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1. Full Text Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis
by Torchia, Jonathon, MSc and Picard, Daniel, MSc and Lafay-Cousin, Lucie, MD and Hawkins, Cynthia E, PhD and Kim, Seung-Ki, MD and Letourneau, Louis, BSc and Ra, Young-Shin, Prof and Ho, King Ching, MSc and Chan, Tiffany Sin Yu, PhD and Sin-Chan, Patrick, MSc and Dunham, Christopher P, MD and Yip, Stephen, FRCPC and Ng, Ho-keung, MD and Lu, Jian-Qiang, FRCPC and Albrecht, Steffen, MD and Pimentel, José, PhD and Chan, Jennifer A, MD and Somers, Gino R, MBBS and Zielenska, Maria, PhD and Faria, Claudia C, PhD and Roque, Lucia, PhD and Baskin, Berivan, PhD and Birks, Diane, MS and Foreman, Nick, Prof and Strother, Douglas, MD and Klekner, Almos, PhD and Garami, Miklos, PhD and Hauser, Peter, PhD and Hortobágyi, Tibor, PhD and Bognár, Laszló, PhD and Wilson, Beverly, MD and Hukin, Juliette, FRCPC and Carret, Anne-Sophie, MD and Van Meter, Timothy E, PhD and Nakamura, Hideo, MD and Toledano, Helen, MD and Fried, Iris, MD and Fults, Daniel, MD and Wataya, Takafumi, PhD and Fryer, Chris, FRCPC and Eisenstat, David D, MD and Scheineman, Katrin, Prof and Johnston, Donna, MD and Michaud, Jean, MD and Zelcer, Shayna, MD and Hammond, Robert, MD and Ramsay, David A, MBChB and Fleming, Adam J, MD and Lulla, Rishi R, MD and Fangusaro, Jason R, MD and Sirachainan, Nongnuch, MD and Larbcharoensub, Noppadol, MD and Hongeng, Suradej, MD and Barakzai, Muhammad Abrar, MD and Montpetit, Alexandre, PhD and Stephens, Derek, MSc and Grundy, Richard G, FRCPCH and Schüller, Ulrich, MD and Nicolaides, Theodore, MD and Tihan, Tarik, PhD and Phillips, Joanna, PhD and Taylor, Michael D, PhD and Rutka, James T, MD and Dirks, Peter, PhD and Bader, Gary D, PhD and Warmuth-Metz, Monika, Prof and Rutkowski, Stefan, Prof and Pietsch, Torsten, Prof and Judkins, Alexander R, MD and Jabado, Nada, PhD and Bouffet, Eric, Prof and Huang, Annie, Dr and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Uppsala universitet and Medicinsk genetik och genomik
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 5, pp. 569 - 582
Summary Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are lethal childhood cancers with characteristic genetic alterations... 
Hematology, Oncology and Palliative Medicine | SURVIVAL | CELLS | FOREBRAIN | THERAPY | PROGNOSTIC-FACTORS | ONCOLOGY | GENE-EXPRESSION | MUTATIONS | HSNF5/INI1 | TERATOID/RHABDOID TUMORS | Immunohistochemistry | Basic Helix-Loop-Helix Transcription Factors - genetics | Prognosis | Genomics | Humans | Risk Factors | Gene Expression Regulation, Neoplastic | Child, Preschool | Infant | Male | Receptors, Notch - genetics | Signal Transduction - genetics | Rhabdoid Tumor - pathology | Teratoma - pathology | Rhabdoid Tumor - genetics | Receptors, Notch - biosynthesis | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Teratoma - genetics | Female | Child | Genetic research | Analysis | Tumors | Clinical Medicine | Medical and Health Sciences | Cancer and Oncology | Klinisk medicin | Medicin och hälsovetenskap | Cancer och onkologi
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2. Full Text Emergencies in Children and Young Adults with Central Nervous System Tumors
by Lulla, Rishi R., MD, MS and Foy, Andrew B., MD and DiPatri, Arthur J., MD and Fangusaro, Jason, MD
Clinical Pediatric Emergency Medicine, ISSN 1522-8401, 2011, Volume 12, Issue 3, pp. 213 - 223
Central nervous system (CNS) tumors are the most common solid tumors in childhood and adolescence. Evaluation and management of patients with CNS tumors by... 
