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1. Full Text Distinctive single-channel properties of α4β2-nicotinic acetylcholine receptor isoforms
by Weltzin, Maegan M and George, Andrew A and Lukas, Ronald J and Whiteaker, Paul
PloS one, ISSN 1932-6203, 2019, Volume 14, Issue 3, p. e0213143
Central nervous system nicotinic acetylcholine receptors (nAChR) are predominantly of the α4β2 subtype. Two isoforms exist, with high or low agonist... 
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2. Full Text Isoform-specific mechanisms of a3β4∗-nicotinic acetylcholine receptor modulation by the prototoxin lynx1
by George, Andrew A and Bloy, Abigail and Miwa, Julie M and Lindstrom, Jon M and Lukas, Ronald J and Whiteaker, Paul
FASEB Journal, ISSN 0892-6638, 04/2017, Volume 31, Issue 4, pp. 1398 - 1420
Concatenated receptor subunits | Neurotoxins | Single-channel electrophysiology | TEVC | GPI-linked proteins
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3. Full Text Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol
by Gao, Ming and Gao, Fenfei and Chen, Dejie and Ma, Xiaokuang and Sudweeks, Sterling and Yorgason, Jordan T and Turner, Dharshaun and Eaton, Jason Brek and McIntosh, J. Michael and Lukas, Ronald J and Whiteaker, Paul and Chang, Yongchang and Steffensen, Scott C and Wu, Jie
Neuropharmacology, ISSN 0028-3908, 05/2019, Volume 149, pp. 45 - 54
Alcohol use disorder (AUD) is a serious public health problem that results in tremendous social, legal and medical costs to society. Unlike other addictive... 
Alcohol | Ethanol | Patch-clamp | SH-EP1 cells | Nicotinic acetylcholine receptor | Alpha 6 subunit | DOPAMINE RELEASE | SUBTYPES | SUBUNIT COMPOSITION | NEUROSCIENCES | VENTRAL TEGMENTAL AREA | NUCLEUS-ACCUMBENS | CHOLINERGIC INTERNEURONS | ION CURRENT | PHARMACOLOGY & PHARMACY | GABA(A) RECEPTORS | MODULATION | Physiological aspects | Marine toxins | Neurons | Alcohols | Neurophysiology
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4. Full Text Distinctive single-channel properties of [alpha]4[beta]2-nicotinic acetylcholine receptor isoforms.(Research Article)
by Weltzin, Maegan M and George, Andrew A and Lukas, Ronald J and Whiteaker, Paul
PLoS ONE, ISSN 1932-6203, 03/2019, Volume 14, Issue 3, p. e0213143
Receptors | Physiological aspects | Neural transmission | Ion channels | Genetic aspects | Acetylcholine | Research
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5. Full Text Resistance to Inhibitors of Cholinesterase 3 Expression Promotes Selective Protein Associations with the Human [alpha]7-Nicotinic Acetylcholine Receptor Interactome
by Mulcahy, Matthew J and Blattman, Sydney B and Barrantes, Francisco J and Lukas, Ronald J and Hawrot, Edward
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8
Proteins | Biosynthesis | Mass spectrometry
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6. Nicotinic receptors in the nervous system
by Levin, Edward D
2002, Methods & new frontiers in neuroscience, ISBN 084932386X, 289
Nicotinic receptors
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7. Full Text Nocturnal frontal lobe epilepsy-associated intracellular-loop mutant subunits alter single-channel properties of α4β2-nicotinic receptor isoforms
by Weltzin, Maegan M and George, Andrew A and Lukas, Ronald J and Whiteaker, Paul
Biochemical Pharmacology, ISSN 0006-2952, 10/2015, Volume 97, Issue 4, pp. 628 - 628
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8. Full Text Nocturnal frontal lobe epilepsy-associated intracellular-loop mutant subunits alter single-channel properties of [alpha]4[beta]2-nicotinic receptor isoforms
by Weltzin, Maegan M and George, Andrew A and Lukas, Ronald J and Whiteaker, Paul
Biochemical Pharmacology, ISSN 0006-2952, 10/2015, Volume 97, Issue 4, p. 628
Brain | Epilepsy | Analysis
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9. Full Text Modulation of gain-of-function α6-nicotinic acetylcholine receptor by β3 subunits
by Dash, Bhagirathi and Lukas, Ronald J
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 17, pp. 14259 - 14269
We previously have shown that β3 subunits either eliminate (e.g. for all-human (h) or all-mouse (m) α6β4β3-nAChR) or potentiate (e.g. for hybrid mα6hβ4hβ3- or... 
