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Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 670 - 674
The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1 beta, IL-18 and high-mobility group box 1... 
PATHWAYS | APOPTOSIS | ACID | PROTEIN-KINASE PKR | MULTIDISCIPLINARY SCIENCES | INFECTION | NLRP3 INFLAMMASOME | ELF2-ALPHA | STRESS | BINDING | SUBSTRATE RECOGNITION | Crystallins - metabolism | Interleukin-6 - analysis | Phosphorylation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | eIF-2 Kinase - metabolism | Humans | Salmonella Infections - immunology | Male | Salmonella Infections - metabolism | HMGB1 Protein - secretion | Interleukin-1beta - blood | eIF-2 Kinase - deficiency | Adenosine Triphosphate - pharmacology | CARD Signaling Adaptor Proteins - metabolism | Transfection | Interleukin-6 - blood | Rotenone - pharmacology | Female | Membrane Proteins - metabolism | Escherichia coli - physiology | Macrophages, Peritoneal - drug effects | eIF-2 Kinase - genetics | Calcium-Binding Proteins - metabolism | Cell Line | Salmonella typhimurium - physiology | Interleukin-18 - blood | Salmonella typhimurium - immunology | Inflammasomes - agonists | Mice, Inbred C57BL | Peritonitis - metabolism | Cells, Cultured | Escherichia coli - immunology | Antigens, Bacterial - pharmacology | Escherichia coli Infections - metabolism | eIF-2 Kinase - antagonists & inhibitors | Apoptosis Regulatory Proteins - metabolism | Animals | Carrier Proteins - metabolism | Bacterial Toxins - pharmacology | Uric Acid - pharmacology | RNA, Double-Stranded - immunology | RNA, Double-Stranded - pharmacology | Escherichia coli Infections - immunology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | HMGB1 Protein - blood | Physiological aspects | Chromosomal proteins | Research | Cytokines | Aluminum | Health aspects | Proteins | E coli | Pathogenesis | Plasmids | Bone marrow | Bacteria | Kinases | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2014, Volume 111, Issue 8, pp. 3068 - 3073
Extracellular high-mobility group box (HMGB)1 mediates inflammation during sterile and infectious injury and contributes importantly to disease pathogenesis.... 
Cytokines | Secretion | Cell nucleus | Disulfides | Inflammation | Pharmacology | Gene expression regulation | Acetylation | Macrophages | Cytoplasm | Pathogen-associated molecular pattern | Therapy | Innate immunity | Cytokine | Damage-associated molecular pattern | cytokine | CELLS | STERILE INFLAMMATION | therapy | INFLAMMASOME ACTIVATION | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME | RECEPTOR 4 | innate immunity | IMMUNE-RESPONSES | damage-associated molecular pattern | GENE-EXPRESSION | MOBILITY GROUP BOX-1 | CYTOKINE RELEASE | PROTEIN HMGB1 | pathogen-associated molecular pattern | Immunohistochemistry | Enzyme-Linked Immunosorbent Assay | Active Transport, Cell Nucleus - physiology | Escherichia coli | Blotting, Western | Lipopolysaccharides | Janus Kinase 1 - metabolism | Tandem Mass Spectrometry | STAT1 Transcription Factor - metabolism | Animals | Cell Nucleus - metabolism | Analysis of Variance | Signal Transduction - drug effects | Interferon Type I - pharmacology | Active Transport, Cell Nucleus - drug effects | HMGB1 Protein - metabolism | Chromatography, Liquid | Benzimidazoles - pharmacology | Signal Transduction - physiology | Mice | Pyridones - pharmacology | Translocation (Genetics) | Interferon | Research | Properties | Protein kinases | Immunological research | Cellular biology | Pathogenesis | Mass spectrometry | Cells | Index Medicus | Biological Sciences
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2013, Volume 32, Issue 1, pp. 86 - 99
Infection of macrophages by bacterial pathogens can trigger Toll‐like receptor (TLR) activation as well as Nod‐like receptors (NLRs) leading to inflammasome... 