Emergency | hydrocephalus | spinal cord compression | chemotherapy | central nervous system (CNS) tumors | radiation therapy | Chemotherapy | Radiation therapy | Hydrocephalus | Spinal cord compression | Central nervous system (CNS) tumors | Radiotherapy | Central nervous system | Cancer | Tumors | Pediatrics | Stroke | Medical treatment | Brain cancer | Emergencies | Headaches | Neurosurgery | Blood clots
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3. Full Text Identification of micrornas as potential prognostic markers in ependymoma
by Costa, Fabricio F and Bischof, Jared M and Vanin, Elio F and Lulla, Rishi R and Wang, Min and Sredni, Simone T and Rajaram, Veena and de Fátima Bonaldo, Maria and Wang, Deli and Goldman, Stewart and Tomita, Tadanori and Soares, Marcelo B
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 10, p. e25114
Introduction: We have examined expression of microRNAs (miRNAs) in ependymomas to identify molecular markers of value for clinical management. miRNAs are... 
CELLS | GLIOMA | MULTIDISCIPLINARY SCIENCES | LET-7 | INTRACRANIAL EPENDYMOMA | EXPRESSION | PCR | Multivariate Analysis | Prognosis | Humans | Computational Biology | Gene Expression Regulation, Neoplastic | Proportional Hazards Models | Child, Preschool | Infant | Male | MicroRNAs - metabolism | Gene Expression Profiling | Ependymoma - genetics | Case-Control Studies | Regression Analysis | Adolescent | Survival Analysis | Biomarkers, Tumor - metabolism | Ependymoma - pathology | Female | Biomarkers, Tumor - genetics | MicroRNAs - genetics | Child | Development and progression | MicroRNA | Genetic translation | Brain tumors | Brain | Pediatrics | Correlation | Brain cancer | Identification | Biology | Metastasis | Paraffin | Parameter identification | Cancer therapies | Coding | Cell cycle | Chromosome 14 | Research centers | Chromosomes | Markers | MiRNA | Histology | Regression analysis | Gene expression | Children & youth | Medicine | Ependymal cells | Brain research | Hospitals | MicroRNAs | Medical prognosis | Stem cells | Epigenetics | Mutation | mRNA stability | Tumors
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4. Full Text Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors
by Torchia, Jonathon and Golbourn, Brian and Feng, Shengrui and Ho, King Ching and Sin-Chan, Patrick and Vasiljevic, Alexandre and Norman, Joseph D and Guilhamon, Paul and Garzia, Livia and Agamez, Natalia R and Lu, Jian-Qiang and Lu, Mei and Chan, Tiffany S and Chan, Jennifer A and Picard, Daniel and de Antonellis, Pasqualino and Khuong-Quang, Dong-Anh and Planello, Aline C and Zeller, Constanze and Barsyte-Lovejoy, Dalia and Lafay-Cousin, Lucie and Letourneau, Louis and Bourgey, Mathieu and Yu, Man and Gendoo, Deena M.A and Dzamba, Misko and Barszczyk, Mark and Medina, Tiago and Riemenschneider, Alexandra N and Morrissy, A. Sorana and Ra, Young-Shin and Ramaswamy, Vijay and Remke, Marc and Dunham, Christopher P and Yip, Stephen and Ng, Ho-keung and Mehta, Vivek and Albrecht, Steffen and Pimentel, Jose and Somers, Gino R and Faria, Claudia C and Roque, Lucia and Fouladi, Maryam and Hoffman, Lindsey M and Moore, Andrew S and Wang, Yin and Choi, Seung Ah and Hansford, Jordan R and Catchpoole, Daniel and Birks, Diane K and Foreman, Nicholas K and Strother, Doug and Klekner, Almos and Bognár, Laszló and Garami, Miklós and Hauser, Péter and Hortobágyi, Tibor and Wilson, Beverly and Hukin, Juliette and Carret, Anne-Sophie and Van Meter, Timothy E and Hwang, Eugene I and Gajjar, Amar and Chiou, Shih-Hwa and Nakamura, Hideo and Toledano, Helen and Fried, Iris and Fults, Daniel and Wataya, Takafumi and Fryer, Chris and Eisenstat, David D and Scheinemann, Katrin and Fleming, Adam J and Johnston, Donna L and Michaud, Jean and Zelcer, Shayna and Hammond, Robert and Afzal, Samina and Ramsay, David A and Sirachainan, Nongnuch and Hongeng, Suradej and Larbcharoensub, Noppadol and Grundy, Richard G and Lulla, Rishi R and Fangusaro, Jason R and Druker, Harriet and Bartels, Ute and Grant, Ronald and Malkin, David and McGlade, C. Jane and Nicolaides, Theodore and Tihan, Tarik and Phillips, Joanna and Majewski, Jacek and Montpetit, Alexandre and Bourque, Guillaume and Bader, Gary D and Reddy, Alyssa T and Gillespie, G. Yancey and Warmuth-Metz, Monika and ...
