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1. Full Text Spatial heterogeneity in medulloblastoma
by Morrissy, A. Sorana and Cavalli, Florence M. G and Remke, Marc and Ramaswamy, Vijay and Shih, David J. H and Holgado, Borja L and Farooq, Hamza and Donovan, Laura K and Garzia, Livia and Agnihotri, Sameer and Kiehna, Erin N and Mercier, Eloi and Mayoh, Chelsea and Papillon-Cavanagh, Simon and Nikbakht, Hamid and Gayden, Tenzin and Torchia, Jonathon and Picard, Daniel and Merino, Diana M and Vladoiu, Maria and Luu, Betty and Wu, Xiaochong and Daniels, Craig and Horswell, Stuart and Thompson, Yuan Yao and Hovestadt, Volker and Northcott, Paul A and Jones, David T. W and Peacock, John and Wang, Xin and Mack, Stephen C and Reimand, Jüri and Albrecht, Steffen and Fontebasso, Adam M and Thiessen, Nina and Li, Yisu and Schein, Jacqueline E and Lee, Darlene and Carlsen, Rebecca and Mayo, Michael and Tse, Kane and Tam, Angela and Dhalla, Noreen and Ally, Adrian and Chuah, Eric and Cheng, Young and Plettner, Patrick and Li, Haiyan I and Corbett, Richard D and Wong, Tina and Long, William and Loukides, James and Buczkowicz, Pawel and Hawkins, Cynthia E and Tabori, Uri and Rood, Brian R and Myseros, John S and Packer, Roger J and Korshunov, Andrey and Lichter, Peter and Kool, Marcel and Pfister, Stefan M and Schüller, Ulrich and Dirks, Peter and Huang, Annie and Bouffet, Eric and Rutka, James T and Bader, Gary D and Swanton, Charles and Ma, Yusanne and Moore, Richard A and Mungall, Andrew J and Majewski, Jacek and Jones, Steven J. M and Das, Sunit and Malkin, David and Jabado, Nada and Marra, Marco A and Taylor, Michael D
Nature Genetics, ISSN 1061-4036, 05/2017, Volume 49, Issue 5, pp. 780 - 788
Spatial heterogeneity of transcriptional and genetic markers between physically isolated biopsies of a single tumor poses major barriers to the identification... 
IN-VITRO | EVOLUTION | SOLID TUMORS | SUBTYPES | INTRATUMOR HETEROGENEITY | GROWTH | GENETICS & HEREDITY | EXPRESSION | RENAL-CELL CARCINOMA | T-CELLS | LYMPHOCYTES | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Transcriptome | Child, Preschool | Male | INDEL Mutation | DNA Copy Number Variations | Medulloblastoma - pathology | Aged, 80 and over | Adult | Female | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Child | Principal Component Analysis | Genome-Wide Association Study | Gene Expression Profiling - methods | Cerebellar Neoplasms - genetics | Reverse Transcriptase Polymerase Chain Reaction | Genetic Heterogeneity | Aged | Polymorphism, Single Nucleotide | Mutation | Cluster Analysis | Brain | Gene mutations | Biopsy | Medulloblastoma | Genetic aspects | Diagnosis | Health aspects | Methods | Pediatrics | Laboratories | Neuropathology | Brain cancer | Colleges & universities | Oncology | Genomes | Biology | Neurosurgery | Consortia | Heterogeneity | Immunology | Renal cell carcinoma | Genetics | Bioindicators | Research centers | Medical research | Hematology | Gene expression | Children & youth | Genetic markers | Hospitals | Glioma | Biomarkers | Tumors | Index Medicus | Spatial heterogeneity | glioblastoma multiforme | renal cell carcinoma | gene expression profiling | medulloblastoma | whole exome sequencing
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2. Full Text TMOD-10. MOLECULAR CHARACTERIZATION OF A NOVEL HUMAN CLIVAL CHORDOMA XENOGRAFT MODEL DEMONSTRATES INHERENT TUMOR GENOMIC INSTABILITY
by Haider, Ali and Diaz, Roberto Jose and Luck, Amanda and Sabha, Nesrin and Bondoc, Andrew and Golbourn, Brian and Picard, Daniel and Remke, Marc and Loukides, James and Smith, Christian and Cusimano, Michael and Rutka, James
Neuro-Oncology, ISSN 1522-8517, 11/2017, Volume 19, Issue suppl_6, pp. vi256 - vi256
Patient-derived xenografts (PDXs) retain the genotype of the parental tumors more readily than tumor cells maintained in culture. In order to study the... 
