Nature Cell Biology, ISSN 1465-7392, 09/2017, Volume 19, Issue 9, pp. 1017 - 1026
Although normally dormant, hair follicle stem cells (HFSCs) quickly become activated to divide during a new hair cycle. The quiescence of HFSCs is known to be...
MORPHOGENESIS | MITOCHONDRIAL PYRUVATE CARRIER | METABOLISM | QUIESCENCE | C-MYC | NICHE | SKIN | INDUCTION | EXPRESSION | CYCLE | CELL BIOLOGY | L-Lactate Dehydrogenase - metabolism | Mitochondrial Membrane Transport Proteins - antagonists & inhibitors | Cellular Senescence - drug effects | Male | Glycolysis - drug effects | Mitochondrial Membrane Transport Proteins - genetics | Anion Transport Proteins - antagonists & inhibitors | Stem Cells - enzymology | Time Factors | Isoenzymes - metabolism | Acrylates - pharmacology | Female | Mitochondrial Membrane Transport Proteins - metabolism | Signal Transduction | Isoenzymes - genetics | Lactic Acid - metabolism | Mice, Inbred C57BL | Genotype | Hair Follicle - enzymology | Isoenzymes - deficiency | Anion Transport Proteins - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Hair Follicle - drug effects | Hair Follicle - cytology | Phenotype | Animals | L-Lactate Dehydrogenase - genetics | L-Lactate Dehydrogenase - deficiency | Stem Cells - drug effects | Cell Proliferation - drug effects | Anion Transport Proteins - genetics | Cell metabolism | Lactate dehydrogenase | Genetic aspects | Hair follicles | Health aspects | Stem cells | Hair | Dehydrogenases | Pyruvic acid | Epidermis | Activation | Myc protein | Dehydrogenase | Metabolism | L-Lactate dehydrogenase | Mitochondria | Cell activation | Clonal deletion | Glycolysis | Deletion | Lactic acid
MORPHOGENESIS | MITOCHONDRIAL PYRUVATE CARRIER | METABOLISM | QUIESCENCE | C-MYC | NICHE | SKIN | INDUCTION | EXPRESSION | CYCLE | CELL BIOLOGY | L-Lactate Dehydrogenase - metabolism | Mitochondrial Membrane Transport Proteins - antagonists & inhibitors | Cellular Senescence - drug effects | Male | Glycolysis - drug effects | Mitochondrial Membrane Transport Proteins - genetics | Anion Transport Proteins - antagonists & inhibitors | Stem Cells - enzymology | Time Factors | Isoenzymes - metabolism | Acrylates - pharmacology | Female | Mitochondrial Membrane Transport Proteins - metabolism | Signal Transduction | Isoenzymes - genetics | Lactic Acid - metabolism | Mice, Inbred C57BL | Genotype | Hair Follicle - enzymology | Isoenzymes - deficiency | Anion Transport Proteins - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Hair Follicle - drug effects | Hair Follicle - cytology | Phenotype | Animals | L-Lactate Dehydrogenase - genetics | L-Lactate Dehydrogenase - deficiency | Stem Cells - drug effects | Cell Proliferation - drug effects | Anion Transport Proteins - genetics | Cell metabolism | Lactate dehydrogenase | Genetic aspects | Hair follicles | Health aspects | Stem cells | Hair | Dehydrogenases | Pyruvic acid | Epidermis | Activation | Myc protein | Dehydrogenase | Metabolism | L-Lactate dehydrogenase | Mitochondria | Cell activation | Clonal deletion | Glycolysis | Deletion | Lactic acid
Journal Article
Brain Behavior and Immunity, ISSN 0889-1591, 10/2018, Volume 73, pp. 352 - 363
Exposure to stressors induces anxiety- and depressive-like behaviors, which are mediated, in part, by neuroinflammatory processes. Recent findings demonstrate...