Cancer Cell, ISSN 1535-6108, 12/2016, Volume 30, Issue 6, pp. 891 - 908
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however,... 
genomics | epigenomics | subgroup-specific therapeutics | enhancer | ATRT | rhabdoid tumors | GENE | CHROMATIN | ONCOLOGY | CENTRAL-NERVOUS-SYSTEM | MUTATIONS | DIFFERENTIATION | ATYPICAL TERATOID/RHABDOID TUMORS | EXPRESSION | CANCER | GENOME | CHILDREN | CELL BIOLOGY | Cell Survival - drug effects | Rhabdoid Tumor - drug therapy | Central Nervous System Neoplasms - genetics | Humans | Dasatinib - therapeutic use | SMARCB1 Protein - genetics | Pyrimidines - pharmacology | Receptor, Platelet-Derived Growth Factor beta - genetics | Dasatinib - pharmacology | DNA Methylation | Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors | Rhabdoid Tumor - genetics | Epigenomics - methods | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Teratoma - drug therapy | Cell Line, Tumor | Teratoma - genetics | Cell Proliferation - drug effects | Epigenesis, Genetic - drug effects | Protein Kinase Inhibitors - pharmacology | Mutation | Central Nervous System Neoplasms - drug therapy | Chromatin - genetics | Genetic research | Health aspects | Analysis | Tumors | Index Medicus
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5. Full Text Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth
by Hashizume, Rintaro and Zhang, Ali and Mueller, Sabine and Prados, Michael D and Lulla, Rishi R and Goldman, Stewart and Saratsis, Amanda M and Mazar, Andrew P and Stegh, Alexander H and Cheng, Shi-Yuan and Horbinski, Craig and Haas-Kogan, Daphne A and Sarkaria, Jann N and Waldman, Todd and James, C. David
Neuro-Oncology, ISSN 1522-8517, 11/2016, Volume 18, Issue 11, pp. 1519 - 1528
Background. Radiation therapy is the most commonly used postsurgical treatment for primary malignant brain tumors. Consequently, investigating the efficacy of... 