Abstracts
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3. Full Text Characterization of a Clival Chordoma Xenograft Model Reveals Tumor Genomic Instability
by Diaz, Roberto J and Luck, Amanda and Bondoc, Andrew and Golbourn, Brian and Picard, Daniel and Remke, Marc and Loukides, James and Sabha, Nesrin and Smith, Christian and Cusimano, Michael D and Rutka, James T
The American Journal of Pathology, ISSN 0002-9440, 12/2018, Volume 188, Issue 12, pp. 2902 - 2911
Patient-derived xenografts retain the genotype of the parent tumors more readily than tumor cells maintained in culture. The two previously reported clival... 
FHIT GENE | BRACHYURY | SURVIVAL PATTERNS | GENERATION | EXPRESSION PATTERN | PATHOLOGY | ESTABLISHMENT | CELL
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4. Full Text Therapeutic and prognostic implications of BRAF V600E in pediatric low-grade gliomas
by Lassaletta, Alvaro and Zapotocky, Michal and Mistry, Matthew and Ramaswamy, Vijay and Honnorat, Marion and Krishnatry, Rahul and Stucklin, Ana Guerreiro and Zhukova, Nataliya and Arnoldo, Anthony and Ryall, Scott and Ling, Catriona and McKeown, Tara and Loukides, Jim and Cruz, Ofelia and De Torres, Carmen and Ho, Cheng-Ying and Packer, Roger J and Tatevossian, Ruth and Qaddoumi, Ibrahim and Harreld, Julie H and Dalton, James D and Mulcahy-Levy, Jean and Foreman, Nicholas and Karajannis, Matthias A and Wang, Shiyang and Snuderl, Matija and Rao, Amulya Nageswara and Giannini, Caterina and Kieran, Mark and Ligon, Keith L and Garre, Maria Luisa and Nozza, Paolo and Mascelli, Samantha and Raso, Alessandro and Mueller, Sabine and Nicolaides, Theodore and Silva, Karen and Perbet, Romain and Vasiljevic, Alexandre and Conter, Cécile Faure and Frappaz, Didier and Leary, Sarah and Crane, Courtney and Chan, Aden and Ng, Ho-Keung and Shi, Zhi-Feng and Mao, Ying and Finch, Elizabeth and Eisenstat, David and Wilson, Bev and Carret, Anne Sophie and Hauser, Peter and Sumerauer, David and Krskova, Lenka and Larouche, Valerie and Fleming, Adam and Zelcer, Shayna and Jabado, Nada and Rutka, James T and Dirks, Peter and Taylor, Michael D and Chen, Shiyi and Bartels, Ute and Huang, Annie and Ellison, David W and Bouffet, Eric and Hawkins, Cynthia and Tabori, Uri
Journal of Clinical Oncology, ISSN 0732-183X, 09/2017, Volume 35, Issue 25, pp. 2934 - 2941
Purpose BRAF V600E is a potentially highly targetable mutation detected in a subset of pediatric low-grade gliomas (PLGGs). Its biologic and clinical effect... 
