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Journal Article
Drug, healthcare and patient safety, ISSN 1179-1365, 2019, Volume 11, pp. 55 - 64
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 07/2012, Volume 84, Issue 1, pp. 68 - 75
The prostacyclin analogues, iloprost and treprostinil are extensively used in treating pulmonary hypertension. Their binding profile and corresponding... 
Cyclic AMP | Prostacyclin analogues | Prostanoid receptors | Radioligand binding | Calcium influx
Journal Article
JOURNAL OF CLINICAL MEDICINE, ISSN 2077-0383, 04/2019, Volume 8, Issue 4, p. 481
Prostacyclin mimetics (PMs) are effective for the treatment of pulmonary arterial hypertension (PAH). However, their clinical use may be limited by their... 
INHALED ILOPROST | selexipag | 5 INHIBITOR THERAPY | treprostinil | iloprost | prostacyclin | EPOPROSTENOL | COMBINATION THERAPY | meta-analysis | beraprost | adverse events | ENDOTHELIN RECEPTOR ANTAGONIST | MEDICINE, GENERAL & INTERNAL | IP receptor | PROSTANOID RECEPTORS | DOUBLE-BLIND | ORAL TREPROSTINIL | pulmonary arterial hypertension | SMOOTH-MUSCLE PROLIFERATION
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2001, Volume 98, Issue 2, pp. 729 - 734
ATP-sensitive potassium channels are an octomeric complex of four pore-forming subunits of the Kir 6.0 family and four sulfonylurea receptors. The Kir 6.0... 
Proteins | Biological Sciences | Immunoprecipitation | HEK293 cells | Complementary DNA | Cell lines | Antibodies | Dimers | Potassium channels | Pipettes | Electric current | KIR6.2 | SMOOTH-MUSCLE | PANCREATIC-ISLETS | INHIBITION | HETEROMULTIMERIC K+ CHANNELS | MULTIDISCIPLINARY SCIENCES | REGIONS | PROTEINS | BRAIN | UNITARY CONDUCTANCE | Potassium - metabolism | Protein Subunits | Receptors, Drug - genetics | Humans | Protein Multimerization | Potassium Channels - immunology | Molecular Sequence Data | Structure-Activity Relationship | Sulfonylurea Receptors | Biopolymers | Action Potentials | Transfection | Glyburide - pharmacology | Protein Isoforms - chemistry | Peptide Fragments - immunology | Ion Transport - drug effects | Potassium Channel Blockers | Amino Acid Sequence | Cell Line | Rabbits | Receptors, Drug - immunology | Potassium Channels, Inwardly Rectifying | Kidney - cytology | Recombinant Fusion Proteins - chemistry | Macromolecular Substances | Potassium Channels - genetics | Receptors, Drug - chemistry | ATP-Binding Cassette Transporters | Patch-Clamp Techniques | Animals | Potassium Channels - chemistry | Protein Isoforms - immunology | Microscopy, Fluorescence | Receptors, Drug - antagonists & inhibitors | Ion Channel Gating - drug effects | Protein Isoforms - genetics | Physiological aspects | Electrophysiology | Research
Journal Article
Journal Article
Critical Care Medicine, ISSN 0090-3493, 01/2007, Volume 35, Issue 1, pp. 33 - 40
BACKGROUND:Vasopressin is essential for cardiovascular homeostasis, acting via the kidney to regulate water resorption, on the vasculature to regulate smooth... 
Septic shock | Receptors | Potassium channels | Vasopressor agents | Nitric oxide | Vasopressin | septic shock | nitric oxide | receptors | SENSITIVE K+ CHANNELS | NITRIC-OXIDE SYNTHASE | vasopressin | ARGININE-VASOPRESSIN | IN-VITRO | potassium channels | ENDOTHELIAL-CELLS | SMOOTH-MUSCLE-CELLS | ORTHOSTATIC HYPOTENSION | ADVANCED VASODILATORY SHOCK | vasopressor agents | NONSELECTIVE CATION CHANNELS | CRITICAL CARE MEDICINE | Receptors, Oxytocin - physiology | Autonomic Nervous System Diseases - etiology | Shock, Septic - etiology | Sodium-Potassium-Exchanging ATPase - physiology | Vasopressins - therapeutic use | Calcium Signaling - physiology | Humans | Water-Electrolyte Balance - drug effects | Intracellular Fluid - physiology | Receptors, Vasopressin - drug effects | Receptors, Oxytocin - drug effects | Intracellular Fluid - drug effects | Shock, Septic - drug therapy | Homeostasis - drug effects | Hypothalamo-Hypophyseal System - physiology | Antidiuretic Agents - therapeutic use | Kidney - physiopathology | Muscle, Smooth, Vascular - physiology | Pituitary-Adrenal System - physiology | Muscle, Smooth, Vascular - drug effects | Vasoconstrictor Agents - pharmacology | Vasoconstrictor Agents - therapeutic use | Hypothalamo-Hypophyseal System - drug effects | Water-Electrolyte Balance - physiology | Kidney - drug effects | Pituitary-Adrenal System - drug effects | Vasopressins - pharmacology | Catecholamines - physiology | Nitric Oxide - physiology | Shock, Septic - physiopathology | Calcium Signaling - drug effects | Homeostasis - physiology | Receptors, Vasopressin - physiology | Sodium-Potassium-Exchanging ATPase - drug effects | Vasopressins - physiology | Antidiuretic Agents - pharmacology
Journal Article
Nature, ISSN 0028-0836, 02/2004, Volume 427, Issue 6977, p. 853
  Neutrophil leukocytes have a pivotal function in innate immunity. Dogma dictates that the lethal blow is delivered to microbes by reactive oxygen species... 
Leucocytes | Enzymes | Membranes | Immunology | Calcium | Potassium
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2011, Volume 654, Issue 3, p. 258
Prostanoid IP receptors coupled to Gs are thought to be the primary target for prostacyclin (PGI.sub.2) analogues. However, these agents also activate... 
Dilatation | Heterocyclic compounds | Blood vessels
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2011, Volume 654, Issue 3, pp. 258 - 265
Prostanoid IP receptors coupled to Gs are thought to be the primary target for prostacyclin (PGI ) analogues. However, these agents also activate prostanoid EP... 
Prostanoid IP receptor | G i/o, rat tail artery | Prostanoid EP 3 receptor | PGI 2 analogue | Prostanoid EP 4 receptor
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 07/2012, Volume 84, Issue 1, p. 68
Differential activation of human prostanoid receptors expressed in cells: EC.sub.50 values for prostacyclin analogues treprostinil or iloprost in stimulating... 
Medical colleges | Heterocyclic compounds | Prostacyclin
Journal Article
Circulation, ISSN 0009-7322, 08/2014, Volume 130, Issue 6, pp. 496 - 507
Journal Article