bioluminescence imaging | Atypical teratoid rhabdoid tumor | glioblastoma | xenograft | palbociclib | PATHWAYS | CELLS | RADIATION SENSITIVITY | MODEL | P16(INK4A) | DISCOVERY | EGFR | CLINICAL NEUROLOGY | G ARREST | GENE | ONCOLOGY | GROWTH | atypical teratoid rhabdoid tumor | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Glioblastoma - enzymology | Humans | Antineoplastic Agents - therapeutic use | Glioblastoma - radiotherapy | Heterografts | Teratoma - radiotherapy | Female | Brain Neoplasms - radiotherapy | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Pyridines - therapeutic use | DNA Damage - drug effects | Rhabdoid Tumor - drug therapy | Brain Neoplasms - enzymology | Chemoradiotherapy - methods | DNA Repair - drug effects | Teratoma - enzymology | Retinoblastoma Protein - metabolism | Rhabdoid Tumor - radiotherapy | Combined Modality Therapy | Cyclin-Dependent Kinase 6 - metabolism | Piperazines - therapeutic use | Brain Neoplasms - drug therapy | Cyclin-Dependent Kinase 4 - metabolism | Rhabdoid Tumor - enzymology | Xenograft Model Antitumor Assays | Animals | Teratoma - drug therapy | Survival Analysis | Cell Line, Tumor | Cell Proliferation - drug effects | Mice, Inbred BALB C | Glioblastoma - drug therapy | Basic and Translational Investigation
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6. Full Text Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups
by Merino, Diana M and Shlien, Adam and Villani, Anita and Pienkowska, Malgorzata and Mack, Stephen and Ramaswamy, Vijay and Shih, David and Tatevossian, Ruth and Novokmet, Ana and Choufani, Sanaa and Dvir, Rina and Ben-Arush, Myran and Harris, Brent T and Hwang, Eugene I and Lulla, Rishi and Pfister, Stefan M and Achatz, Maria Isabel and Jabado, Nada and Finlay, Jonathan L and Weksberg, Rosanna and Bouffet, Eric and Hawkins, Cynthia and Taylor, Michael D and Tabori, Uri and Ellison, David W and Gilbertson, Richard J and Malkin, David
Clinical Cancer Research, ISSN 1078-0432, 01/2015, Volume 21, Issue 1, pp. 184 - 192
Purpose: To investigate molecular alterations in choroid plexus tumors (CPT) using a genome-wide high-throughput approach to identify diagnostic and prognostic... 
ARTICLE | EXPERIENCE | ONCOLOGY | PROGRESSION | PAPILLOMA | Prognosis | Neoplasm Proteins - biosynthesis | Humans | Gene Expression Regulation, Neoplastic | Child, Preschool | Infant | Male | DNA Methylation - genetics | Choroid Plexus Neoplasms - pathology | Tumor Suppressor Protein p53 - genetics | Disease-Free Survival | Choroid Plexus Neoplasms - genetics | Adolescent | Female | Mutation | Neoplasm Staging | Child | Choroid Plexus Neoplasms - classification
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7. Full Text Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas
by Piunti, Andrea and Hashizume, Rintaro and Morgan, Marc A and Bartom, Elizabeth T and Horbinski, Craig M and Marshall, Stacy A and Rendleman, Emily J and Ma, Quanhong and Takahashi, Yoh-Hei and Woodfin, Ashley R and Misharin, Alexander V and Abshiru, Nebiyu A and Lulla, Rishi R and Saratsis, Amanda M and Kelleher, Neil L and James, C David and Shilatifard, Ali
Nature Medicine, ISSN 1078-8956, 04/2017, Volume 23, Issue 4, pp. 493 - 500
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brainstem tumor characterized by rapid and uniform patient demise(1). A heterozygous... 
MEDICINE, RESEARCH & EXPERIMENTAL | METHYLATION | INHIBITION | ALIGNMENT | HISTONE H3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | MUTATION | GENE-EXPRESSION | CELL | CELL BIOLOGY | Chromatin - metabolism | Humans | Nucleosomes - drug effects | Molecular Targeted Therapy | Glioma - genetics | Neurogenesis - genetics | Histone Code - drug effects | Neurogenesis - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Chromatin - drug effects | Gene Expression Regulation, Neoplastic - genetics | RNA-Binding Proteins - antagonists & inhibitors | Cell Proliferation - genetics | Epigenomics | Nucleosomes - metabolism | Polycomb Repressive Complex 2 - drug effects | Histones - drug effects | Protein Transport | Azepines - pharmacology | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Acetylation - drug effects | Animals | Brain Stem Neoplasms - genetics | Histones - genetics | Methylation - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mutation | Polycomb Repressive Complex 2 - metabolism | Histone Code - genetics | RNA-Binding Proteins - metabolism | Molecular targeted therapy | Care and treatment | Gliomas | Histones | Development and progression | Genetic aspects | Tumor proteins | Health aspects
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8. Full Text Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma
by Huang, Tina Y and Piunti, Andrea and Lulla, Rishi R and Qi, Jin and Horbinski, Craig M and Tomita, Tadanori and James, C David and Shilatifard, Ali and Saratsis, Amanda M
Acta neuropathologica communications, ISSN 2051-5960, 04/2017, Volume 5, Issue 1, pp. 28 - 12
Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise... 
