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Disaster Medicine and Public Health Preparedness, ISSN 1935-7893, 12/2019, pp. 1 - 2
ABSTRACT Hurricane Dorian’s impact on Eastern North Carolina and the Bahamas islands demonstrate the devastation and public health needs that can be left in... 
Journal Article
Japan Medical Association journal : JMAJ, ISSN 1346-8650, 07/2016, Volume 59, Issue 1, p. 38
Journal Article
Japan Medical Association Journal, ISSN 1346-8650, 07/2016, Volume 59, Issue 1, pp. 38 - 40
Journal Article
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 12/2012, Volume 61, Issue 5, pp. 593 - 593
Phase 0 studies can provide initial pharmacokinetics (PKs) data in humans and help to facilitate early drug development, but their predictive value for... 
Journal Article
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 12/2012, Volume 61, Issue 5, pp. 593 - 599
OBJECTIVE:Phase 0 studies can provide initial pharmacokinetics (PKs) data in humans and help to facilitate early drug development, but their predictive value... 
Tenofovir-diphosphate | Microdose | Pharmacokinetics | INFECTIOUS DISEASES | ACTIVATION | VIRUS | IMMUNOLOGY | ACCELERATOR MASS-SPECTROMETRY | BLOOD MONONUCLEAR-CELLS | NUCLEOTIDES | METABOLISM | PHARMACOLOGY | tenofovir-diphosphate | pharmacokinetics | microdose | LAMIVUDINE-TRIPHOSPHATE | SAMPLES | SOLID-PHASE EXTRACTION | Phosphorylation | Reverse Transcriptase Inhibitors - blood | Humans | Middle Aged | Zidovudine - pharmacokinetics | Biological Availability | Male | Reverse Transcriptase Inhibitors - administration & dosage | Zidovudine - administration & dosage | Adenine - blood | Anti-HIV Agents - administration & dosage | Tenofovir | Dideoxynucleotides - pharmacokinetics | Reverse Transcriptase Inhibitors - pharmacokinetics | Dideoxynucleotides - blood | Mass Spectrometry | Adult | Female | Organophosphonates - blood | Anti-HIV Agents - blood | Adenine - analogs & derivatives | CD4-Positive T-Lymphocytes - metabolism | Thymine Nucleotides - blood | Adenine - pharmacokinetics | Adenine - administration & dosage | Organophosphonates - pharmacokinetics | Organophosphonates - administration & dosage | Anti-HIV Agents - pharmacokinetics | Zidovudine - analogs & derivatives | Dideoxynucleotides - administration & dosage | Thymine Nucleotides - administration & dosage | Thymine Nucleotides - pharmacokinetics | Zidovudine - blood | Carbon Radioisotopes | Tenofovir diphosphate
Journal Article
Journal Article
Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 12/2012, Volume 61, Issue 5, p. 593
  Phase 0 studies can provide initial pharmacokinetics (PKs) data in humans and help to facilitate early drug development, but their predictive value for... 
Antiretroviral drugs | Phosphorylation | Human immunodeficiency virus--HIV | Mass spectrometry | Cells
Journal Article
Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 01/2012, Volume 59, Issue 1, p. 10
Describing the distribution and clearance of HIV surrogates within the gastrointestinal tract to inform rectal microbicide development. Radiolabeled simulated... 
Homosexuality | Simulation | Human immunodeficiency virus--HIV | Sexual behavior | Men
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e23136
Background: Measurement of immune mediators and antimicrobial activity in female genital tract secretions may provide biomarkers predictive of risk for HIV-1... 