Protein Structure, Tertiary | Ions - chemistry | Mutagenesis, Site-Directed | Oocytes - metabolism | Humans | Xenopus laevis | Animals | Electrophysiology - methods | Receptors, Nicotinic - chemistry | Receptors, Nicotinic - physiology | Cloning, Molecular | Protein Binding | Female | Ligands | Protein Conformation | Mice | Receptors, Nicotinic - genetics | Ligand-binding Protein | Receptor Structure-Function | Mutagenesis Site-specific | Ion Channels | Nicotinic Acetylcholine Receptors | Neurobiology
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10. Full Text A signal peptide missense mutation associated with nicotine dependence alters [alpha]2-nicotinic acetylcholine receptor function
by Dash, Bhagirathi and Lukas, Ronald J and Li, Ming D
Neuropharmacology, ISSN 0028-3908, 04/2014, Volume 79, p. 715
A cytosine to thymidine (C [right arrow] T) missense mutation in the signal peptide (SP) sequence (rs2472553) of the nicotinic acetylcholine receptor (nAChR)... 
Peptides | Analysis | Genetic aspects
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11. Full Text Proteomic investigation of human α7-nicotinic acetylcholine receptor signaling mechanisms
by Mulcahy, Matthew J and Lukas, Ronald J and Barrantes, Francisco J and Hawrot, Edward
Biochemical Pharmacology, ISSN 0006-2952, 10/2013, Volume 86, Issue 8, pp. 1227 - 1228
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12. Full Text Naturally-expressed nicotinic acetylcholine receptor subtypes
by Wu, Jie and Lukas, Ronald J
Biochemical Pharmacology, ISSN 0006-2952, 2011, Volume 82, Issue 8, pp. 800 - 807
Nicotinic acetylcholine receptors (nAChRs) warrant attention, as they play many critical roles in brain and body function and have been implicated in a number... 
Acetylcholine | Drug dependence | Nicotinic receptor | Alzheimer's disease | Nicotine | EXPOSURE DIFFERENTIALLY AFFECTS | STRIATAL SYNAPTOSOMES | AGONIST-BINDING | RAT HIPPOCAMPAL-NEURONS | BUNGAROTOXIN BINDING-SITES | SUBUNIT MESSENGER-RNAS | MIDBRAIN DOPAMINE NEURONS | 3 BETA 2 | PHARMACOLOGY & PHARMACY | ALPHA-CONOTOXIN-MII | LONG-TERM POTENTIATION | Brain - metabolism | Protein Subunits | Receptors, Nicotinic - metabolism | Animals | Receptors, Nicotinic - physiology | Humans | Receptors, Nicotinic - genetics | Tobacco Use Disorder - metabolism | Drug therapy | Neurological diseases | Brain | Reviews | Mental disorders | Attention | Acetylcholine receptors (nicotinic) | nicotine | nicotinic receptor | acetylcholine | Alzheimer’s disease | drug dependence
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13. Full Text The spliceosome is a therapeutic vulnerability in MYC-driven cancer
by Hsu, Tiffany Y.-T and Simon, Lukas M and Neill, Nicholas J and Marcotte, Richard and Sayad, Azin and Bland, Christopher S and Echeverria, Gloria V and Sun, Tingting and Kurley, Sarah J and Tyagi, Siddhartha and Karlin, Kristen L and Dominguez-Vidaña, Rocio and Hartman, Jessica D and Renwick, Alexander and Scorsone, Kathleen and Bernardi, Ronald J and Skinner, Samuel O and Jain, Antrix and Orellana, Mayra and Lagisetti, Chandraiah and Golding, Ido and Jung, Sung Y and Neilson, Joel R and Zhang, Xiang H.-F and Cooper, Thomas A and Webb, Thomas R and Neel, Benjamin G and Shaw, Chad A and Westbrook, Thomas F
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7569, pp. 384 - 388
MYC (also known as c-MYC) overexpression or hyperactivation is one of the most common drivers of human cancer. Despite intensive study, the MYC oncogene... 
