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Cell Reports, ISSN 2211-1247, 04/2019, Volume 27, Issue 3, pp. 971 - 986.e9
Glioblastoma therapies have remained elusive due to limitations in understanding mechanisms of growth and survival of the tumorigenic population. Using... 
functional genomics | glioblastoma | fitness genes | glioblastoma stem cells | CRISPR-Cas9 | MAINTENANCE | INHIBITION | PURIFICATION | RESISTANCE | PHENOTYPE | MALIGNANT GLIOMAS | SELF-RENEWAL | IDENTIFICATION | SOFTWARE | REVEALS | CELL BIOLOGY
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 1118 - 1118
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2016, Volume 18, Issue suppl_6, pp. vi38 - vi39
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2016, Volume 18, Issue suppl_6, pp. vi83 - vi83
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 2521 - 2521
Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor. Currently, treatment for GBM involves surgical resection, chemotherapy, and... 
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2016, Volume 18, Issue suppl_6, pp. vi44 - vi44
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2016, Volume 18, Issue suppl_6, pp. vi39 - vi40
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2017, Volume 19, Issue suppl_6, pp. vi234 - vi234
Glioblastoma multiforme (GBM) is the most aggressive adult primary brain tumor. Despite a treatment regimen involving surgical resection, chemotherapy, and... 
Abstracts
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2017, Volume 114, Issue 40, p. 10743
IDH1 mutation is the earliest genetic alteration in low-grade gliomas (LGGs), but its role in tumor recurrence is unclear. Mutant IDH1 drives overproduction of... 
Enzymes | Copy number | Cultures | Gene deletion | Amplification | Clonal deletion | Epigenetics | DNA methylation | Deletion | Mutation | Methylation | Deoxyribonucleic acid--DNA | Tumors | CpG islands
Journal Article
Nature Neuroscience, ISSN 1097-6256, 04/2016, Volume 19, Issue 6, pp. 798 - 806
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 2524 - 2524
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2017, Volume 19, Issue suppl_6, pp. vi231 - vi232
The median survival for patients diagnosed with Glioblastoma (GBM) is only 14 months, due to recurrence, despite current treatment options of surgery, radio-... 
Abstracts
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2015, Volume 17, Issue suppl 5, pp. v93.2 - v93
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2015, Volume 17, Issue suppl 5, pp. v29.4 - v29
Journal Article
Neuro-Oncology, ISSN 1522-8517, 02/2013, Volume 15, Issue 2, pp. 198 - 207
Background. Glioblastoma multiforme (GBM) is characterized by an aggressive clinical course, therapeutic resistance, and striking molecular heterogeneity.... 
JAK2/STAT3 | Molecular therapeutics | Brain tumor stem cells | Glioblastoma | APOPTOSIS | MALIGNANT GLIOMA-CELLS | PROLIFERATION | INDUCTION | MULTIFORME | LINES | CLINICAL NEUROLOGY | brain tumor stem cells | TEMOZOLOMIDE | molecular therapeutics | glioblastoma | ONCOLOGY | PATHWAY | IN-VIVO | GROWTH | RNA, Small Interfering - genetics | Cell Proliferation | Triterpenes - pharmacology | Humans | Middle Aged | Brain Neoplasms - pathology | DNA Repair Enzymes - genetics | Male | Promoter Regions, Genetic - genetics | Brain Neoplasms - metabolism | Immunoenzyme Techniques | DNA Methylation | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Neoplastic Stem Cells - metabolism | Janus Kinase 2 - metabolism | Tumor Suppressor Proteins - genetics | Neoplastic Stem Cells - pathology | Female | Glioblastoma - metabolism | Tumor Cells, Cultured | Janus Kinase 2 - antagonists & inhibitors | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Signal Transduction | Glioblastoma - prevention & control | Janus Kinase 2 - genetics | Tumor Suppressor Protein p53 - metabolism | PTEN Phosphohydrolase - metabolism | Tyrphostins - pharmacology | Mice, SCID | Blotting, Western | Disease Progression | Brain Neoplasms - prevention & control | Xenograft Model Antitumor Assays | DNA Modification Methylases - genetics | Animals | Glioblastoma - pathology | Mice, Inbred NOD | Aged | Mice | Pyridines - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors | Apoptosis | JAK2 | Basic and Translational Investigations | STAT3
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2017, Volume 114, Issue 40, pp. 10743 - 10748
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2014, Volume 20, Issue 22, pp. 5756 - 5767
Purpose: The EGFR and PI3K/mTORC1/2 pathways are frequently altered in glioblastoma (GBM), but pharmacologic targeting of EGFR and PI3K signaling has failed to... 
PHASE-II TRIAL | STEM-LIKE CELLS | ONCOLOGY | GLIOMA | RECURRENT GLIOBLASTOMA | GROWTH | PHENOTYPE | KINASE INHIBITORS | MUTATIONS | PTEN-DEFICIENT | CANCER | Receptor, Epidermal Growth Factor - genetics | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Cell Survival - genetics | Apoptosis - genetics | Antineoplastic Agents - administration & dosage | Glioblastoma - genetics | Neoplastic Stem Cells - metabolism | Glioblastoma - metabolism | Brain Neoplasms - mortality | Disease Models, Animal | Cell Survival - drug effects | PTEN Phosphohydrolase - genetics | Dacarbazine - administration & dosage | Tumor Suppressor Proteins - metabolism | DNA Modification Methylases - metabolism | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Drug Synergism | Protein Kinase Inhibitors - administration & dosage | Signal Transduction - drug effects | Glioblastoma - pathology | Cell Line, Tumor | Mice | Mutation | Glioblastoma - drug therapy | Glioblastoma - mortality | Brain Neoplasms - pathology | DNA Repair Enzymes - genetics | Mechanistic Target of Rapamycin Complex 2 | Brain Neoplasms - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | DNA Methylation | Dacarbazine - pharmacology | Tumor Suppressor Proteins - genetics | DNA Repair Enzymes - metabolism | Dacarbazine - analogs & derivatives | Tumor Burden - genetics | Antineoplastic Agents - pharmacology | Promoter Regions, Genetic | Xenograft Model Antitumor Assays | DNA Modification Methylases - genetics | Animals | Tumor Burden - drug effects | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology
Journal Article
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