Liquid biopsy | Cerebrospinal fluid | Diffuse midline glioma | H3K27M | Diffuse intrinsic pontine glioma (DIPG) | H3F3A | BIOPSY | SUBGROUPS | PEDIATRIC GLIOBLASTOMA | NEUROSCIENCES | LINEAR POLYACRYLAMIDE | PRECIPITATION | K27M MUTATION | INTRINSIC PONTINE GLIOMAS | CENTRAL-NERVOUS-SYSTEM | BRAIN | Immunohistochemistry | Humans | Brain Neoplasms - genetics | DNA Mutational Analysis - methods | Glioma - cerebrospinal fluid | Brain Neoplasms - metabolism | Brain Neoplasms - surgery | Feasibility Studies | Glioma - metabolism | Brain - metabolism | Glioma - genetics | Histones - genetics | Biomarkers, Tumor - cerebrospinal fluid | Brain - pathology | Cell Line, Tumor | Brain - surgery | Histones - cerebrospinal fluid | Biomarkers, Tumor - genetics | Mutation | Glioma - surgery | Brain Neoplasms - cerebrospinal fluid | DNA, Neoplasm - cerebrospinal fluid | Gene mutations | Gliomas | DNA | Genetic aspects | Research | Children | Health aspects | Pediatrics | Biopsy | Brain cancer | DNA methylation | Gene expression | Patients | Deoxyribonucleic acid--DNA | Tumors
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9. Full Text A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells
by Malchenko, Sergey and Sredni, Simone Treiger and Hashimoto, Hitoshi and Kasai, Atsushi and Nagayasu, Kazuki and Xie, Jianping and Margaryan, Naira V and Seiriki, Kaoru and Lulla, Rishi R and Seftor, Richard E. B and Pachman, Lauren M and Meltzer, Herbert Y and Hendrix, Mary J. C and Soares, Marcelo B
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0121707 - e0121707
There is growing evidence and a consensus in the field that most pediatric brain tumors originate from stem cells, of which radial glial cells constitute a... 
EPITHELIAL-MESENCHYMAL TRANSITION | STEM-CELLS | ROLES | MULTIDISCIPLINARY SCIENCES | DIFFERENTIATION | MEDULLOBLASTOMA | EXPRESSION | CHROMOSOMAL INSTABILITY | Neuroglia - cytology | Animals | Humans | Cell Line, Tumor | Tumor Microenvironment | Cell Transplantation | Mice, Inbred NOD | Mice | Mice, SCID | Disease Models, Animal | Neuroectodermal Tumors, Primitive - pathology | Brain | Models | Brain tumors | Stem cells | Pediatrics | Transformation | Mesenchyme | Brain stem | Brain cancer | Central nervous system | Radial glial cells | Stem cell transplantation | Oncology | Ventricles (cerebral) | Transplantation | Biology | Glial cells | Drug screening | Subventricular zone | Angiogenesis | Toxicology | Alterations | Genetics | Pharmaceutical sciences | Medical research | Phenotypes | Nervous system diseases | Hematology | Invasiveness | Interdisciplinary aspects | Molecular chains | Endothelial cells | Medicine | Brain research | Cytogenetics | Hypoxia | Ventricle | Mutation | Laboratory animals | Tumors | Cancer | Index Medicus
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10. Full Text Transcriptional repressor REST drives lineage stage-specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma
by Dobson, Tara H W and Dobson, Tara H.W and Tao, Rong-Hua and Tao, Rong-Hua and Swaminathan, Jyothishmathi and Maegawa, Shinji and Shaik, Shavali and Bravo-Alegria, Javiera and Bravo-Alegria, Javiera and Sharma, Ajay and Kennis, Bridget and Yang, Yanwen and Callegari, Keri and Callegari, Keri and Haltom, Amanda R and Taylor, Pete and Taylor, Pete and Kogiso, Mari and Qi, Lin and Khatua, Soumen and Goldman, Stewart and Goldman, Stewart and Lulla, Rishi R and Fangusaro, Jason and Fangusaro, Jason and MacDonald, Tobey J and Li, Xiao-Nan and Li, Xiao-Nan and Hawkins, Cynthia and Hawkins, Cynthia and Rajaram, Veena and Rajaram, Veena and Gopalakrishnan, Vidya and Gopalakrishnan, Vidya
Science signaling, ISSN 1945-0877, 01/2019, Volume 12, Issue 565
In medulloblastomas (MBs), the expression and activity of RE1-silencing transcription factor (REST) is increased in tumors driven by the sonic hedgehog (SHH)... 