TRIAL | EPITHELIAL-CELLS | REPRODUCTIVE-TRACT | CHLAMYDIA-TRACHOMATIS | ACQUISITION | BIOLOGY | DOUBLE-BLIND | HIV-1 INFECTION | LEUKOCYTE PROTEASE INHIBITOR | BACTERIAL VAGINOSIS | IMMUNE MEDIATORS | HIV Infections - prevention & control | Cervix Uteri - metabolism | Cytokines - analysis | Humans | Secretory Leukocyte Peptidase Inhibitor - analysis | Vaginal Smears - methods | Young Adult | HIV Infections - immunology | HIV Infections - diagnosis | alpha-Defensins - analysis | Adult | Female | Genitalia, Female - metabolism | Cytokines - immunology | Risk Factors | Biomarkers - analysis | Solubility | Specimen Handling - methods | Interleukin-8 - analysis | Mucous Membrane - metabolism | Vaginosis, Bacterial - immunology | HIV-1 - immunology | Cervix Uteri - microbiology | Therapeutic Irrigation - methods | alpha-Defensins - immunology | Analysis of Variance | Vaginosis, Bacterial - microbiology | Vagina - metabolism | Vagina - microbiology | Secretory Leukocyte Peptidase Inhibitor - immunology | Interleukin-8 - immunology | Polyethylene terephthalate | Excipients | Cytokines | Biological markers | Escherichia coli | Enzyme-linked immunosorbent assay | Pediatrics | Antimicrobial activity | Genital tract | Mucosa | Clinical trials | Infections | Family medical history | Antiinfectives and antibacterials | Recovery | Vaginosis | Cell adhesion & migration | Eluents | E coli | Protein folding | Human immunodeficiency virus--HIV | Antiviral activity | Antiretroviral drugs | Medical research | Immunoglobulins | Polypeptides | Saline water | Dacron | Gynecology | Health risks | Vagina | Antimicrobial agents | Bioavailability | Secretions | Obstetrics | Medicine | Dilution | Biomarkers | Collection | Sampling methods | Methods | Chemokines | Diluents | HIV | Human immunodeficiency virus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 1, p. e16475
Background: Preclinical and early phase clinical microbicide studies have not consistently predicted the outcome of efficacy trials. To address this gap,... 
VAGINAL FLUID | LAMIVUDINE | TRANSMISSION | ASSAY | SAFETY | MICROBICIDE | MULTIDISCIPLINARY SCIENCES | SIMPLEX-VIRUS INFECTION | ADHERENCE | Anti-HIV Agents - pharmacology | Humans | Anti-HIV Agents - administration & dosage | Immunity, Mucosal - drug effects | Tenofovir | Young Adult | HIV Infections - immunology | Genitalia, Female - secretion | Vaginal Douching | Drug-Related Side Effects and Adverse Reactions | Adult | Female | Mucous Membrane - drug effects | Adenine - immunology | Adenine - analogs & derivatives | Double-Blind Method | Semen | Genitalia, Female - immunology | Biomarkers - analysis | Adenine - pharmacology | Genitalia, Female - drug effects | Organophosphonates - immunology | Adenine - administration & dosage | Organophosphonates - administration & dosage | Organophosphonates - pharmacology | Mucous Membrane - immunology | HIV Infections - drug therapy | Anti-HIV Agents - immunology | Clinical trials | Prognosis | Research | HIV (Viruses) | Escherichia coli | Pediatrics | Antimicrobial activity | Mucosal immunity | Genital tract | Mucosa | Inflammatory response | Viruses | Infections | Immunity | Epidemiology | Randomization | Immunology | E coli | Human immunodeficiency virus--HIV | Spectrum analysis | Antiviral activity | Mathematical models | Bioindicators | Safety | Drug dosages | Antiretroviral drugs | Pharmacodynamics | Effectiveness | Bioassays | Migraine | Gynecology | Antimicrobial agents | Pharmacology | Inflammation | Secretions | Obstetrics | Chromatography | Medicine | Studies | Biomarkers | HIV | Human immunodeficiency virus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1
[...]gluconate adjusted cervicovaginal fluid volumes reported in the manuscript are incorrect and are not correctible. (2012) Correction: Performance of Swabs,... 
Biomarkers | Antiretroviral drugs | Genital tract | Mucosa | Diluents
Journal Article
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 05/2014, Volume 66, Issue 1, pp. 65 - 65
Surrogate markers of HIV-1 pre-exposure prophylaxis and microbicide efficacy are needed. One potential surrogate is the antiviral activity in cervicovaginal... 
Journal Article
Journal of acquired immune deficiency syndromes (1999), ISSN 1525-4135, 5/2014, Volume 66, Issue 1, pp. 65 - 73
Journal Article
Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 05/2014, Volume 66, Issue 1, p. 65
  Surrogate markers of HIV-1 pre-exposure prophylaxis and microbicide efficacy are needed. One potential surrogate is the antiviral activity in cervicovaginal... 
Proteins | Antiretroviral drugs | Correlation analysis | Human immunodeficiency virus--HIV | Herpes viruses | Mass spectrometry
Journal Article
01/2010, ISBN 9781124005973
Drugs for pre-exposure prophylaxis (PrEP) of HIV infection are being developed as an adjunctive measure to prevent sexual HIV transmission. HIV transmission... 
Pharmacology
Dissertation
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