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Journal of Experimental Medicine, ISSN 0022-1007, 04/2018, Volume 215, Issue 4, pp. 1035 - 1045
Journal Article
Immunity, ISSN 1074-7613, 03/2015, Volume 42, Issue 3, pp. 419 - 430
Macrophage polarization involves a coordinated metabolic and transcriptional rewiring that is only partially understood. By using an integrated high-throughput... 
IMMUNITY | CELLS | ACTIVATION | INFLAMMATION | NITRIC-OXIDE | INNATE | GLYCOSYLATION | IMMUNOLOGY | Glutamine - deficiency | Aspartic Acid - immunology | Argininosuccinic Acid - immunology | Mitochondria - immunology | Chemokine CCL22 - immunology | Metabolic Networks and Pathways - immunology | Mitochondria - genetics | Argininosuccinic Acid - metabolism | Gene Regulatory Networks - immunology | Isocitrate Dehydrogenase - immunology | Macrophages - immunology | Uridine Diphosphate N-Acetylglucosamine - metabolism | Nitric Oxide - immunology | Macrophages - classification | Aspartate Aminotransferase, Mitochondrial - immunology | Interleukin-6 - genetics | Signal Transduction | Gene Expression Regulation | Isocitrate Dehydrogenase - genetics | Glycosylation | Mitochondria - metabolism | Macrophages - cytology | Immunity, Innate | Citric Acid Cycle | Uridine Diphosphate N-Acetylglucosamine - immunology | Chemokine CCL22 - genetics | Macrophages - metabolism | Metabolic Networks and Pathways - genetics | Animals | Interleukin-6 - immunology | Transcription, Genetic - immunology | Aspartic Acid - metabolism | Mice | Aspartate Aminotransferase, Mitochondrial - genetics | Nitric Oxide - metabolism | Enzymes | Tracers (Biology) | Analysis | Nitric oxide | Physiological aspects | Aspartate | Genetic aspects | Genetic transcription | Macrophages | Glutamine | Metabolites | Rodents | Scientific imaging | Metabolism | Labeling | Mass spectrometry
Journal Article
Nature, ISSN 0028-0836, 04/2018, Volume 556, Issue 7702, pp. 501 - 504
Journal Article
The Journal of Experimental Medicine, ISSN 0022-1007, 04/2018, Volume 215, Issue 4, pp. 1035 - 1045
Immune-Responsive Gene 1 (Irg1) is a mitochondrial enzyme that produces itaconate under inflammatory conditions, principally in cells of myeloid lineage. Cell... 
Journal Article
Nature, ISSN 0028-0836, 04/2018, Volume 556, Issue 7700, p. 501
Metabolic regulation has been recognized as a powerful principle guiding immune responses. Inflammatory macrophages undergo extensive metabolic rewiring.sup.1... 
Transcription factors | Cellular signal transduction | Research | Metabolites
Journal Article
Journal Article
Cell, ISSN 0092-8674, 08/2017, Volume 170, Issue 4, pp. 649 - 663.e13
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2015, Volume 60, Issue 2, pp. 195 - 207
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 01/2016, Volume 19, Issue 1, pp. 102 - 113
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 01/2016, Volume 19, Issue 1, pp. 91 - 101
Journal Article
Cell, ISSN 0092-8674, 08/2017, Volume 170, Issue 4, pp. 649 - 663.e13
Elevated risk of developing Alzheimer’s disease (AD) is associated with hypomorphic variants of TREM2, a surface receptor required for microglial responses to... 
TREM2 | metabolism | immunity | Alzheimer’s disease | microglia
Journal Article