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1. Full Text Cardiovascular disease genes come together
by Lusis, Aldons J
Atherosclerosis, ISSN 0021-9150, 2015, Volume 242, Issue 2, pp. 630 - 631
Cardiovascular | Gene-by-gene interactions | CAD GWAS loci | TGF beta 1 signaling | ASSOCIATION ANALYSIS | MISSING HERITABILITY | PERIPHERAL VASCULAR DISEASE | LOCI | EPISTASIS | CORONARY-ARTERY-DISEASE | Collagen Type IV - metabolism | Smad3 Protein - metabolism | Coronary Artery Disease - metabolism | Humans | Gene Expression Regulation | Cardiovascular diseases | Genes | Index Medicus
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2. Full Text A comparison between whole transcript and 3' RNA sequencing methods using Kapa and Lexogen library preparation methods
by Ma, FY and Fuqua, BK and Hasin, Y and Yukhtman, C and Vulpe, CD and Lusis, AJ and Pellegrini, M
BMC GENOMICS, ISSN 1471-2164, 01/2019, Volume 20, Issue 1, pp. 9 - 9
Background3' RNA sequencing provides an alternative to whole transcript analysis. However, we do not know a priori the relative advantage of each method. Thus,... 
Iron metabolism | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Traditional RNA-Seq | GENETICS & HEREDITY | IRON | Gene expression | 3' RNA-Seq | EXPRESSION | SEQ | RNA sequencing | Physiological aspects | Usage | Research | Brain | Transcription | Liver | Genes | Genomics | Iron | Genomes | Metabolism | Gene sequencing | Diet | Ribonucleic acids | Reproducibility | Bioinformatics | Methods | Index Medicus | 3’ RNA-Seq
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3. Full Text Systems-based approaches for investigation of inter-tissue communication[S]
by Seldin, MM and Lusis, AJ
JOURNAL OF LIPID RESEARCH, ISSN 0022-2275, 03/2019, Volume 60, Issue 3, pp. 450 - 455
Secreted proteins serve as crucial mediators of many physiology processes, and beginning with the discovery of insulin, studies have revealed numerous... 
CELLS | hormones | BIOCHEMISTRY & MOLECULAR BIOLOGY | MULTIMERIZATION | MICRORNAS | receptors/hormone | genetics | PLASMA | SECRETOME | ADIPONECTIN | GENE-EXPRESSION | cytokines | TISSUES | PROTEINS | diabetes | receptors | JLR s | hormone
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4. Full Text Abstract 10726: Host Genotype and Diet Shaped Microbiome Modulate Atherogenesis in Mice
by Kasahara, Kazuyuki and Zhang, Qijun and Traeger, Lindsay L and Vivas, Eugenio I and Lusis, Aldons J and Rey, Federico E
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A10726 - A10726
Genetic variation drives phenotypic diversity and determines predisposition to cardiovascular disease. Previous work revealed a large degree of variation on... 
Microbiota (Symbiotic organisms) | Atherosclerosis | Physiological aspects | Genotype | Genetic aspects | Research | Gene expression
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5. Full Text Abstract 372: Master Transcriptional Regulators of Cardiac Gene Expression in Heart Failure
by Rau, Christoph D and Wang, Jessica and Ohearn, James and Avetisyan, Rozeta and Lusis, Aldons J and Wang, Yibin
Circulation Research, ISSN 0009-7330, 08/2018, Volume 123, Issue Suppl_1
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6. Full Text Sex differences in metabolism and cardiometabolic disorders
by Chella Krishnan, Karthickeyan and Mehrabian, Margarete and Lusis, Aldons J
Current opinion in lipidology, ISSN 0957-9672, 10/2018, Volume 29, Issue 5, pp. 404 - 410
Purpose of review Sex differences are pervasive in metabolic and cardiovascular traits, yet they have often been ignored in human and animal model research.... 
