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Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6683 - 6683
Transcriptional reprogramming of proliferative melanoma cells into a phenotypically distinct invasive cell subpopulation is a critical event at the origin of... 
TRANSCRIPTION FACTOR-BINDING | ENCYCLOPEDIA | R/BIOCONDUCTOR PACKAGE | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | PHENOTYPE | ENHANCER | MITF | DIFFERENTIATION | CHROMOSOME CONFORMATION CAPTURE | TAZ | Chromatin - metabolism | RNA, Small Interfering - genetics | Transcription Factor AP-1 - genetics | Humans | Gene Expression Regulation, Neoplastic | Transcriptome | Gene Regulatory Networks | Transcription Factor AP-1 - metabolism | DNA-Binding Proteins - metabolism | DNA Methylation | Protein Isoforms - metabolism | Cell Transformation, Neoplastic - genetics | Melanoma - genetics | Transcription, Genetic | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Cellular Reprogramming - genetics | Chromatin - chemistry | Melanoma - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Signal Transduction | Neoplasm Invasiveness | SOXE Transcription Factors - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Melanoma - pathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Transcription Factors - metabolism | Histones - genetics | Melanoma - drug therapy | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Histones - metabolism | Cell Transformation, Neoplastic - pathology | Microphthalmia-Associated Transcription Factor - genetics | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | SOXE Transcription Factors - genetics | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2012, Volume 18, Issue 8, pp. 1239 - 1247
The inactivation of the p53 tumor suppressor pathway, which often occurs through mutations in TP53 (encoding tumor protein 53) is a common step in human... 
MEDICINE, RESEARCH & EXPERIMENTAL | N-RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR ACTIVITY | STAPLED P53 | BRAF | MALIGNANT-MELANOMA | P53 PATHWAY | CELL-DEATH | CELL BIOLOGY | BREAST-CANCER | METASTATIC MELANOMA | IN-VIVO | Up-Regulation | Proto-Oncogene Proteins c-mdm2 - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Recombinant Fusion Proteins - physiology | Skin Neoplasms - chemistry | Male | Melanocytes - metabolism | Neoplasm Proteins - antagonists & inhibitors | Cell Line, Tumor - transplantation | Proto-Oncogene Proteins - biosynthesis | Tumor Suppressor Protein p53 - physiology | Cell-Penetrating Peptides - pharmacology | Nuclear Proteins - biosynthesis | Female | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Cell Line, Tumor - metabolism | Melanoma - chemistry | Proto-Oncogene Proteins c-mdm2 - biosynthesis | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Stem Cell Assay | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | Melanoma, Experimental - etiology | Mice, Inbred C57BL | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Melanoma - pathology | Melanoma - secondary | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Melanoma, Experimental - genetics | GTP Phosphohydrolases - genetics | Keratinocytes - metabolism | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Signal Transduction - physiology | Mice | Nuclear Proteins - physiology | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Melanoma | Diagnosis | Research | Gene expression | Identification and classification | Skin cancer | Proteins | Cell growth | Mutation | Cell cycle | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2017, Volume 127, Issue 6, pp. 2310 - 2325
Journal Article
Cancer Research, ISSN 0008-5472, 02/2019, Volume 79, Issue 3, pp. 482 - 494
Although numerous epigenetic aberrancies accumulate in melanoma, their contribution to initiation and progression remain unclear. The epigenetic mark... 
METHYLATION | PROFILES | PROTEIN | ONCOLOGY | MOUSE MODEL | GENE-EXPRESSION | TET2 | LEADS | TUMOR-SUPPRESSOR | 5-HYDROXYMETHYLCYTOSINE | PROMOTES
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 2010, Volume 102, Issue 15, pp. 1148 - 1159
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 08/2017, Volume 109, Issue 8, p. djw340
Background: MITF encodes an oncogenic lineage-specific transcription factor in which a germline mutation ([MITF.sup.E318K]) was identified in human patients... 
Animal experimentation | Development and progression | Transcription factors | Research | Gene mutations | Melanoma
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2009, Volume 284, Issue 28, pp. 18699 - 18706
Melanins are synthesized in melanocytes within specialized organelles called melanosomes. Numerous studies have shown that the pH of melanosome plays a key... 
SKIN PIGMENTATION | INHIBITION | GENE | OCULOCUTANEOUS ALBINISM | TYROSINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PINK-EYED DILUTION | CELL DIFFERENTIATION | H+-ATPASE | MELANOGENESIS | MELANOCYTES | Mechanisms of Signal Transduction
Journal Article