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dna methylation (87) 87
animals (76) 76
index medicus (74) 74
humans (66) 66
methylation (62) 62
biochemistry & molecular biology (39) 39
cancer (35) 35
dna (33) 33
dna-methyltransferases - metabolism (29) 29
cell biology (27) 27
research (27) 27
dna-methyltransferases - genetics (26) 26
epigenetics (26) 26
mice (26) 26
epigenesis, genetic (25) 25
genetics & heredity (23) 23
methyltransferases (21) 21
expression (20) 20
gene expression (20) 20
oncology (20) 20
drosophila (19) 19
female (19) 19
epigenetic inheritance (18) 18
male (18) 18
5-methylcytosine (17) 17
biology (17) 17
genome (17) 17
deoxyribonucleic acid--dna (16) 16
genes (16) 16
cells (15) 15
dna methylation - drug effects (15) 15
dnmt2 (15) 15
genetics (15) 15
genetic aspects (14) 14
trna (14) 14
chromatin (13) 13
developmental biology (13) 13
differentiation (13) 13
dna-methyltransferases - antagonists & inhibitors (13) 13
enzymes (13) 13
gene (13) 13
genomics (13) 13
proteins (13) 13
azacitidine - analogs & derivatives (12) 12
deoxyribonucleic acid (12) 12
embryonic stem-cells (12) 12
enzyme inhibitors - pharmacology (12) 12
multidisciplinary sciences (12) 12
cell line, tumor (11) 11
cpg islands (11) 11
dna methyltransferase (11) 11
dna-methyltransferase 1 (11) 11
drosophila melanogaster - genetics (11) 11
genomes (11) 11
neoplasms - genetics (11) 11
analysis (10) 10
azacitidine - pharmacology (10) 10
cell differentiation (10) 10
gene-expression (10) 10
insects (10) 10
molecular sequence data (10) 10
physiological aspects (10) 10
protein (10) 10
rna (10) 10
article (9) 9
blasting (9) 9
chemistry (9) 9
cytosine - metabolism (9) 9
dna methylation - genetics (9) 9
drosophila proteins - metabolism (9) 9
engine plants in general (9) 9
genetic research (9) 9
heating (9) 9
hypermethylation (9) 9
lighting (9) 9
machines or engines in general (9) 9
mechanical engineering (9) 9
mutation (9) 9
myelodysplastic syndrome (9) 9
non-positive displacement machines or engines, e.g. steamturbines (9) 9
steam engines (9) 9
testing (9) 9
transfer rna (9) 9
weapons (9) 9
5-aza-2'-deoxycytidine (8) 8
animals, genetically modified (8) 8
biotechnology & applied microbiology (8) 8
drosophila - genetics (8) 8
gene silencing (8) 8
health aspects (8) 8
human necessities (8) 8
identification (8) 8
measuring (8) 8
metallurgy (8) 8
mice, knockout (8) 8
molecular biology (8) 8
neoplasms - drug therapy (8) 8
organic chemistry (8) 8
phenotype (8) 8
physics (8) 8
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1. Full Text The DNA methyltransferase family: A versatile toolkit for epigenetic regulation
by Lyko, Frank
Nature Reviews Genetics, ISSN 1471-0056, 02/2018, Volume 19, Issue 2, pp. 81 - 92
The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying enzymes that have a central role in epigenetic gene regulation. Recent... 
TRANSCRIPTION FACTORS | SEQUENCE SPECIFICITY | ICF SYNDROME | EMBRYONIC STEM-CELLS | CANCER EPIGENOME | GENETICS & HEREDITY | MALE GERM-CELLS | GENOME-WIDE | DE-NOVO METHYLATION | CYTOSINE METHYLATION | ENHANCER ACTIVITY | Epigenetic inheritance | Methyltransferases | DNA | Genetic research | Genetic transcription | Methylation | Transfer RNA | Enzymes | Post-transcription | tRNA | Gene regulation | Molecular interactions | DNMT1 protein | Gene expression | Gene silencing | Transcription activation | DNA methylation | Epigenetics | DNA methyltransferase | Deoxyribonucleic acid--DNA
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2. Full Text The marbled crayfish (Decapoda: Cambaridae) represents an independent new species
by Lyko, Frank
Zootaxa, ISSN 1175-5326, 12/2017, Volume 4363, Issue 4, pp. 544 - 552
Marbled crayfish are a globally expanding population of parthenogenetically reproducing freshwater decapods. They are closely related to the sexually... 