Neuroinflammation | M. vaccae | Alarmin | Immunoregulation | Stress | Microglia | C-REACTIVE PROTEIN | SICKNESS RESPONSES | VENTRAL HIPPOCAMPUS | NLRP3 INFLAMMASOME | IMMUNOLOGY | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | PREFRONTAL CORTEX | CD200-DEFICIENT MICE | IMMUNE-SYSTEM | PSYCHIATRIC-DISORDERS | CENTRAL-NERVOUS-SYSTEM | Microglia - metabolism | Hippocampus - immunology | Mycobacterium - immunology | Anti-Inflammatory Agents - pharmacology | Immunization - methods | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Alarmins - metabolism | Rats | Male | Anti-Inflammatory Agents - metabolism | Rats, Sprague-Dawley | Stress, Psychological - immunology | Central Nervous System - physiology | Inflammation - metabolism | Animals | Microglia - physiology | Vaccination - methods | HMGB1 Protein - metabolism | Stress, Psychological - metabolism | Alarmins - immunology | Anxiety - metabolism | Central Nervous System - microbiology | Immunization | Chromosomal proteins | Anti-inflammatory drugs | RNA | stress | immunoregulation | alarmin | neuroinflammation | microglia
Neuroinflammation | M. vaccae | Alarmin | Immunoregulation | Stress | Microglia | C-REACTIVE PROTEIN | SICKNESS RESPONSES | VENTRAL HIPPOCAMPUS | NLRP3 INFLAMMASOME | IMMUNOLOGY | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | PREFRONTAL CORTEX | CD200-DEFICIENT MICE | IMMUNE-SYSTEM | PSYCHIATRIC-DISORDERS | CENTRAL-NERVOUS-SYSTEM | Microglia - metabolism | Hippocampus - immunology | Mycobacterium - immunology | Anti-Inflammatory Agents - pharmacology | Immunization - methods | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Alarmins - metabolism | Rats | Male | Anti-Inflammatory Agents - metabolism | Rats, Sprague-Dawley | Stress, Psychological - immunology | Central Nervous System - physiology | Inflammation - metabolism | Animals | Microglia - physiology | Vaccination - methods | HMGB1 Protein - metabolism | Stress, Psychological - metabolism | Alarmins - immunology | Anxiety - metabolism | Central Nervous System - microbiology | Immunization | Chromosomal proteins | Anti-inflammatory drugs | RNA | stress | immunoregulation | alarmin | neuroinflammation | microglia
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2013, Volume 288, Issue 6, pp. 4174 - 4193
High levels of NO generated in the vasculature under inflammatory conditions are usually attributed to inducible nitric-oxide synthase (iNOS), but the role of...
BARRIER DYSFUNCTION | S-NITROSYLATION | HETEROTRIMERIC G-PROTEINS | CELL-MIGRATION | CARBOXYPEPTIDASE-M | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-TERMINAL KINASE | POSTTRANSLATIONAL ACTIVATION | CONTROL ELEMENT | DEPENDENT ACTIVATION | MICROVASCULAR PERMEABILITY | Gene Expression Regulation, Enzymologic - drug effects | Inflammation - pathology | Calcium - metabolism | Humans | Vasculitis - pathology | Endothelium, Vascular - enzymology | Inflammation - drug therapy | Interleukin-1beta - metabolism | HEK293 Cells | Nitric Oxide Synthase Type III - metabolism | Nitric Oxide - biosynthesis | Bradykinin - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - biosynthesis | Mitogen-Activated Protein Kinase 9 - metabolism | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Enzyme Activation - drug effects | Inflammation - therapy | MAP Kinase Signaling System - drug effects | Calcium Signaling - drug effects | Endothelium, Vascular - metabolism | Vasculitis - drug therapy | Receptor, Bradykinin B2 - metabolism | Vasculitis - enzymology | Endothelial Cells - pathology | Endothelial Cells - enzymology | Inflammation - enzymology | Arginine - metabolism | Signal Transduction | Nitric-oxide Synthase | Inflammation | Jun N-terminal kinase (JNK) | Nitric Oxide | Endothelial Cell | G Protein-coupled Receptors
