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index medicus (41) 41
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subcellular fractions - metabolism (3) 3
tracers (3) 3
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cellular biology (2) 2
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1. Full Text Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells
by Zhou, Kejin and Wang, Yiguang and Huang, Xiaonan and Luby-Phelps, Katherine and Sumer, Baran D and Gao, Jinming
Angewandte Chemie - International Edition, ISSN 1433-7851, 06/2011, Volume 50, Issue 27, pp. 6109 - 6114
pH activation | micelles | cell cycle | nanostructures | fluorescent probes | CANCER-CELLS | DRUG-DELIVERY | INTRACELLULAR PH | BLOCK-COPOLYMER MICELLES | RELEASE | TRANSFER RADICAL POLYMERIZATION | CHEMISTRY, MULTIDISCIPLINARY | PHARMACEUTICAL NANOCARRIERS | TUMOR PH | ENDOSOME DISRUPTION | MULTIFUNCTIONAL POLYMERIC MICELLE | Drug Carriers - metabolism | Amines | Magnetic Resonance Spectroscopy | Nanoparticles - chemistry | Humans | Fluorescence | Polyethylene Glycols - chemistry | Structure-Activity Relationship | Drug Carriers - chemistry | Endosomes - metabolism | Lysosomes - metabolism | Micelles | Rhodamines | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Hydrogen-Ion Concentration | Index Medicus
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2. Full Text Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal
by Acar, Melih and Kocherlakota, Kiranmai S and Murphy, Malea M and Peyer, James G and Oguro, Hideyuki and Inra, Christopher N and Jaiyeola, Christabel and Zhao, Zhiyu and Luby-Phelps, Katherine and Morrison, Sean J
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7571, pp. 126 - 130
Haematopoietic stem cells (HSCs) reside in a perivascular niche but the specific location of this niche remains controversial(1). HSCs are rare and few can be... 
PROGENITOR CELLS | MOUSE-BRAIN | MAINTENANCE | SINUSOIDS | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | NICHE | MICE | HEMATOPOIETIC STEM | alpha Catenin - metabolism | Tibia - anatomy & histology | Male | Molecular Imaging | Proto-Oncogene Proteins c-kit - metabolism | Tibia - blood supply | Bone Marrow - anatomy & histology | alpha Catenin - analysis | Cell Division | Female | Biomarkers - metabolism | Stem Cell Niche | Mice, Inbred C57BL | Biomarkers - analysis | Diaphyses - metabolism | Hematopoietic Stem Cells - metabolism | Tibia - cytology | Cell Lineage | Microscopy, Confocal | Animals | Arterioles - metabolism | Chemokine CXCL12 - metabolism | Image Processing, Computer-Assisted | Hematopoietic Stem Cells - cytology | Mice | Receptors, Leptin - metabolism | Diaphyses - cytology | Bone marrow | Genetic aspects | Diagnostic imaging | Health aspects | Hematopoietic stem cells | Methods | Scientific imaging | Transplants & implants | Gene expression | Stem cells | Index Medicus
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3. Full Text Image-based genome-wide siRNA screen identifies selective autophagy factors
by Orvedahl, Anthony and Sumpter Jr, Rhea and Xiao, Guanghua and Ng, Aylwin and Zou, Zhongju and Tang, Yi and Narimatsu, Masahiro and Gilpin, Christopher and Sun, Qihua and Roth, Michael and Forst, Christian V and Wrana, Jeffrey L and Zhang, Ying E and Luby-Phelps, Katherine and Xavier, Ramnik J and Xie, Yang and Levine, Beth
Nature, ISSN 0028-0836, 12/2011, Volume 480, Issue 7375, pp. 113 - 117
Selective autophagy involves the recognition and targeting of specific cargo, such as damaged organelles, misfolded proteins, or invading pathogens for... 
