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by Laurance, William F and Carolina Useche, D and Rendeiro, Julio and Kalka, Margareta and Bradshaw, Corey J. A and Sloan, Sean P and Laurance, Susan G and Campbell, Mason and Abernethy, Kate and Alvarez, Patricia and Arroyo-Rodriguez, Victor and Ashton, Peter and Benítez-Malvido, Julieta and Blom, Allard and Bobo, Kadiri S and Cannon, Charles H and Cao, Min and Carroll, Richard and Chapman, Colin and Coates, Rosamond and Cords, Marina and Danielsen, Finn and De Dijn, Bart and Dinerstein, Eric and Donnelly, Maureen A and Edwards, David and Edwards, Felicity and Farwig, Nina and Fashing, Peter and Forget, Pierre-Michel and Foster, Mercedes and Gale, George and Harris, David and Harrison, Rhett and Hart, John and Karpanty, Sarah and John Kress, W and Krishnaswamy, Jagdish and Logsdon, Willis and Lovett, Jon and Magnusson, William and Maisels, Fiona and Marshall, Andrew R and McClearn, Deedra and Mudappa, Divya and Nielsen, Martin R and Pearson, Richard and Pitman, Nigel and Van Der Ploeg, Jan and Plumptre, Andrew and Poulsen, John and Quesada, Mauricio and Rainey, Hugo and Robinson, Douglas and Roetgers, Christiane and Rovero, Francesco and Scatena, Frederick and Schulze, Christian and Sheil, Douglas and Struhsaker, Thomas and Terborgh, John and Thomas, Duncan and Timm, Robert and Nicolas Urbina-Cardona, J and Vasudevan, Karthikeyan and Joseph Wright, S and Carlos Arias-G, Juan and Arroyo, Luzmila and Ashton, Mark and Auzel, Philippe and Babaasa, Dennis and Babweteera, Fred and Baker, Patrick and Banki, Olaf and Bass, Margot and Bila-Isia, Inogwabini and Blake, Stephen and Brockelman, Warren and Brokaw, Nicholas and Brühl, Carsten A and Bunyavejchewin, Sarayudh and Chao, Jung-Tai and Chave, Jerome and Chellam, Ravi and Clark, Connie J and Clavijo, José and Congdon, Robert and Corlett, Richard and Dattaraja, H.S and Dave, Chittaranjan and Davies, Glyn and De Mello Beisiegel, Beatriz and De Nazaré Paes Da Silva, Rosa and Di Fiore, Anthony and Diesmos, Arvin and Dirzo, Rodolfo and Doran-Sheehy, Diane and Eaton, Mitchell and Emmons, Louise and Estrada, Alejandro and ...
Nature, ISSN 0028-0836, 09/2012, Volume 489, Issue 7415, pp. 290 - 293
Journal Article
Nature, ISSN 0028-0836, 10/2011, Volume 478, Issue 7370, pp. 529 - 533
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7570, pp. 538 - 542
Bromodomain and extra terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a newtherapeutic opportunity by directly targeting... 
SELECTIVE-INHIBITION | ACCURATE | CHROMATIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | MUTATIONS | SEQUENCING DATA | CANCER | DISCOVERY | Chromatin - metabolism | Transcription, Genetic - drug effects | Clone Cells - drug effects | Neoplastic Stem Cells - drug effects | Epigenesis, Genetic | Humans | Leukemia, Myeloid, Acute - metabolism | Molecular Targeted Therapy | Neoplastic Stem Cells - metabolism | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Gene Expression Regulation, Neoplastic - drug effects | Hematopoietic Stem Cells - drug effects | Benzodiazepines - pharmacology | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Clone Cells - metabolism | beta Catenin - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Clone Cells - pathology | Wnt Signaling Pathway - drug effects | Genes, myc - genetics | Hematopoietic Stem Cells - cytology | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Proteins | Leukemia | Cloning | Cell cycle | Stem cells | Epigenetics | Apoptosis
Journal Article
Science, ISSN 0036-8075, 06/2017, Volume 356, Issue 6345, pp. 1397 - 1401
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 07/2016, Volume 23, Issue 7, pp. 673 - 681
Targeted therapies against disruptor of telomeric silencing 1-like (DOT1 L) and bromodomain-containing protein 4 (BRD4) are currently being evaluated in... 