BARRIER DYSFUNCTION | S-NITROSYLATION | HETEROTRIMERIC G-PROTEINS | CELL-MIGRATION | CARBOXYPEPTIDASE-M | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-TERMINAL KINASE | POSTTRANSLATIONAL ACTIVATION | CONTROL ELEMENT | DEPENDENT ACTIVATION | MICROVASCULAR PERMEABILITY | Gene Expression Regulation, Enzymologic - drug effects | Inflammation - pathology | Calcium - metabolism | Humans | Vasculitis - pathology | Endothelium, Vascular - enzymology | Inflammation - drug therapy | Interleukin-1beta - metabolism | HEK293 Cells | Nitric Oxide Synthase Type III - metabolism | Nitric Oxide - biosynthesis | Bradykinin - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - biosynthesis | Mitogen-Activated Protein Kinase 9 - metabolism | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Enzyme Activation - drug effects | Inflammation - therapy | MAP Kinase Signaling System - drug effects | Calcium Signaling - drug effects | Endothelium, Vascular - metabolism | Vasculitis - drug therapy | Receptor, Bradykinin B2 - metabolism | Vasculitis - enzymology | Endothelial Cells - pathology | Endothelial Cells - enzymology | Inflammation - enzymology | Arginine - metabolism | Signal Transduction | Nitric-oxide Synthase | Inflammation | Jun N-terminal kinase (JNK) | Nitric Oxide | Endothelial Cell | G Protein-coupled Receptors
Journal Article
Biological Chemistry, ISSN 1431-6730, 03/2013, Volume 394, Issue 3, pp. 335 - 345
The G protein-coupled receptors (GPCRs) are the largest class of membrane proteins that play key roles in transducing extracellular signals to intracellular...
glycosylphosphatidylinositol anchor | G protein-coupled receptor | protein-protein interaction | peroxynitrite | inflammation | inducible nitric oxide synthase | ANCHOR | CELLS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | POSTTRANSLATIONAL ACTIVATION | MECHANISMS | G-PROTEIN | SYNTHASE | CONVERTING-ENZYME INHIBITORS | ANGIOTENSIN-I | BRADYKININ | Signal Transduction | Endothelial Cells - metabolism | Humans | Protein Binding | Metalloendopeptidases - metabolism | Receptor, Bradykinin B1 - metabolism | Nitric Oxide - metabolism | Endothelial Cells - enzymology | GPI-Linked Proteins - metabolism | Cell interaction | Cellular signal transduction | Research | Properties | Observations | Membrane proteins
glycosylphosphatidylinositol anchor | G protein-coupled receptor | protein-protein interaction | peroxynitrite | inflammation | inducible nitric oxide synthase | ANCHOR | CELLS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | POSTTRANSLATIONAL ACTIVATION | MECHANISMS | G-PROTEIN | SYNTHASE | CONVERTING-ENZYME INHIBITORS | ANGIOTENSIN-I | BRADYKININ | Signal Transduction | Endothelial Cells - metabolism | Humans | Protein Binding | Metalloendopeptidases - metabolism | Receptor, Bradykinin B1 - metabolism | Nitric Oxide - metabolism | Endothelial Cells - enzymology | GPI-Linked Proteins - metabolism | Cell interaction | Cellular signal transduction | Research | Properties | Observations | Membrane proteins
Journal Article
Cellular Signalling, ISSN 0898-6568, 08/2012, Volume 24, Issue 8, pp. 1619 - 1631
Kinin B1 and B2 receptors (kB1R and kB2R) play important roles in many physiological and pathological processes. In some cases, kB1R or kB2R activation can...