Parthenogenesis | Annulus ventralis | Mitochondrial DNA | Genetic analysis | mitochondrial DNA | annulus ventralis | PROCAMBARUS-FALLAX HAGEN | EUROPE | parthenogenesis | MADAGASCAR | ORIGIN | genetic analysis | F VIRGINALIS | ZOOLOGY | PARTHENOGENETIC CRAYFISH | ASTACIDA | MARMORKREBS DECAPODA | LIFE
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3. Full Text Whole-genome bisulfite sequencing for the methylation analysis of insect genomes
by Gatzmann, Fanny and Lyko, Frank
Methods in Molecular Biology, ISSN 1064-3745, 2019, Volume 1858, pp. 141 - 156
DNA methylation is a conserved epigenetic modification of animal genomes, but genome methylation patterns appear surprisingly diverse in insects. Whole-genome... 
Whole-genome bisulfite sequencing | Epigenetics | WGBS | DNA methylation detection | Computational Biology - methods | DNA Methylation | Animals | Epigenesis, Genetic | Software | Genome, Insect | Whole Genome Sequencing - methods | High-Throughput Nucleotide Sequencing - methods | Insecta - genetics | Sequence Analysis, DNA - methods | Sulfites - chemistry
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4. Full Text Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
by Stresemann, Carlo and Lyko, Frank
International Journal of Cancer, ISSN 0020-7136, 07/2008, Volume 123, Issue 1, pp. 8 - 13
The cytosine analogues 5‐azacytosine (azacytidine) and 2′‐deoxy‐5‐azacytidine (decitabine) are the currently most advanced drugs for epigenetic cancer... 
DNA methylation | DNA methyltransferase | cancer | azacytidine | decitabine | Azacytidine | Decitabine | Cancer | CYTOSINE-ARABINOSIDE | ACUTE MYELOID-LEUKEMIA | MYELODYSPLASTIC SYNDROME | CYTIDINE DEAMINASE | EPIGENETIC THERAPY | IN-VITRO | DEOXYCYTIDINE KINASE | ONCOLOGY | EQUILIBRATIVE NUCLEOSIDE TRANSPORTER-1 | CANCER-CELL LINES | CHRONIC LYMPHOCYTIC-LEUKEMIA | Azacitidine - pharmacokinetics | Antimetabolites, Antineoplastic - pharmacokinetics | DNA Modification Methylases - metabolism | DNA Modification Methylases - antagonists & inhibitors | Humans | Enzyme Inhibitors - pharmacology | Neoplasms - enzymology | Azacitidine - analogs & derivatives | Enzyme Activation - drug effects | Neoplasms - drug therapy | Azacitidine - pharmacology | Animals | Neoplasms - genetics | Antimetabolites, Antineoplastic - pharmacology | Epigenesis, Genetic - drug effects | DNA Methylation - drug effects | Index Medicus
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5. Full Text Ein Krebs fur die Krebsforschung
by Lyko, Frank
Biologie in unserer Zeit, ISSN 0045-205X, 06/2017, Volume 47, Issue 3, p. 172
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6. Full Text The honey bee epigenomes: Differential methylation of brain DNA in queens and workers
by Lyko, Frank and Foret, Sylvain and Kucharski, Robert and Wolf, Stephan and Falckenhayn, Cassandra and Maleszka, Ryszard
PLoS Biology, ISSN 1544-9173, 11/2010, Volume 8, Issue 11, p. e1000506
In honey bees (Apis mellifera) the behaviorally and reproductively distinct queen and worker female castes derive from the same genome as a result of... 
GENE-EXPRESSION | CPG METHYLATION | MICROARRAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DROSOPHILA | BIOLOGY | Brain - metabolism | DNA Methylation | RNA Splicing | Animals | Epigenesis, Genetic | CpG Islands | Female | Male | Bees - genetics | Genome | Alternative splicing | DNA methylation | Genetics | Deoxyribonucleic acid | DNA | Bees
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7. Full Text Solving the Dnmt2 enigma
by Schaefer, Matthias and Schaefer, Matthias and Lyko, Frank and Lyko, Frank
Chromosoma, ISSN 0009-5915, 2/2010, Volume 119, Issue 1, pp. 35 - 40
Dnmt2 is a member of the animal DNA methyltransferase family of enzymes. While the role of other Dnmt proteins has been extensively characterized, comparably... 