CELLS | METHYLTRANSFERASE | CHROMATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | ACUTE MYELOID-LEUKEMIA | MYELODYSPLASTIC SYNDROME | CELL BIOLOGY | INHIBITION | BIOPHYSICS | EXPRESSION | TRANSCRIPTIONAL ELONGATION | FUSION PROTEINS | Chromatin - metabolism | RNA, Small Interfering - genetics | Cell Proliferation | Humans | Methyltransferases - metabolism | Methyltransferases - genetics | Male | T-Lymphocytes - metabolism | Female | Transcription, Genetic | Acetylation | B-Lymphocytes - pathology | Proteomics - methods | T-Lymphocytes - pathology | Nuclear Proteins - genetics | B-Lymphocytes - metabolism | Chromatin - chemistry | Disease Models, Animal | Leukemia, Biphenotypic, Acute - pathology | Signal Transduction | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Clinical Trials as Topic | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Histones - genetics | Methyltransferases - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Leukemia, Biphenotypic, Acute - metabolism | Protein Binding | Mice | Histones - metabolism | Primary Cell Culture | Leukemia, Biphenotypic, Acute - genetics | RNA, Small Interfering - metabolism | Epigenetic inheritance | Genetic transcription | Analysis | Leukemia | Protein expression | Molecular biology | Medical prognosis | Stem cells
Journal Article
Gut, ISSN 0017-5749, 11/2013, Volume 62, Issue 11, pp. 1581 - 1590
Objective Intestinal inflammation resulting from manipulation-induced mast cell activation is a crucial mechanism in the pathophysiology of postoperative ileus... 
RHEUMATOID-ARTHRITIS | ACTIVATION | SYK | G-PROTEINS | RECEPTOR | Inflammation | Intestinal Motility | Macrophages | Abdominal Surgery | SUBSTANCE-P | KETOTIFEN | GASTROENTEROLOGY & HEPATOLOGY | MAST-CELL DEGRANULATION | EXPRESSION | Mast Cells | Phosphodiesterase Inhibitors - therapeutic use | Postoperative Complications - prevention & control | Thioxanthenes - therapeutic use | Substance P - pharmacology | Dose-Response Relationship, Drug | Ovalbumin - antagonists & inhibitors | Syk Kinase | Aniline Compounds - administration & dosage | Xanthones - therapeutic use | Drug Evaluation, Preclinical - methods | Substance P - antagonists & inhibitors | Aniline Compounds - pharmacology | Postoperative Complications - physiopathology | Pyrimidines - administration & dosage | Ileus - physiopathology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Mast Cells - physiology | Gastrointestinal Transit - drug effects | Pyrimidines - pharmacology | Ovalbumin - pharmacology | Mast Cells - drug effects | Protein Kinase Inhibitors - administration & dosage | Animals | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Ileus - prevention & control | Mice | Protein Kinase Inhibitors - pharmacology | Aniline Compounds - therapeutic use | Macrophage Activation - drug effects | Cytokines - biosynthesis | Cell Degranulation - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors | Treatment outcome | Evaluation | Physiology, Pathological | Intestines | Obstructions | Care and treatment | Mast cells | Research | Abdominal surgery | Studies | Spleen | Phosphorylation | Cytokines | Surgery | Laboratory animals | Experiments | Abdomen
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e80746
Recent studies suggest that BET inhibitors are effective anti-cancer therapeutics. Here we show that BET inhibitors are effective against murine primary... 
MITOTIC CHROMOSOMES | CHROMATIN | NUT MIDLINE CARCINOMA | HISTONE TAILS | MULTIDISCIPLINARY SCIENCES | BREAST-CANCER SURVIVAL | C-MYC | FLUORESCENCE COMPLEMENTATION | BROMODOMAIN PROTEIN BRD4 | P-TEFB | BET BROMODOMAINS | Neoplasms - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | GTPase-Activating Proteins - metabolism | Heterocyclic Compounds, 4 or More Rings - pharmacology | Neoplasm Metastasis | Cell Nucleus - metabolism | Female | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Disease Models, Animal | Chromosomal Proteins, Non-Histone - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Protein Transport | Transcription Factors - metabolism | Nuclear Envelope - metabolism | Animals | Tumor Burden - drug effects | Protein Isoforms | Cell Line, Tumor | Protein Binding | Mice | Histones - metabolism | Neoplasms - pathology | N-Terminal Acetyltransferase E - metabolism | Proteins | Development and progression | Care and treatment | Metastasis | Mass spectrometry | Cancer | Laboratories | Childrens health | Biology | Genomes | Metastases | Anticancer properties | Genetics | Extracellular matrix | Localization | Binding | Medical research | Fractionation | Mortality | Mass spectroscopy | Breast cancer | Pharmacology | Inflammation | Gene expression | Inhibitors | Medical prognosis | Isoforms | Proteomics | Tumors
Journal Article
Cancer Research, ISSN 0008-5472, 12/2015, Volume 75, Issue 23, pp. 5106 - 5119
Journal Article
Science, ISSN 0036-8075, 06/2017, Volume 356, Issue 6345, p. 1397
The success of new therapies hinges on our ability to understand their molecular and cellular mechanisms of action. We modified BET bromodomain inhibitors, an... 
Epigenetic inheritance | Enzyme inhibitors | Patient outcomes | Chemical properties | Gene therapy | Health aspects | Testing
Journal Article