ASTROCYTOMA | ONCOLOGY | RECURRENT | MUTATION | PHASE-II | STEM GANGLIOGLIOMA | CHILDHOOD | TUMORS | GENETIC ALTERATIONS | VEMURAFENIB | CHILDREN | Prognosis | Brain Stem Neoplasms - pathology | Humans | Brain Neoplasms - pathology | Child, Preschool | Infant | Male | Glioma - genetics | Neoplasm Grading | Glioma - pathology | Glioma - therapy | Female | Child | Diencephalon - pathology | Brain Stem Neoplasms - enzymology | Brain Neoplasms - enzymology | Glioma - enzymology | Brain Neoplasms - genetics | Diencephalon - enzymology | Brain Stem Neoplasms - genetics | Brain Stem Neoplasms - therapy | Proto-Oncogene Proteins B-raf - genetics | Adolescent | Brain Neoplasms - therapy | Mutation | Cohort Studies | Index Medicus | Original Reports
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5. Bash cookbook
by Albing, Carl and Vossen, J. P and Newham, Cameron
2007, 1st ed., ISBN 0596526784, xxi, 598
User interfaces (Computer systems) | UNIX Shells | UNIX (Computer file)
Book
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6. Full Text Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695
by M. Azhar Chishti and Dun-Shen Yang and Christopher Janus and Amie L. Phinney and Patrick Horne and Jacqueline Pearson and Robert Strome and Noah Zuker and James Loukides and Janet French and Sherry Turner and Gianluca Lozza and Mariagrazia Grilli and Suzanne Kunicki and Céline Morissette and Julie Paquette and Francine Gervais and Catherine Bergeron and Paul E. Fraser and George A. Carlson and Peter St. George-Hyslop and David Westaway
Journal of Biological Chemistry, ISSN 0021-9258, 06/2001, Volume 276, Issue 24, pp. 21562 - 21570
We have created early-onset transgenic (Tg) models by exploiting the synergistic effects of familial Alzheimer's disease mutations on amyloid β-peptide (Aβ)... 
NEUROFIBRILLARY TANGLES | CELLS | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | FAMILIAL ALZHEIMERS-DISEASE | A-BETA PEPTIDE | PLAQUES | NEURONAL LOSS | BRAIN | PRESENILIN-1 | Amyloid beta-Protein Precursor - chemistry | Humans | Male | Amyloid beta-Protein Precursor - analysis | Brain - growth & development | Restriction Mapping | Amyloid - analysis | Amyloidosis - genetics | Amyloid beta-Protein Precursor - metabolism | Aging | Female | Amyloid - genetics | Promoter Regions, Genetic | Mutagenesis, Site-Directed | Amyloidosis - pathology | Amyloidosis - psychology | Maze Learning - physiology | Mice, Inbred C57BL | Cognition Disorders - pathology | Mice, Transgenic | Cognition Disorders - genetics | Mice, Inbred C3H | Amyloid beta-Protein Precursor - genetics | Animals | Brain - pathology | Mice | Amino Acid Substitution | Crosses, Genetic | PrP gene | Index Medicus
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7. Full Text Abstract B35: BMP regulation of cancer stem cell quiescence is responsible for chemotherapeutic resistance in glioblastoma
by Wu, Megan YiJun and Celebre, Angela and Chan, Jeffrey and Guan, Jennifer and Dhand, Karan and Loukides, James and Karamchandani, Jason and Das, Sunit
Cancer Research, ISSN 0008-5472, 12/2015, Volume 75, Issue 23 Supplement, pp. B35 - B35
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8. Full Text Congress Calendar
Respiration, ISSN 0025-7931, 02/2000, Volume 67, Issue 1, pp. 115 - 116
Further Section
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9. Full Text A Comparison of the Cellular Electrophysiology of Mexiletine and Sotalol, Singly and Combined, in Canine Purkinje Fibers
by Berman, Neil D and Loukides, James E
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 09/1988, Volume 12, Issue 3, pp. 286 - 292
To determine if combinations of mexiletine and sotalol retain Class I and III electrophysiologic actions, using standard microelectrode techniques, we examined... 
Evoked Potentials - drug effects | Animals | Purkinje Fibers - drug effects | Sotalol - pharmacology | Mexiletine - pharmacology | Dogs | Heart Conduction System - drug effects | In Vitro Techniques | Action Potentials - drug effects | Purkinje Fibers - physiology | Index Medicus
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10. Head first EJB
by Sierra, Kathy and Bates, Bert
2003, 1st ed., ISBN 9780596005719, xxx, 700
Java (Computer program language) | Java (Langage de programmation)
Book
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11. Full Text The cellular electropharmacology of the simultaneous administration of propranolol and mexiletine: A class I and II antiarrhythmic drug combination
by Berman, Neil D and Loukides, James E
Journal of Electrocardiology, ISSN 0022-0736, 1987, Volume 20, Issue 5, pp. 297 - 302
The addition of propranolol to mexiletine may reduce the adverse effects of mexiletine and possibly increase its efficacy. We compared the cellular... 
