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science & technology (17) 17
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1. Full Text The AIM2 inflammasome: Sensor of pathogens and cellular perturbations
by Lugrin, Jérôme and Martinon, Fabio
Immunological reviews, ISSN 0105-2896, 01/2018, Volume 281, Issue 1, pp. 99 - 114
innate immunity | nuclear envelop stress | inflammasomes | DNA damage | DNA sensors | Life Sciences & Biomedicine | Immunology | Science & Technology | DNA-Binding Proteins - metabolism | Host-Pathogen Interactions | Animals | Caspases - metabolism | Inflammasomes - metabolism | DNA - immunology | Humans | Cell Death | Homeostasis | Pathogen-Associated Molecular Pattern Molecules - immunology | DNA Damage - immunology | Immunity, Innate | Analysis | Pathogenic microorganisms | Pathogens | Deregulation | Cytokines | Viruses | Activation | Inflammation | Parasites | Cytosol | Physiological responses | Interleukin 18 | Diseases | Damage detection | Cell death | Interleukin 1 | Life cycle engineering | Bacteria | Sensors | Aberration | Deoxyribonucleic acid--DNA | Cancer | Integrity | Life cycles | Index Medicus
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2. Full Text Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation
by Castelblanco, Mariela and Lugrin, Jérôme and Ehirchiou, Driss and Nasi, Sonia and Ishii, Isao and So, Alexander and Martinon, Fabio and Busso, Nathalie
The Journal of biological chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 7, pp. 2546 - 2557
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Interleukin-6 - genetics | Humans | Mice, Inbred C57BL | Interleukin-1beta - immunology | Inflammation - immunology | Interleukin-1beta - genetics | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Animals | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Inflammasomes - immunology | Interleukin-6 - immunology | Inflammation - genetics | Mice | Hydrogen Sulfide - immunology | Macrophages - immunology | Index Medicus | cystathionine γ-lyase | Molecular Bases of Disease | hydrogen sulfide | monosodium urate | caspase 1 (CASP1) | inflammasome | apoptosis-associated speck-like protein containing a CARD | NLRP3 | reactive oxygen species (ROS) | xanthine oxidase
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3. Full Text Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
by Ciarlo, Eleonora and Heinonen, Tytti and Lugrin, Jérôme and Acha-Orbea, Hans and Le Roy, Didier and Auwerx, Johan and Roger, Thierry
Scientific reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 3853 - 10
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Thymocytes - metabolism | Dendritic Cells - immunology | Humans | Immunophenotyping | Mycoses - genetics | Sirtuin 3 - deficiency | Mice, Knockout | Thymocytes - immunology | Bacterial Infections - genetics | Macrophages - metabolism | Animals | Host-Pathogen Interactions - genetics | Biomarkers | Mice | Disease Resistance - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Cell proliferation | Candidiasis | Immune response | Cytokines | Dendritic cells | Neurodegenerative diseases | Homeostasis | Listeriosis | T cell receptors | Infections | Macrophages | Mitochondria | Splenocytes | Rodents | Peritonitis | Endotoxemia | Index Medicus
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4. Full Text Histone Deacetylase Inhibitors Impair Antibacterial Defenses of Macrophages
by Matteo Mombelli and Jérôme Lugrin and Ivana Rubino and Anne-Laure Chanson and Marlyse Giddey and Thierry Calandra and Thierry Roger
The Journal of infectious diseases, ISSN 0022-1899, 11/2011, Volume 204, Issue 9, pp. 1367 - 1374
Oxidases | Phagocytes | Receptors | Histone deacetylase inhibitors | Cytokines | Histones | Bacteria | Infections | Macrophages | Phagocytosis | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Infectious diseases | Medical sciences | Phagocytosis - drug effects | Reactive Oxygen Species - metabolism | Reactive Nitrogen Species - metabolism | Immunologic Factors - physiology | NADPH Oxidases - antagonists & inhibitors | Phagocytosis - immunology | Escherichia coli - immunology | Microbial Viability | Animals | Nitric Oxide Synthase Type II - antagonists & inhibitors | Female | Histone Deacetylase Inhibitors - pharmacology | Macrophages - drug effects | Staphylococcus aureus - immunology | Mice | Mice, Inbred BALB C | Macrophages - immunology | Macrophages - microbiology | Enzyme inhibitors | Bacterial infections | Immune response | Physiological aspects | Causes of | Dosage and administration | Research | Drug therapy | Index Medicus | Abridged Index Medicus
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5. Full Text The role of oxidative stress during inflammatory processes
by Lugrin, Jérôme and Rosenblatt-Velin, Nathalie and Parapanov, Roumen and Liaudet, Lucas
Biological chemistry, ISSN 1431-6730, 02/2014, Volume 395, Issue 2, pp. 203 - 230
innate immunity | inflammation | inflammasome | cell signaling | Toll-like receptors | danger signals | oxidative stress | Oxidative stress | Danger signals | Innate immunity | Inflammasome | Inflammation | Cell signaling | Inflammasomes - metabolism | Oxidation-Reduction | Reactive Nitrogen Species - metabolism | Humans | Oxidative Stress - physiology | Oxidative Stress - immunology | Inflammation - immunology | Free Radicals - immunology | Immunity, Innate | Signal Transduction - immunology | Inflammation - metabolism | Animals | Inflammasomes - immunology | Free Radicals - metabolism | Reactive Nitrogen Species - immunology | Physiological aspects | Reactive oxygen species | Health aspects | Index Medicus
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6. Full Text Periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis syndrome is associated with a card8 variant unable to bind the nlrp3 inflammasome
by Cheung, Ming Sin and Theodoropoulou, Katerina and Lugrin, Jerome and Martinon, Fabio and Busso, Nathalie and Hofer, Michael
The Journal of immunology (1950), ISSN 0022-1767, 03/2017, Volume 198, Issue 5, pp. 2063 - 2069
Life Sciences & Biomedicine | Immunology | Science & Technology | Genetic Predisposition to Disease | Protein Binding - genetics | Inflammasomes - metabolism | Genetic Association Studies | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Gene Frequency | Humans | Genotype | Risk | Neoplasm Proteins - metabolism | Syndrome | CARD Signaling Adaptor Proteins - genetics | CARD Signaling Adaptor Proteins - metabolism | DNA Mutational Analysis | Fever - genetics | High-Throughput Nucleotide Sequencing | Polymorphism, Single Nucleotide | Stomatitis, Aphthous | Pharyngitis | Lymphadenitis | Neoplasm Proteins - genetics | Child | Frameshift Mutation - genetics | Hereditary Autoinflammatory Diseases - genetics | Aphthous stomatitis | Health risks | Genetic diversity | Patients | Fever | Carriers | Confidence intervals | Proteins | Stomatitis | Adenitis | Foot-and-mouth disease | Children | Polymorphism | Index Medicus | Abridged Index Medicus
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