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1. Full Text The Thought of Death and the Memory of War
by Marc Crépon
2013, ISBN 081668006X, 184
Death | War | Sociology | Philosophy | Movements | PHILOSOPHY
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2. Full Text Oncogenic CSF3R Mutations in Chronic Neutrophilic Leukemia and Atypical CML
by Maxson, Julia E and Gotlib, Jason and Pollyea, Daniel A and Fleischman, Angela G and Agarwal, Anupriya and Eide, Christopher A and Bottomly, Daniel and Wilmot, Beth and McWeeney, Shannon K and Tognon, Cristina E and Pond, J. Blake and Collins, Robert H and Goueli, Basem and Oh, Stephen T and Deininger, Michael W and Chang, Bill H and Loriaux, Marc M and Druker, Brian J and Tyner, Jeffrey W
The New England journal of medicine, ISSN 0028-4793, 05/2013, Volume 368, Issue 19, pp. 1781 - 1790
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | General aspects | Medical sciences | Leukemia, Neutrophilic, Chronic - diagnosis | Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative - diagnosis | Humans | Janus Kinases - antagonists & inhibitors | Animals | Receptors, Colony-Stimulating Factor - genetics | Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative - genetics | Signal Transduction - physiology | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Leukemia, Neutrophilic, Chronic - genetics | Mutation | Leukemia, Lymphoid - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | Dasatinib | Care and treatment | Gene mutations | Causes of | Genetic aspects | Dosage and administration | Chronic myeloid leukemia | Diagnosis | Research | Drug therapy | Health aspects | Oncogenes | Tyrosine | BCR protein | Transformation | Myeloid leukemia | Colonies | Leukemia | Colleges & universities | Leukocytes (neutrophilic) | Patients | Lymphoma | Bone marrow | Janus kinase | Colony-stimulating factor | Protein-tyrosine kinase | Adapter proteins | Tumors | Index Medicus | Abridged Index Medicus
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3. Full Text Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia
by Bicocca, Vincent T and Chang, Bill H and Masouleh, Behzad Kharabi and Muschen, Markus and Loriaux, Marc M and Druker, Brian J and Tyner, Jeffrey W
Cancer cell, ISSN 1535-6108, 11/2012, Volume 22, Issue 5, pp. 656 - 667
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Dasatinib | Translocation, Genetic | Phosphorylation | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Gene Silencing | Pyrimidines - pharmacology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Receptor Tyrosine Kinase-like Orphan Receptors - physiology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Chromosomes, Human, Pair 19 | Chromosomes, Human, Pair 1 | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Pre-B Cell Receptors - metabolism | Developmental biology | Lymphomas | Index Medicus
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4. Full Text Mast cell sarcoma with concurrent mast cell leukaemia
by Raymond, Lauren M and Funk, Tracy and Braziel, Rita M and Fan, Guang and Gatter, Ken and Loriaux, Marc and Dunlap, Jennifer and Raess, Philipp W
British journal of haematology, ISSN 0007-1048, 05/2020, Volume 189, Issue 4, pp. e160 - e164
Life Sciences & Biomedicine | Hematology | Science & Technology | Sarcoma | Leukemia | Index Medicus
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5. Full Text Multiplex high-throughput gene mutation analysis in acute myeloid leukemia
by Dunlap, Jennifer, MD and Beadling, Carol, PhD and Warrick, Andrea, BS and Neff, Tanaya, MS and Fleming, William H., MD, PhD and Loriaux, Marc, MD, PhD and Heinrich, Michael C., MD, PhD and Kovacsovics, Tibor, MD and Kelemen, Katalin, MD, PhD and Leeborg, Nicky, MD and Gatter, Ken, MD and Braziel, Rita M., MD and Press, Richard, MD, PhD and Corless, Christopher L., MD, PhD and Fan, Guang, MD, PhD