Mexiletine - administration & dosage | Mexiletine - pharmacology | Mexiletine - pharmacokinetics | Male | Heart Conduction System - drug effects | Propranolol - pharmacokinetics | Dose-Response Relationship, Drug | Propranolol - pharmacology | Animals | Purkinje Fibers - drug effects | Propranolol - administration & dosage | Dogs | Female | Action Potentials - drug effects | Drug Combinations | Index Medicus
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12. Full Text Effects of Simultaneous Administration of Mexiletine and Quinidine on the Electrophysiologic Parameters of Canine Purkinje Fibers
by Burke, Graham H and Loukides, James E and Berman, Neil D
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 11/1986, Volume 8, Issue 6, pp. 1138 - 1143
SUMMARYThe electropharmacologic effects of an equimolar combination of mexiletine and quinidine on canine Purkinje action potential parameters were compared... 
Purkinje fibers | Electropharmacology | Mexiletine | Quinidine | Antiarrhthmic drugs | Mexiletine - pharmacology | Anti-Arrhythmia Agents - pharmacology | Male | Heart Conduction System - drug effects | Quinidine - pharmacology | Animals | Purkinje Fibers - drug effects | Dogs | Female | Blood Pressure - drug effects | Kinetics | In Vitro Techniques | Action Potentials - drug effects | Index Medicus
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13. Full Text Persistence of the electrophysiologic effects of mexiletine in canine Purkinje fibers alters the response to subsequent hypoxia
by Berman, Neil D and Ogilvie, Richard I and Loukides, James E
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 10/1987, Volume 65, Issue 10, pp. 2104 - 2109
The persistence of cellular electropharmacologic effects of mexiletine on canine Purkinje fibers was studied utilizing standard microelectrode techniques and... 
Animals | Purkinje Fibers - drug effects | Mexiletine - pharmacology | Oxygen - physiology | Dogs | Electrophysiology | Female | Male | Heart Conduction System - drug effects | Kinetics | Action Potentials - drug effects | Purkinje Fibers - physiology | Index Medicus
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14. A simple liver preparation orally effective in the treatment of human amyloid disease
by Loukides, James and Grayzel, Harold G and Jacobi, Mendel
The Journal of Laboratory and Clinical Medicine, ISSN 0022-2143, 08/1943, Volume 28, Issue 11, pp. 1321 - 1322
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15. R cookbook
by Teetor, Paul
2011, 1st ed., ISBN 9780596809157, xviii, 413
computer programs | Mathematical statistics | Multiple comparisons (Statistics) | mathematics | Data processing | R (Computer program language) | graphics | statistical analysis | Statistics | Graphic methods
Book
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16. Beyond the stars
by Loukides, Paul and Fuller, Linda K
1990, ISBN 9780879725181, v.
Motion pictures | Characters and characteristics in motion pictures
Book
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17. Full Text Unraveling the mysteries of the asthmatic airway epithelium
by Loukides, Stylianos and Bakakos, Petros
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 07/2018, Volume 59, Issue 1, pp. 9 - 10
Asthma encompasses a set of disease states of varying etiologies and phenotypes. Clinical and functional phenotypes are clearly associated with changes in the... 