pyroptosis | Toll‐like receptor | HMGB1 | inflammasome | Nod‐like receptor C4 | Nod-like receptor C4 | Toll-like receptor | APOPTOSIS | CASPASE-1 | INFLAMMASOME ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NLRC4 INFLAMMASOME | NLRP3 INFLAMMASOME | CELL-DEATH | CELL BIOLOGY | III SECRETION APPARATUS | INFECTION | CYTOKINE RELEASE | Inflammasomes - metabolism | Calcium-Binding Proteins - agonists | Molecular Sequence Data | Caspase 1 - metabolism | Neuronal Apoptosis-Inhibitory Protein - immunology | Protein Isoforms - metabolism | Calcium-Binding Proteins - immunology | HMGB1 Protein - metabolism | Cell Death | Acetylation | Toll-Like Receptors - metabolism | Macrophages - immunology | Macrophages - microbiology | Neuronal Apoptosis-Inhibitory Protein - agonists | Calcium-Binding Proteins - metabolism | Macrophage Activation - physiology | Macrophages - physiology | Amino Acid Sequence | Cell Line | Apoptosis Regulatory Proteins - immunology | Gene Expression | HMGB1 Protein - analysis | Signal Transduction | Toll-Like Receptors - immunology | Neuronal Apoptosis-Inhibitory Protein - metabolism | Apoptosis Regulatory Proteins - metabolism | Host-Pathogen Interactions | Animals | Inflammasomes - immunology | Apoptosis Regulatory Proteins - agonists | Bacterial Proteins - metabolism | Mice | Apoptosis | Molecular biology | Immunology | Index Medicus | Klinisk medicin | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Infektionsmedicin | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal Article
Hepatology, ISSN 0270-9139, 11/2016, Volume 64, Issue 5, pp. 1699 - 1710
Journal Article
Diabetologia, ISSN 0012-186X, 5/2018, Volume 61, Issue 5, pp. 1112 - 1123
Journal Article
Molecular medicine (Cambridge, Mass.), ISSN 1076-1551, 2011, Volume 17, Issue 9-10, pp. 1039 - 1044
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2015, Volume 212, Issue 1, pp. 5 - 14
Journal Article
by Busse, William W and Bleecker, Eugene R and Bleecker, Eugene and FitzGerald, J Mark and Ferguson, Gary T and Ferguson, Gary and Barker, Peter and Sproule, Stephanie and Olsson, Richard F and Martin, James and Martin, Ubaldo J and Goldman, Mitchell and Yañez, Anahí and Fernández, Marcelo and Tolcachier, Alberto and Belloni, Juan and Taborda, Jorge and De Salvo, Maria and Maspero, Jorge and Victorio, Carlos and Navarta, Miguel Chirino and Grilli, Monica and Rodríguez, Pablo and Otaola, María and Cambursano, Víctor and Malamud, Patricia and Stok, Ana and Arce, German and Roza, Osiris and Scherbovsky, Fernando and Elias, Pedro and Saez, Maria Salazan and Peters, Matthew and Phillips, Martin and Upham, John and Gibson, Peter and Thien, Francis and Douglass, Jo and Thomas, Paul and Bardin, Philip and Sajkov, Dimitar and Hew, Mark and Langton, David and Pez, Andreia and Fritscher, Carlos and Hetzel, Jorge and Mattos, Waldo and Stelmach, Rafael and Antila, Martti and Fernandes, Ana Luisa and Metev, Hristo and Ivanov, Yavor and Bogdanova, Aneliya and Markova, Ana Dancheva and Peneva, Marinka and Veselinova, Rumyana and Petkova, Tatyana and Petrova, Vanushka and Petrova, Galina and Shopova, Elena and Ivanova, Yuliya and Yotsova, Rumyana and Kirkova, Ginka and Dachev, Svetoslav and Sotirova, Kostadinka and Stoyanova, Mariyana and Yakov, Oleg and Ilieva-Fartunova, Vanya and Lemiere, Catherine and Laviolette, Michel and Yang, William and Pek, Bonavuth and Killorn, William Patrick and Poirier, Claude and Chouinard, Guy and Melenka, Lyle and Leigh, Richard and Nair, Parameswaran and Dorscheid, Delbert and Pavie, Juana and Rosenblut, Andres and Cartagena, Claudia and Quilodran, Carlos and Muñoz, Silvia and Malkusova, Ivana and Veverka, Josef and Holub, Stanislav and Mares, Jaroslav and Kozel, Radovan and Kopecka, Daniela and Zindr, Vladimir and Cerva, Pavel and Chanez, Pascal and Bourdin, Arnaud and Devouassoux, Gilles and Taille, Camille and De Blay, Frédéric and Goupil, Francois and Leroyer, Christophe and Gourcerol, Delphine and ... and BORA Study Investigators and BORA study investigators
The Lancet Respiratory Medicine, ISSN 2213-2600, 01/2019, Volume 7, Issue 1, pp. 46 - 59
Benralizumab is an interleukin-5 receptor α-directed cytolytic monoclonal antibody that has been shown to safely reduce exacerbations and improve lung function... 
BIOMARKERS | ANTIBODY | RECEPTOR | SIROCCO | RESPIRATORY SYSTEM | CRITICAL CARE MEDICINE | Drug therapy | Research | Asthma | Life Sciences | Human health and pathology | Pulmonology and respiratory tract
Journal Article