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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 46, pp. 20087 - 20092
At present, there are few means to track symptomatic stages of CNS aging. Thus, although metabolic changes are implicated in mtDNA mutation-driven aging, the... 
Lactates | Brain | Cerebral cortex | Messenger RNA | Dehydrogenases | Neurons | Mitochondrial DNA | Premature aging | Mice | Hippocampus | Proton magnetic resonance spectroscopy | MtDNA mutator mouse | In situ hybridization | HPLC | COX/SDH enzyme histochemistry | OXIDATIVE-PHOSPHORYLATION | PROTEIN | MUTATOR MICE | MULTIDISCIPLINARY SCIENCES | MOUSE | proton magnetic resonance spectroscopy | POINT MUTATIONS | SKELETAL-MUSCLE | GLUCOSE | mtDNA mutator mouse | MITOCHONDRIAL-DNA DELETIONS | CEREBROSPINAL-FLUID LACTATE | in situ hybridization | AGE | L-Lactate Dehydrogenase - metabolism | Mitochondria - enzymology | Isoenzymes - genetics | Lactic Acid - metabolism | Brain - enzymology | Mitochondria - pathology | Mutation - genetics | Organ Specificity | Gene Expression Regulation, Enzymologic | Animals | DNA, Mitochondrial - genetics | L-Lactate Dehydrogenase - genetics | Isoenzymes - metabolism | Aging - metabolism | Aging | Lactate dehydrogenase | Nuclear magnetic resonance spectroscopy | Genetic aspects | Research | Properties | Methods | Enzymes | Transcription | Isoenzymes | Central nervous system | Pyruvic acid | High-performance liquid chromatography | Metabolism | L-Lactate dehydrogenase | Magnetic resonance spectroscopy | Mitochondria | Lactic acid | Electron transport | Spectrophotometry | Biological Sciences | SDH enzyme histochemistry | COX
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 01/2012, Volume 15, Issue 1, pp. 100 - 109
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2016, Volume 23, Issue 4, pp. 635 - 648
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2013, Volume 288, Issue 22, pp. 15510 - 15519
Journal Article
Journal Article
Current Protocols in Toxicology, ISSN 1934-9254, 08/2018, Volume 77, Issue 1, pp. e56 - e56
Mitochondria are multifunctional organelles with their own genome and protein synthesis machinery. The 13 proteins encoded by mitochondrial DNA (mtDNA) are... 
protein synthesis | OXPHOS complexes | proteostasis | mitochondria
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2013, Volume 17, Issue 4, pp. 618 - 626
Journal Article
The FEBS Journal, ISSN 1742-464X, 04/2008, Volume 275, Issue 7, pp. 1384 - 1391
Parkinson’s disease (PD), a common progressive neurodegenerative disorder, is characterized by degeneration of dopamine neurons in the substantia nigra and... 
intracellular aggregates | dopamine system | PARK genes | conditional knockout mice | DAT‐cre | Engrailed | mitochondrial dysfunction | MPTP | 6‐OHDA | α‐synuclein | progressive neurodegeneration
Journal Article
FEBS Journal, ISSN 1742-464X, 04/2008, Volume 275, Issue 7, pp. 1384 - 1391
Journal Article
Novartis Foundation Symposium, ISSN 1528-2511, 2007, Volume 287, pp. 197 - 208
Ageing is likely a multifactorial process caused by accumulated damage to a variety of cellular components. Increasing age in mammals correlates with increased... 
Mitochondrial Diseases - genetics | Animals | Reactive Oxygen Species - metabolism | Aging - genetics | Humans | Oxidative Stress - genetics | Mitochondria - pathology | Mutation - genetics
Conference Proceeding
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2007, Volume 104, Issue 4, p. 1325
  Mitochondrial dysfunction is implicated in the pathophysiology of Parkinson's disease (PD), a common age-associated neurodegenerative disease characterized... 
Neurons | Rodents | Parkinsons disease | Mitochondrial DNA | Cells
Journal Article