Human pathology, ISSN 0046-8177, 2012, Volume 43, Issue 12, pp. 2167 - 2176
Pathology | Genetics | Molecular | Gene mutation | Acute myeloid leukemia | Life Sciences & Biomedicine | Science & Technology | Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Investigative techniques, diagnostic techniques (general aspects) | Medical sciences | Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques | Multiplex Polymerase Chain Reaction - methods | Prognosis | Humans | Middle Aged | Male | DNA Mutational Analysis - methods | fms-Like Tyrosine Kinase 3 - genetics | High-Throughput Screening Assays | Female | Proto-Oncogene Proteins c-kit - genetics | Biomarkers, Tumor - genetics | CCAAT-Enhancer-Binding Proteins - genetics | Nuclear Proteins - genetics | Leukemia, Myeloid, Acute - genetics | Molecular genetics | Gene mutations | Analysis | Oncology, Experimental | Genes | Genetic research | Cytogenetics | Genetic aspects | Research | Cancer | Studies | Pathogenesis | Leukemia | Classification | Clinical trials | Mutation | Kinases | Gene expression | Blood | Deoxyribonucleic acid--DNA | Index Medicus
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6. Full Text A cis-regulatory map of the Drosophila genome
by NĂ©gre, Nicolas and Brown, Christopher D and Ma, Lijia and Bristow, Christopher Aaron and Miller, Steven W and Wagner, Ulrich and Kheradpour, Pouya and Eaton, Matthew L and Loriaux, Paul and Sealfon, Rachel and Li, Zirong and Ishii, Haruhiko and Spokony, Rebecca F and Chen, Jia and Hwang, Lindsay and Cheng, Chao and Auburn, Richard P and Davis, Melissa B and Domanus, Marc and Shah, Parantu K and Morrison, Carolyn A and Zieba, Jennifer and Suchy, Sarah and Senderowicz, Lionel and Victorsen, Alec and Bild, Nicholas A and Grundstad, A. Jason and Hanley, David and MacAlpine, David M and Mannervik, Mattias and Venken, Koen and Bellen, Hugo and White, Robert and Gerstein, Mark and Russell, Steven and Grossman, Robert L and Ren, Bing and Posakony, James W and Kellis, Manolis and White, Kevin P
Nature (London), ISSN 0028-0836, 03/2011, Volume 471, Issue 7339, pp. 527 - 531
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Chromatin. Chromosome | Molecular and cellular biology | Molecular genetics | Chromatin - metabolism | Insulator Elements - genetics | Reproducibility of Results | Molecular Sequence Annotation | Silencer Elements, Transcriptional - genetics | Genome, Insect - genetics | Chromatin Assembly and Disassembly | Histone Deacetylases - metabolism | Drosophila melanogaster - genetics | Promoter Regions, Genetic - genetics | Regulatory Sequences, Nucleic Acid - genetics | Transcription Factors - metabolism | Animals | Chromatin Immunoprecipitation | Enhancer Elements, Genetic - genetics | Embryonic development | Drosophila | Physiological aspects | Genetic aspects | Models | DNA binding proteins | Research | Genomes | RNA polymerase | Insects | Gene expression | Apoptosis | Index Medicus
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7. Full Text AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance
by O'Hare, Thomas and Shakespeare, William C and Zhu, Xiaotian and Eide, Christopher A and Rivera, Victor M and Wang, Frank and Adrian, Lauren T and Zhou, Tianjun and Huang, Wei-Sheng and Xu, Qihong and Metcalf, Chester A and Tyner, Jeffrey W and Loriaux, Marc M and Corbin, Amie S and Wardwell, Scott and Ning, Yaoyu and Keats, Jeffrey A and Wang, Yihan and Sundaramoorthi, Raji and Thomas, Mathew and Zhou, Dong and Snodgrass, Joseph and Commodore, Lois and Sawyer, Tomi K and Dalgarno, David C and Deininger, Michael W.N and Druker, Brian J and Clackson, Tim
Cancer cell, ISSN 1535-6108, 2009, Volume 16, Issue 5, pp. 401 - 412
