-OF-CONCEPT | Cognition Disorders - physiopathology | Humans | Quinuclidines - pharmacology | Rats | Male | Spiro Compounds - therapeutic use | alpha7 Nicotinic Acetylcholine Receptor - agonists | Cognition Disorders - drug therapy | Patch-Clamp Techniques | Animals | Quinuclidines - therapeutic use | Schizophrenia - physiopathology | HEK293 Cells | Mice | Radioligand Assay | Schizophrenia - drug therapy | Drug Evaluation, Preclinical | Spiro Compounds - pharmacology | Complications and side effects | Attentional bias | Care and treatment | Analysis | Schizophrenia | Research | Neurophysiology | Neonates | Animal models | Serotonin S3 receptors | Calcium | Mental disorders | Memory | Cognitive ability | Fluorescence | Electrophysiology | Clinical trials | Oxazol | Cognition | Biology | Extradimensional shift | MK-801 | Auditory discrimination | Receptors | Phencyclidine | Mismatch negativity | Sensory integration | Rodents | Chief executive officers | Gating | Recombinant | Binding | Dopamine | Channel gating | Calcium channels (voltage-gated) | Pattern recognition | Object recognition | Generic drugs | Ketamine | Cognition & reasoning | Information processing | Acetylcholine receptors (nicotinic) | Acetylcholine
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2011, Volume 21, Issue 8, pp. 2484 - 2488
A series of -(3-fluoroalkyl)-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl- -alkylpyrazolo[1,5- ][1,3,5]triazin-4-amines were prepared and evaluated as... 
Imaging agents | Depression | Corticotropin-releasing factor | Anxiety | Positron emission tomography
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2017, Volume 807, p. 1
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.ejphar.2017.04.024 The... 
Attentional bias | Neurosciences | Cognition
Journal Article
Journal Article
Journal Article
Journal Article