mouse models | UNITED-STATES | SKELETAL-MUSCLE MASS | RISK-FACTORS | mitochondria | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMPAIRED GLUCOSE-TOLERANCE | sex chromosomes | BODY-FAT | INSULIN-RESISTANCE | ESTROGEN-RECEPTOR-ALPHA | DEFICIENT ARKO MICE | ENDOCRINOLOGY & METABOLISM | PERIPHERAL VASCULAR DISEASE | genetic interactions | gonadal hormones | ADIPOSE-TISSUE | Sex chromosomes | Care and treatment | Metabolic diseases | Development and progression | Genetic aspects | Gene expression | Health aspects
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7. Full Text A comparison between whole transcript and 3' RNA sequencing methods using Kapa and Lexogen library preparation methods 06 Biological Sciences 0604 Genetics
by Ma, Feiyang and Fuqua, Brie K and Hasin, Yehudit and Yukhtman, Clara and Vulpe, Chris D and Lusis, Aldons J and Pellegrini, Matteo
BMC Genomics, 01/2019, Volume 20, Issue 1
Iron metabolism | Gene expression | 3' RNA-Seq | Traditional RNA-Seq
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8. Full Text Abstract 18760: Interactions Between Dietary Fiber and Gut Microbiota Modulate the Development of Atherosclerosis
by Kasahara, Kazuyuki and Kerby, Robert L and Romano, Kymberleigh A and Vivas, Eugenio I and Mehrabian, Margarete and Lusis, Aldons J and Rey, Federico E
Circulation, ISSN 0009-7322, 11/2016, Volume 134, Issue Suppl_1 Suppl 1, pp. A18760 - A18760
Diets rich in plant polysaccharides (i.e., fiber) confer protection against cardiovascular disease (CVD). Some of these benefits are derived from the... 
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9. Full Text The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002)
by Shaposhnik, Zory and Wang, Xuping and Trias, Joaquim and Fraser, Heather and Lusis, Aldons J
Journal of Lipid Research, ISSN 0022-2275, 03/2009, Volume 50, Issue 4, pp. 623 - 629
Secretory phospholipase A2 (sPLA2) activity promotes foam cell formation, increases proinflammatory bioactive lipid levels, decreases HDL levels, increases... 
Drugs | Lipoproteins | Secretory phospholipase A2 | Varespladib | Aryldialkylphosphatase - blood | Prodrugs - administration & dosage | Atherosclerosis - pathology | Apolipoproteins E - deficiency | Mice, Inbred C57BL | Male | Indoles - administration & dosage | Mice, Knockout | Atherosclerosis - blood | Drug Synergism | Enzyme Inhibitors - administration & dosage | Animals | Acetates - administration & dosage | Pravastatin - administration & dosage | Phospholipases A2, Secretory - antagonists & inhibitors | Apolipoproteins E - genetics | Lipids - blood | Mice | Atherosclerosis - prevention & control | Index Medicus
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10. Full Text Abstract 18346: Transcriptional Characterization of Glo1 Knockdown and Transgenic Mouse Models Implies a Role in Cardiometabolic Diseases
by Shu, Le and Davis, Richard C and Wu, Xiuju and Lusis, Aldons J and Palmer, Abraham A and Yang, Xia
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue Suppl_3 Suppl 3, pp. A18346 - A18346
Accumulation of advanced glycation end-products (AGEs) has been associated with atherosclerosis and diabetes. As the major detoxifying enzyme for AGE... 
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11. Full Text Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems
by Shu, Le and Zhao, Yuqi and Kurt, Zeyneb and Byars, Sean Geoffrey and Tukiainen, Taru and Kettunen, Johannes and Orozco, Luz D and Pellegrini, Matteo and Lusis, Aldons J and Ripatti, Samuli and Zhang, Bin and Inouye, Michael and Mäkinen, Ville-Petteri and Yang, Xia
BMC genomics, 11/2016, Volume 17, Issue 1, p. 874
Complex diseases are characterized by multiple subtle perturbations to biological processes. New omics platforms can detect these perturbations, but... 
Computational Biology - methods | Genome-Wide Association Study | Reproducibility of Results | Animals | Disease Susceptibility | Humans | Biomarkers | Databases, Genetic | Glucose - metabolism | Polymorphism, Single Nucleotide | Software | Web Browser
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12. Full Text Perspective future of osteoporosis genetics: Enhancing genome-wide association studies
by Farber, Charles R and Lusis, Aldons J
Journal of Bone and Mineral Research, ISSN 0884-0431, 12/2009, Volume 24, Issue 12, pp. 1937 - 1942
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13. Full Text Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis
by Wang, Zeneng and Roberts, Adam B and Buffa, Jennifer A and Levison, Bruce S and Zhu, Weifei and Org, Elin and Gu, Xiaodong and Huang, Ying and Zamanian-Daryoush, Maryam and Culley, Miranda K and DiDonato, Anthony J and DiDonato, Joseph A and Fu, Xiaoming and Hazen, Stanley L and Hazen, Jennie E and Krajcik, Daniel and Lusis, Aldons J
Cell, ISSN 0092-8674, 12/2015, Volume 163, Issue 7, pp. 1585 - 1595
Trimethylamine (TMA) N-oxide (TMAO), a gut-microbiota-dependent metabolite, both enhances atherosclerosis in animal models and is associated with... 