SYSTEM | PARKIN | PROTEIN | UBIQUITIN LIGASE | MULTIDISCIPLINARY SCIENCES | P62/SQSTM1 | DEGRADATION | MITOPHAGY | VDAC1 | RNA, Small Interfering - genetics | Genome-Wide Association Study | Capsid Proteins - metabolism | Humans | Mitochondria - metabolism | Protein Transport - genetics | Sindbis Virus - metabolism | Animals | Lysosomes - metabolism | Ubiquitin-Protein Ligases - deficiency | Mice | Autophagy - genetics | HeLa Cells | Ubiquitin-Protein Ligases - genetics | Proteins | Enzymes | Lipids | Mitochondria | Genomes | Autophagy | Index Medicus
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4. Full Text SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function
by McMahon, Kerrie-Ann and Peyton, Michael J and Anderson, Richard G W and Luby-Phelps, Katherine and Minna, John D and Li, Wei-Ping and Hernandez, V James and Zajicek, Hubert
The EMBO Journal, ISSN 0261-4189, 04/2009, Volume 28, Issue 8, pp. 1001 - 1015
Caveolae are a major membrane domain common to most cells. One of the defining features of this domain is the protein caveolin. The exact function of caveolin,... 
adapter protein | endocytosis | caveolae | caveolin | Caveolae | Caveolin | Adapter protein | RNA-POLYMERASE-I | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | BINDING PROTEIN | CELL BIOLOGY | LUNG CANCERS | SMOOTH-MUSCLE | FACTOR PTRF | TRANSCRIPT-RELEASE FACTOR | LIVING CELLS | RNA-Binding Proteins - genetics | Fluorescence Recovery After Photobleaching | Humans | Caveolins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Caveolins - genetics | Recombinant Fusion Proteins - metabolism | Tissue Distribution | Protein Isoforms - metabolism | Protein Kinase C - metabolism | Cytoplasmic Vesicles - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Fibroblasts - metabolism | Cell Line | Mutagenesis, Site-Directed | Caveolae - metabolism | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cytoplasmic Vesicles - ultrastructure | Recombinant Fusion Proteins - genetics | Fibroblasts - cytology | Mice | RNA-Binding Proteins - metabolism | Protein Isoforms - genetics | Proteins | Membranes | Cellular biology | Molecular biology | Binding sites | Index Medicus
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5. Full Text Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-β1: Potential role in idiopathic pulmonary fibrosis
by Willis, Brigham C and Liebler, Janice M and Luby-Phelps, Katherine and Nicholson, Andrew G and Crandall, Edward D and Du Bois, Roland M and Borok, Zea
American Journal of Pathology, ISSN 0002-9440, 2005, Volume 166, Issue 5, pp. 1321 - 1332
The hallmark of idiopathic pulmonary fibrosis (IPF) is the myofibroblast, the cellular origin of which in the lung is unknown. We hypothesized that alveolar... 
Original Research Paper
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6. Full Text A compact fiber-optic SHG scanning endomicroscope and its application to visualize cervical remodeling during pregnancy
by Yuying Zhang and Meredith L. Akins and Kartikeya Murari and Jiefeng Xi and Ming-Jun Li and Katherine Luby-Phelps and Mala Mahendroo and Xingde Li
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2012, Volume 109, Issue 32, pp. 12878 - 12883
We report the development of an all-fiber-optic scanning endomicroscope capable of high-resolution second harmonic generation (SHG) imaging of biological... 
Pregnancy | Cantilevers | Cervix uteri | Microscopy | Imaging | Collagens | Epithelium | Laser beams | Microscopes | Renovations | Cervical collagen remodeling | Nonlinear endomicroscopy | Parturition | Fiber-optic scanning probe | fiber-optic scanning probe | cervical collagen remodeling | COLLAGEN | OPTICAL COHERENCE TOMOGRAPHY | MULTIDISCIPLINARY SCIENCES | 2-PHOTON FLUORESCENCE MICROENDOSCOPE | PRETERM BIRTH | MU-M | nonlinear endomicroscopy | parturition | IMAGING MICROSCOPY | ENDOSCOPE | 2ND-HARMONIC GENERATION | TISSUES | Animals | Analysis of Variance | Collagen - ultrastructure | Humans | Fiber Optic Technology - instrumentation | Endoscopy - methods | Cervix Uteri - ultrastructure | Endoscopy - instrumentation | Female | Mice | Fiber Optic Technology - methods | Usage | Physiological aspects | Equipment and supplies | Health aspects | Scanning microscopy | Methods | Fiber optics | Medical imaging | Morphology | Collagen | Computer based modeling | Index Medicus | Physical Sciences
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7. Full Text Cervical Softening During Pregnancy: Regulated Changes in Collagen Cross-Linking and Composition of Matricellular Proteins in the Mouse
by Akins, Meredith L and Luby-Phelps, Katherine and Bank, Ruud A and Mahenoo, Mala
Biology of Reproduction, ISSN 0006-3363, 05/2011, Volume 84, Issue 5, pp. 1053 - 1062
A greater understanding of the parturition process is essential in the prevention of preterm birth, which occurs in 12.7% of infants born in the United States... 