TARGET | REST/NRSF | REGULATOR | PROTEIN | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOLECULAR SUBGROUPS | PROLIFERATION | EXPRESSION | G9A | SONIC-HEDGEHOG | CELL BIOLOGY | Cell proliferation | Cerebellum | Brain | Brain tumors | AKT protein | Activation | Infants | Subgroups | Signal transduction | Rest | Rodents | Tumorigenesis | Children | Maturation | Therapeutic applications | Transgenic mice | Patients | Chromatin remodeling | Gene silencing | Signaling | Hedgehog protein | Medulloblastoma | Neural stem cells | Methylation | PTEN protein | Tumors | Apoptosis
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11. Full Text REST upregulates gremlin to modulate diffuse intrinsic pontine glioma vasculature
by Shaik, Shavali and Kennis, Bridget and Maegawa, Shinji and Schadler, Keri and Yanwen, Yang and Callegari, Keri and Lulla, Rishi R and Goldman, Stewart and Nazarian, Javad and Rajaram, Veena and Fangusaro, Jason and Gopalakrishnan, Vidya
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 4, pp. 5233 - 5250
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive glial tumor that occurs in children. The extremely poor median and 5-year survival in children... 
VEGFR2 | REST | Gremlin | DIPG | Vasculature | vasculature | PEDIATRIC GLIOMAS | BONE MORPHOGENETIC PROTEIN | ACTIVATING ACVR1 MUTATIONS | BRAIN-TUMORS | CELL BIOLOGY | GLIOBLASTOMA STEM-CELLS | gremlin | NEURONAL GENES | RESTRICTIVE SILENCER FACTOR | HIGH-GRADE GLIOMAS | ONCOGENIC PROPERTIES | ENDOTHELIAL GROWTH-FACTOR
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12. Full Text Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110 alpha inhibition
by Iqbal, A and Eckerdt, F and Bell, J and Nakano, I and Giles, FJ and Cheng, SY and Lulla, RR and Goldman, S and Platanias, LC
ONCOTARGET, ISSN 1949-2553, 05/2016, Volume 7, Issue 22, pp. 33192 - 33201
The PIM family of proteins encodes serine/threonine kinases with important roles in protein synthesis and cancer cell metabolism. In glioblastoma (GBM) cell... 
ACTIVATION | PIM kinase | PHOSPHORYLATION | mTOR signaling | MULTIFORME | MTOR | CELL BIOLOGY | glioblastoma | CANCER GENOMICS | PIK3CA GENE | SIGNALING PATHWAY | GROWTH | p110 alpha | REGULATORS | MUTATIONS | Class I Phosphatidylinositol 3-Kinases - metabolism | Neoplastic Stem Cells - drug effects | Humans | Brain Neoplasms - pathology | Proto-Oncogene Proteins c-pim-1 - metabolism | Pyridazines - pharmacology | Molecular Targeted Therapy | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Biphenyl Compounds - pharmacology | Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors | Glioma - pathology | Neoplastic Stem Cells - pathology | Thiazolidines - pharmacology | Brain Neoplasms - enzymology | Glioma - enzymology | Imidazoles - pharmacology | Brain Neoplasms - drug therapy | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Signal Transduction - drug effects | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Neoplastic Stem Cells - enzymology | Glioma - drug therapy
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