N-OXIDE | METABOLISM | INTESTINAL MICROBIOTA | CHOLINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | BETAINE | DEGRADATION | PHOSPHATIDYLCHOLINE | CONTAINING MONOOXYGENASE 3 | PROGNOSTIC VALUE | CELL BIOLOGY | Choline - metabolism | Hexanols - administration & dosage | Atherosclerosis - drug therapy | Humans | Mice, Inbred C57BL | Gastrointestinal Tract - microbiology | Cholesterol - metabolism | Lyases - metabolism | Atherosclerosis - metabolism | Microbiota | Animals | Feces - chemistry | Diet | Apolipoproteins E - genetics | Choline - analogs & derivatives | Mice | Lyases - antagonists & inhibitors | Foam Cells - metabolism | Methylamines - metabolism | Medical colleges | Metabolites | Microbiota (Symbiotic organisms) | Analysis | Choline | Atherosclerosis | Levocarnitine | Drug therapy | Apolipoproteins | Cardiovascular agents | Medical research | Enzymes | Medicine, Experimental | Cardiology | Index Medicus
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14. Full Text Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
by Koeth, Robert A and Wang, Zeneng and Levison, Bruce S and Buffa, Jennifer A and Org, Elin and Sheehy, Brendan T and Britt, Earl B and Fu, Xiaoming and Wu, Yuping and Li, Lin and Smith, Jonathan D and Didonato, Joseph A and Chen, Jun and Li, Hongzhe and Wu, Gary D and Lewis, James D and Warrier, Manya and Brown, J Mark and Krauss, Ronald M and Tang, W.H. Wilson and Bushman, Frederic D and Lusis, Aldons J and Hazen, Stanley L
Nature Medicine, ISSN 1078-8956, 05/2013, Volume 19, Issue 5, pp. 576 - 585
Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (MA), which is further metabolized to a proatherogenic species,... 
MEDICINE, RESEARCH & EXPERIMENTAL | BILE-ACID | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | DIET | REVERSE CHOLESTEROL TRANSPORT | GUT MICROBIOME | CARDIOVASCULAR-DISEASE | MICE | CORONARY-HEART-DISEASE | RECEPTORS | EXPRESSION | Atherosclerosis - physiopathology | Humans | Methylamines - blood | Carnitine - chemistry | Carnitine - metabolism | Cholesterol - metabolism | Choline - chemistry | Desmosterol - metabolism | Meat | Mice, Knockout | Atherosclerosis - etiology | Macrophages - metabolism | Animals | Intestines - microbiology | Time Factors | Mass Spectrometry | Female | Atherosclerosis - microbiology | Mice | Metagenome | Methylamines - metabolism | RNA - metabolism | Physiological aspects | Levocarnitine | Genetic aspects | Research | Microbiota (Symbiotic organisms) | Microbial metabolism | Biomedical research | Diet | Risk factors | Atherosclerosis | Index Medicus
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15. Full Text Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation
by Bennett, Brian J and Vallim, Thomas Q. de Aguiar and Wang, Zeneng and Shih, Diana M and Meng, Yonghong and Gregory, Jill and Allayee, Hooman and Lee, Richard and Graham, Mark and Crooke, Rosanne and Edwards, Peter A and Hazen, Stanley L and Lusis, Aldons J
Cell Metabolism, ISSN 1550-4131, 01/2013, Volume 17, Issue 1, pp. 49 - 60
Circulating trimethylamine-N-oxide (TMAO) levels are strongly associated with atherosclerosis. We now examine genetic, dietary, and hormonal factors regulating... 