CHEMBIO | HUMDISEASE | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Imidazoles - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Crystallography, X-Ray | Pyridazines - pharmacology | Protein Kinase Inhibitors - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Antineoplastic Agents - pharmacology | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Proto-Oncogene Proteins c-abl - genetics | Cell Growth Processes - drug effects | Proto-Oncogene Proteins c-abl - chemistry | Models, Molecular | Imidazoles - pharmacology | Antineoplastic Agents - chemistry | Mice, SCID | Pyridazines - chemistry | Fusion Proteins, bcr-abl - genetics | Animals | Signal Transduction - drug effects | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Proto-Oncogene Proteins c-abl - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Fusion Proteins, bcr-abl - metabolism | Chronic myeloid leukemia | BCR protein | Imatinib | Mutagenesis | Abl protein | Mutation | Fusion protein | Tumors | Index Medicus | imatinib resistance | dasatinib | nilotinib | compound mutation
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8. Full Text Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening
by Tyner, Jeffrey and Yang, Wayne and Bankhead, Armand and Fan, Guang and Fletcher, Luke and Bryant, Jade and Glover, Jason and Chang, Bill and Spurgeon, Stephen and Fleming, William and Kovacsovics, T and Gotlib, Jason and Oh, Stephen and Deininger, Michael W and Zwaan, Michel and Boer, Monique and Heuvel-Eibrink, Marry and O'Hare, Thomas and ker, Brian and Loriaux, Marc
Cancer research (Chicago, Ill.), ISSN 0008-5472, 01/2013, Volume 73, Issue 1, pp. 285 - 296
Life Sciences & Biomedicine | Oncology | Science & Technology | Hematologic and hematopoietic diseases | Pharmacology. Drug treatments | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | Drug Resistance, Neoplasm - genetics | Protein-Tyrosine Kinases - genetics | Algorithms | Humans | Leukemia - enzymology | Gene Expression Profiling - methods | Signal Transduction - genetics | Leukemia - genetics | Cluster Analysis | Index Medicus | AML | ALL | CLL | CML | CMML | MPN | molecular diagnosis | personalized medicine
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9. Full Text Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies
by Gozgit, Joseph M and Wong, Matthew J and Wardwell, Scott and Tyner, Jeffrey W and Loriaux, Marc M and Mohemmad, Qurish K and Narasimhan, Narayana I and Shakespeare, William C and Wang, Frank and Druker, Brian J and Clackson, Tim and Rivera, Victor M
Molecular cancer therapeutics, ISSN 1535-7163, 06/2011, Volume 10, Issue 6, pp. 1028 - 1035
Life Sciences & Biomedicine | Oncology | Science & Technology | Apoptosis - drug effects | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Hematologic Neoplasms - enzymology | Hematologic Neoplasms - pathology | Pyridazines - pharmacology | Proto-Oncogene Proteins c-kit - metabolism | Leukemia, Myeloid, Acute - enzymology | Leukemia, Myeloid, Acute - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Phosphorylation - drug effects | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Leukemia, Myeloid, Acute - pathology | Imidazoles - pharmacology | Mice, SCID | Receptor Protein-Tyrosine Kinases - metabolism | fms-Like Tyrosine Kinase 3 - metabolism | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Hematologic Neoplasms - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Index Medicus
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10. Full Text CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
by Lannutti, Brian J and Meadows, Sarah A and Herman, Sarah E. M and Kashishian, Adam and Steiner, Bart and Johnson, Amy J and Byrd, John C and Tyner, Jeffrey W and Loriaux, Marc M and Deininger, Mike and Druker, Brian J and Puri, Kamal D and Ulrich, Roger G and Giese, Neill A
Blood, ISSN 0006-4971, 01/2011, Volume 117, Issue 2, pp. 591 - 594
Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Biological and medical sciences | Medical sciences | Lymphoid Neoplasia | Brief Report