Parturition | Cervix | Cervical softening | Cervical remodeling | Collagen crosslinking | MOLECULAR CHARACTERIZATION | cervix | DERMATAN SULFATE PROTEOGLYCAN | KNOCKOUT MICE | FIBRILLOGENESIS | cervical softening | parturition | UTERINE CERVIX | REPRODUCTIVE BIOLOGY | cervical remodeling | RAT GESTATION | CELL-FUNCTION | collagen cross-linking | CONNECTIVE-TISSUE | FIBRIL MORPHOLOGY | Cervical Ripening - metabolism | Pregnancy Proteins - chemistry | Extracellular Matrix Proteins - ultrastructure | Tenascin - genetics | Thrombospondins - genetics | Pregnancy Proteins - genetics | Collagen - chemistry | Pregnancy Proteins - metabolism | Mice, 129 Strain | RNA, Messenger - metabolism | Tenascin - metabolism | Gene Expression Regulation, Developmental | Isoenzymes - metabolism | Fibrillar Collagens - ultrastructure | Female | Collagen - genetics | Extracellular Matrix Proteins - metabolism | Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - genetics | Fibrillar Collagens - metabolism | Microscopy, Electron, Transmission | Extracellular Matrix Proteins - chemistry | Pregnancy Proteins - ultrastructure | Procollagen - genetics | Fibrillar Collagens - genetics | Collagen - ultrastructure | Isoenzymes - genetics | Mice, Inbred C57BL | Procollagen - chemistry | Fibrillar Collagens - chemistry | Procollagen - metabolism | Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - metabolism | Pregnancy | Collagen - metabolism | Animals | Procollagen - ultrastructure | Mice | Protein Processing, Post-Translational | Thrombospondins - metabolism | Index Medicus
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8. Full Text Second harmonic generation imaging as a potential tool for staging pregnancy and predicting preterm birth
by Akins, Meredith L and Luby-Phelps, Katherine and Mahendroo, Mala
Journal of Biomedical Optics, ISSN 1083-3668, 03/2010, Volume 15, Issue 2, pp. 026020 - 026020
We use second harmonic generation (SHG) microscopy to assess changes in collagen structure of murine cervix during cervical remodeling of normal pregnancy and... 
Parturition | Second harmonic generation | Cervical ripening | Collagen | Tissue remodeling | TISSUE | BIOCHEMICAL RESEARCH METHODS | collagen | HYALURONAN | KNOCKOUT MICE | MICROSCOPY | MECHANICAL-PROPERTIES | parturition | cervical ripening | FLUORESCENCE | COLLAGEN CHANGES | second harmonic generation | tissue remodeling | OPTICS | HUMAN UTERINE CERVIX | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CONSTITUENTS | Pregnancy | Fibrillar Collagens - analysis | Cervix Uteri - metabolism | Animals | Microscopy, Fluorescence - methods | Fibrillar Collagens - ultrastructure | Premature Birth - metabolism | Cervix Uteri - ultrastructure | Female | Mice | Premature Birth - diagnosis | Index Medicus | Research Papers | Imaging
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9. Full Text Afadin orients cell division to position the tubule lumen in developing renal tubules
by Gao, Lei and Yang, Zhufeng and Hiremath, Chitkale and Zimmerman, Susan E and Long, Blake and Brakeman, Paul R and Mostov, Keith E and Bryant, David M and Luby-Phelps, Katherine and Marciano, Denise K
Development (Cambridge), ISSN 0950-1991, 10/2017, Volume 144, Issue 19, pp. 3511 - 3520
In many types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate lumen continuity in vivo is not known. We recently... 
