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PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e32366
Neutrophils play an important role in innate immunity by defending the host organism against invading microorganisms. Antimicrobial activity of neutrophils is... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | NETTING NEUTROPHILS | MYELOPEROXIDASE | MEDICAL PROGRESS | ENDOTOXIN | BIOLOGY | RECOMBINANT HUMAN DNASE | LIPOPOLYSACCHARIDE | ACUTE LUNG INJURY | CYSTIC-FIBROSIS | RESPIRATORY-DISTRESS-SYNDROME | Bronchoalveolar Lavage Fluid | Neutrophils - chemistry | Histones - pharmacology | Leukocyte Elastase - pharmacology | Epithelial Cells - drug effects | Humans | Mice, Inbred C57BL | Cells, Cultured | Animals | Leukocyte Elastase - chemistry | Cell Death - physiology | Endothelial Cells - cytology | Cell Line, Tumor | Mice | Cell Death - drug effects | Histones - metabolism | Epithelial Cells - cytology | Neutrophils - metabolism | Microscopy, Fluorescence | Endothelial Cells - drug effects | Viral antibodies | Acute respiratory distress syndrome | Cell death | Histones | Antibodies | Biochemistry | DNA binding proteins | Endothelium | Antimicrobial activity | Peptides | Toxicity | Epithelial cells | Cytotoxicity | Innate immunity | Antiinfectives and antibacterials | Immunity | Lipopolysaccharides | Proteins | Microorganisms | Bronchoalveolar lavage | Antimicrobial peptides | Peroxidase | Elastase | Alveoli | Deoxyribonucleic acid--DNA | Lupus | Biodegradation | Enzymes | Pathogens | Incubation | Pulmonary arteries | Polysialic acid | Neutrophils | Bronchus | Cystic fibrosis | Leukocytes (neutrophilic) | Activated protein C | Endothelial cells | Medicine | Hypotheses | Inhibitors | Cysts | Lungs | Influenza | Gas exchange | Phagocytosis | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 2011, Volume 2
Lung macrophages are long living cells with broad differentiation potential, which reside in the lung interstitium and alveoli or are organ-recruited upon... 
Inflammation | Repair | Lung | Macrophage | Resolution | lung | repair | macrophage | IMMUNOLOGY | inflammation | resolution
Journal Article
PLoS Pathogens, ISSN 1553-7366, 02/2013, Volume 9, Issue 2, p. e1003188
Influenza viruses (IV) cause pneumonia in humans with progression to lung failure and fatal outcome. Dysregulated release of cytokines including type I... 
TRAIL | MICROBIOLOGY | INDUCTION | H1N1 | A VIRUS | INTERFERON | IMPACT | VIROLOGY | PKR | HOST-DEFENSE | INFECTION | LIGAND | PARASITOLOGY
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2016, Volume 126, Issue 4, pp. 1566 - 1580
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, pp. 3652 - 3664
textabstractInfluenza viruses (IVs) cause pneumonia in humans with progression to lung failure. Pulmonary DCs are key players in the antiviral immune response,... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | RESPIRATORY DENDRITIC CELLS | COLONY-STIMULATING FACTOR | GM-CSF | INFLAMMATION | INFLUENZA-VIRUS | LUNG INFECTION | H1N1 INFLUENZA | EXPRESSION | LANGERHANS CELLS | Influenza, Human - pathology | Instillation, Drug | Humans | Dendritic Cells - physiology | Lectins, C-Type - genetics | Antigens, CD - analysis | Epithelial Cells - physiology | Lung - virology | Granulocyte-Macrophage Colony-Stimulating Factor - secretion | Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis | Influenza A Virus, H1N1 Subtype - isolation & purification | Bone Marrow Transplantation | Cells, Cultured - virology | Cells, Cultured - immunology | Trachea | Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage | Pulmonary Alveoli - pathology | Specific Pathogen-Free Organisms | Mice, Inbred C57BL | Orthomyxoviridae Infections - pathology | Pneumonia, Viral - pathology | Antigens, Surface - genetics | Integrin alpha Chains - analysis | Mice, Transgenic | Radiation Chimera | Pneumonia, Viral - immunology | Animals | Mannose-Binding Lectins - genetics | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - physiology | Mice | Lung - immunology | Orthomyxoviridae Infections - immunology | Pulmonary Alveoli - immunology | Influenza, Human - immunology | Viral pneumonia | Dendritic cells | Epithelial cells | Physiological aspects | Development and progression | Research | Risk factors
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 06/2016, Volume 12, Issue 6, p. e1005544
Journal Article
PLoS pathogens, ISSN 1553-7374, 06/2016, Volume 12, Issue 6, p. e1005716
[This corrects the article DOI: 10.1371/journal.ppat.1003188.]. 