Life Sciences | Human Genetics | Biochemistry, general | Developmental Biology | Eukaryotic Microbiology | Animal Genetics and Genomics | Cell Biology | FISSION YEAST | METHYLATION | NUCLEAR-MATRIX | RNA | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | DNA METHYLTRANSFERASE EHMETH | HOMOLOG | TRNA(ASP) | ENTAMOEBA-HISTOLYTICA | DROSOPHILA | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA (Cytosine-5-)-Methyltransferases - genetics | DNA Methylation | Animals | Eukaryota - genetics | Eukaryota - classification | Humans | Phylogeny | Eukaryota - enzymology | Evolution, Molecular | Cell research | Methyltransferases | Oncology, Experimental | DNA | Research | Methylation | Cancer
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8. Full Text Insects as innovative models for functional studies of DNA methylation
by Lyko, Frank and Maleszka, Ryszard
Trends in Genetics, ISSN 0168-9525, 2011, Volume 27, Issue 4, pp. 127 - 131
The emerging field of epigenomics has the potential to bridge the gap between static genomic sequences and complex phenotypes that arise from multigenic,... 
Medical Education | SYSTEM | MEMORY | BEHAVIOR | SEQUENCE | GENETICS & HEREDITY | PLANTS | EPIGENOMICS | CPG | DROSOPHILA | REVEALS | PLASTICITY | DNA Methylation | Animals | Insecta - enzymology | Alternative Splicing | DNA Modification Methylases - metabolism | Epigenesis, Genetic | Humans | Models, Genetic | Insecta - genetics
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9. Full Text Ein Krebs für die Krebsforschung
by Lyko, Frank
Biologie in unserer Zeit, ISSN 0045-205X, 06/2017, Volume 47, Issue 3, pp. 172 - 177
Zusammenfassung Der Marmorkrebs ist ein seit Mitte der 1990er Jahre bekannter triploider Flusskrebs, der sich parthenogenetisch fortpflanzt. Er stammt von der... 
Marmorkrebs | Epigenetik | Tumorbiologie | klonale Evolution
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10. Full Text Ein Krebs für die Krebsforschung: Modellorganismus Marmorkrebs
by Lyko, Frank
Biologie in Unserer Zeit, ISSN 0045-205X, 06/2017, Volume 47, Issue 3, pp. 172 - 177
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11. Full Text Epigenetic Regulation by Heritable RNA
by Liebers, Reinhard and Rassoulzadegan, Minoo and Lyko, Frank
PLoS Genetics, ISSN 1553-7390, 2014, Volume 10, Issue 4, p. e1004296
Genomic concepts are based on the assumption that phenotypes arise from the expression of genetic variants. However, the presence of non-Mendelian inheritance... 
NON-MENDELIAN INHERITANCE | NONCODING RNA | ENDOGENOUS SIRNAS | METHYLTRANSFERASE | DNMT2 | DNA METHYLATION | 5-METHYLCYTOSINE | NSUN2 | STABILITY | GENETICS & HEREDITY | GENE-EXPRESSION | Animals | Gene Regulatory Networks - genetics | Epigenesis, Genetic - genetics | Humans | Heredity - genetics | RNA - genetics | RNA sequencing | Genetic research | Epigenetic inheritance | Research | Genetic regulation | Life Sciences | RNA | Epigenesis, Genetic | Heredity | Development Biology | Gene Regulatory Networks | Genotype & phenotype | Disease | Deoxyribonucleic acid | DNA | DNA methylation | Epigenetics | Genetic diversity | Mutation | Gene expression
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12. Full Text The importance of non-histone protein methylation in cancer therapy
by Rodriguez-Paredes, M and Lyko, F
NATURE REVIEWS MOLECULAR CELL BIOLOGY, ISSN 1471-0072, 10/2019, Volume 20, Issue 10, pp. 569 - 570
Epigenetic regulatory enzymes are generally considered innovative targets for cancer therapy and several histone methyltransferase inhibitors are currently... 
CELL BIOLOGY | Antimitotic agents | Epigenetic inheritance | Care and treatment | Histones | Product development | Forecasts and trends | Antineoplastic agents | Methylation | Health aspects | Testing | Cancer | Therapy | Medical innovations | Clinical trials | Histone methyltransferase | Cancer therapies | Substrates
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13. Full Text RNA cytosine methylation analysis by bisulfite sequencing
by Schaefer, Matthias and Pollex, Tim and Hanna, Katharina and Lyko, Frank
Nucleic Acids Research, ISSN 0305-1048, 2/2009, Volume 37, Issue 2, pp. e12 - e12
Covalent modifications of nucleic acids play an important role in regulating their functions. Among these modifications, (cytosine-5) DNA methylation is best... 