Mouse | Tubulogenesis | Afadin | Lumen | Nephron | Polarity | Kidney development | KIDNEY-DISEASE | NETWORK | DEVELOPMENTAL BIOLOGY | EPITHELIAL MORPHOGENESIS | ADHERENS JUNCTIONS | DROSOPHILA NEUROBLASTS | NEPHRON PROGENITOR POPULATION | APICAL POLARITY | BINDING | MITOTIC SPINDLE ORIENTATION | Epithelial Cells - metabolism | Kidney Tubules - embryology | Cells, Cultured | Epithelial Cells - pathology | Male | Nephrons - pathology | Kidney Diseases, Cystic - pathology | Morphogenesis | Animals | Spindle Apparatus - metabolism | Cell Division | Dogs | Madin Darby Canine Kidney Cells | Female | Mice | Microfilament Proteins - metabolism | Kidney Tubules - pathology | Kidney Tubules - metabolism | Nephrons - metabolism | Cell division | Kidneys | Actin | Renal tubules | Nephrons | Index Medicus
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10. Full Text WNK1 is required for mitosis and abscission
by Szu-wei Tu and Abhijit Bugde and Katherine Luby-Phelps and Melanie H. Cobb
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 4, pp. 1385 - 1390
WNK [with no lysine (K)] protein kinases are found in all sequenced multicellular and many unicellular organisms. WNKs influence ion balance. Two WNK family... 
Phenotypes | Mitosis | Oligonucleotides | HeLa cells | Small interfering RNA | Antibodies | Gene expression regulation | Mitotic spindle apparatus | Daughter cells | Abscission | Proline | Alanine-rich kinase | Cytokinesis | Microtubules | Serine | serine | CELLS | SPAK | SPINDLE POLES | cytokinesis | PROTEIN-KINASE | OSR1 | MULTIDISCIPLINARY SCIENCES | microtubules | proline | BLOOD-PRESSURE CONTROL | COTRANSPORTERS | HYPERTENSION | alanine-rich kinase | AURORA-A | Minor Histocompatibility Antigens | Humans | Cell Survival - genetics | Cytoplasm - metabolism | Immunoblotting | Green Fluorescent Proteins - genetics | Mitosis - genetics | Genetic Complementation Test | Cytokinesis - genetics | Spindle Apparatus - metabolism | WNK Lysine-Deficient Protein Kinase 1 | RNA Interference | Cytokinesis - physiology | Cell Survival - physiology | Protein-Serine-Threonine Kinases - metabolism | Green Fluorescent Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Rats | HT29 Cells | Animals | Analysis of Variance | Mitosis - physiology | Fluorescent Antibody Technique | Cell Line, Tumor | HeLa Cells | Cellular control mechanisms | Physiological aspects | Genetic aspects | Research | Molecular biology | Protein kinases | Cell division | Survival analysis | Kinases | Chromosomes | Rodents | Cells | Index Medicus | Hypertension | double prime K protein | Oxidative stress | Cell survival | RNA-mediated interference | Nuclei | Osmotic stress | Lysine | Protein kinase | Spindles | Biological Sciences
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11. Full Text Role of Substrates and Products of PI 3-Kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav
by Jaewon Han and Katherine Luby-Phelps and Balaka Das and Xiaodong Shu and Yi Xia and Raymond D. Mosteller and U. Murali Krishna and John R. Falck and Michael A. White and Daniel Broek
Science, ISSN 0036-8075, 1/1998, Volume 279, Issue 5350, pp. 558 - 560
Mitogen stimulation of cytoskeletal changes and c-jun amino-terminal kinases is mediated by Rac small guanine nucleotide-binding proteins. Vav, a guanosine... 