BREAST-CANCER | CELLS | PROTEIN | GENE | INITIATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | GROWTH | C-MYC | PRINCIPLES | RNA Precursors - biosynthesis | Humans | Phosphoproteins - metabolism | RNA, Messenger - biosynthesis | Spliceosomes - metabolism | Splicing Factor U2AF | Ribonucleoprotein, U2 Small Nuclear - metabolism | Neoplasm Metastasis - drug therapy | Female | Gene Expression Regulation, Neoplastic - drug effects | Cell Survival - drug effects | RNA Splicing - drug effects | Introns - genetics | RNA, Messenger - genetics | RNA Splicing Factors | Nuclear Proteins - metabolism | RNA Precursors - genetics | Ribonucleoproteins - metabolism | Breast Neoplasms - drug therapy | Proto-Oncogene Proteins c-myc - metabolism | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Mice, Nude | Genes, myc - genetics | Cell Line, Tumor | Mice | Proto-Oncogene Proteins c-myc - genetics | Cell Transformation, Neoplastic - drug effects | HeLa Cells | Spliceosomes - drug effects | Care and treatment | Transcription factors | Gene therapy | Health aspects | Methods | Cancer | Proteins | Breast cancer | Mutation | Gene expression | Apoptosis
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14. Full Text β-amyloid directly inhibits human α4β3-nicotinic acetylcholine receptors heterologously expressed in human SH-EP1 cells
by Wut, Jie and Kuo, Yen-Ping and George, Andrew A and Xu, Lin and Hu, Jun and Lukas, Ronald J
Journal of Biological Chemistry, ISSN 0021-9258, 09/2004, Volume 279, Issue 36, pp. 37842 - 37851
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15. Full Text Roles for N-terminal extracellular domains of nicotinic acetylcholine receptor (nAChR) β3 subunits in enhanced functional expression of mouse α6β2β3- and α6β4β3-nAChRs
by Dash, Bhagirathi and Li, Ming D and Lukas, Ronald J
Journal of Biological Chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 41, pp. 28338 - 28351
Functional heterologous expression of naturally expressed mouse α6*-nicotinic acetylcholine receptors (mα6*-nAChRs; where "*" indicates the presence of... 
Humans | Protein Multimerization | Amino Acids - chemistry | Molecular Sequence Data | Oocysts - drug effects | Recombinant Fusion Proteins - metabolism | Protein Subunits - metabolism | Nicotine - pharmacology | Amino Acids - metabolism | Oocysts - cytology | Receptors, Nicotinic - chemistry | Female | Protein Subunits - genetics | Membrane Potentials - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Atropine - metabolism | Gene Expression | Receptors, Nicotinic - metabolism | Protein Structure, Secondary | Xenopus laevis | Atropine - pharmacology | Recombinant Fusion Proteins - chemistry | Sequence Homology, Amino Acid | Animals | Nicotine - metabolism | Recombinant Fusion Proteins - genetics | Mice | Protein Subunits - chemistry | Receptors, Nicotinic - genetics | Oocysts - metabolism | Index Medicus | Neurotransmitter Receptor | Electrophysiology | Receptor Structure-Function | Ion Channel | Nicotinic Acetylcholine Receptors (nAChR) | Neurobiology
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16. Full Text Reporter mutation studies show that nicotinic acetylcholine receptor (nAChR) α5 subunits and/or variants modulate function of α6-nAChR
by Dash, Bhagirathi and Chang, Yongchang and Lukas, Ronald J
Journal of Biological Chemistry, ISSN 0021-9258, 11/2011, Volume 286, Issue 44, pp. 37905 - 37918
To further the understanding of functional α6α5*-nicotinic acetylcholine receptors (nAChR; the asterisk (*) indicates known or possible presence of other... 