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11. Full Text Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
by Corbin, Amie S and Agarwal, Anupriya and Loriaux, Marc and Cortes, Jorge and Deininger, Michael W and Druker, Brian J
The Journal of clinical investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 396 - 409
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Cell Survival - drug effects | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Drug Resistance, Neoplasm | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Neoplastic Stem Cells - metabolism | Models, Biological | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Fusion Proteins, bcr-abl - antagonists & inhibitors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Benzamides | In Vitro Techniques | Cytokines - pharmacology | Stem cells | Physiological aspects | Genetic aspects | Research | Chronic myeloid leukemia | Drug therapy | Oncogenes | Index Medicus | Abridged Index Medicus
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12. Full Text Functional genomic landscape of acute myeloid leukaemia
by Tyner, Jeffrey W and Tognon, Cristina E and Bottomly, Daniel and Wilmot, Beth and Kurtz, Stephen E and Savage, Samantha L and Long, Nicola and Schultz, Anna Reister and Traer, Elie and Abel, Melissa and Agarwal, Anupriya and Blucher, Aurora and Borate, Uma and Bryant, Jade and Burke, Russell and Carlos, Amy and Carpenter, Richie and Carroll, Joseph and Chang, Bill H and Coblentz, Cody and d’Almeida, Amanda and Cook, Rachel and Danilov, Alexey and Dao, Kim-Hien T and Degnin, Michie and Devine, Deirdre and Dibb, James and Edwards, David K and Eide, Christopher A and English, Isabel and Glover, Jason and Henson, Rachel and Ho, Hibery and Jemal, Abdusebur and Johnson, Kara and Johnson, Ryan and Junio, Brian and Kaempf, Andy and Leonard, Jessica and Lin, Chenwei and Liu, Selina Qiuying and Lo, Pierrette and Loriaux, Marc M and Luty, Samuel and Macey, Tara and MacManiman, Jason and Martinez, Jacqueline and Mori, Motomi and Nelson, Dylan and Nichols, Ceilidh and Peters, Jill and Ramsdill, Justin and Rofelty, Angela and Schuff, Robert and Searles, Robert and Segerdell, Erik and Smith, Rebecca L and Spurgeon, Stephen E and Sweeney, Tyler and Thapa, Aashis and Visser, Corinne and Wagner, Jake and Watanabe-Smith, Kevin and Werth, Kristen and Wolf, Joelle and White, Libbey and Yates, Amy and Zhang, Haijiao and Cogle, Christopher R and Collins, Robert H and Connolly, Denise C and Deininger, Michael W and Drusbosky, Leylah and Hourigan, Christopher S and Jordan, Craig T and Kropf, Patricia and Lin, Tara L and Martinez, Micaela E and Medeiros, Bruno C and Pallapati, Rachel R and Pollyea, Daniel A and Swords, Ronan T and Watts, Justin M and Weir, Scott J and Wiest, David L and Winters, Ryan M and McWeeney, Shannon K and Druker, Brian J
Nature (London), ISSN 0028-0836, 10/2018, Volume 562, Issue 7728, pp. 526 - 531
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Datasets as Topic | Genomics | Humans | Leukemia, Myeloid, Acute - metabolism | Repressor Proteins - genetics | Male | Proto-Oncogene Proteins - genetics | Molecular Targeted Therapy | Serine-Arginine Splicing Factors - genetics | Genome, Human - genetics | DNA (Cytosine-5-)-Methyltransferases - genetics | Exome - genetics | Sequence Analysis, RNA | Leukemia, Myeloid, Acute - drug therapy | Female | Nuclear Proteins - genetics | Core Binding Factor Alpha 2 Subunit - genetics | Gene Expression Regulation, Neoplastic - genetics | Leukemia, Myeloid, Acute - genetics | RNA sequencing | Medical research | Usage | Gene mutations | Myelocytic leukemia | Medicine, Experimental | Genetic aspects | Nonlymphoid leukemia | Research | Discriminant analysis | Sensitivity analysis | Leukemia | Principal components analysis | Pharmacology | Genomes |