Polymerase chain reaction | Phosphorylation | Memory interference | Plasmids | Antibodies | Reports | Gene expression regulation | Physiological regulation | Mitogens | Phosphatidylinositols | Mutant proteins | Phosphatidylinositol Phosphates - metabolism | Inositol 1,4,5-Trisphosphate - pharmacology | Guanosine Triphosphate - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 4,5-Diphosphate - metabolism | Phosphatidylinositol Phosphates - pharmacology | Proto-Oncogene Proteins c-vav | Phosphatidylinositols - metabolism | ras Guanine Nucleotide Exchange Factors | Guanosine Diphosphate - metabolism | rac GTP-Binding Proteins | Amino Acid Sequence | Cell Line | Mutagenesis, Site-Directed | Oncogene Proteins - chemistry | Oncogene Proteins - metabolism | Phosphatidylinositols - pharmacology | Rats | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Guanine Nucleotide Exchange Factors | Animals | GTP Phosphohydrolases - metabolism | Proteins - metabolism | Phosphatidylinositol 4,5-Diphosphate - pharmacology | Enzyme Activation | Inositol 1,4,5-Trisphosphate - metabolism | GTP-Binding Proteins - metabolism | Proteins | Molecular biology | Biochemistry | Index Medicus
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12. Full Text Sterol-induced dislocation of 3-Hydroxy-3-methylglutaryl coenzyme a reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets
by Hartman, Isamu Z and Liu, Pingsheng and Zehmer, John K and Luby-Phelps, Katherine and Jo, Youngah and Anderson, Richard G. W and DeBose-Boyd, Russell A
Journal of Biological Chemistry, ISSN 0021-9258, 06/2010, Volume 285, Issue 25, pp. 19288 - 19298
Sterol-induced binding to Insigs in the endoplasmic reticulum ( ER) allows for ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the... 
CELLS | MESSENGER-RNA | INSIG-1 | PROTEASOMAL DEGRADATION | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HMG-COA REDUCTASE | DIFFERENTIATION-RELATED PROTEIN | APOLIPOPROTEIN-B | BINDING | Cricetinae | Sterols - metabolism | Cricetulus | Sterols - chemistry | Ubiquitin - chemistry | Endoplasmic Reticulum - metabolism | Subcellular Fractions - metabolism | Lipids - chemistry | Animals | RNA Interference | Protein Binding | Cytosol - metabolism | Proteasome Endopeptidase Complex - metabolism | Hydroxymethylglutaryl CoA Reductases - chemistry | CHO Cells | Index Medicus | Ubiquitination | Cholesterol Metabolism | Enzyme Degradation | Protein Synthesis and Degradation | Lipids | Cholesterol Regulation | Endoplasmic Reticulum (ER) | Proteasome
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13. Full Text IFT20 Links Kinesin II with a Mammalian Intraflagellar Transport Complex That Is Conserved in Motile Flagella and Sensory Cilia
by Sheila A. Baker and Katie Freeman and Katherine Luby-Phelps and Gregory J. Pazour and Joseph C. Besharse
Journal of Biological Chemistry, ISSN 0021-9258, 09/2003, Volume 278, Issue 36, pp. 34211 - 34218
Intraflagellar transport (IFT) is an evolutionarily conserved mechanism thought to be required for the assembly and maintenance of all eukaryotic cilia and... 
CHLAMYDOMONAS FLAGELLA | CYTOPLASMIC DYNEIN | CAENORHABDITIS-ELEGANS | MOLECULAR-STRUCTURE | POLYCYSTIC KIDNEY-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE TG737 | MOTOR PROTEIN | SUPERFAMILY | HOMOLOG | LEFT-RIGHT ASYMMETRY | Retina - metabolism | Testis - metabolism | Rod Cell Outer Segment - metabolism | Male | alpha-Galactosidase - metabolism | Kidney - metabolism | Biological Transport | Cattle | Adenosine Triphosphate - metabolism | Flagella - chemistry | Cytoskeletal Proteins - metabolism | Dimerization | Cilia - chemistry | Kinesin | Calcium-Binding Proteins - chemistry | Protein Structure, Tertiary | Ions | Cytoskeletal Proteins - chemistry | Blotting, Western | Precipitin Tests | Hydrolysis | Two-Hybrid System Techniques | Animals | Models, Biological | Photoreceptor Cells - metabolism | Protein Binding | Mice | Muscle Proteins - chemistry | Index Medicus
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14. Full Text Cervical Softening During Pregnancy: Regulated Changes in Collagen Cross-Linking and Composition of Matricellular Proteins in the Mouse1
by Meredith L. Akins and Katherine Luby-Phelps and Ruud A. Bank and Mala Mahendroo
Biology of Reproduction, ISSN 0006-3363, 2011, Volume 84, Issue 5, pp. 1053 - 1062
A greater understanding of the parturition process is essential in the prevention of preterm birth, which occurs in 12.7% of infants born in the United States... 
cervix | cervical remodeling | collagen cross-linking | cervical softening | parturition
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