Protein Structure, Tertiary | Receptors, Nicotinic - metabolism | Oocytes - metabolism | Humans | Xenopus laevis | Cytoplasm - metabolism | Recombinant Fusion Proteins - chemistry | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Point Mutation | Animals | Electrophysiology - methods | Nicotine - metabolism | Female | Ligands | Mutation | DNA, Complementary - metabolism | Receptors, Nicotinic - genetics | Neurotransmitter Receptors | Ligand-binding Protein | Ion Channels | Nicotinic Acetylcholine Receptors | Receptor Structure-function | Neurobiology
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17. Full Text Modulation of recombinant, α2, α3 or α4-nicotinic acetylcholine receptor (nAChR) function by nAChR β3 subunits
: Nicotinic receptor modulation by β3 subunits
by Dash, Bhagirathi and Bhakta, Minoti and Chang, Yongchang and Lukas, Ronald J
Journal of Neurochemistry, ISSN 0022-3042, 05/2012, Volume 121, Issue 3, pp. 349 - 361
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18. Full Text Nicotine-morphine interactions at [alpha]4[beta]2, [alpha]7 and [alpha]3.sup.[cor] nicotinic acetylcholine receptors
by Talka, Reeta and Salminen, Outi and Whiteaker, Paul and Lukas, Ronald J and Tuominen, Raimo K
European Journal of Pharmacology, ISSN 0014-2999, 02/2013, Volume 701, Issue 1-3, p. 57
Nicotine and opioids share several behavioral and rewarding properties. Although both opioids and nicotine have their own specific mechanism of action, there... 
Morphine | Nicotine
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19. Nicotine-morphine interactions at alpha 4 beta 2, alpha 7 and alpha 3 super() nicotinic acetylcholine receptors
by Talka, Reeta and Salminen, Outi and Whiteaker, Paul and Lukas, Ronald J and Tuominen, Raimo K
European Journal of Pharmacology, ISSN 0014-2999, 02/2013, Volume 701, Issue 1-3, pp. 57 - 64
Nicotine and opioids share several behavioral and rewarding properties. Although both opioids and nicotine have their own specific mechanism of action, there... 
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20. Full Text A signal peptide missense mutation associated with nicotine dependence alters α2-nicotinic acetylcholine receptor function
by Dash, Bhagirathi and Lukas, Ronald J and Li, Ming D
Neuropharmacology, ISSN 0028-3908, 04/2014, Volume 79, pp. 715 - 725
A cytosine to thymidine (C → T) missense mutation in the signal peptide (SP) sequence (rs2472553) of the nicotinic acetylcholine receptor (nAChR) α2 subunit... 
Receptor structure-function | Electrophysiology | Signal peptide | Missense mutation | Single nucleotide polymorphism | Nicotinic acetylcholine receptor | Membrane Potentials - drug effects | Amino Acid Sequence | Genetic Predisposition to Disease | Receptors, Nicotinic - metabolism | Species Specificity | Humans | Xenopus laevis | Acetylcholine - metabolism | Nicotinic Antagonists - pharmacology | Mutation, Missense | Membrane Potentials - physiology | Nicotine - pharmacology | Nerve Tissue Proteins - metabolism | Patch-Clamp Techniques | Animals | Mecamylamine - pharmacology | Tobacco Use Disorder - genetics | Polymorphism, Single Nucleotide | Receptors, Nicotinic - genetics | Nicotinic Agonists - pharmacology | signal peptide | electrophysiology | single nucleotide polymorphism | missense mutation | receptor structure-function
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