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Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2287 - 12
Journal Article
Molecular Cancer, ISSN 1476-4598, 04/2017, Volume 16, Issue 1, pp. 86 - 15
Background: Enhancing the antitumor activity of the DNA-damaging drugs is an attractive strategy to improve current treatment options. Trabectedin is an... 
PARP1 inhibitors | DNA-damaging agents | Bone and soft tissue sarcomas | Predictive biomarkers | Olaparib | Trabectedin | Drug synergism | POLY(ADP-RIBOSE) POLYMERASE | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | OLAPARIB MAINTENANCE THERAPY | EWING SARCOMA | BREAST-CANCER | ONCOLOGY | ADP-RIBOSE POLYMERASE | HOMOLOGOUS RECOMBINATION | VELIPARIB ABT-888 | REFRACTORY SOLID TUMORS | PHASE-I | DNA Damage - drug effects | Piperazines - administration & dosage | Phthalazines - administration & dosage | Apoptosis - drug effects | Humans | Tetrahydroisoquinolines - administration & dosage | Sarcoma - drug therapy | Sarcoma - pathology | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Comparative Genomic Hybridization | Dioxoles - administration & dosage | Cell Line, Tumor | Biomarkers, Tumor - genetics | Mice | Gene Expression Regulation, Neoplastic - drug effects | Sarcoma - genetics | Poly (ADP-Ribose) Polymerase-1 - genetics | Drugs | Biotechnology | Animal models | Profiling | DNA damage | Lung cancer | Hybridization | Kinases | DNA repair | Synergism | Alkylation | Anticancer properties | Biomedical materials | Pathways | Osteosarcoma | Rodents | Xenografts | Cell cycle | Biocompatibility | Bioindicators | Damage | Deoxyribonucleic acid--DNA | Enzymes | Sarcoma | Tumor cells | Breast cancer | Gene expression | Polymerase chain reaction | Poly(ADP-ribose) Polymerase 1 | Chemotherapy | Inhibitors | Cell death | Cell lines | Biomarkers | Antitumor activity | In vitro methods and tests | Apoptosis
Journal Article
GENOME MEDICINE, ISSN 1756-994X, 06/2019, Volume 11, Issue 1, pp. 42 - 22
BackgroundNeoantigens that arise as a consequence of tumor-specific mutations can be recognized by T lymphocytes leading to effective immune surveillance. In... 
HUMAN COLON | MUTATIONAL SIGNATURES | DRUG-SENSITIVITY | Immune response | Mutational signature | MICROSATELLITE INSTABILITY | Colorectal cancer | DNA repair | GENOMIC LANDSCAPE | EVOLUTION | GENETICS & HEREDITY | RESISTANCE | GENERATION | EGFR BLOCKADE | Neoantigen | XENOGRAFTS | Antigens | Care and treatment | Cancer patients | Gene mutations | Genetic aspects | Research | Health aspects
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 08/2012, Volume 32, Issue 15, pp. 3081 - 3094
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
LKB1-AMPK PATHWAY | BREAST-CANCER | SOLID-TUMOR | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COUPLED RECEPTORS | HYDRATASE | GROWTH-FACTOR | RENAL-CANCER | DEFICIENT CELLS | CANCER-THERAPY | CELL BIOLOGY | AMP-Activated Protein Kinases - metabolism | Kidney Neoplasms - genetics | Humans | Fumarate Hydratase - deficiency | AMP-Activated Protein Kinases - deficiency | Fumarate Hydratase - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Tumor Suppressor Proteins - deficiency | Mitogen-Activated Protein Kinase 3 - biosynthesis | Tumor Suppressor Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Neoplastic Syndromes, Hereditary - genetics | Cell Line | Tumor Suppressor Proteins - metabolism | Signal Transduction | Fumarate Hydratase - genetics | Reactive Oxygen Species - analysis | Mitogen-Activated Protein Kinase 1 - biosynthesis | Uterine Neoplasms | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Skin Neoplasms | Fumarates - metabolism | Mice | RNA, Small Interfering | Leiomyomatosis - genetics | AMP-Activated Protein Kinases - genetics | Apoptosis | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2013, Volume 319, Issue 17, pp. 2627 - 2636
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2018, Volume 34, Issue 1, pp. 148 - 162.e7
Targeting HER2 is effective in 24% of amplified metastatic colorectal cancer; however, secondary resistance occurs in most of the cases. We studied the... 
trastuzumab | targeted therapy | rapid autopsy | colorectal cancer | clonal evolution | HER2 amplification | lapatinib | liquid biopsy | ctDNA | resistance | BREAST-CANCER | HETEROGENEITY | PIK3CA MUTATIONS | THERAPY | AMPLIFICATION | SOLID TUMORS | GENE | ONCOLOGY | ACQUIRED-RESISTANCE | EGFR BLOCKADE | PATHOLOGICAL COMPLETE RESPONSE | CELL BIOLOGY | Predictive Value of Tests | ras Proteins - genetics | Liquid Biopsy | Class I Phosphatidylinositol 3-Kinases - genetics | Receptor, ErbB-2 - genetics | Colorectal Neoplasms - genetics | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Tomography, X-Ray Computed | Protein Kinase Inhibitors - adverse effects | Time Factors | DNA Mutational Analysis | Clinical Decision-Making | Colorectal Neoplasms - drug therapy | Female | Adenocarcinoma - genetics | Receptor, ErbB-2 - antagonists & inhibitors | Tumor Cells, Cultured | Liver Neoplasms - secondary | Lapatinib - adverse effects | Liver Neoplasms - genetics | Risk Factors | Liver Neoplasms - drug therapy | Trastuzumab - adverse effects | Mice, Transgenic | Treatment Outcome | Colorectal Neoplasms - diagnostic imaging | Trastuzumab - administration & dosage | Mice, SCID | Adenocarcinoma - drug therapy | Liver Neoplasms - diagnostic imaging | Adenocarcinoma - secondary | Disease Progression | Magnetic Resonance Imaging | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Animals | Gene Amplification | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Progression-Free Survival | Italy | Mice, Inbred NOD | Adenocarcinoma - diagnostic imaging | Colorectal Neoplasms - pathology | Lapatinib - administration & dosage | Genetic research | Genetic aspects | Metastasis | Analysis | Colorectal cancer | Cancer
Journal Article
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 11/2005, Volume 14, Issue 21, pp. 3263 - 3269
The genes encoding succinate dehydrogenase (SDH) subunits B, C and D, act as tumour suppressors in neuro-endocrine tissues. Tumour formation has been... 
RESPIRATORY-CHAIN | CELLS | GENE | HIF | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | HEREDITARY PARAGANGLIOMA | COMPLEX II | MUTATIONS | TUMOR-GROWTH | DEHYDROGENASE
Journal Article
Cancer Research, ISSN 0008-5472, 04/2010, Volume 70, Issue 8 Supplement, pp. 215 - 215
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 04/2010, Volume 70, Issue 8 Supplement, pp. LB-259 - LB-259
Journal Article