Kinin B1 receptor | Kinin B2 receptor | Endocytosis | G protein-coupled receptors | Biased agonist | Kinin peptides | MEMBRANE-BOUND CARBOXYPEPTIDASE | NITRIC-OXIDE SYNTHASE | POSTTRANSLATIONAL ACTIVATION | BETA-ARRESTIN | DIABETIC-NEPHROPATHY | BRADYKININ RECEPTOR | CELL BIOLOGY | SIGNAL-TRANSDUCTION | ENDOTHELIAL-CELLS | TRANSMEMBRANE DOMAINS | B-1 RECEPTORS | Receptor, Bradykinin B1 - agonists | Cricetinae | Phosphorylation | Receptor, Bradykinin B2 - agonists | Animals | Humans | HEK293 Cells | Receptor, Bradykinin B2 - metabolism | Receptor, Bradykinin B1 - metabolism | CHO Cells | Phosphates | Nitrogen oxide | Inositol | Peptides | Bradykinin | Nitric oxide | Physiological aspects | Endothelium | Membrane proteins | Human | Inositols | Receptors | Calcium | Activation | Endothelial cells | Modulators | endocytosis | G protein–coupled receptors | kinin peptides | kinin B2 receptor | biased agonist
Kinin B1 receptor | Kinin B2 receptor | Endocytosis | G protein-coupled receptors | Biased agonist | Kinin peptides | MEMBRANE-BOUND CARBOXYPEPTIDASE | NITRIC-OXIDE SYNTHASE | POSTTRANSLATIONAL ACTIVATION | BETA-ARRESTIN | DIABETIC-NEPHROPATHY | BRADYKININ RECEPTOR | CELL BIOLOGY | SIGNAL-TRANSDUCTION | ENDOTHELIAL-CELLS | TRANSMEMBRANE DOMAINS | B-1 RECEPTORS | Receptor, Bradykinin B1 - agonists | Cricetinae | Phosphorylation | Receptor, Bradykinin B2 - agonists | Animals | Humans | HEK293 Cells | Receptor, Bradykinin B2 - metabolism | Receptor, Bradykinin B1 - metabolism | CHO Cells | Phosphates | Nitrogen oxide | Inositol | Peptides | Bradykinin | Nitric oxide | Physiological aspects | Endothelium | Membrane proteins | Human | Inositols | Receptors | Calcium | Activation | Endothelial cells | Modulators | endocytosis | G protein–coupled receptors | kinin peptides | kinin B2 receptor | biased agonist
Journal Article
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, ISSN 2167-8421, 12/2014, Volume 15, Issue 7-8, pp. 569 - 580
Abstract Our objective was to present clinicopathologic evidence of anterior visual pathway involvement in patients with amyotrophic lateral sclerosis (ALS)...
Pathology | retina | c9orf72 | midget bipolar cells | amyotrophic lateral sclerosis | neuropathology | ubiquitin | Midget bipolar cells | Ubiquitin | Neuropathology | Amyotrophic lateral sclerosis | Retina | C9orf72 | HEXANUCLEOTIDE REPEAT EXPANSION | OPTICAL COHERENCE TOMOGRAPHY | ABNORMALITIES | COGNITIVE IMPAIRMENT | AMYOTROPHIC-LATERAL-SCLEROSIS | MOTOR-NEURON DISEASE | FRONTOTEMPORAL LOBAR DEGENERATION | MAMMALIAN RETINA | CLINICAL NEUROLOGY | BIPOLAR CELLS | MONKEY RETINA | Glutamate Plasma Membrane Transport Proteins - metabolism | Retina - metabolism | Myelin Basic Protein - metabolism | Amyotrophic Lateral Sclerosis - genetics | Humans | Middle Aged | Ubiquitin - metabolism | Male | Vision Disorders - pathology | Mutation - genetics | Amyotrophic Lateral Sclerosis - complications | DNA-Binding Proteins - metabolism | Proteins - genetics | Neurologic Examination | DNA Mutational Analysis | Pedigree | Female | C9orf72 Protein | Diagnostic Techniques, Ophthalmological | Vision Disorders - etiology
Pathology | retina | c9orf72 | midget bipolar cells | amyotrophic lateral sclerosis | neuropathology | ubiquitin | Midget bipolar cells | Ubiquitin | Neuropathology | Amyotrophic lateral sclerosis | Retina | C9orf72 | HEXANUCLEOTIDE REPEAT EXPANSION | OPTICAL COHERENCE TOMOGRAPHY | ABNORMALITIES | COGNITIVE IMPAIRMENT | AMYOTROPHIC-LATERAL-SCLEROSIS | MOTOR-NEURON DISEASE | FRONTOTEMPORAL LOBAR DEGENERATION | MAMMALIAN RETINA | CLINICAL NEUROLOGY | BIPOLAR CELLS | MONKEY RETINA | Glutamate Plasma Membrane Transport Proteins - metabolism | Retina - metabolism | Myelin Basic Protein - metabolism | Amyotrophic Lateral Sclerosis - genetics | Humans | Middle Aged | Ubiquitin - metabolism | Male | Vision Disorders - pathology | Mutation - genetics | Amyotrophic Lateral Sclerosis - complications | DNA-Binding Proteins - metabolism | Proteins - genetics | Neurologic Examination | DNA Mutational Analysis | Pedigree | Female | C9orf72 Protein | Diagnostic Techniques, Ophthalmological | Vision Disorders - etiology
Journal Article
Transatlantica, 05/2019
Le comité de rédaction dédie l’intégralité de ce numéro à la mémoire de François Brunet, membre du comité scientifique de Transatlantica depuis sa fondation en...