ACTIVIN-A | RESPIRATORY SYSTEM | FOLLISTATIN | BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Follistatin-Related Proteins - metabolism | Epithelium - pathology | Lung - pathology | Animals | Humans | Asthma - therapy | Fibroblasts - pathology | Asthma - pathology | Allergens | Phenotypes | Smooth muscle | Infections | Inflammation | Epithelium | Allergies | Asthma | Respiratory tract | Proteins | Angiogenesis | Airway management | Collagen | Fibrosis | Fibroblasts | Extracellular matrix | Respiratory tract diseases | Pollutants | Activin | Index Medicus
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18. Full Text Lack of effect of sleep apnea on oxidative stress in obstructive sleep apnea syndrome (OSAS) patients
by Simiakakis, M and Kapsimalis, F and Chaligiannis, E and Loukides, S and Sitaras, N and Alchanatis, M
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, pp. e39172 - e39172
Purpose: The aim of this study was to evaluate markers of systemic oxidative stress and antioxidant capacity in subjects with and without OSAS in order to... 
OBESITY | IMPACT | LIPID-PEROXIDATION | BIOLOGY | CARDIOVASCULAR-DISEASE | DISORDER | MECHANISMS | BLOOD | Body Mass Index | Smoking - adverse effects | Sleep Apnea, Obstructive - physiopathology | Prognosis | Oxidation-Reduction | Oxidative Stress | Obesity - complications | Humans | Middle Aged | Risk Factors | Biomarkers - analysis | Male | Polysomnography | Case-Control Studies | Sex Factors | Hypertension - complications | Female | Hypertension | Antioxidants | Oxidative stress | Obesity | Medical research | Metabolites | Medicine, Experimental | Sleep apnea syndromes | Risk factors | Laboratories | Heart surgery | Sex | Lipids | Cardiovascular disease | Sleep apnea | Blood | Medical schools | Sleep disorders | Apnea | Oxidation | Desaturation | Stresses | Oxygen | Free radicals | Risk analysis | Patients | Stress | Morbidity | Medicine | Studies | Hospitals | Sleep | Hypoxia | Diabetes | Smoking | Index Medicus
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19. Full Text Medical Data Privacy Handbook
by Gkoulalas-Divanis, Aris and Loukides, Grigorios
2015, 1st ed. 2015, ISBN 3319236326, 854
This handbook covers Electronic Medical Record (EMR) systems, which enable the storage, management, and sharing of massive amounts of demographic, diagnosis,... 
Medical records | Computer Communications & Networking | Medical records_xData processing | Health Informatics | Systems and Data Security | Data Structures, Cryptology and Information Theory | Computer Science | Database Management | Medicine | Data protection | Medical informatics
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20. Full Text Towards precision medicine in severe asthma: Treatment algorithms based on treatable traits
by Papaioannou, Andriana I and Diamant, Zuzana and Bakakos, Petros and Loukides, Stelios
Respiratory Medicine, ISSN 0954-6111, 09/2018, Volume 142, pp. 15 - 22
Asthma is a common disease, and although its clinical manifestations may be similar among patients, recent research discoveries have shown that it consists of... 
Biomarkers | Phenotype | Endotype | Precision medicine | Biologics | Asthma | CARDIAC & CARDIOVASCULAR SYSTEMS | NON-EOSINOPHILIC ASTHMA | SPUTUM CELL COUNTS | ASPIRIN-INTOLERANT ASTHMA | RANDOMIZED CONTROLLED-TRIAL | CONTROLLED CLINICAL-TRIAL | RESPIRATORY SYSTEM | EXERCISE-INDUCED BRONCHOCONSTRICTION | SEVERE PERSISTENT ASTHMA | AIRWAY SMOOTH-MUSCLE | EXACERBATED RESPIRATORY-DISEASE | PLACEBO-CONTROLLED TRIAL | Severity of Illness Index | Algorithms | Leukotriene Antagonists - administration & dosage | Humans | Adrenergic beta-2 Receptor Agonists - administration & dosage | Asthma - therapy | Asthma - etiology | Adrenal Cortex Hormones - administration & dosage | Precision Medicine | Medical colleges | Medical research | Medicine, Experimental | Respiratory agents | Drug therapy | Phenotypes | Cytokines | Medical services | Inflammation | Patients | Medicine | Genotype & phenotype | Airway management | Immunology | Biopsy | Phenotyping | Population | Drug dosages | Index Medicus | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Lungmedicin och allergi | Klinisk medicin | Respiratory Medicine and Allergy
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