FXR | ACTIVATION | CONTAINING MONOOXYGENASE ACTIVITY | POLYMORPHISMS | LIVER | ENDOCRINOLOGY & METABOLISM | GUT MICROBIOTA | REVEALS | CELL BIOLOGY | Choline - metabolism | Atherosclerosis - genetics | Humans | Male | Oxygenases - metabolism | Base Sequence | HEK293 Cells | Female | Methylamines - metabolism | Atherosclerosis - pathology | Gene Silencing | Methylamines - blood | Receptors, Cytoplasmic and Nuclear - genetics | Down-Regulation - drug effects | Bile Acids and Salts | Atherosclerosis - metabolism | Mice, Knockout | Animals | Androgens - pharmacology | Diet | Sex Factors | Mice | Polymorphism, Single Nucleotide | Oxygenases - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Bile acids | Metabolites | Molecular genetics | Analysis | Choline | Atherosclerosis | Exhibitions | Genetic aspects | Medicine, Preventive | Preventive health services | Index Medicus
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16. Full Text Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort
by Org, Elin and Blum, Yuna and Kasela, Silva and Mehrabian, Margarete and Kuusisto, Johanna and Kangas, Antti J and Soininen, Pasi and Wang, Zeneng and Ala-Korpela, Mika and Hazen, Stanley L and Laakso, Markku and Lusis, Aldons J
Genome Biology, ISSN 1474-7596, 04/2017, Volume 18, Issue 1, pp. 70 - 70
Background: The gut microbiome is a complex and metabolically active community that directly influences host phenotypes. In this study, we profile gut... 
TMAO | Type 2 diabetes | Host-microbiota interactions | Serum metabolites | Metabolic traits | HIGH-FAT | POPULATION | ENTEROTYPES | RISK | INSULIN SENSITIVITY | L-CARNITINE | DIET | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | DIVERSITY | PHOSPHATIDYLCHOLINE | REVEALS | Body Mass Index | Amino Acids - blood | Bacteria - metabolism | Glucose Tolerance Test | Microbiota - physiology | Diabetes Mellitus, Type 2 - microbiology | Humans | Middle Aged | Gastrointestinal Microbiome | Male | Metabolic Syndrome - blood | Diabetes Mellitus, Type 2 - blood | Phenotype | Metabolic Syndrome - microbiology | Lipids - blood | Bacteria - classification | Aged | Methylamines | Fatty Acids - blood | Blood Glucose - metabolism | Cohort Studies | rRNA 16S | Taxonomy | Microbiomes | Glucose | Metabolic syndrome | Body mass index | Microbiota | Metabolites | Population | Physiology | Blood pressure | Lipid metabolism | Bioinformatics | Heart diseases | Community structure | Phenotypes | Fasting | Diabetes mellitus | Coronary artery | Fatty acids | Multiculturalism & pluralism | Serum levels | Studies | Glucose tolerance | Trimethylamine | Insulin resistance | Metabolic disorders | Index Medicus
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17. Full Text Individual diet has sex-dependent effects on vertebrate gut microbiota
by Bolnick, Daniel I and Snowberg, Lisa K and Hirsch, Philipp E and Lauber, Christian L and Org, Elin and Parks, Brian and Lusis, Aldons J and Knight, Rob and Caporaso, J. Gregory and Svanbäck, Richard and Teknisk-naturvetenskapliga vetenskapsområdet and Biologiska sektionen and Uppsala universitet and Institutionen för ekologi och genetik and Limnologi
Nature Communications, ISSN 2041-1723, 07/2014, Volume 5, Issue 1, pp. 4500 - 4500
Vertebrates harbour diverse communities of symbiotic gut microbes. Host diet is known to alter microbiota composition, implying that dietary treatments might... 
STABLE-ISOTOPES | POPULATION | TROPHIC POSITION | MULTIDISCIPLINARY SCIENCES | HABITAT | ECOLOGY | DIVERSITY | THREESPINE STICKLEBACK | COMMUNITIES | SPECIALIZATION | EURASIAN PERCH | Mice - microbiology | Dysbiosis - drug therapy | Species Specificity | Humans | Gastrointestinal Tract - microbiology | Molecular Sequence Data | Male | DNA Primers - genetics | Dysbiosis - microbiology | Sequence Analysis, DNA | Smegmamorpha - microbiology | Microbiota | Phenotype | Animals | Analysis of Variance | Diet | Base Sequence | Sex Factors | RNA, Ribosomal, 16S - genetics | Female | Perches - microbiology | Index Medicus | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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