Journal Article
MSYSTEMS, ISSN 2379-5077, 05/2018, Volume 3, Issue 3, p. e00031-18
Although much work has linked the human microbiome to specific phenotypes and lifestyle variables, data from different projects have been challenging to...
REGRESSION | BACTERIA | MASS-SPECTROMETRY DATA | MOLECULAR NETWORKING | CARBOHYDRATE-ACTIVE ENZYMES | citizen science | MICROBIOLOGY | COMMUNITIES | microbiome | DISCOVERY | METAGENOMICS | DIVERSITY | MAJOR DEPRESSIVE DISORDER | BASIC BIOLOGICAL SCIENCES
REGRESSION | BACTERIA | MASS-SPECTROMETRY DATA | MOLECULAR NETWORKING | CARBOHYDRATE-ACTIVE ENZYMES | citizen science | MICROBIOLOGY | COMMUNITIES | microbiome | DISCOVERY | METAGENOMICS | DIVERSITY | MAJOR DEPRESSIVE DISORDER | BASIC BIOLOGICAL SCIENCES
Journal Article
Medicine & Science in Sports & Exercise, ISSN 0195-9131, 05/2011, Volume 43, Issue Suppl 1, p. 950
Journal Article
01/2013, ISBN 9781303435454
Dissertation
Science Advances, ISSN 2375-2548, 09/2019, Volume 5, Issue 9, p. eaaw3095
Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here,...
OBESITY | EARLY-LIFE | FTO GENE | METABOLIC RISK | BODY-MASS INDEX | ADIPOSITY | BIRTH COHORT | BLOOD-PRESSURE | GENOME-WIDE ASSOCIATION | AGE | MULTIDISCIPLINARY SCIENCES
OBESITY | EARLY-LIFE | FTO GENE | METABOLIC RISK | BODY-MASS INDEX | ADIPOSITY | BIRTH COHORT | BLOOD-PRESSURE | GENOME-WIDE ASSOCIATION | AGE | MULTIDISCIPLINARY SCIENCES
Journal Article
Archives of Physical Medicine and Rehabilitation, ISSN 0003-9993, 04/2010, Volume 91, Issue 4, pp. 632 - 638
Lowry KA, Carrel AJ, McIlrath JM, Smiley-Oyen AL. Use of harmonic ratios to examine the effect of cueing strategies on gait stability in persons with...
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AIDS Research and Human Retroviruses, ISSN 0889-2229, 10/2016, Volume 32, Issue S1, pp. 1 - 409
Journal Article
Science, ISSN 0036-8075, 01/2015, Volume 347, Issue 6220, pp. aaa3905 - aaa3905
Critical measurements for understanding accretion and the dust/gas ratio in the solar nebula, where planets were forming 4.5 billion years ago, are being...
WILD-2 | NUCLEI | GIOTTO | PARTICLES | MULTIDISCIPLINARY SCIENCES | ROSETTA MISSION | SIZE | ORBITS | MODEL | P/HALLEY | Comets | Planetology | Dust | Comet heads | Clouds | Grains | Perihelions | Spectrometers | Nuclei | Solar and Stellar Astrophysics | Sciences of the Universe | Astrophysics | Fysik | Physical Sciences | Naturvetenskap | Natural Sciences
WILD-2 | NUCLEI | GIOTTO | PARTICLES | MULTIDISCIPLINARY SCIENCES | ROSETTA MISSION | SIZE | ORBITS | MODEL | P/HALLEY | Comets | Planetology | Dust | Comet heads | Clouds | Grains | Perihelions | Spectrometers | Nuclei | Solar and Stellar Astrophysics | Sciences of the Universe | Astrophysics | Fysik | Physical Sciences | Naturvetenskap | Natural Sciences
Journal Article