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 12/2008, Volume 205, Issue 13, pp. 3065 - 3077
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 03/2009, Volume 296, Issue 3, pp. 442 - 452
Journal Article
Antiviral Research, ISSN 0166-3542, 10/2011, Volume 92, Issue 1, pp. 45 - 56
Influenza virus (IV) infection can cause severe pneumonia and death. Therapeutic actions are limited to vaccines and a few anti-viral drugs. These target viral... 
Signal transduction | NF-kappaB | Cytokines | Influenza virus | IKK-inhibition | MEK-inhibition | IMMUNE-RESPONSE | BRONCHIAL EPITHELIAL-CELLS | PROTEIN-KINASE KINASE | A H5N1 VIRUSES | ANTIVIRAL RESPONSE | NS1 PROTEIN | VIROLOGY | SIGNALING PATHWAY | GENE-EXPRESSION | B KINASE | PHARMACOLOGY & PHARMACY | INFECTION | Mitogen-Activated Protein Kinase Kinases - genetics | Nitriles - pharmacology | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Influenza, Human - enzymology | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Sulfones - pharmacology | Extracellular Signal-Regulated MAP Kinases - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Influenza, Human - virology | Orthomyxoviridae - drug effects | Cytokines - genetics | Cell Line | Influenza, Human - metabolism | Virus Replication - drug effects | Antiviral Agents - pharmacology | NF-kappa B - antagonists & inhibitors | Proto-Oncogene Proteins c-raf - genetics | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Down-Regulation - drug effects | Enzyme Activation - drug effects | Proto-Oncogene Proteins c-raf - metabolism | Animals | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | Influenza, Human - genetics | Orthomyxoviridae - genetics | Mice | Viral Load - drug effects | Cytokines - biosynthesis | Orthomyxoviridae - physiology | Avian influenza viruses | Antiviral agents | Health aspects | Analysis | Influenza
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 22, pp. 5588 - 5598
Cell surface-associated proteolysis plays a crucial role in the migration of mononuclear phagocytes to sites of inflammation. The glycolytic enzyme enolase-1... 
HUMAN PERIPHERAL MONOCYTES | FOAM CELL | FIBRINOLYTIC COMPONENTS | HISTONE H2B | ALPHA-ENOLASE | ENDOTHELIAL-CELLS | ANNEXIN-II | CELL-SURFACE | MATRIX INVASION | INDUCED MIGRATION | HEMATOLOGY | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Pneumonia - pathology | Monocytes - metabolism | Phosphopyruvate Hydratase - metabolism | Plasminogen - metabolism | Protein Transport - drug effects | DNA-Binding Proteins - metabolism | Chemotaxis, Leukocyte - genetics | Chemotaxis, Leukocyte - drug effects | Phosphopyruvate Hydratase - genetics | Protein Processing, Post-Translational - drug effects | Plasminogen - pharmacology | U937 Cells | Tumor Suppressor Proteins - genetics | Antigens, Surface - metabolism | Biomarkers, Tumor - metabolism | Pneumonia - immunology | Biomarkers, Tumor - antagonists & inhibitors | Phosphopyruvate Hydratase - physiology | Acute Disease | Cell Adhesion - genetics | DNA-Binding Proteins - physiology | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Cells, Cultured | Phosphopyruvate Hydratase - antagonists & inhibitors | Biomarkers, Tumor - physiology | Cell Adhesion - drug effects | DNA-Binding Proteins - genetics | Antibodies - pharmacology | Monocytes - drug effects | Tumor Suppressor Proteins - physiology | Animals | Lipopolysaccharides - pharmacology | Biomarkers, Tumor - genetics | Mice | Mice, Inbred BALB C
Journal Article