CELLS | DNMT2 | GENE | 5-METHYLCYTOSINE | GENOMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | TRNA(ASP) | RIBOSOMAL-RNA | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | RNA, Ribosomal, 16S - metabolism | 5-Methylcytosine - analysis | RNA, Transfer, Asp - chemistry | RNA, Transfer, Asp - metabolism | Cytosine - chemistry | RNA - chemistry | Drosophila melanogaster - genetics | Sulfites - chemistry | Sequence Analysis, RNA - methods | RNA, Ribosomal, 16S - chemistry | Animals | Cytosine - metabolism | Methylation | Methods Online
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14. Full Text DNA methyltransferase inhibitors and the development of epigenetic cancer therapies
by Lyko, Frank and Brown, Robert
Journal of the National Cancer Institute, ISSN 0027-8874, 10/2005, Volume 97, Issue 20, pp. 1498 - 1506
Epimutations, such as the hypermethylation and epigenetic silencing of tumor suppressor genes, play a role in the etiology of human cancers. In contrast to DNA... 
HUMAN TUMOR XENOGRAFTS | PHASE-II TRIALS | ONCOLOGY | 5-AZA-2'-DEOXYCYTIDINE DECITABINE | HYPOMETHYLATING AGENT | CPG ISLAND HYPERMETHYLATION | CELL-LINES | MYELODYSPLASTIC SYNDROME | HISTONE DEACETYLASE | GENOMIC DNA | CYTOSINE METHYLTRANSFERASE | Gene Silencing - drug effects | DNA Modification Methylases - antagonists & inhibitors | DNA, Neoplasm - metabolism | Humans | Clinical Trials as Topic | DNA, Neoplasm - drug effects | Genes, Tumor Suppressor - drug effects | Neoplasms - drug therapy | Animals | Neoplasms - genetics | Antimetabolites, Antineoplastic - pharmacology | Epigenesis, Genetic - drug effects | DNA Methylation - drug effects | Care and treatment | Gene mutations | DNA | Research | Health aspects | Oncogenes | Cancer
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15. Full Text Epigenetic cancer therapy: Proof of concept and remaining challenges
by Mund, Cora and Lyko, Frank
BioEssays, ISSN 0265-9247, 11/2010, Volume 32, Issue 11, pp. 949 - 957
Over the past few years several drugs that target epigenetic modifications have shown clinical benefits, thus seemingly validating epigenetic cancer therapy.... 
DNA methylation | cancer | histone modifications | drugs | epigenetics | Drugs | Epigenetics | Histone modifications | Cancer | BREAST-CARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR GENES | INTESTINAL NEOPLASIA | HISTONE-DEACETYLASE INHIBITORS | DNA METHYLTRANSFERASE INHIBITORS | DE-NOVO METHYLATION | EMBRYONIC STEM-CELLS | PROSTATE-CANCER | LYSINE-9 METHYLATION | BIOLOGY | CPG-ISLAND HYPERMETHYLATION | Neoplasms - metabolism | Histone-Lysine N-Methyltransferase - genetics | Histone Demethylases - antagonists & inhibitors | Histone Deacetylases - genetics | Epigenesis, Genetic | Humans | Histone Deacetylases - metabolism | Antineoplastic Agents - therapeutic use | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Molecular Targeted Therapy | Biomarkers, Tumor | Enzyme Inhibitors - therapeutic use | Histone Demethylases - genetics | Neoplasms - drug therapy | DNA (Cytosine-5-)-Methyltransferases - metabolism | Histone Demethylases - metabolism | DNA Methylation | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | Animals | Histone-Lysine N-Methyltransferase - metabolism | Neoplasms - genetics | Histone Deacetylase Inhibitors - therapeutic use | Histones - metabolism | Methylation | Epigenetic inheritance | Care and treatment | Analysis | DNA | Histones | Research | Chemical properties | Structure | Enzymes | Chromatin | Cancer therapies
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16. Full Text Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond
by Breiling, Achim and Lyko, Frank
Epigenetics and Chromatin, ISSN 1756-8935, 07/2015, Volume 8, Issue 1, p. 24
The chemical modification of DNA bases plays a key role in epigenetic gene regulation. While much attention has been focused on the classical epigenetic mark,... 
Modified DNA bases | Chromatin | Epigenetic marks | 5-Hydroxymethylcytosine | 5-Methylcytosine | Gene regulation | Inheritance | DNA methylation | N6-methyladenine | DNA demethylation | DNA modification | METHYLATION | MAMMALIAN DNA | TRANSCRIPTION | TET PROTEINS | START SITES | HEMATOPOIETIC STEM-CELLS | GENETICS & HEREDITY | GENOME-WIDE ANALYSIS | ENHANCER ACTIVITY | Epigenetic inheritance | Enzymes | DNA replication | Pyrimidines | Wildlife conservation | Genes | Genomics | DNA | Genomes | Genetic transcription | Methylation
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